ASpdb: an integrative knowledgebase of human protein isoforms from experimental and AI-predicted structures

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	Protein Summary
	AS Summary
	Protein Functional Features
	Gene Isoform Structures and Expression Levels
	Protein Structures
	pLDDT Score Distribution
	Ramachandran Plot of Protein Structures
	Potential Active Site Information
	Protein Structure and Feature Comparision
	Protein-Protein Interaction
	Related Drugs
	Related Diseases
	Clinically Important Variants

Protein:NFATC2

Protein Summary

Gene summary

Gene name: NFATC2
ASpdb.0 ID: 4773
	Gene
Gene symbol	NFATC2
Gene ID	4773
Gene name	nuclear factor of activated T cells 2
Synonyms	JCOSL\|NFAT1\|NFATP
Cytomap	20q13.2
Type of gene	protein-coding
Description	nuclear factor of activated T-cells, cytoplasmic 2NF-ATc2NFAT pre-existing subunitNFAT transcription complex, preexisting componentT cell transcription factor NFAT1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2nuclear fact
Modification date	20240317
UniProtAcc	Q13469

Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Gene	NFATC2	GO:0005634	nucleus	12370307\|12656674
Gene	NFATC2	GO:0005654	nucleoplasm	-
Gene	NFATC2	GO:0005737	cytoplasm	12656674
Gene	NFATC2	GO:0005829	cytosol	-
Gene	NFATC2	GO:0016477	cell migration	21871017
Gene	NFATC2	GO:0045893	positive regulation of DNA-templated transcription	15790681
Gene	NFATC2	GO:1905064	negative regulation of vascular associated smooth muscle cell differentiation	23853098
Gene	NFATC2	GO:1990837	sequence-specific double-stranded DNA binding	28473536

AS Summary

Information of the canonical protein with experimentally identified structure from PDB (2023).

UniProt Acc	File name	PDB ID	Method	Resolution	Chain	Start	End
Q13469-1	Q13469-1_2as5_M.pdb	2AS5	X-ray	2.7	M	392	678

ASpdb's canonical and alternatively spliced isoform information.

accession_id

gene_name

canonical_id

alternative_id

canonical_length

alternative_length

canonical_start

canonical_end

type

originalSEQ

variationSEQ

alternative_start

alternative_end

Q13469

NFATC2

Q13469-1

Q13469-2

925

921

908

925

Substitution

VNEIIRKEFSGPPARNQT

ELIDTHLSWIQNIL

908

921

Q13469

NFATC2

Q13469-1

Q13469-3

925

901

Substitution

MNAPERQPQPDGGDAPGHEPGGSPQDELDFSILFDYEYLNPNE

MQREAAFRLGHCHPLRIMGSVDQ

Q13469

NFATC2

Q13469-1

Q13469-3

925

901

908

925

Substitution

VNEIIRKEFSGPPARNQT

ELIDTHLSWIQNIL

888

901

Q13469

NFATC2

Q13469-1

Q13469-4

925

905

Substitution

MNAPERQPQPDGGDAPGHEPGGSPQDELDFSILFDYEYLNPNE

MQREAAFRLGHCHPLRIMGSVDQ

Q13469

NFATC2

Q13469-1

Q13469-5

925

702

219

Deletion

none

Q13469

NFATC2

Q13469-1

Q13469-5

925

702

908

925

Substitution

VNEIIRKEFSGPPARNQT

ELIDTHLSWIQNIL

689

702

Multiple sequence alignment of our canonical and alternatively spliced NFATC2

Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of NFATC2

UniProt-id	ENSG	ENST	ENSP
Q13469-1	ENSG00000101096.20	ENST00000396009.7	ENSP00000379330.3
Q13469-2	ENSG00000101096.20	ENST00000371564.8	ENSP00000360619.3
Q13469-3	ENSG00000101096.20	ENST00000414705.5	ENSP00000396471.1
Q13469-4	ENSG00000101096.20	ENST00000609943.5	ENSP00000477370.1
Q13469-5	ENSG00000101096.20	ENST00000609507.1	ENSP00000477342.1
Q13469-5	ENSG00000101096.20	ENST00000610033.5	ENSP00000477142.1

UniProt-id	NM ID	NP ID
Q13469-1	NM_173091.3	NP_775114.1
Q13469-2	NM_012340.4	NP_036472.2
Q13469-3	NM_001136021.2	NP_001129493.1
Q13469-4	NM_001258292.1	NP_001245221.1
Q13469-5	NM_001258294.1	NP_001245223.1
Q13469-5	NM_001258296.1	NP_001245225.1

Amino acid sequences of our canonical and alternatively spliced NFATC2

accession_id	Protein sequence
Q13469-1	MNAPERQPQPDGGDAPGHEPGGSPQDELDFSILFDYEYLNPNEEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPD RVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFIS DTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQ RSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGER RNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYME NKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNT RVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDK DKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSC LVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALMAAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPV IHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYPTVIQQQNATSQRAAKNGPPVSDQKEVLPAGVTIKQEQNL
Q13469-2	MNAPERQPQPDGGDAPGHEPGGSPQDELDFSILFDYEYLNPNEEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPD RVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFIS DTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQ RSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGER RNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYME NKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNT RVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDK DKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSC LVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALMAAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPV IHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYPTVIQQQNATSQRAAKNGPPVSDQKEVLPAGVTIKQEQNL
Q13469-3	MQREAAFRLGHCHPLRIMGSVDQEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAAKPAGASGLS PRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDD LCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGS PAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLV PAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKP HAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSL QTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHI RTPVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDA RYQQQNPAAVLYQRSKSLSPSLLGYQQPALMAAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQH IMYCENFAPGTTRPGPPPVSQGQRLSPGSYPTVIQQQNATSQRAAKNGPPVSDQKEVLPAGVTIKQEQNLDQTYLDDELIDTHLSWIQNI
Q13469-4	MQREAAFRLGHCHPLRIMGSVDQEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAAKPAGASGLS PRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDD LCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGS PAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLV PAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKP HAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSL QTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHI RTPVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDA RYQQQNPAAVLYQRSKSLSPSLLGYQQPALMAAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQH IMYCENFAPGTTRPGPPPVSQGQRLSPGSYPTVIQQQNATSQRAAKNGPPVSDQKEVLPAGVTIKQEQNLDQTYLDDVNEIIRKEFSGPP
Q13469-5	MSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNS LATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEW PLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSY EKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPM VERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQ PQHFTYHPVPAIKTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLS PSLLGYQQPALMAAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPV

Protein Functional Features

Main function of this protein. (from UniProt)

NFATC2 (go to UniProt):Q13469

Retention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Accession_id	Subsection	Start	End	Funcitonal feature	Splicing information
Q13469	Repeat	184	200	Note=1	Type=Deletion;Start=1;End=219
Q13469	Repeat	213	229	Note=2	Type=Deletion;Start=1;End=219
Q13469	Region	1	95	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Substitution;Start=1;End=43
Q13469	Region	1	95	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Substitution;Start=1;End=43
Q13469	Region	1	95	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=1;End=219
Q13469	Region	111	116	Note=Calcineurin-binding;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:26248042;Dbxref=PMID:26248042	Type=Deletion;Start=1;End=219
Q13469	Region	119	199	Note=Transactivation domain A (TAD-A)	Type=Deletion;Start=1;End=219
Q13469	Region	161	175	Note=Required for cytoplasmic retention of the phosphorylated form;Ontology_term=ECO:0000250;evidence=ECO:0000250	Type=Deletion;Start=1;End=219
Q13469	Region	184	286	Note=3 X approximate SP repeats	Type=Deletion;Start=1;End=219
Q13469	Region	195	297	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=1;End=219
Q13469	Motif	26	34	Note=9aaTAD	Type=Substitution;Start=1;End=43
Q13469	Motif	26	34	Note=9aaTAD	Type=Substitution;Start=1;End=43
Q13469	Motif	26	34	Note=9aaTAD	Type=Deletion;Start=1;End=219
Q13469	Motif	904	913	Note=Nuclear export signal	Type=Substitution;Start=908;End=925
Q13469	Motif	904	913	Note=Nuclear export signal	Type=Substitution;Start=908;End=925
Q13469	Motif	904	913	Note=Nuclear export signal	Type=Substitution;Start=908;End=925
Q13469	Compositional bias	209	224	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=1;End=219

Gene Isoform Structures and Expression Levels for NFATC2

Gene structures of our canonical and alternative spliced genes of NFATC2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Expression levels of gene isoforms across GTEx.

Expression levels of gene isoforms across TCGA.

Protein Structures

PDB and CIF files of the predicted protein structures
* Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

3D view using mol* of Q13469-1

3D view using mol* of Q13469-2

3D view using mol* of Q13469-3

3D view using mol* of Q13469-4

3D view using mol* of Q13469-5

pLDDT Score Distribution

pLDDT score distribution of the predicted protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

pLDDT distribution across the protein length of Q13469-1

pLDDT distribution across the protein length of Q13469-2

pLDDT distribution across the protein length of Q13469-3

pLDDT distribution across the protein length of Q13469-4

pLDDT distribution across the protein length of Q13469-5

Ramachandran Plot of Protein Structures

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide.

Ramachandran plot of Q13469-1

Ramachandran plot of Q13469-4

Ramachandran plot of Q13469-5

Potential Active Site Information

The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite.

UniProt-id	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
Q13469-1	0.997	121	1.02	281.946	0.598	0.689	0.909	0.327	1.022	0.32	0.776	385,386,388,393,394,395,396,397,398,454,455,457,46 0,470,471,472,474,475,491,493,494,495,496,500,521, 526,529,530,547,549,551
Q13469-2	1.007	104	1.04	376.957	0.71	0.681	0.798	0.257	0.946	0.272	0.879	416,418,463,464,465,466,468,538,539,540,541,543,56 5,566,577,578,579,580,581,582,583,668,669,670,671, 672
Q13469-3	0.987	116	1.002	326.879	0.637	0.679	0.937	0.562	1.06	0.53	0.729	365,366,368,374,375,376,377,378,405,434,435,437,43 9,440,449,450,451,452,454,455,456,471,473,474,475, 476,477,480,501,506,509,510,512,527,529,531
Q13469-4	1.021	129	1.073	344.029	0.617	0.664	0.904	0.65	0.814	0.799	0.943	365,366,367,368,374,375,376,377,378,405,433,434,43 5,437,440,449,450,451,452,454,455,471,473,474,475, 476,480,501,505,506,509,510,527,529,531,537
Q13469-5	0.991	138	1.004	399.252	0.656	0.684	0.861	0.209	1.062	0.197	0.829	197,198,199,217,243,244,245,246,247,250,251,252,25 3,254,313,314,316,317,320,321,322,324,346,347,349, 354,358,359,360,361,362,364,448,449,450,451,452,45 3

Protein Structure and Feature Comparision

Protein Structure Comparision Using Template Modeling Scores (TM-score).

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green)

3D view using mol* of Q13469-1_Q13469-1_2as5_M.pdb

Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of Q13469-1_2as5_M_Q13469-2.pdb

3D view using mol* of Q13469-1_2as5_M_Q13469-3.pdb

3D view using mol* of Q13469-1_2as5_M_Q13469-4.pdb

3D view using mol* of Q13469-1_2as5_M_Q13469-5.pdb

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of Q13469-1_Q13469-2.pdb

3D view using mol* of Q13469-1_Q13469-3.pdb

3D view using mol* of Q13469-1_Q13469-4.pdb

3D view using mol* of Q13469-1_Q13469-5.pdb

Protein Feature Comparison of the protein sequendary structures among the protiens.

./stats/secondary_structure/figure/Q13469-1_vs_Q13469-2.png

./stats/secondary_structure/figure/Q13469-1_vs_Q13469-3.png

./stats/secondary_structure/figure/Q13469-1_vs_Q13469-4.png

./stats/secondary_structure/figure/Q13469-1_vs_Q13469-5.png

Protein Feature Comparison of the relative accessible surface area (ASA) among the protiens.

./stats/relative_asa/Q13469-1_vs_Q13469-2.png

./stats/relative_asa/Q13469-1_vs_Q13469-3.png

./stats/relative_asa/Q13469-1_vs_Q13469-4.png

./stats/relative_asa/Q13469-1_vs_Q13469-5.png

Protein-Protein Interaction

Interactors from UniProt.

Accession_id

Subsection

Start

End

Funcitonal feature

Splicing information

Interactors from STRING.

Gene name

Interactors

Related Drugs to NFATC2

Drugs targeting this gene/protein.
(DrugBank)

UniProt accession

Gene name

DrugBank ID

Drug name

Drug group

Actions

Related Diseases to NFATC2

Previous studies relating to the alternative splicing of NFATC2 and disease information from the MeSH term (PubMed)

Gene	PMID	Title	Abstract	MeSH ID	MeSH term
NFATC2	22116621	NFAT regulates the expression of AIF-1 and IRT-1: yin and yang splice variants of neointima formation and atherosclerosis.	Alternative transcription and splicing of the allograft inflammatory factor-1 (AIF-1) gene results in the expression of two different proteins: AIF-1 and interferon responsive transcript-1 (IRT-1).Â Here, we explore the impact of AIF-1 and IRT-1 on vascular smooth muscle cell (VSMC) activation and neointima formation, the mechanisms underlying their alternative splicing, and associations of AIF-1 and IRT-1 mRNA with parameters defining human atherosclerotic plaque phenotype.	D002340	Carotid Artery Diseases
NFATC2	22116621	NFAT regulates the expression of AIF-1 and IRT-1: yin and yang splice variants of neointima formation and atherosclerosis.	Alternative transcription and splicing of the allograft inflammatory factor-1 (AIF-1) gene results in the expression of two different proteins: AIF-1 and interferon responsive transcript-1 (IRT-1).Â Here, we explore the impact of AIF-1 and IRT-1 on vascular smooth muscle cell (VSMC) activation and neointima formation, the mechanisms underlying their alternative splicing, and associations of AIF-1 and IRT-1 mRNA with parameters defining human atherosclerotic plaque phenotype.	D020212	Carotid Artery Injuries
NFATC2	22116621	NFAT regulates the expression of AIF-1 and IRT-1: yin and yang splice variants of neointima formation and atherosclerosis.	Alternative transcription and splicing of the allograft inflammatory factor-1 (AIF-1) gene results in the expression of two different proteins: AIF-1 and interferon responsive transcript-1 (IRT-1).Â Here, we explore the impact of AIF-1 and IRT-1 on vascular smooth muscle cell (VSMC) activation and neointima formation, the mechanisms underlying their alternative splicing, and associations of AIF-1 and IRT-1 mRNA with parameters defining human atherosclerotic plaque phenotype.	D003324	Coronary Artery Disease
NFATC2	22116621	NFAT regulates the expression of AIF-1 and IRT-1: yin and yang splice variants of neointima formation and atherosclerosis.	Alternative transcription and splicing of the allograft inflammatory factor-1 (AIF-1) gene results in the expression of two different proteins: AIF-1 and interferon responsive transcript-1 (IRT-1).Â Here, we explore the impact of AIF-1 and IRT-1 on vascular smooth muscle cell (VSMC) activation and neointima formation, the mechanisms underlying their alternative splicing, and associations of AIF-1 and IRT-1 mRNA with parameters defining human atherosclerotic plaque phenotype.	D023903	Coronary Restenosis
NFATC2	22116621	NFAT regulates the expression of AIF-1 and IRT-1: yin and yang splice variants of neointima formation and atherosclerosis.	Alternative transcription and splicing of the allograft inflammatory factor-1 (AIF-1) gene results in the expression of two different proteins: AIF-1 and interferon responsive transcript-1 (IRT-1).Â Here, we explore the impact of AIF-1 and IRT-1 on vascular smooth muscle cell (VSMC) activation and neointima formation, the mechanisms underlying their alternative splicing, and associations of AIF-1 and IRT-1 mRNA with parameters defining human atherosclerotic plaque phenotype.	D004195	Disease Models, Animal
NFATC2	22116621	NFAT regulates the expression of AIF-1 and IRT-1: yin and yang splice variants of neointima formation and atherosclerosis.	Alternative transcription and splicing of the allograft inflammatory factor-1 (AIF-1) gene results in the expression of two different proteins: AIF-1 and interferon responsive transcript-1 (IRT-1).Â Here, we explore the impact of AIF-1 and IRT-1 on vascular smooth muscle cell (VSMC) activation and neointima formation, the mechanisms underlying their alternative splicing, and associations of AIF-1 and IRT-1 mRNA with parameters defining human atherosclerotic plaque phenotype.	D058426	Neointima

Clinically important variants in NFATC2

(ClinVar, 04/20/2024)

accession_id

uniprot_id

gene_name

Type

Variant

Clinical_significance