ASpdb: an integrative knowledgebase of human protein isoforms from experimental and AI-predicted structures

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	Protein Summary
	AS Summary
	Protein Functional Features
	Gene Isoform Structures and Expression Levels
	Protein Structures
	pLDDT Score Distribution
	Ramachandran Plot of Protein Structures
	Potential Active Site Information
	Protein Structure and Feature Comparision
	Protein-Protein Interaction
	Related Drugs
	Related Diseases
	Clinically Important Variants

Protein:NOS2

Protein Summary

Gene summary

Gene name: NOS2
ASpdb.0 ID: 4843
	Gene
Gene symbol	NOS2
Gene ID	4843
Gene name	nitric oxide synthase 2
Synonyms	HEP-NOS\|INOS\|NOS\|NOS2A
Cytomap	17q11.2
Type of gene	protein-coding
Description	nitric oxide synthase, inducibleNOS, type IIhepatocyte NOSinducible NO synthaseinducible NOSnitric oxide synthase 2, induciblenitric oxide synthase 2A (inducible, hepatocytes)nitric oxide synthase, macrophagepeptidyl-cysteine S-nitrosylase NOS2
Modification date	20240305
UniProtAcc	P35228

Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Gene	NOS2	GO:0004517	nitric-oxide synthase activity	7504305\|7682706\|35772285
Gene	NOS2	GO:0005737	cytoplasm	9916929\|12085352
Gene	NOS2	GO:0005777	peroxisome	12085352
Gene	NOS2	GO:0006527	arginine catabolic process	7504305
Gene	NOS2	GO:0006809	nitric oxide biosynthetic process	7504305\|7682706
Gene	NOS2	GO:0032310	prostaglandin secretion	19688109
Gene	NOS2	GO:0032755	positive regulation of interleukin-6 production	19688109
Gene	NOS2	GO:0032757	positive regulation of interleukin-8 production	19688109
Gene	NOS2	GO:1900015	regulation of cytokine production involved in inflammatory response	19688109

AS Summary

Information of the canonical protein with experimentally identified structure from PDB (2023).

UniProt Acc	File name	PDB ID	Method	Resolution	Chain	Start	End
P35228-1	P35228-1_3e7g_C.pdb	3E7G	X-ray	2.2	C	83	505

ASpdb's canonical and alternatively spliced isoform information.

accession_id

gene_name

canonical_id

alternative_id

canonical_length

alternative_length

canonical_start

canonical_end

type

originalSEQ

variationSEQ

alternative_start

alternative_end

P35228

NOS2

P35228-1

P35228-2

1153

1114

264

288

Deletion

none

263

P35228

NOS2

P35228-1

P35228-2

1153

1114

298

311

Deletion

none

272

Multiple sequence alignment of our canonical and alternatively spliced NOS2

Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of NOS2

UniProt-id	ENSG	ENST	ENSP
P35228-1	ENSG00000007171.19	ENST00000313735.11	ENSP00000327251.6

UniProt-id	NM ID	NP ID
P35228-1	NM_000625.4	NP_000616.3

Amino acid sequences of our canonical and alternatively spliced NOS2

accession_id	Protein sequence
P35228-1	MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLSKQQNESPQPLVETGKKSPESLVKLDATPLSSPRHVRIKNW GSGMTFQDTLHHKAKGILTCRSKSCLGSIMTPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQ LTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNIRSAITVFPQRSDGKHDFRVWNAQLIRYAGY QMPDGSIRGDPANVEFTQLCIDLGWKPKYGRFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVG GLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINIAVLHSFQKQNVTIMDHHSAAESFMKYMQNE YRSRGGCPADWIWLVPPMSGSITPVFHQEMLNYVLSPFYYYQVEAWKTHVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVT ILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPGNGEKLKKSLFMLKELNNKFRYAVFGLGSSM YPRFCAFAHDIDQKLSHLGASQLTPMGEGDELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHHYRLVQDSQPLDL SKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQPALVQGILERVVDGPTPHQTVRLEALDESG SYWVSDKRLPPCSLSQALTYFLDITTPPTQLLLQKLAQVATEEPERQRLEALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQL PILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDPVPCFVRNASGFHLPEDPSHPCILIGPGTGIAPFR SFWQQRLHDSQHKGVRGGRMTLVFGCRRPDEDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGHLY
P35228-2	MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLSKQQNESPQPLVETGKKSPESLVKLDATPLSSPRHVRIKNW GSGMTFQDTLHHKAKGILTCRSKSCLGSIMTPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQ LTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNIRSAITVFPQRSDGKHDFRVWNAQLCIDLGW KPNGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVGGLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRM GLETHKLASLWKDQAVVEINIAVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEMLNYVLSPFY YYQVEAWKTHVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVTILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSC LEEERLLLVVTSTFGNGDCPGNGEKLKKSLFMLKELNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGDELSGQEDAF RSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHHYRLVQDSQPLDLSKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSC EDGQGLNYLPGEHLGVCPGNQPALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQLLLQKLAQV ATEEPERQRLEALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQLPILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPL HHGVCSTWLNSLKPQDPVPCFVRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRRPDEDHIYQEEM LEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGHLYVCGDVRMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKS

Protein Functional Features

Main function of this protein. (from UniProt)

NOS2 (go to UniProt):P35228

Retention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Accession_id

Subsection

Start

End

Funcitonal feature

Splicing information

Gene Isoform Structures and Expression Levels for NOS2

Gene structures of our canonical and alternative spliced genes of NOS2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Expression levels of gene isoforms across GTEx.

Expression levels of gene isoforms across TCGA.

Protein Structures

PDB and CIF files of the predicted protein structures
* Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

3D view using mol* of P35228-1

3D view using mol* of P35228-2

pLDDT Score Distribution

pLDDT score distribution of the predicted protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

pLDDT distribution across the protein length of P35228-1

pLDDT distribution across the protein length of P35228-2

Ramachandran Plot of Protein Structures

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide.

Ramachandran plot of P35228-1

Ramachandran plot of P35228-2

Potential Active Site Information

The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite.

UniProt-id	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
P35228-1	1.077	349	1.042	1020.425	0.474	0.814	1.051	0.612	1.183	0.517	0.822	120,121,125,126,129,194,197,198,199,200,201,202,20 4,205,242,250,258,259,260,261,262,263,266,267,280, 282,283,284,285,286,305,346,347,350,352,354,355,36 9,370,371,372,373,374,376,377,380,381,382,385,387, 388,434,439,442,443,462,463,464,465,466,467,488,48 9,491,492,493,494,495,496
P35228-2	1.062	131	1.079	577.612	0.502	0.783	1.046	0.832	1.014	0.82	0.672	705,711,712,713,887,888,889,890,943,944,945,946,97 6,977,978,983,985,1005,1007,1008,1014,1015,1016,10 17,1018,1044,1045,1047,1048,1051,1089,1096,1099,11 00

Protein Structure and Feature Comparision

Protein Structure Comparision Using Template Modeling Scores (TM-score).

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green)

3D view using mol* of P35228-1_P35228-1_3e7g_C.pdb

Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of P35228-1_3e7g_C_P35228-2.pdb

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of P35228-1_P35228-2.pdb

Protein Feature Comparison of the protein sequendary structures among the protiens.

./stats/secondary_structure/figure/P35228-1_vs_P35228-2.png

Protein Feature Comparison of the relative accessible surface area (ASA) among the protiens.

./stats/relative_asa/P35228-1_vs_P35228-2.png

Protein-Protein Interaction

Interactors from UniProt.

Accession_id

Subsection

Start

End

Funcitonal feature

Splicing information

Interactors from STRING.

Gene name

Interactors

Related Drugs to NOS2

Drugs targeting this gene/protein.
(DrugBank)

UniProt accession	Gene name	DrugBank ID	Drug name	Drug group	Actions
P35228	NOS2	DB02644	N-omega-propyl-L-arginine	experimental
P35228	NOS2	DB02234	S-Ethylisothiourea	experimental
P35228	NOS2	DB14649	Dexamethasone acetate	approved, investigational, vet_approved	negative modulator
P35228	NOS2	DB07388	ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE	experimental
P35228	NOS2	DB05383	Pimagedine	investigational	inhibitor, downregulator
P35228	NOS2	DB06879	5-(4'-AMINO-1'-ETHYL-5',8'-DIFLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE	experimental
P35228	NOS2	DB05252	Fenoxaprop-ethyl	investigational
P35228	NOS2	DB03449	N-(4-{2-[(3-chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide	experimental
P35228	NOS2	DB08814	Triflusal	approved, investigational	agonist
P35228	NOS2	DB03366	Imidazole	experimental, investigational
P35228	NOS2	DB06916	N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDE	experimental
P35228	NOS2	DB07389	N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDE	experimental
P35228	NOS2	DB02462	Thiocoumarin	experimental
P35228	NOS2	DB01234	Dexamethasone	approved, investigational, vet_approved	negative modulator
P35228	NOS2	DB07003	(2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine	experimental
P35228	NOS2	DB08214	4-(1H-IMIDAZOL-1-YL)PHENOL	experimental
P35228	NOS2	DB04534	5-Nitroindazole	experimental
P35228	NOS2	DB07029	4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINE	experimental
P35228	NOS2	DB09237	Levamlodipine	approved, investigational	agonist
P35228	NOS2	DB07011	(3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PIPERIDINE	experimental
P35228	NOS2	DB11327	Dipyrithione	approved	antagonist
P35228	NOS2	DB04400	L-erythro-7,8-dihydrobiopterin	experimental
P35228	NOS2	DB01017	Minocycline	approved, investigational	inhibitor
P35228	NOS2	DB07008	4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE	experimental
P35228	NOS2	DB07007	(3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine	experimental
P35228	NOS2	DB07318	N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE	experimental
P35228	NOS2	DB01686	N,N-dimethylarginine	experimental
P35228	NOS2	DB02207	7-Nitroindazole	experimental
P35228	NOS2	DB00244	Mesalazine	approved	inhibitor
P35228	NOS2	DB07002	4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile	experimental
P35228	NOS2	DB01381	Ginkgo biloba	approved, investigational, nutraceutical	inhibitor
P35228	NOS2	DB00125	Arginine	investigational, nutraceutical
P35228	NOS2	DB01835	4R-Fluoro-N6-ethanimidoyl-L-lysine	experimental
P35228	NOS2	DB00155	Citrulline	investigational, nutraceutical
P35228	NOS2	DB07306	ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE	experimental
P35228	NOS2	DB07405	1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[PIPERIDINE-4,2'(1'H)-QUINAZOLINE]-4'-AMINE	experimental
P35228	NOS2	DB01997	3-Bromo-7-Nitroindazole	experimental
P35228	NOS2	DB03953	Thiocitrulline	experimental
P35228	NOS2	DB05214	KD7040	investigational
P35228	NOS2	DB03100	6-Nitroindazole	experimental
P35228	NOS2	DB02044	N-[3-(aminomethyl)benzyl]acetamidine	experimental
P35228	NOS2	DB08750	1-[4-(AMINOMETHYL)BENZOYL]-5'-FLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLIN]-4'-AMINE	experimental
P35228	NOS2	DB03144	N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine	experimental
P35228	NOS2	DB01110	Miconazole	approved, investigational, vet_approved	inhibitor

Related Diseases to NOS2

Previous studies relating to the alternative splicing of NOS2 and disease information from the MeSH term (PubMed)

Gene

PMID

Title

Abstract

MeSH ID

MeSH term

Clinically important variants in NOS2

(ClinVar, 04/20/2024)

accession_id	uniprot_id	gene_name	Type	Variant	Clinical_significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg1086Cys	Likely benign
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg1086Cys	Likely benign
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg1018Ser	Likely benign
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg1018Ser	Likely benign
P35228	P35228-1	NOS2	single nucleotide variant	p.Ala782Val	Likely benign
P35228	P35228-1	NOS2	single nucleotide variant	p.Ala782Val	Likely benign
P35228	P35228-1	NOS2	single nucleotide variant	p.Asn701Ser	Likely benign
P35228	P35228-1	NOS2	single nucleotide variant	p.Asn701Ser	Likely benign
P35228	P35228-1	NOS2	Duplication	p.Leu392fs	Uncertain significance
P35228	P35228-1	NOS2	Duplication	p.Leu392fs	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Leu757Val	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Leu757Val	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Gly379Arg	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Gly379Arg	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Met355Ile	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Met355Ile	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Pro458Leu	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Pro458Leu	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Leu49Phe	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Leu49Phe	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.His1002Leu	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.His1002Leu	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Cys681Tyr	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Cys681Tyr	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Val415Ile	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Val415Ile	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg454Cys	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg454Cys	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Phe1132Tyr	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Phe1132Tyr	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Pro514Leu	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Pro514Leu	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Val943Leu	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Val943Leu	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg1089Trp	Likely benign
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg1089Trp	Likely benign
P35228	P35228-1	NOS2	single nucleotide variant	p.Met656Thr	Likely benign
P35228	P35228-1	NOS2	single nucleotide variant	p.Met656Thr	Likely benign
P35228	P35228-1	NOS2	single nucleotide variant	p.Thr683Met	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Thr683Met	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Ser114Tyr	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Ser114Tyr	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Cys228Phe	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Cys228Phe	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Ile265Val	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Ile265Val	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Tyr1134His	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Tyr1134His	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Met1029Thr	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Met1029Thr	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Tyr1045Cys	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Tyr1045Cys	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg890Leu	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg890Leu	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg452Gln	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg452Gln	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Ser1066Arg	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Ser1066Arg	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Ile227Met	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Ile227Met	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Asn419Ser	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Asn419Ser	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Cys776Phe	Likely benign
P35228	P35228-1	NOS2	single nucleotide variant	p.Cys776Phe	Likely benign
P35228	P35228-1	NOS2	single nucleotide variant	p.Ala168Val	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Ala168Val	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Pro68Ser	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Pro68Ser	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Ser118Cys	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Ser118Cys	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Glu1031Ala	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Glu1031Ala	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Pro837Thr	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Pro837Thr	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg232His	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg232His	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg530Gly	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg530Gly	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Ser425Gly	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Ser425Gly	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.His499Asp	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.His499Asp	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg278Gly	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg278Gly	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Thr63Met	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Thr63Met	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg750His	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg750His	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg452Trp	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg452Trp	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Glu402Ala	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Glu402Ala	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg914Gln	Likely benign
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg914Gln	Likely benign
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg1006Trp	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg1006Trp	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Ser114Phe	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Ser114Phe	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg740Trp	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg740Trp	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Lys171Met	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Lys171Met	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Tyr336His	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Tyr336His	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Pro781Leu	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Pro781Leu	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Lys952Arg	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Lys952Arg	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg1047His	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Arg1047His	Uncertain significance
P35228	P35228-1	NOS2	single nucleotide variant	p.Ser608Leu	Benign
P35228	P35228-1	NOS2	single nucleotide variant	p.Ser608Leu	Benign
P35228	P35228-1	NOS2	single nucleotide variant	p.Thr182Met	Likely benign
P35228	P35228-1	NOS2	single nucleotide variant	p.Thr182Met	Likely benign