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Center for Computational Systems Medicine
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Protein Summary

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AS Summary

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Protein Functional Features

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Gene Isoform Structures and Expression Levels

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Protein Structures

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pLDDT Score Distribution

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Ramachandran Plot of Protein Structures

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Potential Active Site Information

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Protein Structure and Feature Comparision

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Protein-Protein Interaction

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Related Drugs

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Related Diseases

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Clinically Important Variants

Protein:CDK2

Protein Summary

check button Gene summary
Gene name: CDK2
ASpdb.0 ID: 1017
Gene
Gene symbol

CDK2

Gene ID

1017

Gene namecyclin dependent kinase 2
SynonymsCDKN2|p33(CDK2)
Cytomap

12q13.2

Type of geneprotein-coding
Descriptioncyclin-dependent kinase 2cdc2-related protein kinasecell division protein kinase 2p33 protein kinase
Modification date20240413
UniProtAcc

P24941


check button Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
GeneCDK2

GO:0000307

cyclin-dependent protein kinase holoenzyme complex

1312467|8692841

GeneCDK2

GO:0004674

protein serine/threonine kinase activity

11953320

GeneCDK2

GO:0004693

cyclin-dependent protein serine/threonine kinase activity

21596315|28216226

GeneCDK2

GO:0005634

nucleus

10767298

GeneCDK2

GO:0005654

nucleoplasm

8245034

GeneCDK2

GO:0005737

cytoplasm

10767298

GeneCDK2

GO:0005768

endosome

21262353

GeneCDK2

GO:0005813

centrosome

-

GeneCDK2

GO:0006468

protein phosphorylation

12944431|28666995

GeneCDK2

GO:0008284

positive regulation of cell population proliferation

10767298

GeneCDK2

GO:0015030

Cajal body

10995387

GeneCDK2

GO:0018105

peptidyl-serine phosphorylation

23184662

GeneCDK2

GO:0030332

cyclin binding

1653904|23781148

GeneCDK2

GO:0031453

positive regulation of heterochromatin formation

20935635

GeneCDK2

GO:0035173

histone kinase activity

8692841

GeneCDK2

GO:0043687

post-translational protein modification

11746698

GeneCDK2

GO:0097124

cyclin A2-CDK2 complex

1312467|8684460|8876165|11746698|15024385

GeneCDK2

GO:0097472

cyclin-dependent protein kinase activity

1312467|28666995



AS Summary

check button Information of the canonical protein with experimentally identified structure from PDB (2023).
UniProt AccFile namePDB IDMethodResolutionChainStartEnd
P24941-1P24941-1_6q4g_A.pdb6Q4GX-ray0.98A1298

check button ASpdb's canonical and alternatively spliced isoform information.
accession_idgene_namecanonical_idalternative_idcanonical_lengthalternative_lengthcanonical_startcanonical_endtypeoriginalSEQvariationSEQalternative_startalternative_end
P24941CDK2P24941-1P24941-2298264163196Deletionnonenone162162

check buttonMultiple sequence alignment of our canonical and alternatively spliced CDK2

check button Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of CDK2
UniProt-idENSGENSTENSP
P24941-1ENSG00000123374.11ENST00000266970.9ENSP00000266970.4
P24941-2ENSG00000123374.11ENST00000354056.4ENSP00000243067.4

UniProt-idNM IDNP ID
P24941-1NM_001798.4NP_001789.2
P24941-2NM_052827.3NP_439892.2

check buttonAmino acid sequences of our canonical and alternatively spliced CDK2
accession_idProtein sequence
P24941-1MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKF
MDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYD
P24941-2MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKF
MDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVTRRALFPGDSEIDQLFR

Protein Functional Features

check buttonMain function of this protein. (from UniProt)
CDK2 (go to UniProt):P24941

check buttonRetention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
Accession_idSubsectionStartEndFuncitonal featureSplicing information
P24941Domain4286Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159Type=Deletion;Start=163;End=196


Gene Isoform Structures and Expression Levels for CDK2

check buttonGene structures of our canonical and alternative spliced genes of CDK2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
gene isoform structure of CDK2

check button Expression levels of gene isoforms across GTEx.
gtex expression

check button Expression levels of gene isoforms across TCGA.
tcga expression


Protein Structures

check button PDB and CIF files of the predicted protein structures
* Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
3D view using mol* of P24941-1
3D view using mol* of P24941-2


pLDDT Score Distribution

check button pLDDT score distribution of the predicted protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
pLDDT distribution across the protein length of P24941-1
all structure
pLDDT distribution across the protein length of P24941-2
all structure


Ramachandran Plot of Protein Structures


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide.
Ramachandran plot of P24941-1
all structure
Ramachandran plot of P24941-2
all structure

Potential Active Site Information


check button The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite.
UniProt-idSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
P24941-11.014471.0431203.5870.5670.6870.8770.580.950.610.8038,10,11,12,13,14,15,16,18,20,31,33,34,35,36,37,38,
39,41,43,51,54,55,57,58,64,74,75,76,80,81,82,83,84
,85,86,88,89,93,121,122,123,124,126,127,128,129,13
0,131,132,134,144,145,146,147,148,149,150,151,152,
154,155,156,157,158,159,160,161,162,163,164,165,16
6,167,168,169,170,173,184,185,187,188,297,298
P24941-21.0595271.0971754.7880.5490.7390.940.9970.8791.1351.0018,10,11,12,13,14,15,16,18,20,31,33,51,54,55,57,58,
64,80,81,82,83,84,85,86,87,88,89,91,92,94,95,98,99
,101,104,107,108,111,112,115,116,119,121,123,124,1
25,126,127,128,129,130,131,132,133,134,141,143,144
,145,146,147,148,149,150,151,154,155,156,157,158,1
59,160,161,162,163,164,165,166,167,168,169,170,171
,173,174,177,217,218,219,220,221,225,228,229,232,2
40,241,242,243,244,246,251,264

Protein Structure and Feature Comparision


check button Protein Structure Comparision Using Template Modeling Scores (TM-score).
all structure

check button Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green)
3D view using mol* of P24941-1_P24941-1_6q4g_A.pdb

check button Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green)
3D view using mol* of P24941-1_6q4g_A_P24941-2.pdb

check button Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green)
3D view using mol* of P24941-1_P24941-2.pdb

check button Protein Feature Comparison of the protein sequendary structures among the protiens.
./stats/secondary_structure/figure/P24941-1_vs_P24941-2.png
all structure<

check button Protein Feature Comparison of the relative accessible surface area (ASA) among the protiens.
./stats/relative_asa/P24941-1_vs_P24941-2.png
all structure<


Protein-Protein Interaction


check button Interactors from UniProt.
Accession_idSubsectionStartEndFuncitonal featureSplicing information


check button Interactors from STRING.
Gene nameInteractors


Related Drugs to CDK2


check button Drugs targeting this gene/protein.
(DrugBank)
UniProt accessionGene nameDrugBank IDDrug nameDrug groupActions
P24941CDK2DB071635-[(2-AMINOETHYL)AMINO]-6-FLUORO-3-(1H-PYRROL-2-YL)BENZO[CD]INDOL-2(1H)-ONEexperimental
P24941CDK2DB08463(2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-olexperimental
P24941CDK2DB07751(2S)-1-[4-({6-[(2,6-Difluorophenyl)amino]-4-pyrimidinyl}amino)phenoxy]-3-(dimethylamino)-2-propanolexperimental
P24941CDK2DB07164N-cyclopropyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amineexperimental
P24941CDK2DB08218HYDROXY(OXO)(3-{[(2Z)-4-[3-(1H-1,2,4-TRIAZOL-1-YLMETHYL)PHENYL]PYRIMIDIN-2(5H)-YLIDENE]AMINO}PHENYL)AMMONIUMexperimental
P24941CDK2DB07731CAN-508experimental
P24941CDK2DB07750(2R)-1-[4-({4-[(2,5-Dichlorophenyl)amino]-2-pyrimidinyl}amino)phenoxy]-3-(dimethylamino)-2-propanolexperimental
P24941CDK2DB07431(3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-oneexperimental
P24941CDK2DB02538N-[4-(2-Methylimidazo[1,2-a]Pyridin-3-Yl)-2-Pyrimidinyl]Acetamideexperimental
P24941CDK2DB07755(2S)-1-[4-({4-[(2,5-Dichlorophenyl)amino]-2-pyrimidinyl}amino)phenoxy]-3-(dimethylamino)-2-propanolexperimental
P24941CDK2DB076066-(3,4-DIHYDROXYBENZYL)-3-ETHYL-1-(2,4,6-TRICHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4(5H)-ONEexperimental
P24941CDK2DB06983(5-phenyl-7-(pyridin-3-ylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl)methanolexperimental
P24941CDK2DB02833[4-(2-Amino-4-Methyl-Thiazol-5-Yl)-Pyrimidin-2-Yl]-(3-Nitro-Phenyl)-Amineexperimental
P24941CDK2DB045183-[4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamino]-Phenolexperimental
P24941CDK2DB076126-(3-AMINOPHENYL)-N-(TERT-BUTYL)-2-(TRIFLUOROMETHYL)QUINAZOLIN-4-AMINEexperimental
P24941CDK2DB044074-[4-(4-Methyl-2-Methylamino-Thiazol-5-Yl)-Pyrimidin-2-Ylamino]-Phenolexperimental
P24941CDK2DB081824-(4-propoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amineexperimental
P24941CDK2DB072036-CYCLOHEXYLMETHOXY-2-(3'-CHLOROANILINO) PURINEexperimental
P24941CDK2DB02950Hymenialdisineexperimentalinhibitor
P24941CDK2DB02898(5R)-5-{[(2-Amino-3H-purin-6-yl)oxy]methyl}-2-pyrrolidinoneexperimental
P24941CDK2DB02647N-(5-Cyclopropyl-1h-Pyrazol-3-Yl)Benzamideexperimental
P24941CDK2DB081784-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amineexperimental
P24941CDK2DB083551-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acidexperimental
P24941CDK2DB082414-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)--BENZAMIDEexperimental
P24941CDK2DB072103-bromo-5-phenyl-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amineexperimental
P24941CDK2DB070242-(3,4-DIHYDROXYPHENYL)-8-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-3-HYDROXY-6-METHYL-4H-CHROMEN-4-ONEexperimental
P24941CDK2DB082476-(CYCLOHEXYLMETHOXY)-8-ISOPROPYL-9H-PURIN-2-AMINEexperimental
P24941CDK2DB083093-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OLexperimental
P24941CDK2DB08285(2R)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-olexperimental
P24941CDK2DB082483-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)-BENZENESULFONAMIDEexperimental
P24941CDK2DB029154-(2,4-Dimethyl-1,3-thiazol-5-yl)-N-[4-(trifluoromethyl)phenyl]-2-pyrimidinamineexperimental
P24941CDK2DB083126-CYCLOHEXYLMETHYLOXY-5-NITROSO-PYRIMIDINE-2,4-DIAMINEexperimental
P24941CDK2DB042882-[Trans-(4-Aminocyclohexyl)Amino]-6-(Benzyl-Amino)-9-Cyclopentylpurineexperimental
P24941CDK2DB082336-CYCLOHEXYLMETHYLOXY-2-(4'-HYDROXYANILINO)PURINEexperimental
P24941CDK2DB07220N-[5-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-1H-INDAZOL-3-YL]-2-(4-PIPERIDIN-1-YLPHENYL)ACETAMIDEexperimental
P24941CDK2DB082194-Methyl-5-[(2Z)-2-{[4-(4-morpholinyl)phenyl]imino}-2,5-dihydro-4-pyrimidinyl]-1,3-thiazol-2-amineexperimental
P24941CDK2DB04669TRIAZOLOPYRIMIDINEexperimental
P24941CDK2DB04662OLOMOUCINE IIexperimental
P24941CDK2DB071793-((3-bromo-5-o-tolylpyrazolo[1,5-a]pyrimidin-7-ylamino)methyl)pyridine 1-oxideexperimental
P24941CDK2DB084416-BROMO-13-THIA-2,4,8,12,19-PENTAAZATRICYCLO[12.3.1.1~3,7~]NONADECA-1(18),3(19),4,6,14,16-HEXAENE 13,13-DIOXIDEexperimental
P24941CDK2DB026031-Amino-6-Cyclohex-3-Enylmethyloxypurineexperimental
P24941CDK2DB08066N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDEexperimental
P24941CDK2DB02733Purvalanolexperimental
P24941CDK2DB076182-(4-(AMINOMETHYL)PIPERIDIN-1-YL)-N-(3_CYCLOHEXYL-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)ACETAMIDEexperimental
P24941CDK2DB076221-(3-(2,4-DIMETHYLTHIAZOL-5-YL)-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)-3-(4-METHYLPIPERAZIN-1-YL)UREAexperimental
P24941CDK2DB04607PHENYLAMINOIMIDAZO(1,2-ALPHA)PYRIDINEexperimental
P24941CDK2DB076884-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDEexperimental
P24941CDK2DB076874-({5-[(4-AMINOCYCLOHEXYL)AMINO][1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)BENZENESULFONAMIDEexperimental
P24941CDK2DB076864-{[5-(CYCLOHEXYLAMINO)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDEexperimental
P24941CDK2DB02963(5-Chloropyrazolo[1,5-a]Pyrimidin-7-Yl)-(4-Methanesulfonylphenyl)Amineexperimental
P24941CDK2DB076854-{[5-(CYCLOHEXYLMETHOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDEexperimental
P24941CDK2DB029734-(5-Bromo-2-Oxo-2h-Indol-3-Ylazo)-Benzenesulfonamideexperimental
P24941CDK2DB074715-[5,6-BIS(METHYLOXY)-1H-BENZIMIDAZOL-1-YL]-3-{[1-(2-CHLOROPHENYL)ETHYL]OXY}-2-THIOPHENECARBOXAMIDEexperimental
P24941CDK2DB07137(2S)-N-[(3E)-5-Cyclopropyl-3H-pyrazol-3-ylidene]-2-[4-(2-oxo-1-imidazolidinyl)phenyl]propanamideexperimental
P24941CDK2DB04186N'-(Pyrrolidino[2,1-B]Isoindolin-4-On-8-Yl)-N-(Pyridin-2-Yl)Ureaexperimental
P24941CDK2DB075384-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}-2-(TRIFLUOROMETHYL)BENZENESULFONAMIDEexperimental
P24941CDK2DB07501(2S)-1-{4-[(4-Anilino-5-bromo-2-pyrimidinyl)amino]phenoxy}-3-(dimethylamino)-2-propanolexperimental
P24941CDK2DB081395-chloro-7-[(1-methylethyl)amino]pyrazolo[1,5-a]pyrimidine-3-carbonitrileexperimental
P24941CDK2DB081405-[(4-AMINOCYCLOHEXYL)AMINO]-7-(PROPAN-2-YLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILEexperimental
P24941CDK2DB08694Variolin Bexperimental
P24941CDK2DB03801Lysine Nz-Carboxylic Acidexperimental
P24941CDK2DB024076-O-Cyclohexylmethyl Guanineexperimental
P24941CDK2DB077914-{[4-(1-CYCLOPROPYL-2-METHYL-1H-IMIDAZOL-5-YL)PYRIMIDIN-2-YL]AMINO}-N-METHYLBENZENESULFONAMIDEexperimental
P24941CDK2DB018884-[5-(Trans-4-Aminocyclohexylamino)-3-Isopropylpyrazolo[1,5-a]Pyrimidin-7-Ylamino]-N,N-Dimethylbenzenesulfonamideexperimental
P24941CDK2DB08677N-(5-Isopropyl-thiazol-2-YL)-2-pyridin-3-YL-acetamideexperimental
P24941CDK2DB03428SU9516experimentalinhibitor
P24941CDK2DB086734-[(5-ISOPROPYL-1,3-THIAZOL-2-YL)AMINO]BENZENESULFONAMIDEexperimental
P24941CDK2DB08094RO-4584820investigational
P24941CDK2DB075344-{5-[(Z)-(2-Imino-4-Oxo-1,3-Thiazolidin-5-Ylidene)methyl]furan-2-Yl}benzenesulfonamideexperimental
P24941CDK2DB081414-{[(2,6-difluorophenyl)carbonyl]amino}-N-[(3S)-piperidin-3-yl]-1H-pyrazole-3-carboxamideexperimental
P24941CDK2DB033654-[3-Hydroxyanilino]-6,7-Dimethoxyquinazolineexperimental
P24941CDK2DB075334-{5-[(Z)-(2-Imino-4-Oxo-1,3-Thiazolidin-5-Ylidene)methyl]-2-Furyl}-N-Methylbenzenesulfonamideexperimental
P24941CDK2DB075314-{5-[(Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZENESULFONAMIDEexperimental
P24941CDK2DB07790N-(2-METHOXYETHYL)-4-({4-[2-METHYL-1-(1-METHYLETHYL)-1H-IMIDAZOL-5-YL]PYRIMIDIN-2-YL}AMINO)BENZENESULFONAMIDEexperimental
P24941CDK2DB07529(5E)-2-Amino-5-(2-pyridinylmethylene)-1,3-thiazol-4(5H)-oneexperimental
P24941CDK2DB08142AT-7519investigational
P24941CDK2DB02116Olomoucineexperimentalinhibitor
P24941CDK2DB079822-{4-[4-({4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)phenyl]piperazin-1-yl}-2-oxoethanolexperimental
P24941CDK2DB08122N-Methyl-4-{[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]amino}benzenesulfonamideexperimental
P24941CDK2DB075394-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZOIC ACIDexperimental
P24941CDK2DB08138{[(2,6-difluorophenyl)carbonyl]amino}-N-(4-fluorophenyl)-1H-pyrazole-3-carboxamideexperimental
P24941CDK2DB075404-{5-[(1Z)-1-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)ETHYL]-2-FURYL}BENZENESULFONAMIDEexperimental
P24941CDK2DB021974-[(4-Imidazo[1,2-a]Pyridin-3-Ylpyrimidin-2-Yl)Amino]Benzenesulfonamideexperimental
P24941CDK2DB07936N-(4-{[(3S)-3-(dimethylamino)pyrrolidin-1-yl]carbonyl}phenyl)-5-fluoro-4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]pyrimidin-2-amineexperimental
P24941CDK2DB034903-Pyridin-4-Yl-2,4-Dihydro-Indeno[1,2-.C.]Pyrazoleexperimental
P24941CDK2DB03583(2E,3S)-3-hydroxy-5'-[(4-hydroxypiperidin-1-yl)sulfonyl]-3-methyl-1,3-dihydro-2,3'-biindol-2'(1'H)-oneexperimental
P24941CDK2DB078521-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACIDexperimental
P24941CDK2DB068444-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)-AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDEexperimental
P24941CDK2DB15442Trilaciclibapproved, investigationalinhibitor
P24941CDK2DB07562N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N',N'-DIMETHYL-BENZENE-1,4-DIAMINEexperimental
P24941CDK2DB081325-hydroxynaphthalene-1-sulfonamideexperimental
P24941CDK2DB081263-{[4-([amino(imino)methyl]aminosulfonyl)anilino]methylene}-2-oxo-2,3-dihydro-1H-indoleexperimental
P24941CDK2DB036631-[(2-Amino-6,9-Dihydro-1h-Purin-6-Yl)Oxy]-3-Methyl-2-Butanolexperimental
P24941CDK2DB022972-Amino-6-Chloropyrazineexperimental
P24941CDK2DB08768N(6)-dimethylallyladenineexperimental
P24941CDK2DB08133N-(4-sulfamoylphenyl)-1H-indazole-3-carboxamideexperimental
P24941CDK2DB081344-[(6-chloropyrazin-2-yl)amino]benzenesulfonamideexperimental
P24941CDK2DB08135N-phenyl-1H-pyrazole-3-carboxamideexperimental
P24941CDK2DB081254-{[(2-Oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]amino}-N-(1,3-thiazol-2-yl)benzenesulfonamideexperimental
P24941CDK2DB081243-{[(2,2-dioxido-1,3-dihydro-2-benzothien-5-yl)amino]methylene}-5-(1,3-oxazol-5-yl)-1,3-dihydro-2H-indol-2-oneexperimental
P24941CDK2DB08123N-methyl-{4-[2-(7-oxo-6,7-dihydro-8H-[1,3]thiazolo[5,4-e]indol-8-ylidene)hydrazino]phenyl}methanesulfonamideexperimental
P24941CDK2DB081364-(acetylamino)-N-(4-fluorophenyl)-1H-pyrazole-3-carboxamideexperimental
P24941CDK2DB037374-((3r,4s,5r)-4-Amino-3,5-Dihydroxy-Hex-1-Ynyl)-5-Fluoro-3-[1-(3-Methoxy-1h-Pyrrol-2-Yl)-Meth-(Z)-Ylidene]-1,3-Dihydro-Indol-2-Oneexperimental
P24941CDK2DB08137(4E)-N-(4-fluorophenyl)-4-[(phenylcarbonyl)imino]-4H-pyrazole-3-carboxamideexperimental
P24941CDK2DB07126O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINEexperimental
P24941CDK2DB069482-ANILINO-6-CYCLOHEXYLMETHOXYPURINEexperimental
P24941CDK2DB06888(13R,15S)-13-METHYL-16-OXA-8,9,12,22,24-PENTAAZAHEXACYCLO[15.6.2.16,9.1,12,15.0,2,7.0,21,25]HEPTACOSA-1(24),2,4,6,17(25),18,20-HEPTAENE-23,26-DIONEexperimental
P24941CDK2DB03496Alvocidibexperimental, investigationalinhibitor
P24941CDK2DB030194-(2,5-Dichloro-Thiophen-3-Yl)-Pyrimidin-2-Ylamineexperimental
P24941CDK2DB085315-(2,3-dichlorophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amineexperimental
P24941CDK2DB07889(2S)-1-(Dimethylamino)-3-(4-{[4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-pyrimidinyl]amino}phenoxy)-2-propanolexperimental
P24941CDK2DB06195Seliciclibinvestigational
P24941CDK2DB07054(2R)-1-(DIMETHYLAMINO)-3-{4-[(6-{[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-4-YL)AMINO]PHENOXY}PROPAN-2-OLexperimental
P24941CDK2DB02052Indirubin-3'-monoximeexperimentalinhibitor
P24941CDK2DB07595(5Z)-5-(3-BROMOCYCLOHEXA-2,5-DIEN-1-YLIDENE)-N-(PYRIDIN-4-YLMETHYL)-1,5-DIHYDROPYRAZOLO[1,5-A]PYRIMIDIN-7-AMINEexperimental
P24941CDK2DB085326-(2-fluorophenyl)-N-(pyridin-3-ylmethyl)imidazo[1,2-a]pyrazin-8-amineexperimental
P24941CDK2DB08538N-((2-aminopyrimidin-5-yl)methyl)-5-(2,6-difluorophenyl)-3-ethylpyrazolo[1,5-a]pyrimidin-7-amineexperimental
P24941CDK2DB07504(2R)-1-{4-[(4-Anilino-5-bromo-2-pyrimidinyl)amino]phenoxy}-3-(dimethylamino)-2-propanolexperimental
P24941CDK2DB085373-bromo-6-phenyl-N-(pyrimidin-5-ylmethyl)imidazo[1,2-a]pyridin-8-amineexperimental
P24941CDK2DB085345-(2-fluorophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amineexperimental
P24941CDK2DB085353-bromo-5-phenyl-N-(pyridin-3-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amineexperimental
P24941CDK2DB04101N'-[4-(2,4-Dimethyl-1,3-thiazol-5-yl)-2-pyrimidinyl]-N-hydroxyimidoformamideexperimental
P24941CDK2DB085333-methyl-N-(pyridin-4-ylmethyl)imidazo[1,2-a]pyrazin-8-amineexperimental
P24941CDK2DB085393-cyclopropyl-5-phenyl-N-(pyridin-3-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amineexperimental
P24941CDK2DB085363-bromo-5-phenyl-N-(pyrimidin-5-ylmethyl)pyrazolo[1,5-a]pyridin-7-amineexperimental
P24941CDK2DB07761(2R)-1-[4-({6-[(2,6-Difluorophenyl)amino]-4-pyrimidinyl}amino)phenoxy]-3-(dimethylamino)-2-propanolexperimental
P24941CDK2DB020914-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamineexperimental
P24941CDK2DB085724-{[4-AMINO-6-(CYCLOHEXYLMETHOXY)-5-NITROSOPYRIMIDIN-2-YL]AMINO}BENZAMIDEexperimental
P24941CDK2DB06944N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(2-naphthyl)acetamideexperimental
P24941CDK2DB070655-(2,3-dichlorophenyl)-N-(pyridin-4-ylmethyl)-3-thiocyanatopyrazolo[1,5-a]pyrimidin-7-amineexperimental
P24941CDK2DB04006[2-Amino-6-(2,6-Difluoro-Benzoyl)-Imidazo[1,2-a]Pyridin-3-Yl]-Phenyl-Methanoneexperimental
P24941CDK2DB074935-Bromoindirubinexperimental
P24941CDK2DB085271-[4-(AMINOSULFONYL)PHENYL]-1,6-DIHYDROPYRAZOLO[3,4-E]INDAZOLE-3-CARBOXAMIDEexperimental
P24941CDK2DB033074-[(6-Amino-4-Pyrimidinyl)Amino]Benzenesulfonamideexperimental
P24941CDK2DB02010Staurosporineexperimental
P24941CDK2DB069761-(5-OXO-2,3,5,9B-TETRAHYDRO-1H-PYRROLO[2,1-A]ISOINDOL-9-YL)-3-(5-PYRROLIDIN-2-YL-1H-PYRAZOL-3-YL)-UREAexperimental

Related Diseases to CDK2


check button Previous studies relating to the alternative splicing of CDK2 and disease information from the MeSH term (PubMed)
GenePMIDTitleAbstractMeSH IDMeSH term


Clinically important variants in CDK2


check button (ClinVar, 04/20/2024)
accession_iduniprot_idgene_nameTypeVariantClinical_significance