ASpdb: an integrative knowledgebase of human protein isoforms from experimental and AI-predicted structures

Home

Download

Statistics

Examples

Help

Contact

	Protein Summary
	AS Summary
	Protein Functional Features
	Gene Isoform Structures and Expression Levels
	Protein Structures
	pLDDT Score Distribution
	Ramachandran Plot of Protein Structures
	Potential Active Site Information
	Protein Structure and Feature Comparision
	Protein-Protein Interaction
	Related Drugs
	Related Diseases
	Clinically Important Variants

Protein:GRM7

Protein Summary

Gene summary

Gene name: GRM7
ASpdb.0 ID: 2917
	Gene
Gene symbol	GRM7
Gene ID	2917
Gene name	glutamate metabotropic receptor 7
Synonyms	GLUR7\|GPRC1G\|MGLU7\|MGLUR7\|NEDSHBA\|PPP1R87
Cytomap	3p26.1
Type of gene	protein-coding
Description	metabotropic glutamate receptor 7glutamate receptor, metabotropic 7protein phosphatase 1, regulatory subunit 87
Modification date	20240411
UniProtAcc	Q14831

Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Gene	GRM7	GO:0001642	group III metabotropic glutamate receptor activity	9144652\|9473604
Gene	GRM7	GO:0005938	cell cortex	9630572
Gene	GRM7	GO:0007196	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	9473604
Gene	GRM7	GO:0007268	chemical synaptic transmission	9473604
Gene	GRM7	GO:0008066	glutamate receptor activity	9473604
Gene	GRM7	GO:0010855	adenylate cyclase inhibitor activity	9473604
Gene	GRM7	GO:0016020	membrane	12746871
Gene	GRM7	GO:0030425	dendrite	9630572
Gene	GRM7	GO:0043235	receptor complex	23382219
Gene	GRM7	GO:0070085	glycosylation	33500274
Gene	GRM7	GO:0070905	serine binding	9144652

AS Summary

Information of the canonical protein with experimentally identified structure from PDB (2023).

UniProt Acc	File name	PDB ID	Method	Resolution	Chain	Start	End
Q14831-1	Q14831-1_5c5c_A.pdb	5C5C	X-ray	1.86	A	40	511

ASpdb's canonical and alternatively spliced isoform information.

accession_id

gene_name

canonical_id

alternative_id

canonical_length

alternative_length

canonical_start

canonical_end

type

originalSEQ

variationSEQ

alternative_start

alternative_end

Q14831

GRM7

Q14831-1

Q14831-2

915

922

900

915

Substitution

SPAAKKKYVSYNNLVI

NCIPPVRKSVQKSVTWYTIPPTV

900

922

Q14831

GRM7

Q14831-1

Q14831-3

915

910

900

915

Substitution

SPAAKKKYVSYNNLVI

NFFFWLYSGTW

900

910

Q14831

GRM7

Q14831-1

Q14831-4

915

911

900

915

Substitution

SPAAKKKYVSYNNLVI

ITSEDLSLHKED

900

911

Q14831

GRM7

Q14831-1

Q14831-5

915

906

900

915

Substitution

SPAAKKKYVSYNNLVI

SEKCNCY

900

906

Multiple sequence alignment of our canonical and alternatively spliced GRM7

Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of GRM7

UniProt-id	ENSG	ENST	ENSP
Q14831-1	ENSG00000196277.17	ENST00000357716.9	ENSP00000350348.4
Q14831-2	ENSG00000196277.17	ENST00000467425.5	ENSP00000419835.1
Q14831-2	ENSG00000196277.17	ENST00000486284.5	ENSP00000417536.1
Q14831-4	ENSG00000196277.17	ENST00000389335.7	ENSP00000373986.3
Q14831-5	ENSG00000196277.17	ENST00000389336.8	ENSP00000373987.4

UniProt-id	NM ID	NP ID
Q14831-1	NM_000844.3	NP_000835.1
Q14831-2	NM_181874.2	NP_870989.1

Amino acid sequences of our canonical and alternatively spliced GRM7

accession_id	Protein sequence
Q14831-1	MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQIN SDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRI IKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLK YIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTP CCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSY VLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIW FGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFG TAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNS
Q14831-2	MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQIN SDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRI IKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLK YIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTP CCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSY VLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIW FGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFG TAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNN
Q14831-3	MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQIN SDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRI IKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLK YIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTP CCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSY VLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIW FGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFG TAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNN
Q14831-4	MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQIN SDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRI IKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLK YIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTP CCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSY VLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIW FGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFG TAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNI
Q14831-5	MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQIN SDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRI IKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLK YIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTP CCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSY VLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIW FGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFG TAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNS

Protein Functional Features

Main function of this protein. (from UniProt)

GRM7 (go to UniProt):Q14831

Retention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Accession_id	Subsection	Start	End	Funcitonal feature	Splicing information
Q14831	Topological domain	851	915	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=900;End=915
Q14831	Topological domain	851	915	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=900;End=915
Q14831	Topological domain	851	915	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=900;End=915
Q14831	Topological domain	851	915	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=900;End=915

Gene Isoform Structures and Expression Levels for GRM7

Gene structures of our canonical and alternative spliced genes of GRM7
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Expression levels of gene isoforms across GTEx.

Expression levels of gene isoforms across TCGA.

Protein Structures

PDB and CIF files of the predicted protein structures
* Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

3D view using mol* of Q14831-1

3D view using mol* of Q14831-2

3D view using mol* of Q14831-3

3D view using mol* of Q14831-4

3D view using mol* of Q14831-5

pLDDT Score Distribution

pLDDT score distribution of the predicted protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

pLDDT distribution across the protein length of Q14831-1

pLDDT distribution across the protein length of Q14831-2

pLDDT distribution across the protein length of Q14831-3

pLDDT distribution across the protein length of Q14831-4

pLDDT distribution across the protein length of Q14831-5

Ramachandran Plot of Protein Structures

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide.

Ramachandran plot of Q14831-1

Ramachandran plot of Q14831-2

Ramachandran plot of Q14831-3

Ramachandran plot of Q14831-4

Ramachandran plot of Q14831-5

Potential Active Site Information

The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite.

UniProt-id	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
Q14831-1	1.103	134	0.991	211.974	0.38	0.852	1.131	0.764	1.412	0.541	0.581	583,584,585,646,647,648,649,650,658,659,662,720,72 9,734,735,746,747,748,749,750,751,752,753,756,808, 815,817,818,821,822,825
Q14831-2	1.082	108	1.041	186.592	0.407	0.821	1.042	0.792	1.201	0.66	0.784	584,646,658,659,662,720,729,734,735,748,749,750,75 1,752,753,756,808,817,818,821,822,825
Q14831-3	1.115	124	0.954	205.8	0.377	0.87	1.133	0.676	1.557	0.434	0.687	584,646,650,658,662,729,731,734,735,746,748,749,75 0,751,752,753,756,808,815,816,817,818,819,821,822, 825
Q14831-4	1.079	112	1.037	178.017	0.356	0.816	1.032	0.688	1.203	0.572	0.798	584,646,650,658,662,729,734,748,749,750,751,752,75 3,754,756,808,817,818,821,822,825
Q14831-5	1.077	235	0.913	617.4	0.447	0.814	1.044	0.166	1.581	0.105	0.425	56,59,60,61,62,63,64,65,66,71,74,78,108,110,111,11 2,157,158,159,160,161,180,181,182,226,227,228,229, 230,231,256,258,259,260,263,267,288,289,290,291,29 4,314,315,319,407

Protein Structure and Feature Comparision

Protein Structure Comparision Using Template Modeling Scores (TM-score).

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green)

3D view using mol* of Q14831-1_Q14831-1_5c5c_A.pdb

Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of Q14831-1_5c5c_A_Q14831-2.pdb

3D view using mol* of Q14831-1_5c5c_A_Q14831-3.pdb

3D view using mol* of Q14831-1_5c5c_A_Q14831-4.pdb

3D view using mol* of Q14831-1_5c5c_A_Q14831-5.pdb

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of Q14831-1_Q14831-2.pdb

3D view using mol* of Q14831-1_Q14831-3.pdb

3D view using mol* of Q14831-1_Q14831-4.pdb

3D view using mol* of Q14831-1_Q14831-5.pdb

Protein Feature Comparison of the protein sequendary structures among the protiens.

./stats/secondary_structure/figure/Q14831-1_vs_Q14831-2.png