Protein:ABL2 |
Protein Summary |
 Gene summary |
| Gene name: ABL2 | ASpdb.0 ID: 27 | Gene | Gene symbol | ABL2 | Gene ID | 27 |
| Gene name | ABL proto-oncogene 2, non-receptor tyrosine kinase |
| Synonyms | ABLL|ARG |
| Cytomap | 1q25.2 |
| Type of gene | protein-coding |
| Description | tyrosine-protein kinase ABL2Abelson tyrosine-protein kinase 2abelson-related gene proteinc-abl oncogene 2, non-receptor tyrosine kinasetyrosine-protein kinase ARGv-abl Abelson murine leukemia viral oncogene homolog 2 |
| Modification date | 20240411 |
| UniProtAcc | P42684 |
| Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Gene | ABL2 | GO:0000287 | magnesium ion binding | 15886098 |
| Gene | ABL2 | GO:0004713 | protein tyrosine kinase activity | 15886098 |
| Gene | ABL2 | GO:0018108 | peptidyl-tyrosine phosphorylation | 15886098 |
| Gene | ABL2 | GO:0030145 | manganese ion binding | 15886098 |
| Gene | ABL2 | GO:0051353 | positive regulation of oxidoreductase activity | 12893824 |
AS Summary |
| Information of the canonical protein with experimentally identified structure from PDB (2023). |
| UniProt Acc | File name | PDB ID | Method | Resolution | Chain | Start | End |
| P42684-1 | P42684-1_3hmi_A.pdb | 3HMI | X-ray | 1.65 | A | 279 | 546 |
| ASpdb's canonical and alternatively spliced isoform information. |
| accession_id | gene_name | canonical_id | alternative_id | canonical_length | alternative_length | canonical_start | canonical_end | type | originalSEQ | variationSEQ | alternative_start | alternative_end |
| P42684 | ABL2 | P42684-1 | P42684-8 | 1182 | 542 | 53 | 73 | Deletion | none | none | 52 | 52 |
| P42684 | ABL2 | P42684-1 | P42684-8 | 1182 | 542 | 550 | 564 | Substitution | EEVAEELGRAASSSS | EVLLHCANQTCITL | 529 | 542 |
| P42684 | ABL2 | P42684-1 | P42684-8 | 1182 | 542 | 565 | 1182 | Deletion | none | none | 542 | 542 |
| Multiple sequence alignment of our canonical and alternatively spliced ABL2 |
| Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of ABL2 |
| UniProt-id | ENSG | ENST | ENSP |
| P42684-1 | ENSG00000143322.22 | ENST00000502732.6 | ENSP00000427562.1 |
| UniProt-id | NM ID | NP ID |
| P42684-1 | NM_007314.3 | NP_009298.1 |
| P42684-8 | NM_001136001.1 | NP_001129473.1 |
| Amino acid sequences of our canonical and alternatively spliced ABL2 |
| accession_id | Protein sequence |
| P42684-1 | MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALN EAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPT VYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIK WTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE TMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDK SPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGG SFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKL QLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLG MAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVM RLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKIS ADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLL |
| P42684-8 | MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNL FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESE SSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMK HKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEV TAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAF GVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEVLLHCANQTCI |
Protein Functional Features |
| Main function of this protein. (from UniProt) |
| ABL2 (go to UniProt):P42684 |
| Retention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Accession_id | Subsection | Start | End | Funcitonal feature | Splicing information |
| P42684 | Region | 2 | 106 | Note=CAP | Type=Deletion;Start=53;End=73 |
| P42684 | Region | 60 | 80 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=53;End=73 |
| P42684 | Region | 611 | 641 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=565;End=1182 |
| P42684 | Region | 654 | 674 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=565;End=1182 |
| P42684 | Region | 694 | 930 | Note=F-actin-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250 | Type=Deletion;Start=565;End=1182 |
| P42684 | Region | 763 | 794 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=565;End=1182 |
| P42684 | Region | 807 | 851 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=565;End=1182 |
| P42684 | Region | 964 | 1024 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=565;End=1182 |
| P42684 | Region | 1020 | 1182 | Note=F-actin-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250 | Type=Deletion;Start=565;End=1182 |
| P42684 | Motif | 658 | 660 | Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Deletion;Start=565;End=1182 |
| P42684 | Compositional bias | 774 | 793 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=565;End=1182 |
| P42684 | Compositional bias | 807 | 826 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=565;End=1182 |
| P42684 | Compositional bias | 828 | 851 | Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=565;End=1182 |
| P42684 | Compositional bias | 966 | 980 | Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=565;End=1182 |
| P42684 | Compositional bias | 1000 | 1021 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=565;End=1182 |
Gene Isoform Structures and Expression Levels for ABL2 |
| Gene structures of our canonical and alternative spliced genes of ABL2 * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Expression levels of gene isoforms across GTEx. |
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| Expression levels of gene isoforms across TCGA. |
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Protein Structures |
| PDB and CIF files of the predicted protein structures * Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| 3D view using mol* of P42684-1 |
| 3D view using mol* of P42684-8 |
pLDDT Score Distribution |
| pLDDT score distribution of the predicted protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
| pLDDT distribution across the protein length of P42684-1 |
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| pLDDT distribution across the protein length of P42684-8 |
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Ramachandran Plot of Protein Structures |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide. |
| Ramachandran plot of P42684-1 |
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Potential Active Site Information |
| The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite. |
| UniProt-id | Site score | Size | D score | Volume | Exposure | Enclosure | Contact | Phobic | Philic | Balance | Don/Acc | Residues |
| P42684-1 | 1.035 | 377 | 1.071 | 1435.112 | 0.621 | 0.712 | 0.845 | 0.551 | 0.907 | 0.607 | 0.842 | 88,89,91,92,93,95,100,103,104,113,114,115,116,117, 118,119,121,130,131,133,145,161,165,166,169,170,17 1,172,173,175,178,179,182,185,186,190,191,194,261, 262,263,264,265,266,267,268,269,270,271,273,274,31 0,312,313,314,342,343,346,348,362,363,364,365,388, 391,392,418,419,420,422,424,536,540 |
| P42684-8 | 1.061 | 220 | 1.097 | 992.642 | 0.639 | 0.746 | 0.839 | 0.531 | 0.893 | 0.595 | 0.764 | 94,95,97,98,100,140,148,154,157,158,160,161,164,16 5,244,245,246,247,248,249,250,252,253,289,291,292, 321,322,325,327,341,342,343,344,367,370,371,374,39 7,398,399,401,403,515,519 |
Protein Structure and Feature Comparision |
| Protein Structure Comparision Using Template Modeling Scores (TM-score). |
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| Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green) |
| 3D view using mol* of P42684-1_P42684-1_3hmi_A.pdb |
| Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green) |
| 3D view using mol* of P42684-1_3hmi_A_P42684-8.pdb |
| Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green) |
| 3D view using mol* of P42684-1_P42684-8.pdb |
| Protein Feature Comparison of the protein sequendary structures among the protiens. |
| ./stats/secondary_structure/figure/P42684-1_vs_P42684-8.png |
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| Protein Feature Comparison of the relative accessible surface area (ASA) among the protiens. |
| ./stats/relative_asa/P42684-1_vs_P42684-8.png |
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Protein-Protein Interaction |
| Interactors from UniProt. |
| Accession_id | Subsection | Start | End | Funcitonal feature | Splicing information |
| Interactors from STRING. |
| Gene name | Interactors |
Related Drugs to ABL2 |
| Drugs targeting this gene/protein. (DrugBank) |
| UniProt accession | Gene name | DrugBank ID | Drug name | Drug group | Actions |
| P42684 | ABL2 | DB07664 | K-00546 | experimental | |
| P42684 | ABL2 | DB00171 | ATP | investigational, nutraceutical | inhibitor |
| P42684 | ABL2 | DB01254 | Dasatinib | approved, investigational | multitarget |
| P42684 | ABL2 | DB05184 | XL228 | investigational | |
| P42684 | ABL2 | DB12010 | Fostamatinib | approved, investigational | inhibitor |
Related Diseases to ABL2 |
| Previous studies relating to the alternative splicing of ABL2 and disease information from the MeSH term (PubMed) |
| Gene | PMID | Title | Abstract | MeSH ID | MeSH term |
| ABL2 | 12406085 | Identification of an ETV6-ABL2 fusion transcript in combination with an ETV6 point mutation in a T-cell acute lymphoblastic leukaemia cell line. | ETV6, a member of the Ets family of transcription factors, is frequently rearranged to various translocation partners in human leukaemias. We previously described a CD3+/TCRalpha/beta+ mature T-cell acute lymphoblastic leukaemia (T-ALL) cell line, MT-ALL, carrying a t(1;10;12)(q25; p13;p13) with cytokine-inducible lineage switch into the myeloid lineage. Using reverse transcription polymerase chain reaction with primers complementary to ETV6 and ABL2, two ETV6-ABL2 fusion transcripts were identified in MT-ALL which resulted from alternative splicing of an ABL2 exon. The fusion transcripts code for putative ETV6-ABL2 fusion proteins containing the pointed domain of ETV6 and almost the complete ABL2 protein, including the SH2, SH3 domains and the protein tyrosine kinase domain (PTK). Identical ETV6-ABL2 fusion transcripts have been reported in an acute myeloid leukaemia (AML) M3 cell line, carrying both a t(15;17)(q22;q21) and a t(1;12)(q25;p13) with unusual inducible differentiation to eosinophils, and in a patient with AML-M4eo. Interestingly, the non-rearranged allele of ETV6 in the MT-ALL cell line carries an arginine to histidine (R399H) mutation which affects a conserved amino acid in the ets DNA binding domain. | D015459 | Leukemia-Lymphoma, Adult T-Cell |
Clinically important variants in ABL2 |
| (ClinVar, 04/20/2024) |
| accession_id | uniprot_id | gene_name | Type | Variant | Clinical_significance |
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