Protein:KAT6B |
Protein Summary |
 Gene summary |
| Gene name: KAT6B | ASpdb.0 ID: 23522 | Gene | Gene symbol | KAT6B | Gene ID | 23522 |
| Gene name | lysine acetyltransferase 6B |
| Synonyms | GTPTS|MORF|MOZ2|MYST4|ZC2HC6B|qkf|querkopf |
| Cytomap | 10q22.2 |
| Type of gene | protein-coding |
| Description | histone acetyltransferase KAT6BK(lysine) acetyltransferase 6BMOZ, YBF2/SAS3, SAS2 and TIP60 protein 4MOZ-related factorMYST histone acetyltransferase (monocytic leukemia) 4MYST-4histone acetyltransferase MORFhistone acetyltransferase MOZ2histone a |
| Modification date | 20240411 |
| UniProtAcc | Q8WYB5 |
| Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Gene | KAT6B | GO:0003713 | transcription coactivator activity | 11965546 |
| Gene | KAT6B | GO:0004402 | histone acetyltransferase activity | 10497217|11965546 |
| Gene | KAT6B | GO:0005634 | nucleus | 18794358 |
| Gene | KAT6B | GO:0006355 | regulation of DNA-templated transcription | 18794358 |
| Gene | KAT6B | GO:0036408 | histone H3K14 acetyltransferase activity | 16387653 |
| Gene | KAT6B | GO:0045892 | negative regulation of DNA-templated transcription | 10497217 |
| Gene | KAT6B | GO:0045893 | positive regulation of DNA-templated transcription | 10497217|11965546 |
| Gene | KAT6B | GO:0061733 | peptide-lysine-N-acetyltransferase activity | 11965546 |
| Gene | KAT6B | GO:0070776 | MOZ/MORF histone acetyltransferase complex | 16387653|18794358 |
AS Summary |
| Information of the canonical protein with experimentally identified structure from PDB (2023). |
| UniProt Acc | File name | PDB ID | Method | Resolution | Chain | Start | End |
| Q8WYB5-1 | Q8WYB5-1_5u2j_A.pdb | 5U2J | X-ray | 1.6 | A | 211 | 320 |
| ASpdb's canonical and alternatively spliced isoform information. |
| accession_id | gene_name | canonical_id | alternative_id | canonical_length | alternative_length | canonical_start | canonical_end | type | originalSEQ | variationSEQ | alternative_start | alternative_end |
| Q8WYB5 | KAT6B | Q8WYB5-1 | Q8WYB5-2 | 2073 | 1890 | 482 | 664 | Deletion | none | none | 481 | 481 |
| Q8WYB5 | KAT6B | Q8WYB5-1 | Q8WYB5-3 | 2073 | 1781 | 373 | 664 | Deletion | none | none | 372 | 372 |
| Multiple sequence alignment of our canonical and alternatively spliced KAT6B |
| Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of KAT6B |
| UniProt-id | ENSG | ENST | ENSP |
| Q8WYB5-1 | ENSG00000156650.14 | ENST00000287239.10 | ENSP00000287239.4 |
| Q8WYB5-1 | ENSG00000281813.4 | ENST00000630001.4 | ENSP00000486595.1 |
| Q8WYB5-1 | ENSG00000281813.4 | ENST00000647630.1 | ENSP00000497352.1 |
| Q8WYB5-1 | ENSG00000281813.4 | ENST00000648605.1 | ENSP00000497718.1 |
| Q8WYB5-1 | ENSG00000156650.14 | ENST00000648725.1 | ENSP00000497841.1 |
| Q8WYB5-1 | ENSG00000156650.14 | ENST00000649463.1 | ENSP00000497166.1 |
| Q8WYB5-2 | ENSG00000156650.14 | ENST00000372711.2 | ENSP00000361796.1 |
| Q8WYB5-2 | ENSG00000156650.14 | ENST00000372724.6 | ENSP00000361809.2 |
| Q8WYB5-2 | ENSG00000281813.4 | ENST00000628523.3 | ENSP00000487238.2 |
| Q8WYB5-2 | ENSG00000281813.4 | ENST00000629879.2 | ENSP00000486731.1 |
| Q8WYB5-3 | ENSG00000156650.14 | ENST00000372714.6 | ENSP00000361799.1 |
| Q8WYB5-3 | ENSG00000156650.14 | ENST00000372725.6 | ENSP00000361810.1 |
| Q8WYB5-3 | ENSG00000281813.4 | ENST00000628038.3 | ENSP00000485896.1 |
| Q8WYB5-3 | ENSG00000281813.4 | ENST00000629233.3 | ENSP00000487219.1 |
| Q8WYB5-3 | ENSG00000156650.14 | ENST00000648892.1 | ENSP00000497048.1 |
| Q8WYB5-3 | ENSG00000156650.14 | ENST00000649006.1 | ENSP00000498139.1 |
| Q8WYB5-3 | ENSG00000281813.4 | ENST00000649574.1 | ENSP00000497416.1 |
| Q8WYB5-3 | ENSG00000281813.4 | ENST00000650575.1 | ENSP00000497453.1 |
| UniProt-id | NM ID | NP ID |
| Q8WYB5-1 | NM_012330.3 | NP_036462.2 |
| Q8WYB5-1 | XM_005269664.2 | XP_005269721.1 |
| Q8WYB5-2 | NM_001256468.1 | NP_001243397.1 |
| Q8WYB5-3 | NM_001256469.1 | NP_001243398.1 |
| Amino acid sequences of our canonical and alternatively spliced KAT6B |
| accession_id | Protein sequence |
| Q8WYB5-1 | MVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGTFPK SAKGSRGSCNDLRNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQSDLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYGSLD GKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCIECK TCSACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVTSDE GSMNAFTGRGSPGRGQKTKVCTTPSSGHAASGKDSSSRLAVTDPTRPGATTKITTTSTYISASTLKVNKKTKGLIDGLTKFFTPSPDGRR SRGEIIDFSKHYRPRKKVSQKQSCTSHVLATGTTQKLKPPPSSLPPPTPISGQSPSSQKSSTATSSPSPQSSSSQCSVPSLSSLTTNSQL KALFDGLSHIYTTQGQSRKKGHPSYAPPKRMRRKTELSSTAKSKAHFFGKRDIRSRFISHSSSSSWGMARGSIFKAIAHFKRTTFLKKHR MLGRLKYKVTPQMGTPSPGKGSLTDGRIKPDQDDDTEIKINIKQESADVNVIGNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCGRYP SVIEFGKYEIQTWYSSPYPQEYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVDGNMSKIYCQNLCLLAKL FLDHKTLYYDVEPFLFYVLTKNDEKGCHLVGYFSKEKLCQQKYNVSCIMIMPQHQRQGFGRFLIDFSYLLSRREGQAGSPEKPLSDLGRL SYLAYWKSVILEYLYHHHERHISIKAISRATGMCPHDIATTLQHLHMIDKRDGRFVIIRREKLILSHMEKLKTCSRANELDPDSLRWTPI LISNAAVSEEEREAEKEAERLMEQASCWEKEEQEILSTRANSRQSPAKVQSKNKYLHSPESRPVTGERGQLLELSKESSEEEEEEEDEEE EEEEEEEEEDEEEEEEEEEEEEEENIQSSPPRLTKPQSVAIKRKRPFVLKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEERPMP QLEPTCEIEVEEDGRKPVLRKAFQHQPGKKRQTEEEEGKDNHCFKNADPCRNNMNDDSSNLKEGSKDNPEPLKCKQVWPKGTKRGLSKWR QNKERKTGFKLNLYTPPETPMEPDEQVTVEEQKETSEGKTSPSPIRIEEEVKETGEALLPQEENRREETCAPVSPNTSPGEKPEDDLIKP EEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEISTEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVE KEELPRESFKEVLENQETFLDLNVQPGHSNPEVLMDCGVDLTASCNSEPKELAGDPEAVPESDEEPPPGEQAQKQDQKNSKEVDTEFKEG NPATMEIDSETVQAVQSLTQESSEQDDTFQDCAETQEACRSLQNYTRADQSPQIATTLDDCQQSDHSSPVSSVHSHPGQSVRSVNSPSVP ALENSYAQISPDQSAISVPSLQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGGSICGNGSSQNSCSYSNLT SSSLTQSSCAVTQQMSNISGSCSMLQQTSISSPPTCSVKSPQGCVVERPPSSSQQLAQCSMAANFTPPMQLAEIPETSNANIGLYERMGQ SDFGAGHYPQPSATFSLAKLQQLTNTLIDHSLPYSHSAAVTSYANSASLSTPLSNTGLVQLSQSPHSVPGGPQAQATMTPPPNLTPPPMN LPPPLLQRNMAASNIGISHSQRLQTQIASKGHISMRTKSASLSPAAATHQSQIYGRSQTVAMQGPARTLTMQRGMNMSVNLMPAPAYNVN SVNMNMNTLNAMNGYSMSQPMMNSGYHSNHGYMNQTPQYPMQMQMGMMGTQPYAQQPMQTPPHGNMMYTAPGHHGYMNTGMSKQSLNGSY |
| Q8WYB5-2 | MVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGTFPK SAKGSRGSCNDLRNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQSDLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYGSLD GKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCIECK TCSACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVTSDE GSMNAFTGRGSPGRGQKTKVCTTPSSGHAASGKDSSSRLAVTDPTRPGATTKITTTSTYISASTLKVNKKTKGLIDGLTKFFTPSPDGRR SRGEIIDFSKHYRPRKKVSQKQSCTSHVLATDTEIKINIKQESADVNVIGNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCGRYPSVI EFGKYEIQTWYSSPYPQEYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVDGNMSKIYCQNLCLLAKLFLD HKTLYYDVEPFLFYVLTKNDEKGCHLVGYFSKEKLCQQKYNVSCIMIMPQHQRQGFGRFLIDFSYLLSRREGQAGSPEKPLSDLGRLSYL AYWKSVILEYLYHHHERHISIKAISRATGMCPHDIATTLQHLHMIDKRDGRFVIIRREKLILSHMEKLKTCSRANELDPDSLRWTPILIS NAAVSEEEREAEKEAERLMEQASCWEKEEQEILSTRANSRQSPAKVQSKNKYLHSPESRPVTGERGQLLELSKESSEEEEEEEDEEEEEE EEEEEEDEEEEEEEEEEEEEENIQSSPPRLTKPQSVAIKRKRPFVLKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEERPMPQLE PTCEIEVEEDGRKPVLRKAFQHQPGKKRQTEEEEGKDNHCFKNADPCRNNMNDDSSNLKEGSKDNPEPLKCKQVWPKGTKRGLSKWRQNK ERKTGFKLNLYTPPETPMEPDEQVTVEEQKETSEGKTSPSPIRIEEEVKETGEALLPQEENRREETCAPVSPNTSPGEKPEDDLIKPEEE EEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEISTEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEE LPRESFKEVLENQETFLDLNVQPGHSNPEVLMDCGVDLTASCNSEPKELAGDPEAVPESDEEPPPGEQAQKQDQKNSKEVDTEFKEGNPA TMEIDSETVQAVQSLTQESSEQDDTFQDCAETQEACRSLQNYTRADQSPQIATTLDDCQQSDHSSPVSSVHSHPGQSVRSVNSPSVPALE NSYAQISPDQSAISVPSLQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGGSICGNGSSQNSCSYSNLTSSS LTQSSCAVTQQMSNISGSCSMLQQTSISSPPTCSVKSPQGCVVERPPSSSQQLAQCSMAANFTPPMQLAEIPETSNANIGLYERMGQSDF GAGHYPQPSATFSLAKLQQLTNTLIDHSLPYSHSAAVTSYANSASLSTPLSNTGLVQLSQSPHSVPGGPQAQATMTPPPNLTPPPMNLPP PLLQRNMAASNIGISHSQRLQTQIASKGHISMRTKSASLSPAAATHQSQIYGRSQTVAMQGPARTLTMQRGMNMSVNLMPAPAYNVNSVN MNMNTLNAMNGYSMSQPMMNSGYHSNHGYMNQTPQYPMQMQMGMMGTQPYAQQPMQTPPHGNMMYTAPGHHGYMNTGMSKQSLNGSYMRR |
| Q8WYB5-3 | MVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGTFPK SAKGSRGSCNDLRNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQSDLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYGSLD GKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCIECK TCSACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVTSDE GSMNAFTGRGSPDTEIKINIKQESADVNVIGNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCGRYPSVIEFGKYEIQTWYSSPYPQEY ARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVDGNMSKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTKN DEKGCHLVGYFSKEKLCQQKYNVSCIMIMPQHQRQGFGRFLIDFSYLLSRREGQAGSPEKPLSDLGRLSYLAYWKSVILEYLYHHHERHI SIKAISRATGMCPHDIATTLQHLHMIDKRDGRFVIIRREKLILSHMEKLKTCSRANELDPDSLRWTPILISNAAVSEEEREAEKEAERLM EQASCWEKEEQEILSTRANSRQSPAKVQSKNKYLHSPESRPVTGERGQLLELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEE EENIQSSPPRLTKPQSVAIKRKRPFVLKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEERPMPQLEPTCEIEVEEDGRKPVLRKA FQHQPGKKRQTEEEEGKDNHCFKNADPCRNNMNDDSSNLKEGSKDNPEPLKCKQVWPKGTKRGLSKWRQNKERKTGFKLNLYTPPETPME PDEQVTVEEQKETSEGKTSPSPIRIEEEVKETGEALLPQEENRREETCAPVSPNTSPGEKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEE EGGGNVEKDPDGAKSQEKEEPEISTEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEELPRESFKEVLENQETFLDL NVQPGHSNPEVLMDCGVDLTASCNSEPKELAGDPEAVPESDEEPPPGEQAQKQDQKNSKEVDTEFKEGNPATMEIDSETVQAVQSLTQES SEQDDTFQDCAETQEACRSLQNYTRADQSPQIATTLDDCQQSDHSSPVSSVHSHPGQSVRSVNSPSVPALENSYAQISPDQSAISVPSLQ NMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGGSICGNGSSQNSCSYSNLTSSSLTQSSCAVTQQMSNISGSC SMLQQTSISSPPTCSVKSPQGCVVERPPSSSQQLAQCSMAANFTPPMQLAEIPETSNANIGLYERMGQSDFGAGHYPQPSATFSLAKLQQ LTNTLIDHSLPYSHSAAVTSYANSASLSTPLSNTGLVQLSQSPHSVPGGPQAQATMTPPPNLTPPPMNLPPPLLQRNMAASNIGISHSQR LQTQIASKGHISMRTKSASLSPAAATHQSQIYGRSQTVAMQGPARTLTMQRGMNMSVNLMPAPAYNVNSVNMNMNTLNAMNGYSMSQPMM |
Protein Functional Features |
| Main function of this protein. (from UniProt) |
| KAT6B (go to UniProt):Q8WYB5 |
| Retention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Accession_id | Subsection | Start | End | Funcitonal feature | Splicing information |
| Q8WYB5 | Region | 360 | 409 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=373;End=664 |
| Q8WYB5 | Region | 361 | 717 | Note=Negatively regulates HAT activity | Type=Deletion;Start=482;End=664 |
| Q8WYB5 | Region | 361 | 717 | Note=Negatively regulates HAT activity | Type=Deletion;Start=373;End=664 |
| Q8WYB5 | Region | 442 | 531 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=482;End=664 |
| Q8WYB5 | Region | 442 | 531 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=373;End=664 |
| Q8WYB5 | Region | 553 | 583 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=482;End=664 |
| Q8WYB5 | Region | 553 | 583 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=373;End=664 |
| Q8WYB5 | Region | 639 | 663 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=482;End=664 |
| Q8WYB5 | Region | 639 | 663 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=373;End=664 |
| Q8WYB5 | Compositional bias | 471 | 488 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=482;End=664 |
| Q8WYB5 | Compositional bias | 471 | 488 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=373;End=664 |
| Q8WYB5 | Compositional bias | 503 | 531 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=482;End=664 |
| Q8WYB5 | Compositional bias | 503 | 531 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=373;End=664 |
| Q8WYB5 | Compositional bias | 569 | 583 | Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=482;End=664 |
| Q8WYB5 | Compositional bias | 569 | 583 | Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=373;End=664 |
Gene Isoform Structures and Expression Levels for KAT6B |
| Gene structures of our canonical and alternative spliced genes of KAT6B * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Expression levels of gene isoforms across GTEx. |
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| Expression levels of gene isoforms across TCGA. |
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Protein Structures |
| PDB and CIF files of the predicted protein structures * Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| 3D view using mol* of Q8WYB5-1 |
| 3D view using mol* of Q8WYB5-2 |
| 3D view using mol* of Q8WYB5-3 |
pLDDT Score Distribution |
| pLDDT score distribution of the predicted protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
| pLDDT distribution across the protein length of Q8WYB5-1 |
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| pLDDT distribution across the protein length of Q8WYB5-2 |
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| pLDDT distribution across the protein length of Q8WYB5-3 |
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Ramachandran Plot of Protein Structures |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide. |
| Ramachandran plot of Q8WYB5-1 |
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| Ramachandran plot of Q8WYB5-2 |
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Potential Active Site Information |
| The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite. |
| UniProt-id | Site score | Size | D score | Volume | Exposure | Enclosure | Contact | Phobic | Philic | Balance | Don/Acc | Residues |
| Q8WYB5-1 | 1.067 | 90 | 1.103 | 310.072 | 0.587 | 0.782 | 0.941 | 0.941 | 0.791 | 1.189 | 1.272 | 825,827,845,846,847,848,849,850,852,853,854,880,88 1,884,886,887,888,934,987,989,990,991,992,994 |
| Q8WYB5-2 | 1.078 | 87 | 1.145 | 335.454 | 0.588 | 0.75 | 0.889 | 1.496 | 0.558 | 2.68 | 1.214 | 709,710,711,716,717,718,719,720,721,723,724,725,75 4,757,758,784,787,1356,1357,1358,1360,1361,1364,13 65 |
| Q8WYB5-3 | 1.076 | 148 | 1.124 | 385.875 | 0.486 | 0.741 | 0.966 | 0.792 | 0.799 | 0.991 | 1.254 | 533,535,553,554,555,556,557,560,561,562,588,589,59 2,594,595,596,695,697,698,699,700,702,703,705,706, 707,710 |
Protein Structure and Feature Comparision |
| Protein Structure Comparision Using Template Modeling Scores (TM-score). |
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| Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green) |
| 3D view using mol* of Q8WYB5-1_Q8WYB5-1_5u2j_A.pdb |
| Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green) |
| 3D view using mol* of Q8WYB5-1_5u2j_A_Q8WYB5-2.pdb |
| 3D view using mol* of Q8WYB5-1_5u2j_A_Q8WYB5-3.pdb |
| Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green) |
| 3D view using mol* of Q8WYB5-1_Q8WYB5-2.pdb |
| 3D view using mol* of Q8WYB5-1_Q8WYB5-3.pdb |
| Protein Feature Comparison of the protein sequendary structures among the protiens. |
| ./stats/secondary_structure/figure/Q8WYB5-1_vs_Q8WYB5-2.png |
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| ./stats/secondary_structure/figure/Q8WYB5-1_vs_Q8WYB5-3.png |
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| Protein Feature Comparison of the relative accessible surface area (ASA) among the protiens. |
| ./stats/relative_asa/Q8WYB5-1_vs_Q8WYB5-2.png |
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| ./stats/relative_asa/Q8WYB5-1_vs_Q8WYB5-3.png |
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Protein-Protein Interaction |
| Interactors from UniProt. |
| Accession_id | Subsection | Start | End | Funcitonal feature | Splicing information |
| Interactors from STRING. |
| Gene name | Interactors |
Related Drugs to KAT6B |
| Drugs targeting this gene/protein. (DrugBank) |
| UniProt accession | Gene name | DrugBank ID | Drug name | Drug group | Actions |
Related Diseases to KAT6B |
| Previous studies relating to the alternative splicing of KAT6B and disease information from the MeSH term (PubMed) |
| Gene | PMID | Title | Abstract | MeSH ID | MeSH term |
Clinically important variants in KAT6B |
| (ClinVar, 04/20/2024) |
| accession_id | uniprot_id | gene_name | Type | Variant | Clinical_significance |
| Q8WYB5 | Q8WYB5-1 | KAT6B | Deletion | p.Asp1227Glufs | Pathogenic |
| Q8WYB5 | Q8WYB5-1 | KAT6B | Deletion | p.Asp1227Glufs | Pathogenic |
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