Protein:CYP2D6 |
Protein Summary |
 Gene summary |
| Gene name: CYP2D6 | ASpdb.0 ID: 1565 | Gene | Gene symbol | CYP2D6 | Gene ID | 1565 |
| Gene name | cytochrome P450 family 2 subfamily D member 6 |
| Synonyms | CPD6|CYP2D|CYP2D7AP|CYP2D7BP|CYP2D7P2|CYP2D8P2|CYP2DL1|CYPIID6|P450-DB1|P450C2D|P450DB1 |
| Cytomap | 22q13.2 |
| Type of gene | protein-coding |
| Description | cytochrome P450 2D6cholesterol 25-hydroxylasecytochrome P450, family 2, subfamily D, polypeptide 6cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2cytochrome P450, sub |
| Modification date | 20240323 |
| UniProtAcc | P10635 |
| Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Gene | CYP2D6 | GO:0004497 | monooxygenase activity | 15327587|19651758 |
| Gene | CYP2D6 | GO:0005739 | mitochondrion | 19438707 |
| Gene | CYP2D6 | GO:0006805 | xenobiotic metabolic process | 19219744 |
| Gene | CYP2D6 | GO:0008210 | estrogen metabolic process | 12865317 |
| Gene | CYP2D6 | GO:0009804 | coumarin metabolic process | 19438707 |
| Gene | CYP2D6 | GO:0009820 | alkaloid metabolic process | 19651758 |
| Gene | CYP2D6 | GO:0009822 | alkaloid catabolic process | 15039299 |
| Gene | CYP2D6 | GO:0016098 | monoterpenoid metabolic process | 16401082 |
| Gene | CYP2D6 | GO:0016491 | oxidoreductase activity | 15039299|16401082|19219744 |
| Gene | CYP2D6 | GO:0020037 | heme binding | 16352597 |
| Gene | CYP2D6 | GO:0033076 | isoquinoline alkaloid metabolic process | 19448135 |
| Gene | CYP2D6 | GO:0042178 | xenobiotic catabolic process | 15039299 |
| Gene | CYP2D6 | GO:0042572 | retinol metabolic process | 10681376 |
| Gene | CYP2D6 | GO:0046483 | heterocycle metabolic process | 15327587|19651758 |
| Gene | CYP2D6 | GO:0051100 | negative regulation of binding | 19448135 |
| Gene | CYP2D6 | GO:0062187 | anandamide 8,9 epoxidase activity | 21289075 |
| Gene | CYP2D6 | GO:0062188 | anandamide 11,12 epoxidase activity | 21289075 |
| Gene | CYP2D6 | GO:0062189 | anandamide 14,15 epoxidase activity | 21289075 |
| Gene | CYP2D6 | GO:0070989 | oxidative demethylation | 15039299|19438707 |
| Gene | CYP2D6 | GO:0090350 | negative regulation of cellular organofluorine metabolic process | 19448135 |
AS Summary |
| Information of the canonical protein with experimentally identified structure from PDB (2023). |
| UniProt Acc | File name | PDB ID | Method | Resolution | Chain | Start | End |
| P10635-1 | P10635-1_3tbg_A.pdb | 3TBG | X-ray | 2.1 | A | 34 | 497 |
| ASpdb's canonical and alternatively spliced isoform information. |
| accession_id | gene_name | canonical_id | alternative_id | canonical_length | alternative_length | canonical_start | canonical_end | type | originalSEQ | variationSEQ | alternative_start | alternative_end |
| P10635 | CYP2D6 | P10635-1 | P10635-2 | 497 | 446 | 118 | 168 | Deletion | none | none | 117 | 117 |
| Multiple sequence alignment of our canonical and alternatively spliced CYP2D6 |
| Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of CYP2D6 |
| UniProt-id | ENSG | ENST | ENSP |
| P10635-1 | ENSG00000100197.23 | ENST00000645361.2 | ENSP00000496150.1 |
| P10635-2 | ENSG00000100197.23 | ENST00000359033.4 | ENSP00000351927.4 |
| UniProt-id | NM ID | NP ID |
| P10635-1 | NM_000106.5 | NP_000097.3 |
| P10635-2 | NM_001025161.2 | NP_001020332.2 |
| Amino acid sequences of our canonical and alternatively spliced CYP2D6 |
| accession_id | Protein sequence |
| P10635-1 | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRD LTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLAR |
| P10635-2 | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREA LVTHGEDTADRPPVPITQILGFGPRSQGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLL HIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK |
Protein Functional Features |
| Main function of this protein. (from UniProt) |
| CYP2D6 (go to UniProt):P10635 |
| Retention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Accession_id | Subsection | Start | End | Funcitonal feature | Splicing information |
Gene Isoform Structures and Expression Levels for CYP2D6 |
| Gene structures of our canonical and alternative spliced genes of CYP2D6 * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Expression levels of gene isoforms across GTEx. |
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| Expression levels of gene isoforms across TCGA. |
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Protein Structures |
| PDB and CIF files of the predicted protein structures * Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| 3D view using mol* of P10635-1 |
| 3D view using mol* of P10635-2 |
pLDDT Score Distribution |
| pLDDT score distribution of the predicted protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
| pLDDT distribution across the protein length of P10635-1 |
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| pLDDT distribution across the protein length of P10635-2 |
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Ramachandran Plot of Protein Structures |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide. |
| Ramachandran plot of P10635-1 |
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Potential Active Site Information |
| The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite. |
| UniProt-id | Site score | Size | D score | Volume | Exposure | Enclosure | Contact | Phobic | Philic | Balance | Don/Acc | Residues |
| P10635-1 | 1.217 | 360 | 1.259 | 549.486 | 0.247 | 0.938 | 1.23 | 2.514 | 0.749 | 3.356 | 1.124 | 101,107,110,112,117,118,119,120,121,122,128,132,18 6,189,209,212,213,216,221,241,244,247,248,297,298, 300,301,302,304,305,306,308,309,310,313,364,369,37 0,373,374,376,397,399,403,435,436,437,441,442,443, 444,445,448,449,452,453,483,484 |
| P10635-2 | 1.087 | 234 | 1.146 | 590.303 | 0.503 | 0.739 | 0.976 | 1.483 | 0.727 | 2.038 | 1.02 | 135,138,139,158,161,162,165,190,193,194,196,197,21 9,220,246,247,249,250,251,253,254,255,258,259,262, 313,318,319,322,323,324,325,346,348,384,385,386,39 0,391,392,393,394,397,398,401,402,432,433 |
Protein Structure and Feature Comparision |
| Protein Structure Comparision Using Template Modeling Scores (TM-score). |
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| Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green) |
| 3D view using mol* of P10635-1_P10635-1_3tbg_A.pdb |
| Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green) |
| 3D view using mol* of P10635-1_3tbg_A_P10635-2.pdb |
| Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green) |
| 3D view using mol* of P10635-1_P10635-2.pdb |
| Protein Feature Comparison of the protein sequendary structures among the protiens. |
| ./stats/secondary_structure/figure/P10635-1_vs_P10635-2.png |
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| Protein Feature Comparison of the relative accessible surface area (ASA) among the protiens. |
| ./stats/relative_asa/P10635-1_vs_P10635-2.png |
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Protein-Protein Interaction |
| Interactors from UniProt. |
| Accession_id | Subsection | Start | End | Funcitonal feature | Splicing information |
| Interactors from STRING. |
| Gene name | Interactors |
Related Drugs to CYP2D6 |
| Drugs targeting this gene/protein. (DrugBank) |
| UniProt accession | Gene name | DrugBank ID | Drug name | Drug group | Actions |
| P10635 | CYP2D6 | DB11994 | Diacerein | approved, investigational | inhibitor |
| P10635 | CYP2D6 | DB14011 | Nabiximols | investigational | substrate, inhibitor |
| P10635 | CYP2D6 | DB09061 | Cannabidiol | approved, investigational | inhibitor |
Related Diseases to CYP2D6 |
| Previous studies relating to the alternative splicing of CYP2D6 and disease information from the MeSH term (PubMed) |
| Gene | PMID | Title | Abstract | MeSH ID | MeSH term |
Clinically important variants in CYP2D6 |
| (ClinVar, 04/20/2024) |
| accession_id | uniprot_id | gene_name | Type | Variant | Clinical_significance |
| P10635 | P10635-1 | CYP2D6 | single nucleotide variant | p.Gly169Ter | Likely benign; other |
| P10635 | P10635-1 | CYP2D6 | single nucleotide variant | p.Gly169Ter | Likely benign; other |
| P10635 | P10635-1 | CYP2D6 | single nucleotide variant | p.His324Pro | Likely benign; other |
| P10635 | P10635-1 | CYP2D6 | single nucleotide variant | p.His324Pro | Likely benign; other |
| P10635 | P10635-1 | CYP2D6 | single nucleotide variant | p.Gly42Arg | Likely benign; other |
| P10635 | P10635-1 | CYP2D6 | single nucleotide variant | p.Gly42Arg | Likely benign; other |
| P10635 | P10635-1 | CYP2D6 | single nucleotide variant | p.Gly169Arg | Likely benign; other |
| P10635 | P10635-1 | CYP2D6 | single nucleotide variant | p.Gly169Arg | Likely benign; other |
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