Protein:NTRK3 |
Protein Summary |
 Gene summary |
| Gene name: NTRK3 | ASpdb.0 ID: 4916 | Gene | Gene symbol | NTRK3 | Gene ID | 4916 |
| Gene name | neurotrophic receptor tyrosine kinase 3 |
| Synonyms | GP145-TrkC|TRKC|gp145(trkC) |
| Cytomap | 15q25.3 |
| Type of gene | protein-coding |
| Description | NT-3 growth factor receptorETS related protein-neurotrophic receptor tyrosine kinase fusion proteinETV6-NTRK3 fusionneurotrophic tyrosine kinase, receptor, type 3tyrosine kinase receptor C |
| Modification date | 20240411 |
| UniProtAcc | Q16288 |
| Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Gene | NTRK3 | GO:0001933 | negative regulation of protein phosphorylation | 23027130 |
| Gene | NTRK3 | GO:0005030 | neurotrophin receptor activity | 23027130 |
| Gene | NTRK3 | GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 23027130 |
| Gene | NTRK3 | GO:0008284 | positive regulation of cell population proliferation | 23027130 |
| Gene | NTRK3 | GO:0010628 | positive regulation of gene expression | 23027130 |
| Gene | NTRK3 | GO:0030335 | positive regulation of cell migration | 23027130 |
| Gene | NTRK3 | GO:0032148 | activation of protein kinase B activity | 23027130 |
| Gene | NTRK3 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 23027130 |
| Gene | NTRK3 | GO:0043235 | receptor complex | 23382219 |
| Gene | NTRK3 | GO:0043406 | positive regulation of MAP kinase activity | 23027130 |
| Gene | NTRK3 | GO:0050927 | positive regulation of positive chemotaxis | 23027130 |
| Gene | NTRK3 | GO:0090630 | activation of GTPase activity | 23027130 |
AS Summary |
| Information of the canonical protein with experimentally identified structure from PDB (2023). |
| UniProt Acc | File name | PDB ID | Method | Resolution | Chain | Start | End |
| Q16288-1 | Q16288-1_6kzd_A.pdb | 6KZD | X-ray | 1.71 | A | 528 | 837 |
| ASpdb's canonical and alternatively spliced isoform information. |
| accession_id | gene_name | canonical_id | alternative_id | canonical_length | alternative_length | canonical_start | canonical_end | type | originalSEQ | variationSEQ | alternative_start | alternative_end |
| Q16288 | NTRK3 | Q16288-1 | Q16288-2 | 839 | 612 | 529 | 612 | Substitution | YVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDP | WVFSNIDNHGILNLKDNRDHLVPSTHYIYEEPEVQSGEVSYPRSHGFREIMLNPISLPGHSKPLNHGIYVEDVNVYFSKGRHGF | 529 | 612 |
| Q16288 | NTRK3 | Q16288-1 | Q16288-2 | 839 | 612 | 613 | 839 | Deletion | none | none | 612 | 612 |
| Q16288 | NTRK3 | Q16288-1 | Q16288-3 | 839 | 825 | 712 | 725 | Deletion | none | none | 711 | 711 |
| Q16288 | NTRK3 | Q16288-1 | Q16288-4 | 839 | 831 | 402 | 410 | Substitution | ESTDNFILF | V | 402 | 402 |
| Q16288 | NTRK3 | Q16288-1 | Q16288-5 | 839 | 817 | 402 | 410 | Substitution | ESTDNFILF | V | 402 | 402 |
| Q16288 | NTRK3 | Q16288-1 | Q16288-5 | 839 | 817 | 712 | 725 | Deletion | none | none | 703 | 703 |
| Multiple sequence alignment of our canonical and alternatively spliced NTRK3 |
| Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of NTRK3 |
| UniProt-id | ENSG | ENST | ENSP |
| Q16288-1 | ENSG00000140538.17 | ENST00000629765.3 | ENSP00000485864.1 |
| Q16288-1 | ENSG00000140538.17 | ENST00000695462.1 | ENSP00000511942.1 |
| Q16288-2 | ENSG00000140538.17 | ENST00000317501.9 | ENSP00000318328.3 |
| Q16288-3 | ENSG00000140538.17 | ENST00000394480.6 | ENSP00000377990.1 |
| Q16288-4 | ENSG00000140538.17 | ENST00000357724.6 | ENSP00000350356.2 |
| Q16288-5 | ENSG00000140538.17 | ENST00000557856.5 | ENSP00000453959.1 |
| UniProt-id | NM ID | NP ID |
| Q16288-1 | NM_001012338.2 | NP_001012338.1 |
| Q16288-3 | NM_002530.3 | NP_002521.2 |
| Amino acid sequences of our canonical and alternatively spliced NTRK3 |
| accession_id | Protein sequence |
| Q16288-1 | MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRS LHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTL VNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLF VMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVL KRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLR AHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDF CIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQRE |
| Q16288-2 | MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRS LHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTL VNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLF VMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTWVFSNIDNHGIL |
| Q16288-3 | MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRS LHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTL VNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLF VMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVL KRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLR AHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPI RWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKIL |
| Q16288-4 | MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRS LHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTL VNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPVDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGR RSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGA FGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMI LVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGG HTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIK |
| Q16288-5 | MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRS LHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTL VNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPVDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGR RSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGA FGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMI LVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESI MYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATP |
Protein Functional Features |
| Main function of this protein. (from UniProt) |
| NTRK3 (go to UniProt):Q16288 |
| Retention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Accession_id | Subsection | Start | End | Funcitonal feature | Splicing information |
| Q16288 | Topological domain | 32 | 429 | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Substitution;Start=402;End=410 |
| Q16288 | Topological domain | 32 | 429 | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Substitution;Start=402;End=410 |
| Q16288 | Topological domain | 454 | 839 | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Substitution;Start=529;End=612 |
| Q16288 | Topological domain | 454 | 839 | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Deletion;Start=613;End=839 |
| Q16288 | Topological domain | 454 | 839 | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Deletion;Start=712;End=725 |
| Q16288 | Topological domain | 454 | 839 | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 | Type=Deletion;Start=712;End=725 |
| Q16288 | Domain | 538 | 839 | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 | Type=Substitution;Start=529;End=612 |
| Q16288 | Domain | 538 | 839 | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 | Type=Deletion;Start=613;End=839 |
| Q16288 | Domain | 538 | 839 | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 | Type=Deletion;Start=712;End=725 |
| Q16288 | Domain | 538 | 839 | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 | Type=Deletion;Start=712;End=725 |
Gene Isoform Structures and Expression Levels for NTRK3 |
| Gene structures of our canonical and alternative spliced genes of NTRK3 * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Expression levels of gene isoforms across GTEx. |
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| Expression levels of gene isoforms across TCGA. |
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Protein Structures |
| PDB and CIF files of the predicted protein structures * Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| 3D view using mol* of Q16288-1 |
| 3D view using mol* of Q16288-2 |
| 3D view using mol* of Q16288-3 |
| 3D view using mol* of Q16288-4 |
| 3D view using mol* of Q16288-5 |
pLDDT Score Distribution |
| pLDDT score distribution of the predicted protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
| pLDDT distribution across the protein length of Q16288-1 |
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| pLDDT distribution across the protein length of Q16288-2 |
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| pLDDT distribution across the protein length of Q16288-3 |
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| pLDDT distribution across the protein length of Q16288-4 |
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| pLDDT distribution across the protein length of Q16288-5 |
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Ramachandran Plot of Protein Structures |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide. |
| Ramachandran plot of Q16288-1 |
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| Ramachandran plot of Q16288-2 |
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Potential Active Site Information |
| The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite. |
| UniProt-id | Site score | Size | D score | Volume | Exposure | Enclosure | Contact | Phobic | Philic | Balance | Don/Acc | Residues |
| Q16288-1 | 1.067 | 585 | 1.098 | 1360.681 | 0.485 | 0.763 | 0.951 | 0.943 | 0.92 | 1.026 | 1.117 | 481,482,498,499,500,501,502,503,504,505,506,507,50 8,509,510,511,512,513,514,515,516,517,525,546,547, 548,549,572,574,575,576,578,581,584,585,587,588,59 1,592,594,595,600,601,603,670,673,674,675,676,677, 678,679,684,695,696,697,698,699,700,701,702,703,70 6,709,711,726,727,729,730,731,732,733,745,746,747, 748,749,750,811,812 |
| Q16288-2 | 0.849 | 72 | 0.794 | 127.253 | 0.604 | 0.638 | 0.925 | 0.261 | 1.186 | 0.22 | 0.918 | 29,30,31,57,58,59,60,61,68,69,70,71,72,73,76
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| Q16288-3 | 1.03 | 298 | 1.032 | 823.543 | 0.525 | 0.744 | 1.002 | 0.77 | 1.085 | 0.71 | 0.933 | 542,544,545,552,570,592,595,600,601,617,618,619,62 0,621,622,623,624,626,627,628,630,631,632,633,634, 636,637,639,640,642,643,644,645,646,647,648,649,65 0,651,655,670,675,677,681,682,683,684,686,688,689, 690,691,695,696,697,698,700,701,702,704,705,707,70 8,722,748,753,754,755,756 |
| Q16288-4 | 1.049 | 269 | 1.031 | 669.536 | 0.504 | 0.771 | 1.056 | 0.764 | 1.14 | 0.671 | 0.723 | 534,536,537,538,539,544,562,564,584,587,592,593,59 4,595,609,610,611,612,613,614,615,616,618,619,620, 622,623,624,628,629,631,632,635,636,637,638,639,64 0,662,669,673,674,675,676,678,687,688,689,690,691, 692,693,694,696,697,699,700,728,754,759,761,764 |
| Q16288-5 | 1.043 | 484 | 1.089 | 1683.444 | 0.589 | 0.705 | 0.858 | 0.808 | 0.842 | 0.959 | 0.951 | 463,468,469,470,471,472,473,474,475,476,477,495,49 6,497,498,499,500,501,502,504,505,507,508,520,540, 541,564,566,567,568,572,573,576,579,580,582,583,58 6,587,665,666,667,668,669,670,671,676,689,690,691, 692,693,694,695,698,701,702,703,704,705,706,707,70 8,709,710,711,712,715,719,720,721,722,723,725,755, 758,759,762 |
Protein Structure and Feature Comparision |
| Protein Structure Comparision Using Template Modeling Scores (TM-score). |
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| Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green) |
| 3D view using mol* of Q16288-1_Q16288-1_6kzd_A.pdb |
| Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green) |
| 3D view using mol* of Q16288-1_6kzd_A_Q16288-2.pdb |
| 3D view using mol* of Q16288-1_6kzd_A_Q16288-3.pdb |
| 3D view using mol* of Q16288-1_6kzd_A_Q16288-4.pdb |
| 3D view using mol* of Q16288-1_6kzd_A_Q16288-5.pdb |
| Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green) |
| 3D view using mol* of Q16288-1_Q16288-2.pdb |
| 3D view using mol* of Q16288-1_Q16288-3.pdb |
| 3D view using mol* of Q16288-1_Q16288-4.pdb |
| 3D view using mol* of Q16288-1_Q16288-5.pdb |
| Protein Feature Comparison of the protein sequendary structures among the protiens. |
| ./stats/secondary_structure/figure/Q16288-1_vs_Q16288-2.png |
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| ./stats/secondary_structure/figure/Q16288-1_vs_Q16288-3.png |
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| ./stats/secondary_structure/figure/Q16288-1_vs_Q16288-4.png |
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| ./stats/secondary_structure/figure/Q16288-1_vs_Q16288-5.png |
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| Protein Feature Comparison of the relative accessible surface area (ASA) among the protiens. |
| ./stats/relative_asa/Q16288-1_vs_Q16288-2.png |
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| ./stats/relative_asa/Q16288-1_vs_Q16288-3.png |
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| ./stats/relative_asa/Q16288-1_vs_Q16288-4.png |
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| ./stats/relative_asa/Q16288-1_vs_Q16288-5.png |
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Protein-Protein Interaction |
| Interactors from UniProt. |
| Accession_id | Subsection | Start | End | Funcitonal feature | Splicing information |
| Interactors from STRING. |
| Gene name | Interactors |
Related Drugs to NTRK3 |
| Drugs targeting this gene/protein. (DrugBank) |
| UniProt accession | Gene name | DrugBank ID | Drug name | Drug group | Actions |
| Q16288 | NTRK3 | DB16826 | Repotrectinib | approved, investigational | inhibitor |
| Q16288 | NTRK3 | DB15822 | Pralsetinib | approved, investigational | inhibitor |
| Q16288 | NTRK3 | DB14723 | Larotrectinib | approved, investigational | inhibitor |
| Q16288 | NTRK3 | DB12010 | Fostamatinib | approved, investigational | inhibitor |
| Q16288 | NTRK3 | DB11986 | Entrectinib | approved, investigational | inhibitor |
Related Diseases to NTRK3 |
| Previous studies relating to the alternative splicing of NTRK3 and disease information from the MeSH term (PubMed) |
| Gene | PMID | Title | Abstract | MeSH ID | MeSH term |
Clinically important variants in NTRK3 |
| (ClinVar, 04/20/2024) |
| accession_id | uniprot_id | gene_name | Type | Variant | Clinical_significance |
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