ASpdb: an integrative knowledgebase of human protein isoforms from experimental and AI-predicted structures

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	Protein Summary
	AS Summary
	Protein Functional Features
	Gene Isoform Structures and Expression Levels
	Protein Structures
	pLDDT Score Distribution
	Ramachandran Plot of Protein Structures
	Potential Active Site Information
	Protein Structure and Feature Comparision
	Protein-Protein Interaction
	Related Drugs
	Related Diseases
	Clinically Important Variants

Protein:FGFR1

Protein Summary

Gene summary

Gene name: FGFR1
ASpdb.0 ID: 2260
	Gene
Gene symbol	FGFR1
Gene ID	2260
Gene name	fibroblast growth factor receptor 1
Synonyms	BFGFR\|CD331\|CEK\|ECCL\|FGFBR\|FGFR-1\|FLG\|FLT-2\|FLT2\|HBGFR\|HH2\|HRTFDS\|KAL2\|N-SAM\|OGD\|bFGF-R-1
Cytomap	8p11.23
Type of gene	protein-coding
Description	fibroblast growth factor receptor 1FGFR1/PLAG1 fusionFMS-like tyrosine kinase 2basic fibroblast growth factor receptor 1fms-related tyrosine kinase 2heparin-binding growth factor receptorhydroxyaryl-protein kinaseproto-oncogene c-Fgr
Modification date	20240416
UniProtAcc	P11362

Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Gene	FGFR1	GO:0004713	protein tyrosine kinase activity	8622701
Gene	FGFR1	GO:0005007	fibroblast growth factor receptor activity	18480409\|20133753
Gene	FGFR1	GO:0005886	plasma membrane	18480409
Gene	FGFR1	GO:0008201	heparin binding	18480409
Gene	FGFR1	GO:0008284	positive regulation of cell population proliferation	8663044
Gene	FGFR1	GO:0008543	fibroblast growth factor receptor signaling pathway	8663044\|21885851
Gene	FGFR1	GO:0010863	positive regulation of phospholipase C activity	18480409
Gene	FGFR1	GO:0017134	fibroblast growth factor binding	8663044\|18480409
Gene	FGFR1	GO:0018108	peptidyl-tyrosine phosphorylation	8622701\|18480409
Gene	FGFR1	GO:0043235	receptor complex	23382219
Gene	FGFR1	GO:0043406	positive regulation of MAP kinase activity	8622701\|18480409
Gene	FGFR1	GO:0044344	cellular response to fibroblast growth factor stimulus	21885851
Gene	FGFR1	GO:0046777	protein autophosphorylation	8622701
Gene	FGFR1	GO:0090722	receptor-receptor interaction	24157794
Gene	FGFR1	GO:2001028	positive regulation of endothelial cell chemotaxis	21885851

AS Summary

Information of the canonical protein with experimentally identified structure from PDB (2023).

UniProt Acc	File name	PDB ID	Method	Resolution	Chain	Start	End
P11362-1	P11362-1_3gql_A.pdb	3GQL	X-ray	2.8	A	463	774

ASpdb's canonical and alternatively spliced isoform information.

accession_id	gene_name	canonical_id	alternative_id	canonical_length	alternative_length	canonical_start	canonical_end	type	originalSEQ	variationSEQ	alternative_start	alternative_end
P11362	FGFR1	P11362-1	P11362-10	822	573	31	119	Deletion	none	none	30	30
P11362	FGFR1	P11362-1	P11362-10	822	573	619	662	Substitution	CIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL	VWNLKAPLVHTPRPGSQECPGDRGQCDEDSRLWPRTGHSPHRLL	530	573
P11362	FGFR1	P11362-1	P11362-10	822	573	663	822	Deletion	none	none	573	573
P11362	FGFR1	P11362-1	P11362-11	822	571	31	119	Deletion	none	none	30	30
P11362	FGFR1	P11362-1	P11362-11	822	571	428	429	Deletion	none	none	338	338
P11362	FGFR1	P11362-1	P11362-11	822	571	619	662	Substitution	CIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL	VWNLKAPLVHTPRPGSQECPGDRGQCDEDSRLWPRTGHSPHRLL	528	571
P11362	FGFR1	P11362-1	P11362-11	822	571	663	822	Deletion	none	none	571	571
P11362	FGFR1	P11362-1	P11362-12	822	502	1	160	Deletion	none	none	0	0
P11362	FGFR1	P11362-1	P11362-12	822	502	619	662	Substitution	CIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL	VWNLKAPLVHTPRPGSQECPGDRGQCDEDSRLWPRTGHSPHRLL	459	502
P11362	FGFR1	P11362-1	P11362-12	822	502	663	822	Deletion	none	none	502	502
P11362	FGFR1	P11362-1	P11362-13	822	500	1	160	Deletion	none	none	0	0
P11362	FGFR1	P11362-1	P11362-13	822	500	428	429	Deletion	none	none	267	267
P11362	FGFR1	P11362-1	P11362-13	822	500	619	662	Substitution	CIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL	VWNLKAPLVHTPRPGSQECPGDRGQCDEDSRLWPRTGHSPHRLL	457	500
P11362	FGFR1	P11362-1	P11362-13	822	500	663	822	Deletion	none	none	500	500
P11362	FGFR1	P11362-1	P11362-14	822	731	31	119	Deletion	none	none	30	30
P11362	FGFR1	P11362-1	P11362-14	822	731	148	149	Deletion	none	none	58	58
P11362	FGFR1	P11362-1	P11362-15	822	150	120	150	Substitution	DALPSSEDDDDDDDSSSEEKETDNTKPNRMP	ACPDLQEAKWCSASFHSITPLPFGLGTRLSD	120	150
P11362	FGFR1	P11362-1	P11362-15	822	150	151	822	Deletion	none	none	150	150
P11362	FGFR1	P11362-1	P11362-16	822	302	31	119	Deletion	none	none	30	30
P11362	FGFR1	P11362-1	P11362-16	822	302	313	391	Substitution	TAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV	VIMAPVFVGQSTGKETTVSGAQVPVGRLSCPRMGSFLTLQAHTLHLSRDLATSPRTSNRGHKVEVSWEQRAAGMGGAGL	224	302
P11362	FGFR1	P11362-1	P11362-16	822	302	392	822	Deletion	none	none	302	302
P11362	FGFR1	P11362-1	P11362-17	822	61	32	61	Substitution	QPWGAPVEVESFLVHPGDLLQLRCRLRDDV	CPDLQEAKSCSASFHSITPLPFGLGTRLSD	32	61
P11362	FGFR1	P11362-1	P11362-17	822	61	62	822	Deletion	none	none	61	61
P11362	FGFR1	P11362-1	P11362-18	822	300	31	119	Deletion	none	none	30	30
P11362	FGFR1	P11362-1	P11362-18	822	300	148	149	Deletion	none	none	58	58
P11362	FGFR1	P11362-1	P11362-18	822	300	313	391	Substitution	TAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV	VIMAPVFVGQSTGKETTVSGAQVPVGRLSCPRMGSFLTLQAHTLHLSRDLATSPRTSNRGHKVEVSWEQRAAGMGGAGL	222	300
P11362	FGFR1	P11362-1	P11362-18	822	300	392	822	Deletion	none	none	300	300
P11362	FGFR1	P11362-1	P11362-19	822	822	119	119	Substitution	S	SVPI	119	122
P11362	FGFR1	P11362-1	P11362-19	822	822	148	149	Deletion	none	none	150	150
P11362	FGFR1	P11362-1	P11362-19	822	822	313	360	Substitution	TAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE	HSGINSSDAEVLTLFNVTEAQSGEYVCKVSNYIGEANQSAWLTVTRP	314	360
P11362	FGFR1	P11362-1	P11362-2	822	820	428	429	Deletion	none	none	427	427
P11362	FGFR1	P11362-1	P11362-20	822	812	1	30	Substitution	MWSWKCLLFWAVLVTATLCTARPSPTLPEQ	MAAVTRDFGEMLLHSGRVLPAE	1	22
P11362	FGFR1	P11362-1	P11362-20	822	812	427	428	Deletion	none	none	418	418
P11362	FGFR1	P11362-1	P11362-21	822	853	1	1	Substitution	M	MEARVSLKRRIELTVEYPWRCGALSPTSNCRTGM	1	34
P11362	FGFR1	P11362-1	P11362-21	822	853	148	149	Deletion	none	none	180	180
P11362	FGFR1	P11362-1	P11362-3	822	733	31	119	Deletion	none	none	30	30
P11362	FGFR1	P11362-1	P11362-4	822	731	31	119	Deletion	none	none	30	30
P11362	FGFR1	P11362-1	P11362-4	822	731	428	429	Deletion	none	none	338	338
P11362	FGFR1	P11362-1	P11362-5	822	662	1	160	Deletion	none	none	0	0
P11362	FGFR1	P11362-1	P11362-6	822	660	1	160	Deletion	none	none	0	0
P11362	FGFR1	P11362-1	P11362-6	822	660	428	429	Deletion	none	none	267	267
P11362	FGFR1	P11362-1	P11362-7	822	820	148	149	Deletion	none	none	147	147
P11362	FGFR1	P11362-1	P11362-8	822	662	619	662	Substitution	CIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL	VWNLKAPLVHTPRPGSQECPGDRGQCDEDSRLWPRTGHSPHRLL	619	662
P11362	FGFR1	P11362-1	P11362-8	822	662	663	822	Deletion	none	none	662	662
P11362	FGFR1	P11362-1	P11362-9	822	660	428	429	Deletion	none	none	427	427
P11362	FGFR1	P11362-1	P11362-9	822	660	619	662	Substitution	CIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL	VWNLKAPLVHTPRPGSQECPGDRGQCDEDSRLWPRTGHSPHRLL	617	660
P11362	FGFR1	P11362-1	P11362-9	822	660	663	822	Deletion	none	none	660	660

Multiple sequence alignment of our canonical and alternatively spliced FGFR1

Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of FGFR1

UniProt-id	ENSG	ENST	ENSP
P11362-1	ENSG00000077782.23	ENST00000447712.7	ENSP00000400162.2
P11362-14	ENSG00000077782.23	ENST00000326324.10	ENSP00000327229.6
P11362-15	ENSG00000077782.23	ENST00000484370.5	ENSP00000433163.1
P11362-2	ENSG00000077782.23	ENST00000532791.5	ENSP00000432972.1
P11362-20	ENSG00000077782.23	ENST00000335922.9	ENSP00000337247.5
P11362-3	ENSG00000077782.23	ENST00000356207.9	ENSP00000348537.5
P11362-7	ENSG00000077782.23	ENST00000397091.9	ENSP00000380280.5
P11362-7	ENSG00000077782.23	ENST00000397108.8	ENSP00000380297.4
P11362-7	ENSG00000077782.23	ENST00000397113.6	ENSP00000380302.2

UniProt-id	NM ID	NP ID
P11362-1	NM_023110.2	NP_075598.2
P11362-14	NM_023106.2	NP_075594.1
P11362-2	NM_001174063.1	NP_001167534.1
P11362-20	NM_001174064.1	NP_001167535.1
P11362-21	NM_001174067.1	NP_001167538.1
P11362-3	NM_001174066.1	NP_001167537.1
P11362-3	NM_023105.2	NP_075593.1
P11362-7	NM_001174065.1	NP_001167536.1
P11362-7	NM_015850.3	NP_056934.2

Amino acid sequences of our canonical and alternatively spliced FGFR1

accession_id	Protein sequence
P11362-1	MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQD SVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALG SNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLS SSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVL VTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMD KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRH
P11362-10	MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRL SSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKVWNLKAPLVHT
P11362-11	MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVSADSSASMNSGVLLVRPSRLSS SGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKH KNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKVWNLKAPLVHTPR
P11362-12	MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVER SPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYT CLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVS ADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARG
P11362-13	MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVER SPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYT CLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVSAD SSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATE KDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGME
P11362-14	MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSS GTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEA LEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSS SGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKH KNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDK PSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHP
P11362-15	MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQD
P11362-16	MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKVIMAPVFVGQSTGKETTVSGAQVPVGRLSCPRMGSFLTLQAHTLHLS
P11362-17
P11362-18	MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSS GTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKVIMAPVFVGQSTGKETTVSGAQVPVGRLSCPRMGSFLTLQAHTLHLSRD
P11362-19	MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQD SVPADSGLYACVTSSPSGSDTTYFSVNVSVPIDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKHSGINSSDAEVLTLFNVTEAQSGEYVCKVSNYIGEANQSAWLTVTRP ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLS SSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVL VTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMD KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRH
P11362-2	MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQD SVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALG SNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVSADSSASMNSGVLLVRPSRLSSS GTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHK NIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT EDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKP SNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPA
P11362-20	MAAVTRDFGEMLLHSGRVLPAEAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGL YACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTL RWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCK VYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAV MTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVSADSSASMNSGVLLVRPSRLSSSGTPMLAGV SEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGA CTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA DFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELY MMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLK
P11362-21	MEARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRL RDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPN PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLR NVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS
P11362-3	MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRL SSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRM DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPR
P11362-4	MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVSADSSASMNSGVLLVRPSRLSS SGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKH KNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDK PSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHP
P11362-5	MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVER SPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYT CLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVS ADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARG MEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP YPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSS
P11362-6	MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVER SPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYT CLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVSAD SSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATE KDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGME YLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYP GVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGE
P11362-7	MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQD SVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSG TPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSN VEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEAL EERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSS GTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHK NIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT EDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKP SNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPA
P11362-8	MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQD SVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALG SNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLS SSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKVWNLKAPLVHTP
P11362-9	MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQD SVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALG SNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVSADSSASMNSGVLLVRPSRLSSS GTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHK NIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKVWNLKAPLVHTPRP

Protein Functional Features

Main function of this protein. (from UniProt)

FGFR1 (go to UniProt):P11362

Retention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Accession_id	Subsection	Start	End	Funcitonal feature	Splicing information
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=31;End=119
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=31;End=119
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=1;End=160
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=1;End=160
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=31;End=119
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=148;End=149
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=120;End=150
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=151;End=822
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=31;End=119
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=313;End=391
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=32;End=61
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=62;End=822
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=31;End=119
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=148;End=149
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=313;End=391
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=119;End=119
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=148;End=149
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=313;End=360
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=1;End=30
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=148;End=149
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=31;End=119
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=31;End=119
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=1;End=160
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=1;End=160
P11362	Topological domain	22	376	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=148;End=149
P11362	Transmembrane	377	397	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=151;End=822
P11362	Transmembrane	377	397	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=313;End=391
P11362	Transmembrane	377	397	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=392;End=822
P11362	Transmembrane	377	397	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=62;End=822
P11362	Transmembrane	377	397	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=313;End=391
P11362	Transmembrane	377	397	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=392;End=822
P11362	Topological domain	398	822	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=619;End=662
P11362	Topological domain	398	822	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=663;End=822
P11362	Topological domain	398	822	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=428;End=429
P11362	Topological domain	398	822	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=619;End=662
P11362	Topological domain	398	822	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=663;End=822
P11362	Topological domain	398	822	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=619;End=662
P11362	Topological domain	398	822	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=663;End=822
P11362	Topological domain	398	822	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=428;End=429
P11362	Topological domain	398	822	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=619;End=662
P11362	Topological domain	398	822	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=663;End=822
P11362	Topological domain	398	822	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=151;End=822
P11362	Topological domain	398	822	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=392;End=822
P11362	Topological domain	398	822	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=62;End=822
P11362	Topological domain	398	822	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=392;End=822
P11362	Topological domain	398	822	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=428;End=429
P11362	Topological domain	398	822	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=427;End=428
P11362	Topological domain	398	822	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=428;End=429
P11362	Topological domain	398	822	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=428;End=429
P11362	Topological domain	398	822	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=619;End=662
P11362	Topological domain	398	822	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=663;End=822
P11362	Topological domain	398	822	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=428;End=429
P11362	Topological domain	398	822	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=619;End=662
P11362	Topological domain	398	822	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=663;End=822
P11362	Domain	25	119	Note=Ig-like C2-type 1	Type=Deletion;Start=31;End=119
P11362	Domain	25	119	Note=Ig-like C2-type 1	Type=Deletion;Start=31;End=119
P11362	Domain	25	119	Note=Ig-like C2-type 1	Type=Deletion;Start=1;End=160
P11362	Domain	25	119	Note=Ig-like C2-type 1	Type=Deletion;Start=1;End=160
P11362	Domain	25	119	Note=Ig-like C2-type 1	Type=Deletion;Start=31;End=119
P11362	Domain	25	119	Note=Ig-like C2-type 1	Type=Deletion;Start=31;End=119
P11362	Domain	25	119	Note=Ig-like C2-type 1	Type=Substitution;Start=32;End=61
P11362	Domain	25	119	Note=Ig-like C2-type 1	Type=Deletion;Start=62;End=822
P11362	Domain	25	119	Note=Ig-like C2-type 1	Type=Deletion;Start=31;End=119
P11362	Domain	25	119	Note=Ig-like C2-type 1	Type=Substitution;Start=119;End=119
P11362	Domain	25	119	Note=Ig-like C2-type 1	Type=Substitution;Start=1;End=30
P11362	Domain	25	119	Note=Ig-like C2-type 1	Type=Deletion;Start=31;End=119
P11362	Domain	25	119	Note=Ig-like C2-type 1	Type=Deletion;Start=31;End=119
P11362	Domain	25	119	Note=Ig-like C2-type 1	Type=Deletion;Start=1;End=160
P11362	Domain	25	119	Note=Ig-like C2-type 1	Type=Deletion;Start=1;End=160
P11362	Domain	158	246	Note=Ig-like C2-type 2	Type=Deletion;Start=1;End=160
P11362	Domain	158	246	Note=Ig-like C2-type 2	Type=Deletion;Start=1;End=160
P11362	Domain	158	246	Note=Ig-like C2-type 2	Type=Deletion;Start=151;End=822
P11362	Domain	158	246	Note=Ig-like C2-type 2	Type=Deletion;Start=62;End=822
P11362	Domain	158	246	Note=Ig-like C2-type 2	Type=Deletion;Start=1;End=160
P11362	Domain	158	246	Note=Ig-like C2-type 2	Type=Deletion;Start=1;End=160
P11362	Domain	255	357	Note=Ig-like C2-type 3	Type=Deletion;Start=151;End=822
P11362	Domain	255	357	Note=Ig-like C2-type 3	Type=Substitution;Start=313;End=391
P11362	Domain	255	357	Note=Ig-like C2-type 3	Type=Deletion;Start=62;End=822
P11362	Domain	255	357	Note=Ig-like C2-type 3	Type=Substitution;Start=313;End=391
P11362	Domain	255	357	Note=Ig-like C2-type 3	Type=Substitution;Start=313;End=360
P11362	Domain	478	767	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159	Type=Substitution;Start=619;End=662
P11362	Domain	478	767	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159	Type=Deletion;Start=663;End=822
P11362	Domain	478	767	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159	Type=Substitution;Start=619;End=662
P11362	Domain	478	767	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159	Type=Deletion;Start=663;End=822
P11362	Domain	478	767	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159	Type=Substitution;Start=619;End=662
P11362	Domain	478	767	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159	Type=Deletion;Start=663;End=822
P11362	Domain	478	767	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159	Type=Substitution;Start=619;End=662
P11362	Domain	478	767	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159	Type=Deletion;Start=663;End=822
P11362	Domain	478	767	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159	Type=Deletion;Start=151;End=822
P11362	Domain	478	767	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159	Type=Deletion;Start=392;End=822
P11362	Domain	478	767	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159	Type=Deletion;Start=62;End=822
P11362	Domain	478	767	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159	Type=Deletion;Start=392;End=822
P11362	Domain	478	767	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159	Type=Substitution;Start=619;End=662
P11362	Domain	478	767	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159	Type=Deletion;Start=663;End=822
P11362	Domain	478	767	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159	Type=Substitution;Start=619;End=662
P11362	Domain	478	767	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159	Type=Deletion;Start=663;End=822
P11362	Region	120	154	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=1;End=160
P11362	Region	120	154	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=1;End=160
P11362	Region	120	154	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=148;End=149
P11362	Region	120	154	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Substitution;Start=120;End=150
P11362	Region	120	154	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=151;End=822
P11362	Region	120	154	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=62;End=822
P11362	Region	120	154	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=148;End=149
P11362	Region	120	154	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=148;End=149
P11362	Region	120	154	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=148;End=149
P11362	Region	120	154	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=1;End=160
P11362	Region	120	154	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=1;End=160
P11362	Region	120	154	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=148;End=149
P11362	Region	160	177	Note=Heparin-binding	Type=Deletion;Start=1;End=160
P11362	Region	160	177	Note=Heparin-binding	Type=Deletion;Start=1;End=160
P11362	Region	160	177	Note=Heparin-binding	Type=Deletion;Start=151;End=822
P11362	Region	160	177	Note=Heparin-binding	Type=Deletion;Start=62;End=822
P11362	Region	160	177	Note=Heparin-binding	Type=Deletion;Start=1;End=160
P11362	Region	160	177	Note=Heparin-binding	Type=Deletion;Start=1;End=160
P11362	Region	778	822	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=663;End=822
P11362	Region	778	822	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=663;End=822
P11362	Region	778	822	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=663;End=822
P11362	Region	778	822	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=663;End=822
P11362	Region	778	822	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=151;End=822
P11362	Region	778	822	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=392;End=822
P11362	Region	778	822	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=62;End=822
P11362	Region	778	822	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=392;End=822
P11362	Region	778	822	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=663;End=822
P11362	Region	778	822	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=663;End=822
P11362	Compositional bias	123	137	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=1;End=160
P11362	Compositional bias	123	137	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=1;End=160
P11362	Compositional bias	123	137	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Substitution;Start=120;End=150
P11362	Compositional bias	123	137	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=62;End=822
P11362	Compositional bias	123	137	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=1;End=160
P11362	Compositional bias	123	137	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=1;End=160
P11362	Compositional bias	778	794	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=663;End=822
P11362	Compositional bias	778	794	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=663;End=822
P11362	Compositional bias	778	794	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=663;End=822
P11362	Compositional bias	778	794	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=663;End=822
P11362	Compositional bias	778	794	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=151;End=822
P11362	Compositional bias	778	794	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=392;End=822
P11362	Compositional bias	778	794	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=62;End=822
P11362	Compositional bias	778	794	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=392;End=822
P11362	Compositional bias	778	794	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=663;End=822
P11362	Compositional bias	778	794	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=663;End=822

Gene Isoform Structures and Expression Levels for FGFR1

Gene structures of our canonical and alternative spliced genes of FGFR1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Expression levels of gene isoforms across GTEx.

Expression levels of gene isoforms across TCGA.

Protein Structures

PDB and CIF files of the predicted protein structures
* Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

3D view using mol* of P11362-1

3D view using mol* of P11362-10

3D view using mol* of P11362-11

3D view using mol* of P11362-12

3D view using mol* of P11362-13

3D view using mol* of P11362-14

3D view using mol* of P11362-15

3D view using mol* of P11362-16

3D view using mol* of P11362-17

3D view using mol* of P11362-18

3D view using mol* of P11362-19

3D view using mol* of P11362-2

3D view using mol* of P11362-20

3D view using mol* of P11362-21

3D view using mol* of P11362-3

3D view using mol* of P11362-4

3D view using mol* of P11362-5

3D view using mol* of P11362-6

3D view using mol* of P11362-7

3D view using mol* of P11362-8

3D view using mol* of P11362-9

pLDDT Score Distribution

pLDDT score distribution of the predicted protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

pLDDT distribution across the protein length of P11362-1

pLDDT distribution across the protein length of P11362-10

pLDDT distribution across the protein length of P11362-11

pLDDT distribution across the protein length of P11362-12

pLDDT distribution across the protein length of P11362-13

pLDDT distribution across the protein length of P11362-14

pLDDT distribution across the protein length of P11362-15

pLDDT distribution across the protein length of P11362-16

pLDDT distribution across the protein length of P11362-17

pLDDT distribution across the protein length of P11362-18

pLDDT distribution across the protein length of P11362-19

pLDDT distribution across the protein length of P11362-2

pLDDT distribution across the protein length of P11362-20

pLDDT distribution across the protein length of P11362-21

pLDDT distribution across the protein length of P11362-3

pLDDT distribution across the protein length of P11362-4

pLDDT distribution across the protein length of P11362-5

pLDDT distribution across the protein length of P11362-6

pLDDT distribution across the protein length of P11362-7

pLDDT distribution across the protein length of P11362-8

pLDDT distribution across the protein length of P11362-9

Ramachandran Plot of Protein Structures

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide.

Ramachandran plot of P11362-1

Ramachandran plot of P11362-13

Ramachandran plot of P11362-14

Ramachandran plot of P11362-15

Ramachandran plot of P11362-16

Ramachandran plot of P11362-17

Ramachandran plot of P11362-2

Ramachandran plot of P11362-20

Ramachandran plot of P11362-21

Ramachandran plot of P11362-5

Ramachandran plot of P11362-7

Ramachandran plot of P11362-9

Potential Active Site Information

The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite.

UniProt-id	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
P11362-1	1.069	227	1.077	673.652	0.454	0.801	1.038	0.952	1.054	0.903	0.623	484,485,487,488,489,490,492,512,514,515,516,523,52 4,527,528,530,531,535,545,559,561,562,563,564,567, 568,571,622,623,627,628,630,640,641,642,643,644,64 6,654,656,657,658,660,661,662,663
P11362-10	1.072	80	1.162	184.191	0.548	0.718	0.895	3.003	0.334	8.987	0.183	4,7,8,10,11,14,15,18,480,481,484,485,488,494,511,5 14,515,518,519,522
P11362-11	1.049	886	1.09	2757.377	0.564	0.72	0.885	0.912	0.863	1.057	0.971	1,2,4,6,7,8,10,11,14,18,84,103,111,112,113,114,115 ,116,117,118,127,128,129,130,132,133,134,135,159,1 60,161,162,164,165,166,167,168,170,191,192,193,260 ,261,262,263,372,374,375,376,377,380,381,393,394,3 95,396,397,398,399,401,421,423,426,428,429,430,431 ,432,433,434,435,436,437,438,439,440,441,442,443,4 44,445,446,451,452,453,454,456,459,461,468,470,471 ,472,473,476,477,478,479,480,481,482,483,492,494,5 09,510,512,513,514,515,516,517,520,521,524,525,527 ,528,529,530,531,532,533,534,535,536,562,563,564,5 65,566,567,568,569,570,571
P11362-12	1.048	304	1.095	995.043	0.548	0.709	0.922	0.863	0.831	1.039	1.048	282,283,284,285,286,287,288,289,303,304,305,306,30 7,308,310,311,312,329,362,363,365,366,367,369,370, 371,372,373,374,376,377,390,392,457,459,460,462,46 3,464,465,466,467,469,470,471,472,491,494,496,497, 498,500,501
P11362-13	1.023	405	1.029	1331.526	0.565	0.732	0.91	0.445	1.074	0.414	0.64	123,124,125,126,127,128,130,148,150,153,154,155,15 6,157,158,160,163,182,184,185,186,188,189,322,323, 324,325,326,327,330,350,352,355,383,399,400,401,40 2,403,405,406,407,408,409,411,412,413,414,415,416, 417,419,420,421,422,423,424,427,428,431,432,438,44 1,442,445,449,485,486,487,488,489,491,498,499,500
P11362-14	1.019	429	1.047	1351.763	0.563	0.707	0.931	0.814	0.975	0.835	0.905	351,352,353,354,355,356,371,372,373,374,375,376,37 7,393,394,396,397,398,399,400,401,421,423,424,425, 431,432,433,434,435,436,437,438,439,440,441,442,44 3,444,445,446,447,454,461,462,470,471,472,473,474, 476,477,480,526,527,528,531,532,536,537,539,549,55 0,551,552,553,555,556,559,560,561,562,563,564,565, 566,567,568,569,570,571,572,576,584,586
P11362-15	0.759	48	0.757	169.099	0.73	0.598	0.727	0.531	0.777	0.683	1.176	32,33,34,36,37,38,39,56,58,103,109,110,111,112,113
P11362-16	1.02	360	1.049	824.915	0.494	0.706	0.947	0.971	0.965	1.006	0.727	161,162,164,165,166,167,168,173,180,184,188,190,19 2,193,194,195,196,197,198,199,200,201,202,203,204, 205,206,207,208,210,217,219,222,225,226,227,229,26 2,263,264,265,266,267,268,286,287,288,289,290,291, 292,293,294,295,296,297
P11362-17	0.641	46	0.55	23.667	0.689	0.514	0.772	0.192	1.216	0.158	0.235	22,24,25,26,27,28,29,30,31,32,33,36
P11362-18	1.018	158	1.077	410.228	0.644	0.647	0.785	0.795	0.772	1.03	0.712	200,201,202,203,208,215,217,218,219,220,221,222,24 2,243,244,245,246,248,249,250,251,254,255,256,257, 258,259,272,273,274,275,276,277,284,289,291
P11362-19	1.065	144	1.06	602.651	0.581	0.795	0.936	0.517	1.096	0.472	0.575	200,201,203,204,205,206,219,220,222,223,224,225,56 8,570,571,574,623,625,626,627,657,658,659,660,661, 662,663,664,665,666,675,692,699,702,703,704,705,70 6,710
P11362-2	1.036	854	1.064	2441.131	0.496	0.731	0.927	0.679	0.965	0.704	0.701	169,170,171,188,189,190,191,196,197,198,199,200,20 2,203,204,205,206,207,208,210,218,219,220,221,222, 223,249,250,252,282,482,483,485,486,487,488,489,49 0,510,512,513,514,521,522,525,526,529,533,543,559, 560,561,562,563,565,566,568,569,570,572,573,575,57 6,577,578,579,580,581,582,583,584,585,586,587,589, 621,625,626,628,638,639,640,641,656,657,658,659,66 0,661,662,663,664,689,692,693,694,696,697,698,699, 700,701,702,703,704,705,715,717,718,719,720,721,72 2,767,768,769,770,771,773,774,775,776
P11362-20	1.032	590	1.065	1955.786	0.563	0.714	0.904	0.629	0.931	0.676	1.059	161,162,163,164,241,242,244,271,272,273,274,275,27 6,277,278,279,306,307,308,310,312,315,316,337,338, 472,473,474,475,477,478,479,480,481,482,502,504,50 5,506,511,513,514,517,518,520,521,523,524,525,527, 528,535,551,552,553,554,555,557,558,607,609,612,61 3,617,618,620,630,631,632,633,634,636,637,640,641, 642,643,644,645,646,647,648,649,650,651,652,653,65 7,662,663,664,665,667,695,696,697,698,700,701,704
P11362-21	1.062	125	1.104	296.695	0.47	0.735	0.983	0.892	0.849	1.051	1.12	230,602,603,605,606,608,609,610,611,612,615,616,61 7,620,622
P11362-3	1.059	130	1.133	230.153	0.49	0.673	0.889	1.015	0.648	1.567	1.58	477,482,483,485,486,487,488,489,490,491,492,493,49 5,496,497,500,502,503
P11362-4	1.11	189	1.13	411.6	0.417	0.841	1.092	1.52	0.966	1.573	0.941	393,394,395,396,397,398,399,400,401,421,423,424,42 5,433,436,437,440,444,454,470,472,473,476,477,480, 532,536,537,539,549,550,551,552,554,555,556,557,56 2
P11362-5	1.055	253	1.04	903.805	0.532	0.78	1.014	0.845	1.128	0.749	0.659	324,325,327,328,329,330,331,332,352,354,355,356,36 3,364,367,368,370,371,375,385,401,402,403,404,405, 407,408,411,461,462,463,467,468,470,480,481,482,48 3,484,485,486,490,491,492,493,495,496,497,498,499, 500,501,502,503,507,515,517,525
P11362-6	1.055	267	1.069	916.839	0.479	0.777	1.031	1.062	1.034	1.026	0.653	322,323,325,326,327,328,329,330,350,352,353,354,36 1,362,365,366,369,373,383,399,400,401,402,403,405, 406,409,460,461,465,466,468,478,479,480,481,482,48 4,488,489,490,491,493,494,495,496,497,498,499,500, 501,505,513,515
P11362-7	1.055	123	1.102	299.439	0.541	0.719	0.955	0.809	0.825	0.981	0.932	454,455,456,457,458,459,460,461,462,463,514,515,51 8,519,520,523,550,551,552,553,554,555
P11362-8	1.069	423	1.119	1340.444	0.526	0.733	0.916	1.001	0.8	1.25	0.931	463,465,466,467,468,471,472,484,485,487,488,489,49 0,492,512,514,516,523,524,526,527,528,529,530,531, 532,533,534,535,536,537,538,543,544,545,550,552,55 9,561,562,563,564,566,567,568,569,570,571,572,603, 606,607,614,619,620,622,623,624,625,626,627,654,65 5,656,657,658,659,660,661,662
P11362-9	1.06	521	1.106	1690.99	0.519	0.726	0.925	0.939	0.827	1.136	0.907	170,222,249,250,253,278,279,280,281,282,283,284,28 5,286,287,314,315,316,317,318,319,320,321,322,324, 342,344,345,346,347,348,349,461,462,464,483,485,48 6,487,488,489,490,512,513,514,519,521,522,524,525, 526,527,528,529,531,532,535,566,567,568,605,617,61 8,620,621,622,623,624,649,650,651,652,653,654,655, 656,657,658,660

Protein Structure and Feature Comparision

Protein Structure Comparision Using Template Modeling Scores (TM-score).

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green)

3D view using mol* of P11362-1_P11362-1_3gql_A.pdb

Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of P11362-1_3gql_A_P11362-10.pdb

3D view using mol* of P11362-1_3gql_A_P11362-11.pdb

3D view using mol* of P11362-1_3gql_A_P11362-12.pdb

3D view using mol* of P11362-1_3gql_A_P11362-13.pdb

3D view using mol* of P11362-1_3gql_A_P11362-14.pdb

3D view using mol* of P11362-1_3gql_A_P11362-15.pdb

3D view using mol* of P11362-1_3gql_A_P11362-16.pdb

3D view using mol* of P11362-1_3gql_A_P11362-17.pdb

3D view using mol* of P11362-1_3gql_A_P11362-18.pdb

3D view using mol* of P11362-1_3gql_A_P11362-19.pdb

3D view using mol* of P11362-1_3gql_A_P11362-2.pdb

3D view using mol* of P11362-1_3gql_A_P11362-20.pdb

3D view using mol* of P11362-1_3gql_A_P11362-21.pdb

3D view using mol* of P11362-1_3gql_A_P11362-3.pdb

3D view using mol* of P11362-1_3gql_A_P11362-4.pdb

3D view using mol* of P11362-1_3gql_A_P11362-5.pdb

3D view using mol* of P11362-1_3gql_A_P11362-6.pdb

3D view using mol* of P11362-1_3gql_A_P11362-7.pdb

3D view using mol* of P11362-1_3gql_A_P11362-8.pdb

3D view using mol* of P11362-1_3gql_A_P11362-9.pdb

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of P11362-1_P11362-10.pdb

3D view using mol* of P11362-1_P11362-11.pdb

3D view using mol* of P11362-1_P11362-12.pdb

3D view using mol* of P11362-1_P11362-13.pdb

3D view using mol* of P11362-1_P11362-14.pdb

3D view using mol* of P11362-1_P11362-15.pdb

3D view using mol* of P11362-1_P11362-16.pdb

3D view using mol* of P11362-1_P11362-17.pdb

3D view using mol* of P11362-1_P11362-18.pdb

3D view using mol* of P11362-1_P11362-19.pdb

3D view using mol* of P11362-1_P11362-2.pdb

3D view using mol* of P11362-1_P11362-20.pdb

3D view using mol* of P11362-1_P11362-21.pdb

3D view using mol* of P11362-1_P11362-3.pdb

3D view using mol* of P11362-1_P11362-4.pdb

3D view using mol* of P11362-1_P11362-5.pdb

3D view using mol* of P11362-1_P11362-6.pdb

3D view using mol* of P11362-1_P11362-7.pdb

3D view using mol* of P11362-1_P11362-8.pdb

3D view using mol* of P11362-1_P11362-9.pdb

Protein Feature Comparison of the protein sequendary structures among the protiens.

./stats/secondary_structure/figure/P11362-1_vs_P11362-10.png

./stats/secondary_structure/figure/P11362-1_vs_P11362-11.png

./stats/secondary_structure/figure/P11362-1_vs_P11362-12.png

./stats/secondary_structure/figure/P11362-1_vs_P11362-13.png

./stats/secondary_structure/figure/P11362-1_vs_P11362-14.png

./stats/secondary_structure/figure/P11362-1_vs_P11362-15.png

./stats/secondary_structure/figure/P11362-1_vs_P11362-16.png

./stats/secondary_structure/figure/P11362-1_vs_P11362-17.png

./stats/secondary_structure/figure/P11362-1_vs_P11362-18.png

./stats/secondary_structure/figure/P11362-1_vs_P11362-19.png

./stats/secondary_structure/figure/P11362-1_vs_P11362-2.png

./stats/secondary_structure/figure/P11362-1_vs_P11362-20.png

./stats/secondary_structure/figure/P11362-1_vs_P11362-21.png

./stats/secondary_structure/figure/P11362-1_vs_P11362-3.png

./stats/secondary_structure/figure/P11362-1_vs_P11362-4.png

./stats/secondary_structure/figure/P11362-1_vs_P11362-5.png

./stats/secondary_structure/figure/P11362-1_vs_P11362-6.png

./stats/secondary_structure/figure/P11362-1_vs_P11362-7.png

./stats/secondary_structure/figure/P11362-1_vs_P11362-8.png

./stats/secondary_structure/figure/P11362-1_vs_P11362-9.png

Protein Feature Comparison of the relative accessible surface area (ASA) among the protiens.

./stats/relative_asa/P11362-1_vs_P11362-10.png

./stats/relative_asa/P11362-1_vs_P11362-11.png

./stats/relative_asa/P11362-1_vs_P11362-12.png

./stats/relative_asa/P11362-1_vs_P11362-13.png

./stats/relative_asa/P11362-1_vs_P11362-14.png

./stats/relative_asa/P11362-1_vs_P11362-15.png

./stats/relative_asa/P11362-1_vs_P11362-16.png

./stats/relative_asa/P11362-1_vs_P11362-17.png

./stats/relative_asa/P11362-1_vs_P11362-18.png

./stats/relative_asa/P11362-1_vs_P11362-19.png

./stats/relative_asa/P11362-1_vs_P11362-2.png

./stats/relative_asa/P11362-1_vs_P11362-20.png

./stats/relative_asa/P11362-1_vs_P11362-21.png

./stats/relative_asa/P11362-1_vs_P11362-3.png

./stats/relative_asa/P11362-1_vs_P11362-4.png

./stats/relative_asa/P11362-1_vs_P11362-5.png

./stats/relative_asa/P11362-1_vs_P11362-6.png

./stats/relative_asa/P11362-1_vs_P11362-7.png

./stats/relative_asa/P11362-1_vs_P11362-8.png

./stats/relative_asa/P11362-1_vs_P11362-9.png

Protein-Protein Interaction

Interactors from UniProt.

Accession_id

Subsection

Start

End

Funcitonal feature

Splicing information

Interactors from STRING.

Gene name

Interactors

Related Drugs to FGFR1

Drugs targeting this gene/protein.
(DrugBank)

UniProt accession	Gene name	DrugBank ID	Drug name	Drug group	Actions
P11362	FGFR1	DB15149	Futibatinib	approved, investigational	inhibitor
P11362	FGFR1	DB09079	Nintedanib	approved	inhibitor
P11362	FGFR1	DB12147	Erdafitinib	approved, investigational	inhibitor
P11362	FGFR1	DB15685	Selpercatinib	approved, investigational	inhibitor
P11362	FGFR1	DB12010	Fostamatinib	approved, investigational	inhibitor
P11362	FGFR1	DB00398	Sorafenib	approved, investigational	inhibitor
P11362	FGFR1	DB01109	Heparin	approved, investigational
P11362	FGFR1	DB15102	Pemigatinib	approved, investigational	inhibitor
P11362	FGFR1	DB07840	(E)-[4-(3,5-Difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol	experimental
P11362	FGFR1	DB08896	Regorafenib	approved	inhibitor
P11362	FGFR1	DB02058	3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinone	experimental
P11362	FGFR1	DB07525	3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine	experimental
P11362	FGFR1	DB11800	Tivozanib	approved, investigational	inhibitor
P11362	FGFR1	DB15822	Pralsetinib	approved, investigational	inhibitor
P11362	FGFR1	DB11886	Infigratinib	approved, investigational	inhibitor
P11362	FGFR1	DB08577	3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE	experimental
P11362	FGFR1	DB09078	Lenvatinib	approved, investigational	inhibitor
P11362	FGFR1	DB00039	Palifermin	approved	agonist
P11362	FGFR1	DB08901	Ponatinib	approved, investigational	inhibitor
P11362	FGFR1	DB05014	XL999	investigational

Related Diseases to FGFR1

Previous studies relating to the alternative splicing of FGFR1 and disease information from the MeSH term (PubMed)

Gene	PMID	Title	Abstract	MeSH ID	MeSH term
FGFR1	1652059	The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain.	To determine the mechanisms by which multiple forms of fibroblast growth factor (FGF) receptors are generated, we have mapped the arrangement of exons and introns in the human FGF receptor 1 (FGFR 1) gene (flg). We found three alternative exons encoding a portion of the third immunoglobulin (Ig)-like domain of the receptor. One of these alternatives encodes a sequence that is part of a secreted form of FGFR 1. The other two encode sequences that are likely part of transmembrane forms of FGFR 1. One of these forms has not been previously reported in published cDNAs. Also, we have determined the structural organization of a portion of the human FGFR 2 gene (bek) and found a similar arrangement of alternative exons for the third Ig-like domain. The arrangement of these genes suggests that there are conserved mechanisms governing the expression of secreted FGF receptors as well as the expression of at least two distinct membrane-spanning forms of the FGF receptors. The diverse forms appear to be generated by alternative splicing of mRNA and selective use of polyadenylation signals.	D001254	Astrocytoma
FGFR1	1652059	The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain.	To determine the mechanisms by which multiple forms of fibroblast growth factor (FGF) receptors are generated, we have mapped the arrangement of exons and introns in the human FGF receptor 1 (FGFR 1) gene (flg). We found three alternative exons encoding a portion of the third immunoglobulin (Ig)-like domain of the receptor. One of these alternatives encodes a sequence that is part of a secreted form of FGFR 1. The other two encode sequences that are likely part of transmembrane forms of FGFR 1. One of these forms has not been previously reported in published cDNAs. Also, we have determined the structural organization of a portion of the human FGFR 2 gene (bek) and found a similar arrangement of alternative exons for the third Ig-like domain. The arrangement of these genes suggests that there are conserved mechanisms governing the expression of secreted FGF receptors as well as the expression of at least two distinct membrane-spanning forms of the FGF receptors. The diverse forms appear to be generated by alternative splicing of mRNA and selective use of polyadenylation signals.	D009447	Neuroblastoma
FGFR1	1652059	The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain.	To determine the mechanisms by which multiple forms of fibroblast growth factor (FGF) receptors are generated, we have mapped the arrangement of exons and introns in the human FGF receptor 1 (FGFR 1) gene (flg). We found three alternative exons encoding a portion of the third immunoglobulin (Ig)-like domain of the receptor. One of these alternatives encodes a sequence that is part of a secreted form of FGFR 1. The other two encode sequences that are likely part of transmembrane forms of FGFR 1. One of these forms has not been previously reported in published cDNAs. Also, we have determined the structural organization of a portion of the human FGFR 2 gene (bek) and found a similar arrangement of alternative exons for the third Ig-like domain. The arrangement of these genes suggests that there are conserved mechanisms governing the expression of secreted FGF receptors as well as the expression of at least two distinct membrane-spanning forms of the FGF receptors. The diverse forms appear to be generated by alternative splicing of mRNA and selective use of polyadenylation signals.	D012509	Sarcoma
FGFR1	18593464	Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.	Despite the advent of biological therapies for the treatment of rheumatoid arthritis, there is a compelling need to develop alternative therapeutic targets for nonresponders to existing treatments. Soluble receptors occur naturally in vivo, such as the splice variant of the cell surface receptor for vascular endothelial growth factor (VEGF)--a key regulator of angiogenesis in rheumatoid arthritis. Bioinformatics analyses predict that the majority of human genes undergo alternative splicing, generating proteins--many of which may have regulatory functions. The objective of the present study was to identify alternative splice variants (ASV) from cell surface receptor genes, and to determine whether the novel proteins encoded exert therapeutic activity in an in vivo model of arthritis.	D001172	Arthritis, Rheumatoid
FGFR1	18593464	Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.	Despite the advent of biological therapies for the treatment of rheumatoid arthritis, there is a compelling need to develop alternative therapeutic targets for nonresponders to existing treatments. Soluble receptors occur naturally in vivo, such as the splice variant of the cell surface receptor for vascular endothelial growth factor (VEGF)--a key regulator of angiogenesis in rheumatoid arthritis. Bioinformatics analyses predict that the majority of human genes undergo alternative splicing, generating proteins--many of which may have regulatory functions. The objective of the present study was to identify alternative splice variants (ASV) from cell surface receptor genes, and to determine whether the novel proteins encoded exert therapeutic activity in an in vivo model of arthritis.	D004195	Disease Models, Animal

Clinically important variants in FGFR1

(ClinVar, 04/20/2024)

accession_id

uniprot_id

gene_name

Type

Variant

Clinical_significance