ASpdb: an integrative knowledgebase of human protein isoforms from experimental and AI-predicted structures

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	Protein Summary
	AS Summary
	Protein Functional Features
	Gene Isoform Structures and Expression Levels
	Protein Structures
	pLDDT Score Distribution
	Ramachandran Plot of Protein Structures
	Potential Active Site Information
	Protein Structure and Feature Comparision
	Protein-Protein Interaction
	Related Drugs
	Related Diseases
	Clinically Important Variants

Protein:NCAM1

Protein Summary

Gene summary

Gene name: NCAM1
ASpdb.0 ID: 4684
	Gene
Gene symbol	NCAM1
Gene ID	4684
Gene name	neural cell adhesion molecule 1
Synonyms	CD56\|MSK39\|NCAM
Cytomap	11q23.2
Type of gene	protein-coding
Description	neural cell adhesion molecule 1antigen recognized by monoclonal antibody 5.1H11neural cell adhesion molecule, NCAM
Modification date	20240305
UniProtAcc	P13591

Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Gene	NCAM1	GO:0005829	cytosol	-
Gene	NCAM1	GO:0005886	plasma membrane	-
Gene	NCAM1	GO:0009897	external side of plasma membrane	17213291
Gene	NCAM1	GO:0009986	cell surface	10766765

AS Summary

Information of the canonical protein with experimentally identified structure from PDB (2023).

UniProt Acc	File name	PDB ID	Method	Resolution	Chain	Start	End
P13591-2	P13591-2_2vkw_A.pdb	2VKW	X-ray	2.3	A	506	702

ASpdb's canonical and alternatively spliced isoform information.

accession_id	gene_name	canonical_id	alternative_id	canonical_length	alternative_length	canonical_start	canonical_end	type	originalSEQ	variationSEQ	alternative_start	alternative_end
P13591	NCAM1	P13591-2	P13591-1	858	848	354	363	Deletion	none	none	353	353
P13591	NCAM1	P13591-2	P13591-3	858	761	354	363	Deletion	none	none	353	353
P13591	NCAM1	P13591-2	P13591-3	858	761	609	609	Substitution	Q	HSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAK	599	634
P13591	NCAM1	P13591-2	P13591-3	858	761	712	736	Substitution	NGSPTSGLSTGAIVGILIVIFVLLL	TLGGNSASYTFVSLLFSAVTLLLLC	737	761
P13591	NCAM1	P13591-2	P13591-3	858	761	737	858	Deletion	none	none	761	761
P13591	NCAM1	P13591-2	P13591-4	858	726	354	363	Deletion	none	none	353	353
P13591	NCAM1	P13591-2	P13591-4	858	726	712	736	Substitution	NGSPTSGLSTGAIVGILIVIFVLLL	TLGGNSASYTFVSLLFSAVTLLLLC	702	726
P13591	NCAM1	P13591-2	P13591-4	858	726	737	858	Deletion	none	none	726	726
P13591	NCAM1	P13591-2	P13591-5	858	665	609	665	Substitution	QGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSG	HSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKNIAQNHCCNMFQAGLHNALMK	609	665
P13591	NCAM1	P13591-2	P13591-5	858	665	666	858	Deletion	none	none	665	665
P13591	NCAM1	P13591-2	P13591-6	858	364	364	364	Substitution	T	V	364	364
P13591	NCAM1	P13591-2	P13591-6	858	364	365	858	Deletion	none	none	364	364

Multiple sequence alignment of our canonical and alternatively spliced NCAM1

Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of NCAM1

UniProt-id	ENSG	ENST	ENSP
P13591-2	ENSG00000149294.18	ENST00000316851.12	ENSP00000318472.8
P13591-1	ENSG00000149294.18	ENST00000531044.5	ENSP00000484943.1
P13591-3	ENSG00000149294.18	ENST00000621850.4	ENSP00000480774.1
P13591-4	ENSG00000149294.18	ENST00000621128.4	ENSP00000481083.1
P13591-6	ENSG00000149294.18	ENST00000529356.5	ENSP00000482205.1

UniProt-id	NM ID	NP ID
P13591-2	NM_181351.4	NP_851996.2
P13591-1	NM_000615.6	NP_000606.3
P13591-3	NM_001076682.3	NP_001070150.1
P13591-4	NM_001242608.1	NP_001229537.1

Amino acid sequences of our canonical and alternatively spliced NCAM1

accession_id	Protein sequence
P13591-2	MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPE KQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFR DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKV NLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLS TGAIVGILIVIFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFSKDESKEPIVEVRTEEERTPNHDGGKHTEPN
P13591-1	MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMV VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNY SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGS PIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIVGILIV IFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFSKDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEPEK
P13591-3	MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMV VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNY SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPALATT EPAKGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKA
P13591-4	MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMV VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNY SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGS PIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPATLGGNSASYTFVSLLFSAV
P13591-5	MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPE KQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFR DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDT
P13591-6	MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPE

Protein Functional Features

Main function of this protein. (from UniProt)

NCAM1 (go to UniProt):P13591

Retention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Accession_id	Subsection	Start	End	Funcitonal feature	Splicing information
P13591	Topological domain	20	718	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=354;End=363
P13591	Topological domain	20	718	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=354;End=363
P13591	Topological domain	20	718	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=609;End=609
P13591	Topological domain	20	718	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=712;End=736
P13591	Topological domain	20	718	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=354;End=363
P13591	Topological domain	20	718	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=712;End=736
P13591	Topological domain	20	718	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=609;End=665
P13591	Topological domain	20	718	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=666;End=858
P13591	Topological domain	20	718	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=364;End=364
P13591	Topological domain	20	718	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=365;End=858
P13591	Transmembrane	719	739	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=712;End=736
P13591	Transmembrane	719	739	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=737;End=858
P13591	Transmembrane	719	739	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Substitution;Start=712;End=736
P13591	Transmembrane	719	739	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=737;End=858
P13591	Transmembrane	719	739	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=666;End=858
P13591	Transmembrane	719	739	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=365;End=858
P13591	Topological domain	740	858	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=737;End=858
P13591	Topological domain	740	858	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=737;End=858
P13591	Topological domain	740	858	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=666;End=858
P13591	Topological domain	740	858	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=365;End=858
P13591	Domain	308	413	Note=Ig-like C2-type 4	Type=Deletion;Start=354;End=363
P13591	Domain	308	413	Note=Ig-like C2-type 4	Type=Deletion;Start=354;End=363
P13591	Domain	308	413	Note=Ig-like C2-type 4	Type=Deletion;Start=354;End=363
P13591	Domain	308	413	Note=Ig-like C2-type 4	Type=Substitution;Start=364;End=364
P13591	Domain	308	413	Note=Ig-like C2-type 4	Type=Deletion;Start=365;End=858
P13591	Domain	416	501	Note=Ig-like C2-type 5	Type=Deletion;Start=365;End=858
P13591	Domain	509	608	Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316	Type=Deletion;Start=365;End=858
P13591	Domain	611	706	Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316	Type=Substitution;Start=609;End=665
P13591	Domain	611	706	Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316	Type=Deletion;Start=666;End=858
P13591	Domain	611	706	Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316	Type=Deletion;Start=365;End=858
P13591	Region	766	858	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=737;End=858
P13591	Region	766	858	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=737;End=858
P13591	Region	766	858	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=666;End=858
P13591	Region	766	858	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=365;End=858
P13591	Compositional bias	767	808	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=737;End=858
P13591	Compositional bias	767	808	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=737;End=858
P13591	Compositional bias	767	808	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=666;End=858
P13591	Compositional bias	767	808	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=365;End=858
P13591	Compositional bias	821	835	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=737;End=858
P13591	Compositional bias	821	835	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=737;End=858
P13591	Compositional bias	821	835	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=666;End=858
P13591	Compositional bias	821	835	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=365;End=858

Gene Isoform Structures and Expression Levels for NCAM1

Gene structures of our canonical and alternative spliced genes of NCAM1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Expression levels of gene isoforms across GTEx.

Expression levels of gene isoforms across TCGA.

Protein Structures

PDB and CIF files of the predicted protein structures
* Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

3D view using mol* of P13591-2

3D view using mol* of P13591-1

3D view using mol* of P13591-3

3D view using mol* of P13591-4

3D view using mol* of P13591-5

3D view using mol* of P13591-6

pLDDT Score Distribution

pLDDT score distribution of the predicted protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

pLDDT distribution across the protein length of P13591-2

pLDDT distribution across the protein length of P13591-1

pLDDT distribution across the protein length of P13591-3

pLDDT distribution across the protein length of P13591-4

pLDDT distribution across the protein length of P13591-5

pLDDT distribution across the protein length of P13591-6

Ramachandran Plot of Protein Structures

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide.

Ramachandran plot of P13591-2

Ramachandran plot of P13591-1

Ramachandran plot of P13591-4

Ramachandran plot of P13591-5

Ramachandran plot of P13591-6

Potential Active Site Information

The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite.

UniProt-id	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
P13591-2	0.944	139	0.949	355.348	0.674	0.615	0.773	0.184	1.103	0.167	0.821	337,338,339,340,341,342,347,348,349,350,351,352,35 3,354,355,356,357,358,359,360,361,362,363,364,369, 371,373,374,375,377,378,396
P13591-1	0.972	124	0.922	392.392	0.611	0.657	0.885	0.092	1.263	0.073	0.823	511,512,514,516,548,550,554,555,557,558,560,561,56 2,564,596,599,600,601,602,603,604,605,606,608,623, 624,625,626,628,682,683,684
P13591-3	0.697	47	0.644	149.891	0.747	0.589	0.755	0.245	1.087	0.225	0.496	615,616,617,618,619,622,623,624,625,673,675,681,68 3,684,708,720
P13591-4	0.837	56	0.724	158.123	0.529	0.73	1.071	0.265	1.281	0.207	0.867	511,512,513,514,596,597,599,624,625,626,627,629,63 1
P13591-5	0.974	190	0.999	652.043	0.664	0.652	0.845	0.275	1.019	0.27	1.017	335,336,337,338,339,340,341,342,343,344,345,346,34 7,348,349,350,351,352,353,354,355,356,357,358,359, 360,361,362,363,364,365,366,368,369,370,371,372,37 3,374,375,377,378,382,388,389,390,391,392,393,398, 399,400
P13591-6	0.913	87	0.939	393.764	0.711	0.61	0.761	0.415	0.931	0.446	0.521	325,326,327,328,329,330,331,337,338,339,340,341,34 2,343,344,346,347,348,350,352,353,354,355,356,357, 359

Protein Structure and Feature Comparision

Protein Structure Comparision Using Template Modeling Scores (TM-score).

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green)

3D view using mol* of P13591-2_P13591-2_2vkw_A.pdb

Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of P13591-2_2vkw_A_P13591-1.pdb

3D view using mol* of P13591-2_2vkw_A_P13591-3.pdb

3D view using mol* of P13591-2_2vkw_A_P13591-4.pdb

3D view using mol* of P13591-2_2vkw_A_P13591-5.pdb

3D view using mol* of P13591-2_2vkw_A_P13591-6.pdb

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of P13591-2_P13591-1.pdb

3D view using mol* of P13591-2_P13591-3.pdb

3D view using mol* of P13591-2_P13591-4.pdb

3D view using mol* of P13591-2_P13591-5.pdb

3D view using mol* of P13591-2_P13591-6.pdb

Protein Feature Comparison of the protein sequendary structures among the protiens.

./stats/secondary_structure/figure/P13591-2_vs_P13591-1.png

./stats/secondary_structure/figure/P13591-2_vs_P13591-3.png

./stats/secondary_structure/figure/P13591-2_vs_P13591-4.png

./stats/secondary_structure/figure/P13591-2_vs_P13591-5.png

./stats/secondary_structure/figure/P13591-2_vs_P13591-6.png

Protein Feature Comparison of the relative accessible surface area (ASA) among the protiens.

./stats/relative_asa/P13591-2_vs_P13591-1.png

./stats/relative_asa/P13591-2_vs_P13591-3.png

./stats/relative_asa/P13591-2_vs_P13591-4.png

./stats/relative_asa/P13591-2_vs_P13591-5.png

./stats/relative_asa/P13591-2_vs_P13591-6.png

Protein-Protein Interaction

Interactors from UniProt.

Accession_id

Subsection

Start

End

Funcitonal feature

Splicing information

Interactors from STRING.

Gene name

Interactors

Related Drugs to NCAM1

Drugs targeting this gene/protein.
(DrugBank)

UniProt accession

Gene name

DrugBank ID

Drug name

Drug group

Actions

Related Diseases to NCAM1

Previous studies relating to the alternative splicing of NCAM1 and disease information from the MeSH term (PubMed)

Gene	PMID	Title	Abstract	MeSH ID	MeSH term
NCAM1	11685193	Alternative mRNA splicing in colon cancer causes loss of expression of neural cell adhesion molecule.	The neural cell adhesion molecule (NCAM) has numerous isoforms resulting from alternative splicing of mRNA. The 3 major isoforms found in adult tissue are (1) a 120-kDa protein that is linked to the plasma membrane by glycosylphosphatidylinositol; (2) a 140-kDa form that has a transmembrane component and a cytoplasmic tail with unknown function; and (3) a 180-kDa isoform that has an intracellular protein that binds the cytoskeleton. NCAM is capable of homotypic binding and therefore plays a role in cell-cell adhesion for cells expressing the 180-kDa isoform by anchoring groups of cells into epithelial sheets. NCAM-180 is the isoform found in colonocytes, and loss of expression is associated with clinically aggressive colon cancers.	D003110	Colonic Neoplasms

Clinically important variants in NCAM1

(ClinVar, 04/20/2024)

accession_id

uniprot_id

gene_name

Type

Variant

Clinical_significance