Protein:HRAS |
Protein Summary |
 Gene summary |
| Gene name: HRAS | ASpdb.0 ID: 3265 | Gene | Gene symbol | HRAS | Gene ID | 3265 |
| Gene name | HRas proto-oncogene, GTPase |
| Synonyms | C-BAS/HAS|C-H-RAS|C-HA-RAS1|CTLO|H-RASIDX|HAMSV|HRAS1|RASH1|p21ras |
| Cytomap | 11p15.5 |
| Type of gene | protein-coding |
| Description | GTPase HRasGTP- and GDP-binding peptide BHa-Ras1 proto-oncoproteinHarvey rat sarcoma viral oncogene homologHarvey rat sarcoma viral oncoproteinRas family small GTP binding protein H-Rasc-has/bas p21 proteinp19 H-RasIDX proteintransformation gene: |
| Modification date | 20240323 |
| UniProtAcc | P01112 |
| Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Gene | HRAS | GO:0001934 | positive regulation of protein phosphorylation | 22065586 |
| Gene | HRAS | GO:0003924 | GTPase activity | 9178006 |
| Gene | HRAS | GO:0005525 | GTP binding | 14500341|17260967 |
| Gene | HRAS | GO:0005654 | nucleoplasm | - |
| Gene | HRAS | GO:0005794 | Golgi apparatus | 14500341|21968647 |
| Gene | HRAS | GO:0005829 | cytosol | - |
| Gene | HRAS | GO:0005886 | plasma membrane | 14500341|17724343|21968647 |
| Gene | HRAS | GO:0006357 | regulation of transcription by RNA polymerase II | 23027131 |
| Gene | HRAS | GO:0007265 | Ras protein signal transduction | 23027131 |
| Gene | HRAS | GO:0008284 | positive regulation of cell population proliferation | 9765203 |
| Gene | HRAS | GO:0008285 | negative regulation of cell population proliferation | 9054499 |
| Gene | HRAS | GO:0010629 | negative regulation of gene expression | 23027131 |
| Gene | HRAS | GO:0010863 | positive regulation of phospholipase C activity | 11022048 |
| Gene | HRAS | GO:0030335 | positive regulation of cell migration | 23027131 |
| Gene | HRAS | GO:0032956 | regulation of actin cytoskeleton organization | 23027131 |
| Gene | HRAS | GO:0034260 | negative regulation of GTPase activity | 23027131 |
| Gene | HRAS | GO:0042127 | regulation of cell population proliferation | 9054499 |
| Gene | HRAS | GO:0043406 | positive regulation of MAP kinase activity | 23027131 |
| Gene | HRAS | GO:0043410 | positive regulation of MAPK cascade | 9765203 |
| Gene | HRAS | GO:0043547 | positive regulation of GTPase activity | 23027131 |
| Gene | HRAS | GO:0045944 | positive regulation of transcription by RNA polymerase II | 22065586|23027131 |
| Gene | HRAS | GO:0046330 | positive regulation of JNK cascade | 22065586 |
| Gene | HRAS | GO:0051726 | regulation of cell cycle | 9054499 |
| Gene | HRAS | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 22065586 |
| Gene | HRAS | GO:0071480 | cellular response to gamma radiation | 16213212 |
| Gene | HRAS | GO:0090303 | positive regulation of wound healing | 23027131 |
| Gene | HRAS | GO:0090398 | cellular senescence | 9054499 |
| Gene | HRAS | GO:0098696 | regulation of neurotransmitter receptor localization to postsynaptic specialization membrane | 12202034 |
| Gene | HRAS | GO:0098978 | glutamatergic synapse | 12202034 |
| Gene | HRAS | GO:1900029 | positive regulation of ruffle assembly | 23027131 |
| Gene | HRAS | GO:2000630 | positive regulation of miRNA metabolic process | 23027131 |
AS Summary |
| Information of the canonical protein with experimentally identified structure from PDB (2023). |
| UniProt Acc | File name | PDB ID | Method | Resolution | Chain | Start | End |
| P01112-1 | P01112-1_6q21_A.pdb | 6Q21 | X-ray | 1.95 | A | 1 | 171 |
| ASpdb's canonical and alternatively spliced isoform information. |
| accession_id | gene_name | canonical_id | alternative_id | canonical_length | alternative_length | canonical_start | canonical_end | type | originalSEQ | variationSEQ | alternative_start | alternative_end |
| P01112 | HRAS | P01112-1 | P01112-2 | 189 | 170 | 152 | 189 | Substitution | VEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS | SRSGSSSSSGTLWDPPGPM | 152 | 170 |
| Multiple sequence alignment of our canonical and alternatively spliced HRAS |
| Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of HRAS |
| UniProt-id | ENSG | ENST | ENSP |
| P01112-1 | ENSG00000174775.18 | ENST00000311189.8 | ENSP00000309845.7 |
| P01112-1 | ENSG00000174775.18 | ENST00000397596.6 | ENSP00000380723.2 |
| P01112-1 | ENSG00000174775.18 | ENST00000451590.5 | ENSP00000407586.1 |
| P01112-1 | ENSG00000276536.4 | ENST00000610977.3 | ENSP00000480686.1 |
| P01112-1 | ENSG00000276536.4 | ENST00000615062.2 | ENSP00000482366.1 |
| P01112-1 | ENSG00000276536.4 | ENST00000631404.1 | ENSP00000488757.1 |
| P01112-2 | ENSG00000174775.18 | ENST00000397594.7 | ENSP00000380722.3 |
| P01112-2 | ENSG00000174775.18 | ENST00000417302.7 | ENSP00000388246.1 |
| P01112-2 | ENSG00000174775.18 | ENST00000493230.5 | ENSP00000434023.1 |
| P01112-2 | ENSG00000276536.4 | ENST00000616241.4 | ENSP00000480317.1 |
| P01112-2 | ENSG00000276536.4 | ENST00000631967.1 | ENSP00000488225.1 |
| P01112-2 | ENSG00000276536.4 | ENST00000634098.1 | ENSP00000488296.1 |
| UniProt-id | NM ID | NP ID |
| P01112-1 | NM_001130442.2 | NP_001123914.1 |
| P01112-1 | NM_005343.3 | NP_005334.1 |
| P01112-2 | NM_176795.4 | NP_789765.1 |
| Amino acid sequences of our canonical and alternatively spliced HRAS |
| accession_id | Protein sequence |
| P01112-1 | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSF EDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG |
| P01112-2 | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSF |
Protein Functional Features |
| Main function of this protein. (from UniProt) |
| HRAS (go to UniProt):P01112 |
| Retention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Accession_id | Subsection | Start | End | Funcitonal feature | Splicing information |
| P01112 | Region | 166 | 185 | Note=Hypervariable region | Type=Substitution;Start=152;End=189 |
Gene Isoform Structures and Expression Levels for HRAS |
| Gene structures of our canonical and alternative spliced genes of HRAS * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Expression levels of gene isoforms across GTEx. |
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| Expression levels of gene isoforms across TCGA. |
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Protein Structures |
| PDB and CIF files of the predicted protein structures * Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| 3D view using mol* of P01112-1 |
| 3D view using mol* of P01112-2 |
pLDDT Score Distribution |
| pLDDT score distribution of the predicted protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
| pLDDT distribution across the protein length of P01112-1 |
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| pLDDT distribution across the protein length of P01112-2 |
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Ramachandran Plot of Protein Structures |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide. |
| Ramachandran plot of P01112-1 |
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Potential Active Site Information |
| The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite. |
| UniProt-id | Site score | Size | D score | Volume | Exposure | Enclosure | Contact | Phobic | Philic | Balance | Don/Acc | Residues |
| P01112-1 | 1.014 | 125 | 0.899 | 239.757 | 0.461 | 0.719 | 0.991 | 0.175 | 1.449 | 0.121 | 0.998 | 11,12,13,14,15,16,17,18,21,28,29,30,31,32,33,34,35 ,58,59,60,61,116,117,119,120,145,146,147 |
| P01112-2 | 1.011 | 109 | 0.937 | 237.013 | 0.511 | 0.714 | 0.962 | 0.17 | 1.323 | 0.128 | 0.877 | 11,12,13,14,15,16,17,18,21,28,29,30,31,32,33,34,35 ,38,40,57,58,59,60,61,116,117,119,120,145,146,147 |
Protein Structure and Feature Comparision |
| Protein Structure Comparision Using Template Modeling Scores (TM-score). |
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| Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green) |
| 3D view using mol* of P01112-1_P01112-1_6q21_A.pdb |
| Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green) |
| 3D view using mol* of P01112-1_6q21_A_P01112-2.pdb |
| Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green) |
| 3D view using mol* of P01112-1_P01112-2.pdb |
| Protein Feature Comparison of the protein sequendary structures among the protiens. |
| ./stats/secondary_structure/figure/P01112-1_vs_P01112-2.png |
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| Protein Feature Comparison of the relative accessible surface area (ASA) among the protiens. |
| ./stats/relative_asa/P01112-1_vs_P01112-2.png |
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Protein-Protein Interaction |
| Interactors from UniProt. |
| Accession_id | Subsection | Start | End | Funcitonal feature | Splicing information |
| Interactors from STRING. |
| Gene name | Interactors |
Related Drugs to HRAS |
| Drugs targeting this gene/protein. (DrugBank) |
| UniProt accession | Gene name | DrugBank ID | Drug name | Drug group | Actions |
| P01112 | HRAS | DB02210 | Hexane-1,6-Diol | experimental | |
| P01112 | HRAS | DB04137 | Guanosine-5'-Triphosphate | experimental | |
| P01112 | HRAS | DB04315 | Guanosine-5'-Diphosphate | experimental | |
| P01112 | HRAS | DB03226 | Trifluoroethanol | experimental | |
| P01112 | HRAS | DB15588 | Ursolic acid | experimental | regulator |
| P01112 | HRAS | DB08751 | N,N'-DIMETHYL-N-(ACETYL)-N'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINE | experimental |
Related Diseases to HRAS |
| Previous studies relating to the alternative splicing of HRAS and disease information from the MeSH term (PubMed) |
| Gene | PMID | Title | Abstract | MeSH ID | MeSH term |
| HRAS | 20046837 | P19 H-ras induces G1/S phase delay maintaining cells in a reversible quiescence state. | Three functional c-ras genes, known as c-H-ras, c-K-ras, and c-N-ras, have been largely studied in mammalian cells with important insights into normal and tumorigenic cellular signal transduction events. Two K-Ras mRNAs are obtained from the same pre-mRNA by alternative splicing. H-Ras pre-mRNA can also be alternatively spliced in the IDX and 4A terminal exons, yielding the p19 and p21 proteins, respectively. However, despite the Ras gene family's established role in tumorigenic cellular signal transduction events, little is known about p19 function. Previous results showed that p19 did not interact with two known p21 effectors, Raf1 and Rin1, but was shown to interact with RACK1, a scaffolding protein that promotes multi-protein complexes in different signaling pathways (Cancer Res 2003, 63 p5178). This observation suggests that p19 and p21 play differential and complementary roles in the cell. | D009362 | Neoplasm Metastasis |
Clinically important variants in HRAS |
| (ClinVar, 04/20/2024) |
| accession_id | uniprot_id | gene_name | Type | Variant | Clinical_significance |
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