Protein:NRG1 |
Protein Summary |
 Gene summary |
| Gene name: NRG1 | ASpdb.0 ID: 3084 | Gene | Gene symbol | NRG1 | Gene ID | 3084 |
| Gene name | neuregulin 1 |
| Synonyms | ARIA|GGF|GGF2|HGL|HRG|HRG1|HRGA|MST131|MSTP131|NDF|NRG1-IT2|SMDF |
| Cytomap | 8p12 |
| Type of gene | protein-coding |
| Description | pro-neuregulin-1, membrane-bound isoformNRG1 class VII isoform alpha 2aNRG1 class VII isoform alpha 2bNRG1 class VII isoform alpha beta 2aNRG1 class VII isoform alpha beta 3NRG1 class VII isoform beta 2aNRG1 class VII isoform beta 3acetylcholine re |
| Modification date | 20240407 |
| UniProtAcc | Q02297 |
| Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Gene | NRG1 | GO:0003222 | ventricular trabecula myocardium morphogenesis | 17336907 |
| Gene | NRG1 | GO:0003712 | transcription coregulator activity | 15073182 |
| Gene | NRG1 | GO:0005178 | integrin binding | 20682778 |
| Gene | NRG1 | GO:0005615 | extracellular space | 8702723|19632177|28822966 |
| Gene | NRG1 | GO:0005654 | nucleoplasm | - |
| Gene | NRG1 | GO:0030296 | protein tyrosine kinase activator activity | 8702723|19632177 |
| Gene | NRG1 | GO:0031334 | positive regulation of protein-containing complex assembly | 10559227 |
| Gene | NRG1 | GO:0038127 | ERBB signaling pathway | 11389077 |
| Gene | NRG1 | GO:0038129 | ERBB3 signaling pathway | 27353365 |
| Gene | NRG1 | GO:0038130 | ERBB4 signaling pathway | 28822966 |
| Gene | NRG1 | GO:0038133 | ERBB2-ERBB3 signaling pathway | 8702723 |
| Gene | NRG1 | GO:0038135 | ERBB2-ERBB4 signaling pathway | 19632177 |
| Gene | NRG1 | GO:0038138 | ERBB4-ERBB4 signaling pathway | 8702723|28822966 |
| Gene | NRG1 | GO:0043125 | ErbB-3 class receptor binding | 20682778 |
| Gene | NRG1 | GO:0045892 | negative regulation of DNA-templated transcription | 15073182 |
| Gene | NRG1 | GO:0048018 | receptor ligand activity | 8702723|19632177|28822966 |
| Gene | NRG1 | GO:0051048 | negative regulation of secretion | 10559227 |
| Gene | NRG1 | GO:0060379 | cardiac muscle cell myoblast differentiation | 17336907 |
| Gene | NRG1 | GO:0060956 | endocardial cell differentiation | 17336907 |
AS Summary |
| Information of the canonical protein with experimentally identified structure from PDB (2023). |
| UniProt Acc | File name | PDB ID | Method | Resolution | Chain | Start | End |
| Q02297-1 | Q02297-1_3u7u_H.pdb | 3U7U | X-ray | 3.03 | H | 176 | 212 |
| ASpdb's canonical and alternatively spliced isoform information. |
| accession_id | gene_name | canonical_id | alternative_id | canonical_length | alternative_length | canonical_start | canonical_end | type | originalSEQ | variationSEQ | alternative_start | alternative_end |
| Q02297 | NRG1 | Q02297-1 | Q02297-10 | 640 | 296 | 1 | 166 | Deletion | none | none | 0 | 0 |
| Q02297 | NRG1 | Q02297-1 | Q02297-10 | 640 | 296 | 167 | 167 | Substitution | S | MEIYSPDMSEVAAERSSSPSTQLSADPSLDGLPAAEDMPEPQTEDGRTPGLVGLAVPCCACLEAERLRGCLNSEKICIVPILACLVSLCLCIAGLKWVFVDKIFEYDSPTHLDPGGLGQDPIISLDATAASAVWVSSEAYTSPVSRAQSESEVQVTVQGDKAVVSFEPSAAPTPKNRIFAFSFLPSTAPSFPSPTRNPEVRTPKSATQPQTTETNLQTAPKL | 1 | 222 |
| Q02297 | NRG1 | Q02297-1 | Q02297-10 | 640 | 296 | 213 | 241 | Substitution | QPGFTGARCTENVPMKVQNQEKAEELYQK | PNEFTGDRCQNYVMASFYSTSTPFLSLPE | 268 | 296 |
| Q02297 | NRG1 | Q02297-1 | Q02297-10 | 640 | 296 | 242 | 640 | Deletion | none | none | 296 | 296 |
| Q02297 | NRG1 | Q02297-1 | Q02297-11 | 640 | 590 | 1 | 21 | Deletion | none | none | 0 | 0 |
| Q02297 | NRG1 | Q02297-1 | Q02297-11 | 640 | 590 | 22 | 33 | Substitution | KKPESAAGSQSP | MGKGRAGRVGTT | 1 | 12 |
| Q02297 | NRG1 | Q02297-1 | Q02297-11 | 640 | 590 | 134 | 168 | Substitution | EIITGMPASTEGAYVSSESPIRISVSTEGANTSSS | A | 113 | 113 |
| Q02297 | NRG1 | Q02297-1 | Q02297-11 | 640 | 590 | 213 | 234 | Substitution | QPGFTGARCTENVPMKVQNQEK | PNEFTGDRCQNYVMASFYKHLGIEFME | 158 | 184 |
| Q02297 | NRG1 | Q02297-1 | Q02297-12 | 640 | 420 | 213 | 233 | Substitution | QPGFTGARCTENVPMKVQNQE | PNEFTGDRCQNYVMASFY | 213 | 230 |
| Q02297 | NRG1 | Q02297-1 | Q02297-12 | 640 | 420 | 424 | 640 | Deletion | none | none | 420 | 420 |
| Q02297 | NRG1 | Q02297-1 | Q02297-2 | 640 | 648 | 234 | 234 | Substitution | K | KHLGIEFIE | 234 | 242 |
| Q02297 | NRG1 | Q02297-1 | Q02297-3 | 640 | 462 | 424 | 462 | Substitution | YVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVS | HNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL | 424 | 462 |
| Q02297 | NRG1 | Q02297-1 | Q02297-3 | 640 | 462 | 463 | 640 | Deletion | none | none | 462 | 462 |
| Q02297 | NRG1 | Q02297-1 | Q02297-6 | 640 | 645 | 213 | 234 | Substitution | QPGFTGARCTENVPMKVQNQEK | PNEFTGDRCQNYVMASFYKHLGIEFME | 213 | 239 |
| Q02297 | NRG1 | Q02297-1 | Q02297-7 | 640 | 637 | 213 | 233 | Substitution | QPGFTGARCTENVPMKVQNQE | PNEFTGDRCQNYVMASFY | 213 | 230 |
| Q02297 | NRG1 | Q02297-1 | Q02297-8 | 640 | 241 | 213 | 241 | Substitution | QPGFTGARCTENVPMKVQNQEKAEELYQK | PNEFTGDRCQNYVMASFYSTSTPFLSLPE | 213 | 241 |
| Q02297 | NRG1 | Q02297-1 | Q02297-8 | 640 | 241 | 242 | 640 | Deletion | none | none | 241 | 241 |
| Q02297 | NRG1 | Q02297-1 | Q02297-9 | 640 | 422 | 1 | 33 | Substitution | MSERKEGRGKGKGKKKERGSGKKPESAAGSQSP | MRWRRAPRRSGRPGPRAQRPGSAARSSPPLPLLPLLLLLGTAALAPGAAAGNEAAPAGASVCYSSPPSVGSVQELAQRAAVVIEGKVHPQRRQQGALDRKAAAAAGEAGAWGGDREPPAAGPRALGPPAEEPLLAANGTVPSWPTAPVPSAGEPGEEAPYLVKVHQVWAVKAGGLKKDSLLTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLETGRNLKKEVSRVLCKRC | 1 | 248 |
| Q02297 | NRG1 | Q02297-1 | Q02297-9 | 640 | 422 | 134 | 168 | Substitution | EIITGMPASTEGAYVSSESPIRISVSTEGANTSSS | A | 349 | 349 |
| Q02297 | NRG1 | Q02297-1 | Q02297-9 | 640 | 422 | 213 | 241 | Substitution | QPGFTGARCTENVPMKVQNQEKAEELYQK | PNEFTGDRCQNYVMASFYSTSTPFLSLPE | 394 | 422 |
| Q02297 | NRG1 | Q02297-1 | Q02297-9 | 640 | 422 | 242 | 640 | Deletion | none | none | 422 | 422 |
| Multiple sequence alignment of our canonical and alternatively spliced NRG1 |
| Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of NRG1 |
| UniProt-id | ENSG | ENST | ENSP |
| Q02297-1 | ENSG00000157168.22 | ENST00000405005.8 | ENSP00000384620.2 |
| Q02297-10 | ENSG00000157168.22 | ENST00000520502.7 | ENSP00000433289.1 |
| Q02297-11 | ENSG00000157168.22 | ENST00000519301.6 | ENSP00000429582.1 |
| Q02297-12 | ENSG00000157168.22 | ENST00000523079.5 | ENSP00000430120.1 |
| Q02297-3 | ENSG00000157168.22 | ENST00000521670.5 | ENSP00000428828.1 |
| Q02297-6 | ENSG00000157168.22 | ENST00000287842.7 | ENSP00000287842.4 |
| Q02297-7 | ENSG00000157168.22 | ENST00000356819.7 | ENSP00000349275.6 |
| Q02297-8 | ENSG00000157168.22 | ENST00000650919.1 | ENSP00000498811.1 |
| Q02297-9 | ENSG00000157168.22 | ENST00000520407.5 | ENSP00000434640.1 |
| UniProt-id | NM ID | NP ID |
| Q02297-1 | NM_013964.4 | NP_039258.1 |
| Q02297-10 | NM_013959.3 | NP_039253.1 |
| Q02297-11 | NM_001160001.2 | NP_001153473.1 |
| Q02297-12 | NM_001160008.1 | NP_001153480.1 |
| Q02297-3 | NM_013960.4 | NP_039254.1 |
| Q02297-6 | NM_013956.4 | NP_039250.2 |
| Q02297-7 | NM_013957.4 | NP_039251.2 |
| Q02297-8 | NM_013958.3 | NP_039252.2 |
| Q02297-9 | NM_013962.2 | NP_039256.2 |
| Amino acid sequences of our canonical and alternatively spliced NRG1 |
| accession_id | Protein sequence |
| Q02297-1 | MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQ RKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPS EMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKK LANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSS |
| Q02297-10 | MEIYSPDMSEVAAERSSSPSTQLSADPSLDGLPAAEDMPEPQTEDGRTPGLVGLAVPCCACLEAERLRGCLNSEKICIVPILACLVSLCL CIAGLKWVFVDKIFEYDSPTHLDPGGLGQDPIISLDATAASAVWVSSEAYTSPVSRAQSESEVQVTVQGDKAVVSFEPSAAPTPKNRIFA FSFLPSTAPSFPSPTRNPEVRTPKSATQPQTTETNLQTAPKLSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNE |
| Q02297-11 | MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM CKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGI EFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISS EHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARE TPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSS FHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLG |
| Q02297-12 | MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKK LHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESI |
| Q02297-2 | MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKHLGIEFIEAEELYQKRVLTITGICIALLVVGIMCVV AYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPS HSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTP SSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYE PAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQE |
| Q02297-3 | MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQ RKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHT ESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHL |
| Q02297-6 | MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYC KTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSP KSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQ EPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQ |
| Q02297-7 | MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKK LHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESI LSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMS PPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLAN SRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIA |
| Q02297-8 | MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV |
| Q02297-9 | MRWRRAPRRSGRPGPRAQRPGSAARSSPPLPLLPLLLLLGTAALAPGAAAGNEAAPAGASVCYSSPPSVGSVQELAQRAAVVIEGKVHPQ RRQQGALDRKAAAAAGEAGAWGGDREPPAAGPRALGPPAEEPLLAANGTVPSWPTAPVPSAGEPGEEAPYLVKVHQVWAVKAGGLKKDSL LTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLETGRNLKKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVL RCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHL |
Protein Functional Features |
| Main function of this protein. (from UniProt) |
| NRG1 (go to UniProt):Q02297 |
| Retention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Accession_id | Subsection | Start | End | Funcitonal feature | Splicing information |
| Q02297 | Topological domain | 20 | 242 | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Deletion;Start=1;End=166 |
| Q02297 | Topological domain | 20 | 242 | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Substitution;Start=167;End=167 |
| Q02297 | Topological domain | 20 | 242 | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Substitution;Start=213;End=241 |
| Q02297 | Topological domain | 20 | 242 | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Deletion;Start=242;End=640 |
| Q02297 | Topological domain | 20 | 242 | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Deletion;Start=1;End=21 |
| Q02297 | Topological domain | 20 | 242 | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Substitution;Start=22;End=33 |
| Q02297 | Topological domain | 20 | 242 | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Substitution;Start=134;End=168 |
| Q02297 | Topological domain | 20 | 242 | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Substitution;Start=213;End=234 |
| Q02297 | Topological domain | 20 | 242 | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Substitution;Start=213;End=233 |
| Q02297 | Topological domain | 20 | 242 | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Substitution;Start=234;End=234 |
| Q02297 | Topological domain | 20 | 242 | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Substitution;Start=213;End=234 |
| Q02297 | Topological domain | 20 | 242 | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Substitution;Start=213;End=233 |
| Q02297 | Topological domain | 20 | 242 | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Substitution;Start=213;End=241 |
| Q02297 | Topological domain | 20 | 242 | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Deletion;Start=242;End=640 |
| Q02297 | Topological domain | 20 | 242 | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Substitution;Start=1;End=33 |
| Q02297 | Topological domain | 20 | 242 | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Substitution;Start=134;End=168 |
| Q02297 | Topological domain | 20 | 242 | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Substitution;Start=213;End=241 |
| Q02297 | Topological domain | 20 | 242 | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Deletion;Start=242;End=640 |
| Q02297 | Transmembrane | 243 | 265 | Note=Helical%3B Note%3DInternal signal sequence;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Deletion;Start=242;End=640 |
| Q02297 | Transmembrane | 243 | 265 | Note=Helical%3B Note%3DInternal signal sequence;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Deletion;Start=242;End=640 |
| Q02297 | Transmembrane | 243 | 265 | Note=Helical%3B Note%3DInternal signal sequence;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Deletion;Start=242;End=640 |
| Q02297 | Topological domain | 266 | 640 | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Deletion;Start=242;End=640 |
| Q02297 | Topological domain | 266 | 640 | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Deletion;Start=424;End=640 |
| Q02297 | Topological domain | 266 | 640 | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Substitution;Start=424;End=462 |
| Q02297 | Topological domain | 266 | 640 | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Deletion;Start=463;End=640 |
| Q02297 | Topological domain | 266 | 640 | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Deletion;Start=242;End=640 |
| Q02297 | Topological domain | 266 | 640 | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Deletion;Start=242;End=640 |
| Q02297 | Domain | 37 | 128 | Note=Ig-like C2-type | Type=Deletion;Start=1;End=166 |
| Q02297 | Domain | 178 | 222 | Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 | Type=Substitution;Start=213;End=241 |
| Q02297 | Domain | 178 | 222 | Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 | Type=Substitution;Start=213;End=234 |
| Q02297 | Domain | 178 | 222 | Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 | Type=Substitution;Start=213;End=233 |
| Q02297 | Domain | 178 | 222 | Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 | Type=Substitution;Start=213;End=234 |
| Q02297 | Domain | 178 | 222 | Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 | Type=Substitution;Start=213;End=233 |
| Q02297 | Domain | 178 | 222 | Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 | Type=Substitution;Start=213;End=241 |
| Q02297 | Domain | 178 | 222 | Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 | Type=Substitution;Start=213;End=241 |
| Q02297 | Region | 1 | 53 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=166 |
| Q02297 | Region | 1 | 53 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=21 |
| Q02297 | Region | 1 | 53 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=22;End=33 |
| Q02297 | Region | 1 | 53 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=1;End=33 |
| Q02297 | Region | 334 | 360 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=242;End=640 |
| Q02297 | Region | 334 | 360 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=242;End=640 |
| Q02297 | Region | 334 | 360 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=242;End=640 |
| Q02297 | Region | 375 | 399 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=242;End=640 |
| Q02297 | Region | 375 | 399 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=242;End=640 |
| Q02297 | Region | 375 | 399 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=242;End=640 |
| Q02297 | Region | 433 | 461 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=242;End=640 |
| Q02297 | Region | 433 | 461 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=424;End=640 |
| Q02297 | Region | 433 | 461 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=424;End=462 |
| Q02297 | Region | 433 | 461 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=242;End=640 |
| Q02297 | Region | 433 | 461 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=242;End=640 |
| Q02297 | Region | 524 | 588 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=242;End=640 |
| Q02297 | Region | 524 | 588 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=424;End=640 |
| Q02297 | Region | 524 | 588 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=463;End=640 |
| Q02297 | Region | 524 | 588 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=242;End=640 |
| Q02297 | Region | 524 | 588 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=242;End=640 |
| Q02297 | Compositional bias | 375 | 389 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=242;End=640 |
| Q02297 | Compositional bias | 375 | 389 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=242;End=640 |
| Q02297 | Compositional bias | 375 | 389 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=242;End=640 |
| Q02297 | Compositional bias | 559 | 573 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=242;End=640 |
| Q02297 | Compositional bias | 559 | 573 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=424;End=640 |
| Q02297 | Compositional bias | 559 | 573 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=463;End=640 |
| Q02297 | Compositional bias | 559 | 573 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=242;End=640 |
| Q02297 | Compositional bias | 559 | 573 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=242;End=640 |
Gene Isoform Structures and Expression Levels for NRG1 |
| Gene structures of our canonical and alternative spliced genes of NRG1 * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Expression levels of gene isoforms across GTEx. |
 |
| Expression levels of gene isoforms across TCGA. |
 |
Protein Structures |
| PDB and CIF files of the predicted protein structures * Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| 3D view using mol* of Q02297-1 |
| 3D view using mol* of Q02297-10 |
| 3D view using mol* of Q02297-11 |
| 3D view using mol* of Q02297-12 |
| 3D view using mol* of Q02297-2 |
| 3D view using mol* of Q02297-3 |
| 3D view using mol* of Q02297-6 |
| 3D view using mol* of Q02297-7 |
| 3D view using mol* of Q02297-8 |
| 3D view using mol* of Q02297-9 |
pLDDT Score Distribution |
| pLDDT score distribution of the predicted protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
| pLDDT distribution across the protein length of Q02297-1 |
 |
| pLDDT distribution across the protein length of Q02297-10 |
 |
| pLDDT distribution across the protein length of Q02297-11 |
 |
| pLDDT distribution across the protein length of Q02297-12 |
 |
| pLDDT distribution across the protein length of Q02297-2 |
 |
| pLDDT distribution across the protein length of Q02297-3 |
 |
| pLDDT distribution across the protein length of Q02297-6 |
 |
| pLDDT distribution across the protein length of Q02297-7 |
 |
| pLDDT distribution across the protein length of Q02297-8 |
 |
| pLDDT distribution across the protein length of Q02297-9 |
 |
Ramachandran Plot of Protein Structures |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide. |
| Ramachandran plot of Q02297-1 |
 |
| Ramachandran plot of Q02297-10 |
 |
| Ramachandran plot of Q02297-12 |
 |
| Ramachandran plot of Q02297-2 |
 |
| Ramachandran plot of Q02297-3 |
 |
| Ramachandran plot of Q02297-6 |
 |
| Ramachandran plot of Q02297-8 |
 |
| Ramachandran plot of Q02297-9 |
 |
Potential Active Site Information |
| The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite. |
| UniProt-id | Site score | Size | D score | Volume | Exposure | Enclosure | Contact | Phobic | Philic | Balance | Don/Acc | Residues |
| Q02297-1 | 0.868 | 76 | 0.889 | 275.772 | 0.726 | 0.597 | 0.778 | 0.347 | 0.886 | 0.391 | 0.555 | 158,160,161,162,163,164,165,195,209,210,211,212,21 3,214,215,216,217,218,225,227,228,229,230,231 |
| Q02297-10 | 0.707 | 28 | 0.732 | 67.914 | 0.663 | 0.573 | 0.732 | 1.313 | 0.335 | 3.92 | 2.051 | 60,61,63,66,67,80,83,84,87
|
| Q02297-11 | 0.892 | 84 | 0.937 | 226.723 | 0.725 | 0.556 | 0.759 | 0.453 | 0.791 | 0.573 | 0.817 | 114,115,116,118,119,120,121,122,123,124,139,140,14 2,154,155,156,157,158,159,161,162,163 |
| Q02297-12 | 0.678 | 40 | 0.511 | 93.296 | 0.643 | 0.619 | 0.848 | 0.125 | 1.395 | 0.089 | 0.699 | 69,70,76,77,78,79,82,87,88,90
|
| Q02297-2 | 1.013 | 93 | 1.06 | 471.968 | 0.653 | 0.684 | 0.782 | 0.617 | 0.786 | 0.784 | 0.901 | 153,154,155,156,157,158,179,197,199,207,208,209,21 0,211,212,213,214,215,216,217,218,219,223,225,230 |
| Q02297-3 | 0.633 | 35 | 0.494 | 76.489 | 0.688 | 0.596 | 0.847 | 0.146 | 1.287 | 0.114 | 0.551 | 68,69,70,76,77,78,79,82,88,90
|
| Q02297-6 | 0.767 | 41 | 0.771 | 220.892 | 0.737 | 0.627 | 0.775 | 0.631 | 0.634 | 0.995 | 0.694 | 43,44,45,46,47,126,128,130,230,233,234
|
| Q02297-7 | 0.645 | 35 | 0.476 | 81.291 | 0.628 | 0.615 | 0.855 | 0.135 | 1.378 | 0.098 | 0.933 | 68,69,70,76,77,78,79,82,88,90
|
| Q02297-8 | 0.759 | 40 | 0.459 | 92.61 | 0.375 | 0.74 | 1.072 | 0 | 1.778 | 0 | 0.787 | 67,68,69,70,76,77,78,79,82,88,90
|
| Q02297-9 | 0.988 | 138 | 0.963 | 322.077 | 0.505 | 0.679 | 0.925 | 0.346 | 1.181 | 0.293 | 0.896 | 61,62,63,64,65,66,195,196,197,198,199,200,205,228, 229,230,231,233,234,235,236,239 |
Protein Structure and Feature Comparision |
| Protein Structure Comparision Using Template Modeling Scores (TM-score). |
 |
| Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green) |
| 3D view using mol* of Q02297-1_Q02297-1_3u7u_H.pdb |
| Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green) |
| 3D view using mol* of Q02297-1_3u7u_H_Q02297-10.pdb |
| 3D view using mol* of Q02297-1_3u7u_H_Q02297-11.pdb |
| 3D view using mol* of Q02297-1_3u7u_H_Q02297-12.pdb |
| 3D view using mol* of Q02297-1_3u7u_H_Q02297-2.pdb |
| 3D view using mol* of Q02297-1_3u7u_H_Q02297-3.pdb |
| 3D view using mol* of Q02297-1_3u7u_H_Q02297-6.pdb |
| 3D view using mol* of Q02297-1_3u7u_H_Q02297-7.pdb |
| 3D view using mol* of Q02297-1_3u7u_H_Q02297-8.pdb |
| 3D view using mol* of Q02297-1_3u7u_H_Q02297-9.pdb |
| Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green) |
| 3D view using mol* of Q02297-1_Q02297-10.pdb |
| 3D view using mol* of Q02297-1_Q02297-11.pdb |
| 3D view using mol* of Q02297-1_Q02297-12.pdb |
| 3D view using mol* of Q02297-1_Q02297-2.pdb |
| 3D view using mol* of Q02297-1_Q02297-3.pdb |
| 3D view using mol* of Q02297-1_Q02297-6.pdb |
| 3D view using mol* of Q02297-1_Q02297-7.pdb |
| 3D view using mol* of Q02297-1_Q02297-8.pdb |
| 3D view using mol* of Q02297-1_Q02297-9.pdb |
| Protein Feature Comparison of the protein sequendary structures among the protiens. |
| ./stats/secondary_structure/figure/Q02297-1_vs_Q02297-10.png |
 < |
| ./stats/secondary_structure/figure/Q02297-1_vs_Q02297-11.png |
 < |
| ./stats/secondary_structure/figure/Q02297-1_vs_Q02297-12.png |
 < |
| ./stats/secondary_structure/figure/Q02297-1_vs_Q02297-2.png |
 < |
| ./stats/secondary_structure/figure/Q02297-1_vs_Q02297-3.png |
 < |
| ./stats/secondary_structure/figure/Q02297-1_vs_Q02297-6.png |
 < |
| ./stats/secondary_structure/figure/Q02297-1_vs_Q02297-7.png |
 < |
| ./stats/secondary_structure/figure/Q02297-1_vs_Q02297-8.png |
 < |
| ./stats/secondary_structure/figure/Q02297-1_vs_Q02297-9.png |
 < |
| Protein Feature Comparison of the relative accessible surface area (ASA) among the protiens. |
| ./stats/relative_asa/Q02297-1_vs_Q02297-10.png |
 < |
| ./stats/relative_asa/Q02297-1_vs_Q02297-11.png |
 < |
| ./stats/relative_asa/Q02297-1_vs_Q02297-12.png |
 < |
| ./stats/relative_asa/Q02297-1_vs_Q02297-2.png |
 < |
| ./stats/relative_asa/Q02297-1_vs_Q02297-3.png |
 < |
| ./stats/relative_asa/Q02297-1_vs_Q02297-6.png |
 < |
| ./stats/relative_asa/Q02297-1_vs_Q02297-7.png |
 < |
| ./stats/relative_asa/Q02297-1_vs_Q02297-8.png |
 < |
| ./stats/relative_asa/Q02297-1_vs_Q02297-9.png |
 < |
Protein-Protein Interaction |
| Interactors from UniProt. |
| Accession_id | Subsection | Start | End | Funcitonal feature | Splicing information |
| Interactors from STRING. |
| Gene name | Interactors |
Related Drugs to NRG1 |
| Drugs targeting this gene/protein. (DrugBank) |
| UniProt accession | Gene name | DrugBank ID | Drug name | Drug group | Actions |
Related Diseases to NRG1 |
| Previous studies relating to the alternative splicing of NRG1 and disease information from the MeSH term (PubMed) |
| Gene | PMID | Title | Abstract | MeSH ID | MeSH term |
Clinically important variants in NRG1 |
| (ClinVar, 04/20/2024) |
| accession_id | uniprot_id | gene_name | Type | Variant | Clinical_significance |
Copyright 2024-PresentThe University of Texas Health Science Center at Houston (UTHealth Houston) Web File Viewing | Emergency Information |