ASpdb: an integrative knowledgebase of human protein isoforms from experimental and AI-predicted structures

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	Protein Summary
	AS Summary
	Protein Functional Features
	Gene Isoform Structures and Expression Levels
	Protein Structures
	pLDDT Score Distribution
	Ramachandran Plot of Protein Structures
	Potential Active Site Information
	Protein Structure and Feature Comparision
	Protein-Protein Interaction
	Related Drugs
	Related Diseases
	Clinically Important Variants

Protein:IL15RA

Protein Summary

Gene summary

Gene name: IL15RA
ASpdb.0 ID: 3601
	Gene
Gene symbol	IL15RA
Gene ID	3601
Gene name	interleukin 15 receptor subunit alpha
Synonyms	CD215
Cytomap	10p15.1
Type of gene	protein-coding
Description	interleukin-15 receptor subunit alphainterleukin 15 receptor, alpha
Modification date	20240411
UniProtAcc	Q13261

Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Gene	IL15RA	GO:0009986	cell surface	15123770
Gene	IL15RA	GO:0042010	interleukin-15 receptor activity	15123770

AS Summary

Information of the canonical protein with experimentally identified structure from PDB (2023).

UniProt Acc	File name	PDB ID	Method	Resolution	Chain	Start	End
Q13261-1	Q13261-1_2z3q_B.pdb	2Z3Q	X-ray	1.85	B	31	108

ASpdb's canonical and alternatively spliced isoform information.

accession_id	gene_name	canonical_id	alternative_id	canonical_length	alternative_length	canonical_start	canonical_end	type	originalSEQ	variationSEQ	alternative_start	alternative_end
Q13261	IL15RA	Q13261-1	Q13261-10	267	231	1	36	Deletion	none	none	0	0
Q13261	IL15RA	Q13261-1	Q13261-3	267	234	95	128	Substitution	RDPALVHQRPAPPSTVTTAGVTPQPESLSPSGKE	K	95	95
Q13261	IL15RA	Q13261-1	Q13261-4	267	252	232	267	Substitution	QTPPLASVEMEAMEALPVTWGTSSRDEDLENCSHHL	ASVCSCHPRSAGHTCSVGSVC	232	252
Q13261	IL15RA	Q13261-1	Q13261-5	267	219	95	128	Substitution	RDPALVHQRPAPPSTVTTAGVTPQPESLSPSGKE	K	95	95
Q13261	IL15RA	Q13261-1	Q13261-5	267	219	232	267	Substitution	QTPPLASVEMEAMEALPVTWGTSSRDEDLENCSHHL	ASVCSCHPRSAGHTCSVGSVC	199	219
Q13261	IL15RA	Q13261-1	Q13261-6	267	202	31	95	Deletion	none	none	30	30
Q13261	IL15RA	Q13261-1	Q13261-7	267	187	31	95	Deletion	none	none	30	30
Q13261	IL15RA	Q13261-1	Q13261-7	267	187	232	267	Substitution	QTPPLASVEMEAMEALPVTWGTSSRDEDLENCSHHL	ASVCSCHPRSAGHTCSVGSVC	167	187
Q13261	IL15RA	Q13261-1	Q13261-8	267	169	30	127	Deletion	none	none	29	29
Q13261	IL15RA	Q13261-1	Q13261-9	267	154	30	127	Deletion	none	none	29	29
Q13261	IL15RA	Q13261-1	Q13261-9	267	154	232	267	Substitution	QTPPLASVEMEAMEALPVTWGTSSRDEDLENCSHHL	ASVCSCHPRSAGHTCSVGSVC	134	154

Multiple sequence alignment of our canonical and alternatively spliced IL15RA

Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of IL15RA

UniProt-id	ENSG	ENST	ENSP
Q13261-1	ENSG00000134470.21	ENST00000379977.8	ENSP00000369312.3
Q13261-10	ENSG00000134470.21	ENST00000525219.6	ENSP00000431529.2
Q13261-3	ENSG00000134470.21	ENST00000528354.5	ENSP00000435454.1
Q13261-4	ENSG00000134470.21	ENST00000397255.7	ENSP00000380426.3
Q13261-5	ENSG00000134470.21	ENST00000530685.5	ENSP00000435995.1
Q13261-8	ENSG00000134470.21	ENST00000397250.6	ENSP00000380422.2
Q13261-9	ENSG00000134470.21	ENST00000379971.5	ENSP00000369306.1

UniProt-id	NM ID	NP ID
Q13261-1	NM_002189.3	NP_002180.1
Q13261-10	NM_001243539.1	NP_001230468.1
Q13261-3	NM_172200.2	NP_751950.2

Amino acid sequences of our canonical and alternatively spliced IL15RA

accession_id	Protein sequence
Q13261-1	MAPRRARGCRTLGLPALLLLLLLRPPATRGITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPS LKCIRDPALVHQRPAPPSTVTTAGVTPQPESLSPSGKEPAASSPSSNNTAATTAAIVPGSQLMPSKSPSTGTTEISSHESSHGTPSQTTA
Q13261-10	MSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSTVTTAGVTPQPESLSPSG KEPAASSPSSNNTAATTAAIVPGSQLMPSKSPSTGTTEISSHESSHGTPSQTTAKNWELTASASHQPPGVYPQGHSDTTVAISTSTVLLC
Q13261-3	MAPRRARGCRTLGLPALLLLLLLRPPATRGITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPS LKCIKPAASSPSSNNTAATTAAIVPGSQLMPSKSPSTGTTEISSHESSHGTPSQTTAKNWELTASASHQPPGVYPQGHSDTTVAISTSTV
Q13261-4	MAPRRARGCRTLGLPALLLLLLLRPPATRGITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPS LKCIRDPALVHQRPAPPSTVTTAGVTPQPESLSPSGKEPAASSPSSNNTAATTAAIVPGSQLMPSKSPSTGTTEISSHESSHGTPSQTTA
Q13261-5	MAPRRARGCRTLGLPALLLLLLLRPPATRGITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPS LKCIKPAASSPSSNNTAATTAAIVPGSQLMPSKSPSTGTTEISSHESSHGTPSQTTAKNWELTASASHQPPGVYPQGHSDTTVAISTSTV
Q13261-6	MAPRRARGCRTLGLPALLLLLLLRPPATRGDPALVHQRPAPPSTVTTAGVTPQPESLSPSGKEPAASSPSSNNTAATTAAIVPGSQLMPS KSPSTGTTEISSHESSHGTPSQTTAKNWELTASASHQPPGVYPQGHSDTTVAISTSTVLLCGLSAVSLLACYLKSRQTPPLASVEMEAME
Q13261-7	MAPRRARGCRTLGLPALLLLLLLRPPATRGDPALVHQRPAPPSTVTTAGVTPQPESLSPSGKEPAASSPSSNNTAATTAAIVPGSQLMPS KSPSTGTTEISSHESSHGTPSQTTAKNWELTASASHQPPGVYPQGHSDTTVAISTSTVLLCGLSAVSLLACYLKSRASVCSCHPRSAGHT
Q13261-8	MAPRRARGCRTLGLPALLLLLLLRPPATREPAASSPSSNNTAATTAAIVPGSQLMPSKSPSTGTTEISSHESSHGTPSQTTAKNWELTAS
Q13261-9	MAPRRARGCRTLGLPALLLLLLLRPPATREPAASSPSSNNTAATTAAIVPGSQLMPSKSPSTGTTEISSHESSHGTPSQTTAKNWELTAS

Protein Functional Features

Main function of this protein. (from UniProt)

IL15RA (go to UniProt):Q13261

Retention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Accession_id	Subsection	Start	End	Funcitonal feature	Splicing information
Q13261	Topological domain	31	205	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=1;End=36
Q13261	Topological domain	31	205	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=95;End=128
Q13261	Topological domain	31	205	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=95;End=128
Q13261	Topological domain	31	205	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=31;End=95
Q13261	Topological domain	31	205	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=31;End=95
Q13261	Topological domain	31	205	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=30;End=127
Q13261	Topological domain	31	205	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=30;End=127
Q13261	Topological domain	229	267	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=232;End=267
Q13261	Topological domain	229	267	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=232;End=267
Q13261	Topological domain	229	267	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=232;End=267
Q13261	Topological domain	229	267	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=232;End=267
Q13261	Domain	31	95	Note=Sushi;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00302	Type=Deletion;Start=1;End=36
Q13261	Domain	31	95	Note=Sushi;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00302	Type=Substitution;Start=95;End=128
Q13261	Domain	31	95	Note=Sushi;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00302	Type=Substitution;Start=95;End=128
Q13261	Domain	31	95	Note=Sushi;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00302	Type=Deletion;Start=31;End=95
Q13261	Domain	31	95	Note=Sushi;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00302	Type=Deletion;Start=31;End=95
Q13261	Domain	31	95	Note=Sushi;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00302	Type=Deletion;Start=30;End=127
Q13261	Domain	31	95	Note=Sushi;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00302	Type=Deletion;Start=30;End=127
Q13261	Region	102	178	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Substitution;Start=95;End=128
Q13261	Region	102	178	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Substitution;Start=95;End=128
Q13261	Region	102	178	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=30;End=127
Q13261	Region	102	178	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=30;End=127
Q13261	Compositional bias	105	178	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Substitution;Start=95;End=128
Q13261	Compositional bias	105	178	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Substitution;Start=95;End=128
Q13261	Compositional bias	105	178	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=30;End=127
Q13261	Compositional bias	105	178	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=30;End=127

Gene Isoform Structures and Expression Levels for IL15RA

Gene structures of our canonical and alternative spliced genes of IL15RA
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Expression levels of gene isoforms across GTEx.

Expression levels of gene isoforms across TCGA.

Protein Structures

PDB and CIF files of the predicted protein structures
* Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

3D view using mol* of Q13261-1

3D view using mol* of Q13261-10

3D view using mol* of Q13261-3

3D view using mol* of Q13261-4

3D view using mol* of Q13261-5

3D view using mol* of Q13261-6

3D view using mol* of Q13261-7

3D view using mol* of Q13261-8

3D view using mol* of Q13261-9

pLDDT Score Distribution

pLDDT score distribution of the predicted protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

pLDDT distribution across the protein length of Q13261-1

pLDDT distribution across the protein length of Q13261-10

pLDDT distribution across the protein length of Q13261-3

pLDDT distribution across the protein length of Q13261-4

pLDDT distribution across the protein length of Q13261-5

pLDDT distribution across the protein length of Q13261-6

pLDDT distribution across the protein length of Q13261-7

pLDDT distribution across the protein length of Q13261-8

pLDDT distribution across the protein length of Q13261-9

Ramachandran Plot of Protein Structures

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide.

Ramachandran plot of Q13261-1

Ramachandran plot of Q13261-10

Ramachandran plot of Q13261-3

Ramachandran plot of Q13261-5

Ramachandran plot of Q13261-6

Ramachandran plot of Q13261-7

Ramachandran plot of Q13261-8

Ramachandran plot of Q13261-9

Potential Active Site Information

The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite.

UniProt-id	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
Q13261-1	0.548	15	0.533	27.783	0.776	0.521	0.673	1.089	0.44	2.478	1.701	62,95,99,100,103,105
Q13261-10	0.473	7	0.416	23.324	0.821	0.572	0.723	0.979	0.54	1.812	1.167	1,8,10,37
Q13261-3	0.787	41	0.81	145.089	0.634	0.617	0.86	1.745	0.497	3.508	12.936	18,19,22,23,24,25,26,183,186,187,190,191,193,194
Q13261-4	0.986	75	1.097	144.746	0.543	0.585	0.786	1.86	0.209	8.893	2.717	15,16,18,19,22,23,24,26,212,215,216,218,219,222,22 3,226
Q13261-5	0.776	33	0.838	81.291	0.697	0.568	0.735	2.221	0.13	17.114	3.417	14,15,18,19,22,182,185,186,189,190
Q13261-6	0.766	22	0.784	67.571	0.532	0.697	1.005	2.872	0.231	12.448	2.61	15,18,19,22,150,153,154,158
Q13261-7	0.912	58	0.993	128.282	0.644	0.605	0.783	1.985	0.262	7.574	6.131	15,18,19,22,24,25,26,146,149,150,153,154,157,158
Q13261-8	0.883	39	0.957	72.03	0.519	0.658	0.975	3.418	0.075	45.291	1.955	15,18,19,22,117,120,121,124,125
Q13261-9	0.816	34	0.873	82.32	0.534	0.624	0.881	2.186	0.151	14.482	11.584	15,18,19,22,117,120,121,124,125

Protein Structure and Feature Comparision

Protein Structure Comparision Using Template Modeling Scores (TM-score).

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green)

3D view using mol* of Q13261-1_Q13261-1_2z3q_B.pdb

Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of Q13261-1_2z3q_B_Q13261-10.pdb

3D view using mol* of Q13261-1_2z3q_B_Q13261-3.pdb

3D view using mol* of Q13261-1_2z3q_B_Q13261-4.pdb

3D view using mol* of Q13261-1_2z3q_B_Q13261-5.pdb

3D view using mol* of Q13261-1_2z3q_B_Q13261-6.pdb

3D view using mol* of Q13261-1_2z3q_B_Q13261-7.pdb

3D view using mol* of Q13261-1_2z3q_B_Q13261-8.pdb

3D view using mol* of Q13261-1_2z3q_B_Q13261-9.pdb

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of Q13261-1_Q13261-10.pdb

3D view using mol* of Q13261-1_Q13261-3.pdb

3D view using mol* of Q13261-1_Q13261-4.pdb

3D view using mol* of Q13261-1_Q13261-5.pdb

3D view using mol* of Q13261-1_Q13261-6.pdb

3D view using mol* of Q13261-1_Q13261-7.pdb

3D view using mol* of Q13261-1_Q13261-8.pdb

3D view using mol* of Q13261-1_Q13261-9.pdb

Protein Feature Comparison of the protein sequendary structures among the protiens.

./stats/secondary_structure/figure/Q13261-1_vs_Q13261-10.png