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	Protein Summary
	AS Summary
	Protein Functional Features
	Gene Isoform Structures and Expression Levels
	Protein Structures
	pLDDT Score Distribution
	Ramachandran Plot of Protein Structures
	Potential Active Site Information
	Protein Structure and Feature Comparision
	Protein-Protein Interaction
	Related Drugs
	Related Diseases
	Clinically Important Variants

Protein:NALCN

Protein Summary

Gene summary

Gene name: NALCN
ASpdb.0 ID: 259232
	Gene
Gene symbol	NALCN
Gene ID	259232
Gene name	sodium leak channel, non-selective
Synonyms	CLIFAHDD\|CanIon\|IHPRF\|IHPRF1\|INNFD\|VGCNL1\|bA430M15.1
Cytomap	13q32.3-q33.1
Type of gene	protein-coding
Description	sodium leak channel NALCNfour repeat voltage-gated ion channelvoltage gated channel like 1
Modification date	20240403
UniProtAcc	Q8IZF0

Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Gene	NALCN	GO:0005248	voltage-gated sodium channel activity	32698188
Gene	NALCN	GO:0005886	plasma membrane	31409833\|32698188

AS Summary

Information of the canonical protein with experimentally identified structure from PDB (2023).

UniProt Acc	File name	PDB ID	Method	Resolution	Chain	Start	End
Q8IZF0-1	Q8IZF0-1_7cm3_A.pdb	7CM3	EM	3.1	A	31	1602

ASpdb's canonical and alternatively spliced isoform information.

accession_id

gene_name

canonical_id

alternative_id

canonical_length

alternative_length

canonical_start

canonical_end

type

originalSEQ

variationSEQ

alternative_start

alternative_end

Q8IZF0

NALCN

Q8IZF0-1

Q8IZF0-2

1738

668

589

668

Substitution

ILLSLFVAVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQMVKISKLPSDFTVPKIRESFMKQFID

PPSLIRDLCGTQDACPSCLPLQPPNHLPGSQTLARLTHQALTTPPGMRSSQLFSKISLLLGICVAWESILGSLSLSHNLQ

589

668

Q8IZF0

NALCN

Q8IZF0-1

Q8IZF0-2

1738

668

669

1738

Deletion

none

668

Q8IZF0

NALCN

Q8IZF0-1

Q8IZF0-3

1738

218

216

218

Substitution

NVT

LSL

216

218

Q8IZF0

NALCN

Q8IZF0-1

Q8IZF0-3

1738

218

219

1738

Deletion

none

218

Multiple sequence alignment of our canonical and alternatively spliced NALCN

Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of NALCN

UniProt-id	ENSG	ENST	ENSP
Q8IZF0-1	ENSG00000102452.18	ENST00000251127.11	ENSP00000251127.6
Q8IZF0-3	ENSG00000102452.18	ENST00000376200.6	ENSP00000365373.5

UniProt-id	NM ID	NP ID
Q8IZF0-1	NM_052867.2	NP_443099.1

Amino acid sequences of our canonical and alternatively spliced NALCN

accession_id	Protein sequence
Q8IZF0-1	MLKRKQSSRVEAQPVTDFGPDESLSDNADILWINKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKM HIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWS VSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSI FTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQ LVAVDVNKPQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFTGYISSSL HKFELLLVIGTTLHVYPDLYHSQFTYFQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDRFTTF PRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANADTKEKLPLR LRIFEKFPNRPQMVKISKLPSDFTVPKIRESFMKQFIDRQQQDTCCLLRSLPTTSSSSCDHSKRSAIEDNKYIDQKLRKSVFSIRARNLL EKETAVTKILRACTRQRMLSGSFEGQPAKERSILSVQHHIRQERRSLRHGSNSQRISRGKSLETLTQDHSNTVRYRNAQREDSEIKMIQE KKEQAEMKRKVQEEELRENHPYFDKPLFIVGREHRFRNFCRVVVRARFNASKTDPVTGAVKNTKYHQLYDLLGLVTYLDWVMIIVTICSC ISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRC LRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEK KPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPIHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTV DQRRWEDLKSRLKIAQPLHLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKI IAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACVIVFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYA FAGVVLFGTVKYGENINRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLN LLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEVDLDKDKLLFKHMCYEMERLHNGGDVTF HDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEEEVAKQTIRMWLKKCLKRIRAKQQQSCSIIHSLRESQQQELSRFLNPPSIETTQPS EDTNANSQDNSMQPETSSQQQLLSPTLSDRGGSRQDAADAGKPQRKFGQWRLPSAPKPISHSVSSVNLRFGGRTTMKSVVCKMNPMTDAA
Q8IZF0-2	MLKRKQSSRVEAQPVTDFGPDESLSDNADILWINKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKM HIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWS VSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSI FTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQ LVAVDVNKPQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFTGYISSSL HKFELLLVIGTTLHVYPDLYHSQFTYFQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDRFTTF PRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLPPSLIRDLCGTQDACPSCLPLQPPNHLPGSQTLARLTHQALT
Q8IZF0-3	MLKRKQSSRVEAQPVTDFGPDESLSDNADILWINKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKM HIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWS

Protein Functional Features

Main function of this protein. (from UniProt)

NALCN (go to UniProt):Q8IZF0

Retention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Accession_id	Subsection	Start	End	Funcitonal feature	Splicing information
Q8IZF0	Topological domain	200	269	"Note=Extracellular;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	200	269	"Note=Extracellular;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Intramembrane	270	289	"Note=Pore-forming;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	290	294	"Note=Extracellular;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	295	322	"Note=Helical%3B Name%3DS6 of repeat I;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	323	382	"Note=Cytoplasmic;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	383	403	"Note=Helical%3B Name%3DS1 of repeat II;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	404	416	"Note=Extracellular;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	417	439	"Note=Helical%3B Name%3DS2 of repeat II;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	440	447	"Note=Cytoplasmic;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	448	468	"Note=Helical%3B Name%3DS3 of repeat II;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	469	472	"Note=Extracellular;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	473	492	"Note=Helical%3B Voltage-sensor%3B Name%3DS4 of repeat II;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	493	502	"Note=Cytoplasmic;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	503	530	"Note=Helical%3B Name%3DS5 of repeat II;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	531	543	"Note=Extracellular;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Intramembrane	544	563	"Note=Pore-forming;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	564	569	"Note=Extracellular;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	570	599	"Note=Helical%3B Name%3DS6 of repeat II;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	570	599	"Note=Helical%3B Name%3DS6 of repeat II;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	600	886	"Note=Cytoplasmic;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	600	886	"Note=Cytoplasmic;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	600	886	"Note=Cytoplasmic;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	887	906	"Note=Helical%3B Name%3DS1 of repeat III;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	887	906	"Note=Helical%3B Name%3DS1 of repeat III;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	907	915	"Note=Extracellular;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	907	915	"Note=Extracellular;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	916	939	"Note=Helical%3B Name%3DS2 of repeat III;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	916	939	"Note=Helical%3B Name%3DS2 of repeat III;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	940	947	"Note=Cytoplasmic;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	940	947	"Note=Cytoplasmic;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	948	972	"Note=Helical%3B Name%3DS3 of repeat III;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	948	972	"Note=Helical%3B Name%3DS3 of repeat III;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	973	980	"Note=Extracellular;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	973	980	"Note=Extracellular;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	981	1003	"Note=Helical%3B Voltage-sensor%3B Name%3DS4 of repeat III;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	981	1003	"Note=Helical%3B Voltage-sensor%3B Name%3DS4 of repeat III;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	1004	1015	"Note=Cytoplasmic;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	1004	1015	"Note=Cytoplasmic;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	1016	1039	"Note=Helical%3B Name%3DS5 of repeat III;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	1016	1039	"Note=Helical%3B Name%3DS5 of repeat III;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	1040	1104	"Note=Extracellular;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	1040	1104	"Note=Extracellular;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Intramembrane	1105	1124	"Note=Pore-forming;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Intramembrane	1105	1124	"Note=Pore-forming;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	1125	1129	"Note=Extracellular;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	1125	1129	"Note=Extracellular;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	1130	1159	"Note=Helical%3B Name%3DS6 of repeat III;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	1130	1159	"Note=Helical%3B Name%3DS6 of repeat III;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	1160	1210	"Note=Cytoplasmic;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	1160	1210	"Note=Cytoplasmic;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	1211	1227	"Note=Helical%3B Name%3DS1 of repeat IV;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	1211	1227	"Note=Helical%3B Name%3DS1 of repeat IV;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	1228	1236	"Note=Extracellular;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	1228	1236	"Note=Extracellular;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	1237	1260	"Note=Helical%3B Name%3DS2 of repeat IV;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	1237	1260	"Note=Helical%3B Name%3DS2 of repeat IV;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	1261	1271	"Note=Cytoplasmic;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	1261	1271	"Note=Cytoplasmic;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	1272	1293	"Note=Helical%3B Name%3DS3 of repeat IV;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	1272	1293	"Note=Helical%3B Name%3DS3 of repeat IV;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	1294	1296	"Note=Extracellular;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	1294	1296	"Note=Extracellular;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	1297	1318	"Note=Helical%3B Voltage-sensor%3B Name%3DS4 of repeat IV;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	1297	1318	"Note=Helical%3B Voltage-sensor%3B Name%3DS4 of repeat IV;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	1319	1331	"Note=Cytoplasmic;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	1319	1331	"Note=Cytoplasmic;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	1332	1357	"Note=Helical%3B Name%3DS5 of repeat IV;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	1332	1357	"Note=Helical%3B Name%3DS5 of repeat IV;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	1358	1378	"Note=Extracellular;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	1358	1378	"Note=Extracellular;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Intramembrane	1379	1398	"Note=Pore-forming;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Intramembrane	1379	1398	"Note=Pore-forming;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	1399	1420	"Note=Extracellular;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	1399	1420	"Note=Extracellular;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	1421	1447	"Note=Helical%3B Name%3DS6 of repeat IV;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Transmembrane	1421	1447	"Note=Helical%3B Name%3DS6 of repeat IV;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	1448	1738	"Note=Cytoplasmic;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Topological domain	1448	1738	"Note=Cytoplasmic;Ontology_term=ECO:0000269	ECO:0007744;evidence=ECO:0000269\|PubMed:32698188
Q8IZF0	Region	762	785	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=669;End=1738
Q8IZF0	Region	762	785	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=219;End=1738
Q8IZF0	Region	1611	1678	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=669;End=1738
Q8IZF0	Region	1611	1678	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=219;End=1738
Q8IZF0	Coiled coil	795	830	Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=669;End=1738
Q8IZF0	Coiled coil	795	830	Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=219;End=1738
Q8IZF0	Compositional bias	1611	1651	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=669;End=1738
Q8IZF0	Compositional bias	1611	1651	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=219;End=1738

Gene Isoform Structures and Expression Levels for NALCN

Gene structures of our canonical and alternative spliced genes of NALCN
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Expression levels of gene isoforms across GTEx.

Expression levels of gene isoforms across TCGA.

Protein Structures

PDB and CIF files of the predicted protein structures
* Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

3D view using mol* of Q8IZF0-1

3D view using mol* of Q8IZF0-2

3D view using mol* of Q8IZF0-3

pLDDT Score Distribution

pLDDT score distribution of the predicted protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

pLDDT distribution across the protein length of Q8IZF0-1

pLDDT distribution across the protein length of Q8IZF0-2

pLDDT distribution across the protein length of Q8IZF0-3

Ramachandran Plot of Protein Structures

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide.

Ramachandran plot of Q8IZF0-1

Ramachandran plot of Q8IZF0-2

Potential Active Site Information

The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite.

UniProt-id	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
Q8IZF0-1	1.057	310	1.096	1016.995	0.538	0.735	0.925	0.979	0.875	1.12	0.596	1178,1181,1182,1184,1185,1186,1187,1188,1189,1190, 1191,1192,1193,1204,1208,1212,1213,1214,1216,1217, 1221,1255,1259,1263,1267,1268,1270,1271,1272,1273, 1274,1276,1277,1312,1313,1314,1315,1316,1317,1318, 1319,1321,1322,1323,1325,1326,1329,1453,1455,1456, 1457,1462,1463,1464,1467,1468,1471,1472,1475,1476, 1478,1479,1481
Q8IZF0-2	1.212	552	1.318	1404.928	0.397	0.814	1.023	2.724	0.34	8.015	2.645	106,107,109,110,113,144,148,151,158,160,162,166,16 7,170,171,174,175,176,178,179,182,185,186,189,190, 255,260,267,268,270,271,274,317,321,325,328,332,33 5,512,516,517,519,520,523,551,564,569,572,573,574, 576,577,578,580,581,582,584,585,588,592,593,596,59 7,643,644,646,647,648,650,651,652,653,654,655,657, 658,660,661,662
Q8IZF0-3	0.933	45	0.983	112.161	0.471	0.741	1.049	3.073	0.283	10.853	0.444	29,32,33,37,38,41,42,81,84,85,88,92

Protein Structure and Feature Comparision

Protein Structure Comparision Using Template Modeling Scores (TM-score).

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green)

3D view using mol* of Q8IZF0-1_Q8IZF0-1_7cm3_A.pdb

Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of Q8IZF0-1_7cm3_A_Q8IZF0-2.pdb

3D view using mol* of Q8IZF0-1_7cm3_A_Q8IZF0-3.pdb

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of Q8IZF0-1_Q8IZF0-2.pdb

3D view using mol* of Q8IZF0-1_Q8IZF0-3.pdb

Protein Feature Comparison of the protein sequendary structures among the protiens.

./stats/secondary_structure/figure/Q8IZF0-1_vs_Q8IZF0-2.png

./stats/secondary_structure/figure/Q8IZF0-1_vs_Q8IZF0-3.png

Protein Feature Comparison of the relative accessible surface area (ASA) among the protiens.

./stats/relative_asa/Q8IZF0-1_vs_Q8IZF0-2.png

./stats/relative_asa/Q8IZF0-1_vs_Q8IZF0-3.png

Protein-Protein Interaction

Interactors from UniProt.

Accession_id

Subsection

Start

End

Funcitonal feature

Splicing information

Interactors from STRING.

Gene name

Interactors

Related Drugs to NALCN

Drugs targeting this gene/protein.
(DrugBank)

UniProt accession

Gene name

DrugBank ID

Drug name

Drug group

Actions

Related Diseases to NALCN

Previous studies relating to the alternative splicing of NALCN and disease information from the MeSH term (PubMed)

Gene

PMID

Title

Abstract

MeSH ID

MeSH term

Clinically important variants in NALCN

(ClinVar, 04/20/2024)

accession_id

uniprot_id

gene_name

Type

Variant

Clinical_significance