ASpdb: an integrative knowledgebase of human protein isoforms from experimental and AI-predicted structures

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	Protein Summary
	AS Summary
	Protein Functional Features
	Gene Isoform Structures and Expression Levels
	Protein Structures
	pLDDT Score Distribution
	Ramachandran Plot of Protein Structures
	Potential Active Site Information
	Protein Structure and Feature Comparision
	Protein-Protein Interaction
	Related Drugs
	Related Diseases
	Clinically Important Variants

Protein:MARK3

Protein Summary

Gene summary

Gene name: MARK3
ASpdb.0 ID: 4140
	Gene
Gene symbol	MARK3
Gene ID	4140
Gene name	microtubule affinity regulating kinase 3
Synonyms	CTAK1\|KP78\|PAR1A\|Par-1a\|VIPB
Cytomap	14q32.32-q32.33
Type of gene	protein-coding
Description	MAP/microtubule affinity-regulating kinase 3C-TAK1ELKL motif kinase 2EMK-2cdc25C-associated protein kinase 1protein kinase STK10ser/Thr protein kinase PAR-1serine/threonine-protein kinase p78
Modification date	20240407
UniProtAcc	P27448

Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Gene	MARK3	GO:0004674	protein serine/threonine kinase activity	9543386\|12941695\|16822840\|16980613
Gene	MARK3	GO:0005737	cytoplasm	23666762
Gene	MARK3	GO:0005886	plasma membrane	21145462
Gene	MARK3	GO:0018105	peptidyl-serine phosphorylation	9543386
Gene	MARK3	GO:0030425	dendrite	23666762
Gene	MARK3	GO:0032092	positive regulation of protein binding	9543386
Gene	MARK3	GO:0035331	negative regulation of hippo signaling	28087714
Gene	MARK3	GO:0036289	peptidyl-serine autophosphorylation	9543386
Gene	MARK3	GO:1900181	negative regulation of protein localization to nucleus	16822840

AS Summary

Information of the canonical protein with experimentally identified structure from PDB (2023).

UniProt Acc	File name	PDB ID	Method	Resolution	Chain	Start	End
P27448-5	P27448-5_2qnj_B.pdb	2QNJ	X-ray	2.7	B	48	367

ASpdb's canonical and alternatively spliced isoform information.

accession_id	gene_name	canonical_id	alternative_id	canonical_length	alternative_length	canonical_start	canonical_end	type	originalSEQ	variationSEQ	alternative_start	alternative_end
P27448	MARK3	P27448-5	P27448-2	753	752	161	161	Substitution	Q	QGCQAGQTIKVQVSFDLLSLMFTF	161	184
P27448	MARK3	P27448-5	P27448-2	753	752	615	638	Deletion	none	none	637	637
P27448	MARK3	P27448-5	P27448-3	753	729	615	638	Deletion	none	none	614	614
P27448	MARK3	P27448-5	P27448-4	753	744	615	623	Deletion	none	none	614	614
P27448	MARK3	P27448-5	P27448-6	753	713	371	386	Deletion	none	none	370	370
P27448	MARK3	P27448-5	P27448-6	753	713	615	638	Deletion	none	none	598	598
P27448	MARK3	P27448-5	P27448-7	753	760	161	161	Substitution	Q	QGCQAGQTIKVQVSFDLLSLMFTF	161	184
P27448	MARK3	P27448-5	P27448-7	753	760	371	386	Deletion	none	none	393	393
P27448	MARK3	P27448-5	P27448-8	753	659	179	257	Deletion	none	none	178	178
P27448	MARK3	P27448-5	P27448-8	753	659	624	638	Deletion	none	none	544	544

Multiple sequence alignment of our canonical and alternatively spliced MARK3

Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of MARK3

UniProt-id	ENSG	ENST	ENSP
P27448-5	ENSG00000075413.19	ENST00000429436.7	ENSP00000411397.2
P27448-2	ENSG00000075413.19	ENST00000416682.6	ENSP00000408092.2
P27448-3	ENSG00000075413.19	ENST00000303622.13	ENSP00000303698.9
P27448-4	ENSG00000075413.19	ENST00000553942.5	ENSP00000450772.1
P27448-6	ENSG00000075413.19	ENST00000216288.11	ENSP00000216288.7
P27448-8	ENSG00000075413.19	ENST00000440884.7	ENSP00000402104.3

UniProt-id	NM ID	NP ID
P27448-5	NM_001128918.2	NP_001122390.2
P27448-3	NM_002376.6	NP_002367.5
P27448-4	NM_001128919.2	NP_001122391.2
P27448-6	NM_001128920.2	NP_001122392.2
P27448-8	NM_001128921.2	NP_001122393.2

Amino acid sequences of our canonical and alternatively spliced MARK3

accession_id	Protein sequence
P27448-5	MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKT QLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY RIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGI SSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVAS THSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYE RNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKL
P27448-2	MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKT QLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQGCQAGQTIKVQVSFDLLSL MFTFIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLV SGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVG MGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVSSSQKQRRYSDHAGPAIP SVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTAD RHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSK LTSKLTRSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLP
P27448-3	MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKT QLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY RIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGI SSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVAS THSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRSRNVSAEQKDENKEAK PRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIA
P27448-4	MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKT QLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY RIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGI SSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVAS THSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRLPTEYERNGRYEGSS RNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVR
P27448-6	MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKT QLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY RIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT YLLLGRKSSEVRPSSDLNNSTGQSPHHKVQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIA PASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFP RGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSM
P27448-7	MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKT QLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQGCQAGQTIKVQVSFDLLSL MFTFIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLV SGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVG MGYSQEEIQESLSKMKYDEITATYLLLGRKSSEVRPSSDLNNSTGQSPHHKVQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADS DLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPD QRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIK RLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQW
P27448-8	MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKT QLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK ELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESL SKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTS TADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENS TIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSF RFIKSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLS

Protein Functional Features

Main function of this protein. (from UniProt)

MARK3 (go to UniProt):P27448

Retention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Accession_id	Subsection	Start	End	Funcitonal feature	Splicing information
P27448	Domain	56	307	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159	Type=Substitution;Start=161;End=161
P27448	Domain	56	307	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159	Type=Substitution;Start=161;End=161
P27448	Domain	56	307	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159	Type=Deletion;Start=179;End=257
P27448	Region	370	600	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=371;End=386
P27448	Region	370	600	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=371;End=386
P27448	Region	632	655	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=615;End=638
P27448	Region	632	655	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=615;End=638
P27448	Region	632	655	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=615;End=638
P27448	Region	632	655	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=624;End=638
P27448	Compositional bias	370	418	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=371;End=386
P27448	Compositional bias	370	418	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=371;End=386

Gene Isoform Structures and Expression Levels for MARK3

Gene structures of our canonical and alternative spliced genes of MARK3
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Expression levels of gene isoforms across GTEx.

Expression levels of gene isoforms across TCGA.

Protein Structures

PDB and CIF files of the predicted protein structures
* Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

3D view using mol* of P27448-5

3D view using mol* of P27448-2

3D view using mol* of P27448-3

3D view using mol* of P27448-4

3D view using mol* of P27448-6

3D view using mol* of P27448-7

3D view using mol* of P27448-8

pLDDT Score Distribution

pLDDT score distribution of the predicted protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

pLDDT distribution across the protein length of P27448-5

pLDDT distribution across the protein length of P27448-2

pLDDT distribution across the protein length of P27448-3

pLDDT distribution across the protein length of P27448-4

pLDDT distribution across the protein length of P27448-6

pLDDT distribution across the protein length of P27448-7

pLDDT distribution across the protein length of P27448-8

Ramachandran Plot of Protein Structures

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide.

Ramachandran plot of P27448-5

Ramachandran plot of P27448-3

Ramachandran plot of P27448-7

Ramachandran plot of P27448-8

Potential Active Site Information

The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite.

UniProt-id	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
P27448-5	1.026	678	1.044	2419.865	0.54	0.735	0.942	0.703	1.035	0.679	0.755	60,62,63,64,65,66,67,68,70,74,79,80,81,82,83,85,87 ,91,92,93,96,99,100,103,107,115,116,119,132,133,13 4,135,136,137,138,139,141,142,147,178,180,181,182, 183,185,187,188,189,190,195,196,197,198,199,210,21 1,212,213,214,215,216,217,218,223,224,225,226,227, 228,229,251,254,255,257,258,261,262,363,366,367,36 8,369,370,371,475,477,478,479,482,483,508,509,510, 511,512,656,657,658,659,660,661,662,697,702,707,70 8,709,710,711,712,714,715,716,720,721,722,723,729, 731,732,733,734,735,736,737,738,739,742,743
P27448-2	1.042	669	1.063	2529.625	0.536	0.751	0.952	0.607	1.004	0.604	0.71	60,62,63,64,65,66,67,68,70,72,74,79,80,81,82,83,85 ,87,91,92,93,94,95,96,98,99,100,102,103,107,111,11 2,113,115,116,117,119,132,133,134,135,136,137,138, 139,141,199,200,201,203,204,205,206,208,210,211,21 2,216,218,219,220,221,222,224,233,234,235,236,237, 238,239,240,241,246,247,249,250,252,268,274,277,27 8,280,281,282,284,285,347,348,354,385,386,388,389, 390,391,392,393,394,395,396,494,495,496,497,498,49 9,500,501,502,505,506,655,656,657,658,659,706,707, 709,711,713,715,720,728,729,730,731,732,733,734,73 5,736,737,738
P27448-3	1.066	174	1.097	563.549	0.547	0.762	0.989	1.022	0.921	1.11	0.812	93,96,98,99,102,177,199,201,209,210,211,212,213,21 5,216,223,224,225,226,227,258,259,262,475,476,477, 478,479,480,482,483,506,507,508,509
P27448-4	1.048	526	1.077	1954.414	0.567	0.744	0.909	0.692	0.95	0.728	0.712	60,61,62,63,64,65,66,67,68,70,72,74,79,80,81,82,83 ,85,87,92,93,96,99,100,102,103,107,112,113,115,116 ,117,119,132,133,134,135,136,137,138,139,141,143,1 47,178,180,182,183,185,187,188,189,190,193,195,196 ,197,198,199,215,216,217,218,245,249,250,251,254,2 55,257,258,261,324,331,362,363,365,366,367,368,369 ,370,371,372,373,647,649,650,651,652,653,693,698,6 99,700,701,705,707,711,712,714,720,722,723,724,725 ,726,727,729,730,732,733
P27448-6	1.051	602	1.094	1948.926	0.556	0.72	0.89	0.84	0.852	0.986	0.711	60,62,63,64,65,66,67,68,70,74,79,80,81,82,83,85,87 ,92,93,95,96,98,99,100,102,103,107,116,119,132,133 ,134,135,136,137,138,139,142,177,178,180,182,183,1 85,187,188,189,190,193,195,196,197,198,199,201,210 ,211,212,213,215,216,217,218,223,224,251,254,255,2 57,258,259,261,262,363,366,367,368,369,371,456,457 ,458,459,460,461,462,463,616,618,619,620,621,622,6 57,662,667,668,669,670,672,674,676,681,689,691,692 ,693,694,695,696,698,699,702,703
P27448-7	1.035	280	1.082	837.949	0.537	0.691	0.912	0.724	0.837	0.866	0.905	137,143,145,146,147,148,149,150,151,154,155,156,15 8,159,162,164,165,167,168,169,170,171,172,173,174, 176,177,181,211,213,665,666,667,668,669,670,671,67 2,673,727,728,729,730,737,752,755,756
P27448-8	1.041	535	1.077	1852.2	0.568	0.72	0.887	0.759	0.905	0.839	0.806	62,63,64,65,66,67,68,70,83,85,87,92,96,99,100,102, 103,107,110,114,115,116,117,118,132,133,134,135,13 6,137,138,139,140,143,150,158,159,161,162,163,165, 166,175,176,177,178,179,180,181,182,183,185,186,18 7,208,209,210,211,213,216,219,421,422,423,424,425, 426,427,428,429,540,542,566,567,597,599,605,607,61 3,614,615,616,617,618,635,637,638,639,640,641,642, 643,644,645

Protein Structure and Feature Comparision

Protein Structure Comparision Using Template Modeling Scores (TM-score).

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green)

3D view using mol* of P27448-5_P27448-5_2qnj_B.pdb

Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of P27448-5_2qnj_B_P27448-2.pdb

3D view using mol* of P27448-5_2qnj_B_P27448-3.pdb

3D view using mol* of P27448-5_2qnj_B_P27448-4.pdb

3D view using mol* of P27448-5_2qnj_B_P27448-6.pdb

3D view using mol* of P27448-5_2qnj_B_P27448-7.pdb

3D view using mol* of P27448-5_2qnj_B_P27448-8.pdb

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of P27448-5_P27448-2.pdb

3D view using mol* of P27448-5_P27448-3.pdb

3D view using mol* of P27448-5_P27448-4.pdb

3D view using mol* of P27448-5_P27448-6.pdb

3D view using mol* of P27448-5_P27448-7.pdb

3D view using mol* of P27448-5_P27448-8.pdb

Protein Feature Comparison of the protein sequendary structures among the protiens.

./stats/secondary_structure/figure/P27448-5_vs_P27448-2.png

./stats/secondary_structure/figure/P27448-5_vs_P27448-3.png

./stats/secondary_structure/figure/P27448-5_vs_P27448-4.png

./stats/secondary_structure/figure/P27448-5_vs_P27448-6.png

./stats/secondary_structure/figure/P27448-5_vs_P27448-7.png

./stats/secondary_structure/figure/P27448-5_vs_P27448-8.png

Protein Feature Comparison of the relative accessible surface area (ASA) among the protiens.

./stats/relative_asa/P27448-5_vs_P27448-2.png

./stats/relative_asa/P27448-5_vs_P27448-3.png

./stats/relative_asa/P27448-5_vs_P27448-4.png

./stats/relative_asa/P27448-5_vs_P27448-6.png

./stats/relative_asa/P27448-5_vs_P27448-7.png

./stats/relative_asa/P27448-5_vs_P27448-8.png

Protein-Protein Interaction

Interactors from UniProt.

Accession_id

Subsection

Start

End

Funcitonal feature

Splicing information

Interactors from STRING.

Gene name

Interactors

Related Drugs to MARK3

Drugs targeting this gene/protein.
(DrugBank)

UniProt accession	Gene name	DrugBank ID	Drug name	Drug group	Actions
P27448	MARK3	DB12010	Fostamatinib	approved, investigational	inhibitor

Related Diseases to MARK3

Previous studies relating to the alternative splicing of MARK3 and disease information from the MeSH term (PubMed)

Gene

PMID

Title

Abstract

MeSH ID

MeSH term

Clinically important variants in MARK3

(ClinVar, 04/20/2024)

accession_id

uniprot_id

gene_name

Type

Variant

Clinical_significance