Protein:NFKB1 |
Protein Summary |
 Gene summary |
| Gene name: NFKB1 | ASpdb.0 ID: 4790 | Gene | Gene symbol | NFKB1 | Gene ID | 4790 |
| Gene name | nuclear factor kappa B subunit 1 |
| Synonyms | CVID12|EBP-1|KBF1|NF-kB|NF-kB1|NF-kappa-B1|NF-kappaB|NF-kappabeta|NFKB-p105|NFKB-p50|NFkappaB |
| Cytomap | 4q24 |
| Type of gene | protein-coding |
| Description | nuclear factor NF-kappa-B p105 subunitDNA-binding factor KBF1nuclear factor NF-kappa-B p50 subunitnuclear factor kappa-B DNA binding subunitnuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
| Modification date | 20240411 |
| UniProtAcc | P19838 |
| Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Gene | NFKB1 | GO:0000785 | chromatin | 8413223 |
| Gene | NFKB1 | GO:0000976 | transcription cis-regulatory region binding | 16938301|17426251|18718911 |
| Gene | NFKB1 | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | 7959007 |
| Gene | NFKB1 | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | 1406630 |
| Gene | NFKB1 | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | 17426251 |
| Gene | NFKB1 | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | 24434510 |
| Gene | NFKB1 | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | 1406630|34721373 |
| Gene | NFKB1 | GO:0003700 | DNA-binding transcription factor activity | 8413223|17426251 |
| Gene | NFKB1 | GO:0005634 | nucleus | 11819787|16938301|25411248 |
| Gene | NFKB1 | GO:0005654 | nucleoplasm | - |
| Gene | NFKB1 | GO:0005737 | cytoplasm | 11819787 |
| Gene | NFKB1 | GO:0005739 | mitochondrion | - |
| Gene | NFKB1 | GO:0005829 | cytosol | - |
| Gene | NFKB1 | GO:0006357 | regulation of transcription by RNA polymerase II | 34721373 |
| Gene | NFKB1 | GO:0007249 | canonical NF-kappaB signal transduction | 34721373 |
| Gene | NFKB1 | GO:0010629 | negative regulation of gene expression | 26687115 |
| Gene | NFKB1 | GO:0010956 | negative regulation of calcidiol 1-monooxygenase activity | 15243130 |
| Gene | NFKB1 | GO:0038061 | non-canonical NF-kappaB signal transduction | 8413223 |
| Gene | NFKB1 | GO:0045893 | positive regulation of DNA-templated transcription | 17426251 |
| Gene | NFKB1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 1406630 |
| Gene | NFKB1 | GO:0140367 | antibacterial innate immune response | 20406817 |
| Gene | NFKB1 | GO:1900127 | positive regulation of hyaluronan biosynthetic process | 17324121 |
AS Summary |
| Information of the canonical protein with experimentally identified structure from PDB (2023). |
| UniProt Acc | File name | PDB ID | Method | Resolution | Chain | Start | End |
| P19838-1 | P19838-1_2o61_B.pdb | 2O61 | X-ray | 2.8 | B | 40 | 352 |
| ASpdb's canonical and alternatively spliced isoform information. |
| accession_id | gene_name | canonical_id | alternative_id | canonical_length | alternative_length | canonical_start | canonical_end | type | originalSEQ | variationSEQ | alternative_start | alternative_end |
| P19838 | NFKB1 | P19838-1 | P19838-2 | 968 | 969 | 39 | 39 | Substitution | T | TA | 39 | 40 |
| P19838 | NFKB1 | P19838-1 | P19838-3 | 968 | 788 | 1 | 180 | Deletion | none | none | 0 | 0 |
| P19838 | NFKB1 | P19838-1 | P19838-3 | 968 | 788 | 181 | 189 | Substitution | EGGGDRQLG | MNGLCCMAL | 1 | 9 |
| Multiple sequence alignment of our canonical and alternatively spliced NFKB1 |
| Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of NFKB1 |
| UniProt-id | ENSG | ENST | ENSP |
| P19838-1 | ENSG00000109320.14 | ENST00000394820.8 | ENSP00000378297.4 |
| P19838-1 | ENSG00000109320.14 | ENST00000505458.5 | ENSP00000424790.1 |
| P19838-2 | ENSG00000109320.14 | ENST00000226574.9 | ENSP00000226574.4 |
| P19838-2 | ENSG00000109320.14 | ENST00000509165.2 | ENSP00000423877.2 |
| UniProt-id | NM ID | NP ID |
| P19838-1 | NM_001165412.1 | NP_001158884.1 |
| P19838-1 | NM_001319226.1 | NP_001306155.1 |
| P19838-2 | NM_003998.3 | NP_003989.2 |
| Amino acid sequences of our canonical and alternatively spliced NFKB1 |
| accession_id | Protein sequence |
| P19838-1 | MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYV GPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQA EGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYL LCDKVQKDDIQIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQ RKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFHPGTTKSNAGMKHGTMDTESKKDPEGCDKSD DKNTVNLFGKVIETTEQDQEPSEATVGNGEVTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQD ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKV LSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGT TPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMATSWQVFDILNGKPYEPEFTSDDLLAQGDMKQ LAEDVKLQLYKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQ |
| P19838-2 | MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTADGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNY VGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQ AEGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIY LLCDKVQKDDIQIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEV QRKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFHPGTTKSNAGMKHGTMDTESKKDPEGCDKS DDKNTVNLFGKVIETTEQDQEPSEATVGNGEVTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQ DENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDK VLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDG TTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMATSWQVFDILNGKPYEPEFTSDDLLAQGDMK QLAEDVKLQLYKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTS |
| P19838-3 | MNGLCCMALDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYL LCDKVQKDDIQIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQ RKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFHPGTTKSNAGMKHGTMDTESKKDPEGCDKSD DKNTVNLFGKVIETTEQDQEPSEATVGNGEVTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQD ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKV LSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGT TPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMATSWQVFDILNGKPYEPEFTSDDLLAQGDMKQ LAEDVKLQLYKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQ |
Protein Functional Features |
| Main function of this protein. (from UniProt) |
| NFKB1 (go to UniProt):P19838 |
| Retention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Accession_id | Subsection | Start | End | Funcitonal feature | Splicing information |
| P19838 | Domain | 42 | 367 | Note=RHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00265 | Type=Deletion;Start=1;End=180 |
| P19838 | Domain | 42 | 367 | Note=RHD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00265 | Type=Substitution;Start=181;End=189 |
Gene Isoform Structures and Expression Levels for NFKB1 |
| Gene structures of our canonical and alternative spliced genes of NFKB1 * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Expression levels of gene isoforms across GTEx. |
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| Expression levels of gene isoforms across TCGA. |
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Protein Structures |
| PDB and CIF files of the predicted protein structures * Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| 3D view using mol* of P19838-1 |
| 3D view using mol* of P19838-2 |
| 3D view using mol* of P19838-3 |
pLDDT Score Distribution |
| pLDDT score distribution of the predicted protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
| pLDDT distribution across the protein length of P19838-1 |
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| pLDDT distribution across the protein length of P19838-2 |
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| pLDDT distribution across the protein length of P19838-3 |
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Ramachandran Plot of Protein Structures |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide. |
| Ramachandran plot of P19838-1 |
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Potential Active Site Information |
| The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite. |
| UniProt-id | Site score | Size | D score | Volume | Exposure | Enclosure | Contact | Phobic | Philic | Balance | Don/Acc | Residues |
| P19838-1 | 1.004 | 286 | 1.061 | 715.841 | 0.595 | 0.632 | 0.819 | 0.945 | 0.793 | 1.192 | 0.97 | 664,696,697,698,699,702,703,705,706,709,710,712,73 1,732,733,734,736,737,739,740,741,782,783,786,787, 790,791,792,793,794,795,796,797,798,799,801,802,80 3,946,947,948,949,950,951,952,953 |
| P19838-2 | 0.897 | 85 | 0.923 | 173.901 | 0.663 | 0.596 | 0.817 | 0.611 | 0.924 | 0.661 | 0.958 | 731,732,733,734,783,784,787,788,792,793,794,795,79 6,797,798,799,802,803,804,805,806,867 |
| P19838-3 | 1.01 | 158 | 1.085 | 551.887 | 0.713 | 0.607 | 0.742 | 0.669 | 0.672 | 0.996 | 1.156 | 234,237,239,241,242,244,246,320,321,324,325,327,32 8,331,334,335,338,347,350,351,353,354,355,357,358, 359,360,361,363,398,399,400,402 |
Protein Structure and Feature Comparision |
| Protein Structure Comparision Using Template Modeling Scores (TM-score). |
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| Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green) |
| 3D view using mol* of P19838-1_P19838-1_2o61_B.pdb |
| Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green) |
| 3D view using mol* of P19838-1_2o61_B_P19838-2.pdb |
| 3D view using mol* of P19838-1_2o61_B_P19838-3.pdb |
| Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green) |
| 3D view using mol* of P19838-1_P19838-2.pdb |
| 3D view using mol* of P19838-1_P19838-3.pdb |
| Protein Feature Comparison of the protein sequendary structures among the protiens. |
| ./stats/secondary_structure/figure/P19838-1_vs_P19838-2.png |
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| ./stats/secondary_structure/figure/P19838-1_vs_P19838-3.png |
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| Protein Feature Comparison of the relative accessible surface area (ASA) among the protiens. |
| ./stats/relative_asa/P19838-1_vs_P19838-2.png |
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| ./stats/relative_asa/P19838-1_vs_P19838-3.png |
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Protein-Protein Interaction |
| Interactors from UniProt. |
| Accession_id | Subsection | Start | End | Funcitonal feature | Splicing information |
| Interactors from STRING. |
| Gene name | Interactors |
Related Drugs to NFKB1 |
| Drugs targeting this gene/protein. (DrugBank) |
| UniProt accession | Gene name | DrugBank ID | Drug name | Drug group | Actions |
| P19838 | NFKB1 | DB01411 | Pranlukast | investigational | other/unknown |
| P19838 | NFKB1 | DB05212 | HE3286 | investigational | |
| P19838 | NFKB1 | DB05471 | SGN-30 | investigational | |
| P19838 | NFKB1 | DB00795 | Sulfasalazine | approved | inhibitor |
| P19838 | NFKB1 | DB00852 | Pseudoephedrine | approved | inhibitor |
| P19838 | NFKB1 | DB05451 | P54 | investigational | |
| P19838 | NFKB1 | DB05767 | Andrographolide | investigational | |
| P19838 | NFKB1 | DB08814 | Triflusal | approved, investigational | antagonist |
| P19838 | NFKB1 | DB05487 | Custirsen | investigational | |
| P19838 | NFKB1 | DB05464 | NOX-700 | investigational |
Related Diseases to NFKB1 |
| Previous studies relating to the alternative splicing of NFKB1 and disease information from the MeSH term (PubMed) |
| Gene | PMID | Title | Abstract | MeSH ID | MeSH term |
| NFKB1 | 22156489 | Exon arrays reveal alternative splicing aberrations in Parkinson's disease leukocytes. | Parkinson's disease (PD) is the second most frequent neurodegenerative disease worldwide. Clinical diagnosis can only be made when the vast majority of the dopaminergic cell population has died. However, the cause(s) for sporadic PD is/are yet unclear. Transcript changes have recently been described in PD patients' whole blood cells, but corresponding splicing patterns remained unknown. | D010300 | Parkinson Disease |
Clinically important variants in NFKB1 |
| (ClinVar, 04/20/2024) |
| accession_id | uniprot_id | gene_name | Type | Variant | Clinical_significance |
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