Protein:PDE4D |
Protein Summary |
 Gene summary |
| Gene name: PDE4D | ASpdb.0 ID: 5144 | Gene | Gene symbol | PDE4D | Gene ID | 5144 |
| Gene name | phosphodiesterase 4D |
| Synonyms | ACRDYS2|DPDE3|HSPDE4D|PDE43|PDE4DN2|STRK1 |
| Cytomap | 5q11.2-q12.1 |
| Type of gene | protein-coding |
| Description | 3',5'-cyclic-AMP phosphodiesterase 4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DcAMP-specific phosphodiesterase PDE4D6phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)testicular tissue protein Li 136 |
| Modification date | 20240416 |
| UniProtAcc | Q08499 |
| Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Gene | PDE4D | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity | 9371713|17404263|20819076 |
| Gene | PDE4D | GO:0005829 | cytosol | - |
| Gene | PDE4D | GO:0005886 | plasma membrane | - |
| Gene | PDE4D | GO:0030552 | cAMP binding | 9371713|15938621|20819076 |
| Gene | PDE4D | GO:0034704 | calcium channel complex | 16213210 |
| Gene | PDE4D | GO:0106072 | negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway | 20819076 |
AS Summary |
| Information of the canonical protein with experimentally identified structure from PDB (2023). |
| UniProt Acc | File name | PDB ID | Method | Resolution | Chain | Start | End |
| Q08499-1 | Q08499-1_3g58_D.pdb | 3G58 | X-ray | 2.05 | D | 381 | 739 |
| ASpdb's canonical and alternatively spliced isoform information. |
| accession_id | gene_name | canonical_id | alternative_id | canonical_length | alternative_length | canonical_start | canonical_end | type | originalSEQ | variationSEQ | alternative_start | alternative_end |
| Q08499 | PDE4D | Q08499-1 | Q08499-10 | 809 | 679 | 1 | 130 | Deletion | none | none | 0 | 0 |
| Q08499 | PDE4D | Q08499-1 | Q08499-10 | 809 | 679 | 131 | 152 | Substitution | GHRPGLKKSRMSWPSSFQGLRR | MSIIMKPRSRSTSSLRTAEAVC | 1 | 22 |
| Q08499 | PDE4D | Q08499-1 | Q08499-11 | 809 | 748 | 1 | 61 | Deletion | none | none | 0 | 0 |
| Q08499 | PDE4D | Q08499-1 | Q08499-11 | 809 | 748 | 62 | 152 | Substitution | PPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRR | MKRNTCDLLSRSKSASEETLHSSNEEEDPFRGMEPYLVRRLSCRNIQLPPLAFRQLEQADLKSESENIQRPTSLPLKILPLIAITSAESSG | 1 | 91 |
| Q08499 | PDE4D | Q08499-1 | Q08499-12 | 809 | 219 | 1 | 152 | Substitution | MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRR | MAQQTSPDTLTVPEVDNPHCPNPWLNEDLVKSLRENLLQHEKSKTARKSVSPKLSPVISPRNSPRLLRRMLLSSNIPKQRRFTVAHTC | 1 | 88 |
| Q08499 | PDE4D | Q08499-1 | Q08499-12 | 809 | 219 | 270 | 283 | Substitution | EEAYQKLASETLEE | GSWMELNPYTLLDM | 206 | 219 |
| Q08499 | PDE4D | Q08499-1 | Q08499-12 | 809 | 219 | 284 | 809 | Deletion | none | none | 219 | 219 |
| Q08499 | PDE4D | Q08499-1 | Q08499-2 | 809 | 673 | 1 | 152 | Substitution | MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRR | MMHVNNFPFRRHSWIC | 1 | 16 |
| Q08499 | PDE4D | Q08499-1 | Q08499-3 | 809 | 604 | 1 | 205 | Deletion | none | none | 0 | 0 |
| Q08499 | PDE4D | Q08499-1 | Q08499-4 | 809 | 584 | 1 | 269 | Substitution | MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATIT | MKEQPSCAGTGHPMAGYGRMAPFELASGPVKRLRTESPFPCLFA | 1 | 44 |
| Q08499 | PDE4D | Q08499-1 | Q08499-5 | 809 | 507 | 1 | 302 | Deletion | none | none | 0 | 0 |
| Q08499 | PDE4D | Q08499-1 | Q08499-6 | 809 | 745 | 1 | 152 | Substitution | MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRR | MAQQTSPDTLTVPEVDNPHCPNPWLNEDLVKSLRENLLQHEKSKTARKSVSPKLSPVISPRNSPRLLRRMLLSSNIPKQRRFTVAHTC | 1 | 88 |
| Q08499 | PDE4D | Q08499-1 | Q08499-7 | 809 | 215 | 1 | 152 | Substitution | MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRR | MAQQTSPDTLTVPEVDNPHCPNPWLNEDLVKSLRENLLQHEKSKTARKSVSPKLSPVISPRNSPRLLRRMLLSSNIPKQRRFTVAHTC | 1 | 88 |
| Q08499 | PDE4D | Q08499-1 | Q08499-7 | 809 | 215 | 270 | 279 | Substitution | EEAYQKLASE | GLYNGIIAFL | 206 | 215 |
| Q08499 | PDE4D | Q08499-1 | Q08499-7 | 809 | 215 | 280 | 809 | Deletion | none | none | 215 | 215 |
| Q08499 | PDE4D | Q08499-1 | Q08499-8 | 809 | 518 | 1 | 291 | Deletion | none | none | 0 | 0 |
| Q08499 | PDE4D | Q08499-1 | Q08499-8 | 809 | 518 | 292 | 306 | Substitution | ETLQTRHSVSEMASN | MPEANYLLSVSWGYI | 1 | 15 |
| Q08499 | PDE4D | Q08499-1 | Q08499-9 | 809 | 687 | 1 | 122 | Deletion | none | none | 0 | 0 |
| Q08499 | PDE4D | Q08499-1 | Q08499-9 | 809 | 687 | 123 | 152 | Substitution | RTSYAVETGHRPGLKKSRMSWPSSFQGLRR | MAFVWDPLGATVPGPSTRAKSRLRFSKSYS | 1 | 30 |
| Multiple sequence alignment of our canonical and alternatively spliced PDE4D |
| Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of PDE4D |
| UniProt-id | ENSG | ENST | ENSP |
| Q08499-1 | ENSG00000113448.21 | ENST00000340635.11 | ENSP00000345502.6 |
| Q08499-10 | ENSG00000113448.21 | ENST00000503258.5 | ENSP00000425605.1 |
| Q08499-11 | ENSG00000113448.21 | ENST00000502484.6 | ENSP00000423094.2 |
| Q08499-12 | ENSG00000113448.21 | ENST00000502575.1 | ENSP00000425917.1 |
| Q08499-2 | ENSG00000113448.21 | ENST00000360047.9 | ENSP00000353152.5 |
| Q08499-5 | ENSG00000113448.21 | ENST00000358923.10 | ENSP00000351800.6 |
| Q08499-6 | ENSG00000113448.21 | ENST00000507116.6 | ENSP00000424852.1 |
| Q08499-7 | ENSG00000113448.21 | ENST00000309641.10 | ENSP00000308485.6 |
| Q08499-8 | ENSG00000113448.21 | ENST00000317118.12 | ENSP00000321739.8 |
| Q08499-9 | ENSG00000113448.21 | ENST00000405755.6 | ENSP00000384806.2 |
| UniProt-id | NM ID | NP ID |
| Q08499-1 | NM_001104631.1 | NP_001098101.1 |
| Q08499-10 | NM_001197220.1 | NP_001184149.1 |
| Q08499-11 | NM_001165899.1 | NP_001159371.1 |
| Q08499-11 | XM_011543473.1 | XP_011541775.1 |
| Q08499-11 | XM_017009566.1 | XP_016865055.1 |
| Q08499-2 | NM_006203.4 | NP_006194.2 |
| Q08499-5 | NM_001197221.1 | NP_001184150.1 |
| Q08499-6 | NM_001197218.1 | NP_001184147.1 |
| Q08499-8 | NM_001197223.1 | NP_001184152.1 |
| Q08499-9 | NM_001197219.1 | NP_001184148.1 |
| Amino acid sequences of our canonical and alternatively spliced PDE4D |
| accession_id | Protein sequence |
| Q08499-1 | MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQPQCPLQPPPPPPLPPPPPPPGA ARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQA NFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITE EAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRP MSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMT LEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGF KLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAP |
| Q08499-10 | MSIIMKPRSRSTSSLRTAEAVCFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDD LIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKR MLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELED VNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDL EILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMN LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKS QVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDT |
| Q08499-11 | MKRNTCDLLSRSKSASEETLHSSNEEEDPFRGMEPYLVRRLSCRNIQLPPLAFRQLEQADLKSESENIQRPTSLPLKILPLIAITSAESS GFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFA ALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSE FISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLT VIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSN QFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLL LDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVH PDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLD |
| Q08499-12 | MAQQTSPDTLTVPEVDNPHCPNPWLNEDLVKSLRENLLQHEKSKTARKSVSPKLSPVISPRNSPRLLRRMLLSSNIPKQRRFTVAHTCFD VDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALT |
| Q08499-2 | MMHVNNFPFRRHSWICFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPF AQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNREL THLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGL HVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAI FASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLK TMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFID YIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSK |
| Q08499-3 | MSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQ TRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFG VKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTH VLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKM VIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGME ISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGE |
| Q08499-4 | MKEQPSCAGTGHPMAGYGRMAPFELASGPVKRLRTESPFPCLFAEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRE LTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWG LHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAA IFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADL KTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFI DYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDS |
| Q08499-5 | MASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQED VLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPA LEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLA TDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDK HNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDS |
| Q08499-6 | MAQQTSPDTLTVPEVDNPHCPNPWLNEDLVKSLRENLLQHEKSKTARKSVSPKLSPVISPRNSPRLLRRMLLSSNIPKQRRFTVAHTCFD VDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALT NLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFIS NTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIM HTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFL INTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDN YSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDA QDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQV |
| Q08499-7 | MAQQTSPDTLTVPEVDNPHCPNPWLNEDLVKSLRENLLQHEKSKTARKSVSPKLSPVISPRNSPRLLRRMLLSSNIPKQRRFTVAHTCFD VDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALT |
| Q08499-8 | MPEANYLLSVSWGYIKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSI PRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVV QSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQS LRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERE RGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLE |
| Q08499-9 | MAFVWDPLGATVPGPSTRAKSRLRFSKSYSFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSI ASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSE MASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQED VLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPA LEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLA TDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDK HNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDS |
Protein Functional Features |
| Main function of this protein. (from UniProt) |
| PDE4D (go to UniProt):Q08499 |
| Retention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Accession_id | Subsection | Start | End | Funcitonal feature | Splicing information |
| Q08499 | Domain | 386 | 715 | Note=PDEase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01192 | Type=Deletion;Start=284;End=809 |
| Q08499 | Domain | 386 | 715 | Note=PDEase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01192 | Type=Deletion;Start=280;End=809 |
| Q08499 | Region | 1 | 107 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=130 |
| Q08499 | Region | 1 | 107 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=61 |
| Q08499 | Region | 1 | 107 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=62;End=152 |
| Q08499 | Region | 1 | 107 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=1;End=152 |
| Q08499 | Region | 1 | 107 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=1;End=152 |
| Q08499 | Region | 1 | 107 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=205 |
| Q08499 | Region | 1 | 107 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=1;End=269 |
| Q08499 | Region | 1 | 107 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=302 |
| Q08499 | Region | 1 | 107 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=1;End=152 |
| Q08499 | Region | 1 | 107 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=1;End=152 |
| Q08499 | Region | 1 | 107 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=291 |
| Q08499 | Region | 1 | 107 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=122 |
| Q08499 | Region | 343 | 364 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=284;End=809 |
| Q08499 | Region | 343 | 364 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=280;End=809 |
| Q08499 | Region | 710 | 729 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=284;End=809 |
| Q08499 | Region | 710 | 729 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=280;End=809 |
| Q08499 | Region | 739 | 809 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=284;End=809 |
| Q08499 | Region | 739 | 809 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=280;End=809 |
| Q08499 | Compositional bias | 53 | 91 | Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=130 |
| Q08499 | Compositional bias | 53 | 91 | Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=61 |
| Q08499 | Compositional bias | 53 | 91 | Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=62;End=152 |
| Q08499 | Compositional bias | 53 | 91 | Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=1;End=152 |
| Q08499 | Compositional bias | 53 | 91 | Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=1;End=152 |
| Q08499 | Compositional bias | 53 | 91 | Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=205 |
| Q08499 | Compositional bias | 53 | 91 | Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=1;End=269 |
| Q08499 | Compositional bias | 53 | 91 | Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=302 |
| Q08499 | Compositional bias | 53 | 91 | Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=1;End=152 |
| Q08499 | Compositional bias | 53 | 91 | Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=1;End=152 |
| Q08499 | Compositional bias | 53 | 91 | Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=291 |
| Q08499 | Compositional bias | 53 | 91 | Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=122 |
| Q08499 | Compositional bias | 345 | 362 | Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=284;End=809 |
| Q08499 | Compositional bias | 345 | 362 | Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=280;End=809 |
| Q08499 | Compositional bias | 758 | 777 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=284;End=809 |
| Q08499 | Compositional bias | 758 | 777 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=280;End=809 |
| Q08499 | Compositional bias | 778 | 798 | Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=284;End=809 |
| Q08499 | Compositional bias | 778 | 798 | Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=280;End=809 |
Gene Isoform Structures and Expression Levels for PDE4D |
| Gene structures of our canonical and alternative spliced genes of PDE4D * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Expression levels of gene isoforms across GTEx. |
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| Expression levels of gene isoforms across TCGA. |
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Protein Structures |
| PDB and CIF files of the predicted protein structures * Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| 3D view using mol* of Q08499-1 |
| 3D view using mol* of Q08499-10 |
| 3D view using mol* of Q08499-11 |
| 3D view using mol* of Q08499-12 |
| 3D view using mol* of Q08499-2 |
| 3D view using mol* of Q08499-3 |
| 3D view using mol* of Q08499-4 |
| 3D view using mol* of Q08499-5 |
| 3D view using mol* of Q08499-6 |
| 3D view using mol* of Q08499-7 |
| 3D view using mol* of Q08499-8 |
| 3D view using mol* of Q08499-9 |
pLDDT Score Distribution |
| pLDDT score distribution of the predicted protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
| pLDDT distribution across the protein length of Q08499-1 |
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| pLDDT distribution across the protein length of Q08499-10 |
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| pLDDT distribution across the protein length of Q08499-11 |
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| pLDDT distribution across the protein length of Q08499-12 |
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| pLDDT distribution across the protein length of Q08499-2 |
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| pLDDT distribution across the protein length of Q08499-3 |
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| pLDDT distribution across the protein length of Q08499-4 |
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| pLDDT distribution across the protein length of Q08499-5 |
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| pLDDT distribution across the protein length of Q08499-6 |
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| pLDDT distribution across the protein length of Q08499-7 |
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| pLDDT distribution across the protein length of Q08499-8 |
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| pLDDT distribution across the protein length of Q08499-9 |
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Ramachandran Plot of Protein Structures |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide. |
| Ramachandran plot of Q08499-1 |
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| Ramachandran plot of Q08499-10 |
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| Ramachandran plot of Q08499-11 |
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| Ramachandran plot of Q08499-12 |
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| Ramachandran plot of Q08499-3 |
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| Ramachandran plot of Q08499-6 |
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| Ramachandran plot of Q08499-8 |
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Potential Active Site Information |
| The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite. |
| UniProt-id | Site score | Size | D score | Volume | Exposure | Enclosure | Contact | Phobic | Philic | Balance | Don/Acc | Residues |
| Q08499-1 | 1.05 | 208 | 1.022 | 667.135 | 0.509 | 0.773 | 1.007 | 0.527 | 1.17 | 0.45 | 0.9 | 461,462,466,502,503,506,508,509,510,511,512,513,51 5,516,527,528,529,530,531,532,535,573,574,575,576, 620,621,623,624,631,634,635,638,639,641,642,645,64 9,654,655,657,658,659,660,670,671,674,678 |
| Q08499-10 | 1.039 | 255 | 1.066 | 903.119 | 0.59 | 0.733 | 0.905 | 0.582 | 0.962 | 0.605 | 0.811 | 1,2,3,4,5,331,332,336,372,373,376,378,379,380,381, 382,383,385,386,397,398,399,400,401,402,405,443,44 4,445,446,448,449,450,490,491,493,494,501,504,505, 508,509,511,512,515,519,524,525,526,527,528,529,53 0,540,541,543,544,547,548,608 |
| Q08499-11 | 1.056 | 131 | 1.146 | 301.154 | 0.608 | 0.64 | 0.834 | 1.201 | 0.545 | 2.203 | 0.847 | 281,282,283,284,285,286,287,288,479,482,483,490,49 5,496,498,499,500,501,502,503,506,507,544 |
| Q08499-12 | 0.584 | 31 | 0.489 | 54.537 | 0.674 | 0.561 | 0.813 | 0.347 | 1.139 | 0.304 | 0.591 | 178,179,180,181,199,200,201,202,203
|
| Q08499-2 | 1.046 | 407 | 1.004 | 1016.309 | 0.502 | 0.766 | 0.941 | 0.533 | 1.214 | 0.439 | 0.799 | 173,188,191,192,193,195,196,197,199,200,201,202,20 3,204,205,206,325,326,330,366,367,370,373,374,375, 376,377,379,380,391,392,393,394,395,396,399,432,43 5,436,437,438,439,440,441,443,444,445,448,477,484, 485,487,488,495,498,499,502,503,505,506,509,513,51 8,519,520,521,522,523,524,525,528,529,534,535,538, 598 |
| Q08499-3 | 1.03 | 331 | 1.026 | 1225.196 | 0.536 | 0.744 | 0.964 | 0.698 | 1.106 | 0.631 | 0.955 | 256,257,297,298,301,303,304,305,306,307,308,310,31 1,322,323,324,325,326,327,330,368,369,370,371,372, 374,375,415,416,418,419,426,429,430,433,436,437,44 0,444,449,450,451,452,453,454,455,456,459,460,461, 465,466,468,469,472,473,531,532,533,534,535,536,53 7,538 |
| Q08499-4 | 1.035 | 306 | 1.055 | 1108.576 | 0.553 | 0.743 | 0.938 | 0.853 | 1.014 | 0.84 | 0.908 | 236,237,277,278,281,284,285,286,287,290,302,303,30 4,305,306,307,310,348,349,350,351,352,353,354,395, 396,397,398,399,406,409,410,413,416,417,420,431,43 2,433,434,435,436,439,440,441,444,445,446,448,449, 452,453,510,511,512,513,514,515,516 |
| Q08499-5 | 1.075 | 416 | 1.007 | 834.862 | 0.394 | 0.81 | 1.065 | 0.565 | 1.283 | 0.44 | 0.937 | 22,25,26,27,29,30,33,34,35,36,37,38,39,40,41,159,1 60,164,200,201,204,206,207,208,209,210,211,213,214 ,225,226,227,228,229,230,233,271,272,273,274,275,3 18,319,321,322,329,332,333,336,339,340,343,347,352 ,353,354,355,356,357,358,359,362,363,368,369,372 |
| Q08499-6 | 1.066 | 157 | 1.048 | 429.093 | 0.471 | 0.797 | 1.021 | 0.809 | 1.136 | 0.712 | 1.378 | 397,398,402,438,439,442,445,446,447,448,467,468,47 1,509,510,511,556,557,559,560,567,570,571,574,575, 577,578,581,595,606,607,609,610 |
| Q08499-7 | 0.81 | 64 | 0.844 | 102.214 | 0.702 | 0.537 | 0.759 | 0.67 | 0.706 | 0.949 | 0.955 | 150,151,152,153,154,155,158,163,164,166,167,170,17 1,174 |
| Q08499-8 | 1.053 | 402 | 1.013 | 851.669 | 0.455 | 0.778 | 0.99 | 0.62 | 1.206 | 0.514 | 0.926 | 33,36,37,38,40,41,42,44,45,46,47,48,49,50,51,52,53 ,170,171,175,211,212,215,218,219,220,221,222,224,2 25,236,237,238,239,240,241,244,282,283,284,285,286 ,329,330,332,333,340,343,344,347,348,350,351,354,3 58,363,364,365,366,367,368,369,370,373,374,379,380 ,383 |
| Q08499-9 | 1.061 | 114 | 1.117 | 246.617 | 0.619 | 0.708 | 0.929 | 1.468 | 0.76 | 1.932 | 0.631 | 1,2,3,4,5,339,501,502,509,512,513,516,517,520,534, 535,536,537,538,539,542,543,548,549,551,552,555,55 6 |
Protein Structure and Feature Comparision |
| Protein Structure Comparision Using Template Modeling Scores (TM-score). |
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| Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green) |
| 3D view using mol* of Q08499-1_Q08499-1_3g58_D.pdb |
| Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green) |
| 3D view using mol* of Q08499-1_3g58_D_Q08499-10.pdb |
| 3D view using mol* of Q08499-1_3g58_D_Q08499-11.pdb |
| 3D view using mol* of Q08499-1_3g58_D_Q08499-12.pdb |
| 3D view using mol* of Q08499-1_3g58_D_Q08499-2.pdb |
| 3D view using mol* of Q08499-1_3g58_D_Q08499-3.pdb |
| 3D view using mol* of Q08499-1_3g58_D_Q08499-4.pdb |
| 3D view using mol* of Q08499-1_3g58_D_Q08499-5.pdb |
| 3D view using mol* of Q08499-1_3g58_D_Q08499-6.pdb |
| 3D view using mol* of Q08499-1_3g58_D_Q08499-7.pdb |
| 3D view using mol* of Q08499-1_3g58_D_Q08499-8.pdb |
| 3D view using mol* of Q08499-1_3g58_D_Q08499-9.pdb |
| Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green) |
| 3D view using mol* of Q08499-1_Q08499-10.pdb |
| 3D view using mol* of Q08499-1_Q08499-11.pdb |
| 3D view using mol* of Q08499-1_Q08499-12.pdb |
| 3D view using mol* of Q08499-1_Q08499-2.pdb |
| 3D view using mol* of Q08499-1_Q08499-3.pdb |
| 3D view using mol* of Q08499-1_Q08499-4.pdb |
| 3D view using mol* of Q08499-1_Q08499-5.pdb |
| 3D view using mol* of Q08499-1_Q08499-6.pdb |
| 3D view using mol* of Q08499-1_Q08499-7.pdb |
| 3D view using mol* of Q08499-1_Q08499-8.pdb |
| 3D view using mol* of Q08499-1_Q08499-9.pdb |
| Protein Feature Comparison of the protein sequendary structures among the protiens. |
| ./stats/secondary_structure/figure/Q08499-1_vs_Q08499-10.png |
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| ./stats/secondary_structure/figure/Q08499-1_vs_Q08499-11.png |
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| ./stats/secondary_structure/figure/Q08499-1_vs_Q08499-12.png |
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| ./stats/secondary_structure/figure/Q08499-1_vs_Q08499-2.png |
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| ./stats/secondary_structure/figure/Q08499-1_vs_Q08499-3.png |
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| ./stats/secondary_structure/figure/Q08499-1_vs_Q08499-4.png |
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| ./stats/secondary_structure/figure/Q08499-1_vs_Q08499-5.png |
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| ./stats/secondary_structure/figure/Q08499-1_vs_Q08499-6.png |
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| ./stats/secondary_structure/figure/Q08499-1_vs_Q08499-7.png |
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| ./stats/secondary_structure/figure/Q08499-1_vs_Q08499-8.png |
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| ./stats/secondary_structure/figure/Q08499-1_vs_Q08499-9.png |
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| Protein Feature Comparison of the relative accessible surface area (ASA) among the protiens. |
| ./stats/relative_asa/Q08499-1_vs_Q08499-10.png |
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| ./stats/relative_asa/Q08499-1_vs_Q08499-11.png |
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| ./stats/relative_asa/Q08499-1_vs_Q08499-12.png |
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| ./stats/relative_asa/Q08499-1_vs_Q08499-2.png |
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| ./stats/relative_asa/Q08499-1_vs_Q08499-3.png |
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| ./stats/relative_asa/Q08499-1_vs_Q08499-4.png |
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| ./stats/relative_asa/Q08499-1_vs_Q08499-5.png |
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| ./stats/relative_asa/Q08499-1_vs_Q08499-6.png |
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| ./stats/relative_asa/Q08499-1_vs_Q08499-7.png |
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| ./stats/relative_asa/Q08499-1_vs_Q08499-8.png |
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| ./stats/relative_asa/Q08499-1_vs_Q08499-9.png |
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Protein-Protein Interaction |
| Interactors from UniProt. |
| Accession_id | Subsection | Start | End | Funcitonal feature | Splicing information |
| Interactors from STRING. |
| Gene name | Interactors |
Related Drugs to PDE4D |
| Drugs targeting this gene/protein. (DrugBank) |
| UniProt accession | Gene name | DrugBank ID | Drug name | Drug group | Actions |
| Q08499 | PDE4D | DB02918 | Zardaverine | experimental | |
| Q08499 | PDE4D | DB01088 | Iloprost | approved, investigational | inducer |
| Q08499 | PDE4D | DB04271 | 3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester | experimental | |
| Q08499 | PDE4D | DB00131 | Adenosine phosphate | approved, investigational, nutraceutical, withdrawn | product of |
| Q08499 | PDE4D | DB07954 | 3-isobutyl-1-methyl-7H-xanthine | experimental | |
| Q08499 | PDE4D | DB07051 | 3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | experimental | |
| Q08499 | PDE4D | DB06842 | (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one | experimental | |
| Q08499 | PDE4D | DB04149 | (R)-Rolipram | experimental | |
| Q08499 | PDE4D | DB01791 | Piclamilast | experimental | |
| Q08499 | PDE4D | DB05298 | Tetomilast | investigational | |
| Q08499 | PDE4D | DB05266 | Ibudilast | investigational | inhibitor |
| Q08499 | PDE4D | DB04469 | 1-(4-Methoxyphenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester | experimental | |
| Q08499 | PDE4D | DB08299 | 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid | experimental | |
| Q08499 | PDE4D | DB03849 | Cilomilast | investigational | inhibitor |
| Q08499 | PDE4D | DB05219 | Crisaborole | approved, investigational | inhibitor |
| Q08499 | PDE4D | DB01959 | 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester | experimental | |
| Q08499 | PDE4D | DB00651 | Dyphylline | approved | inhibitor |
| Q08499 | PDE4D | DB03606 | (S)-Rolipram | experimental | |
| Q08499 | PDE4D | DB03183 | 1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester | experimental | |
| Q08499 | PDE4D | DB02676 | 2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol | experimental | |
| Q08499 | PDE4D | DB01954 | Rolipram | investigational | |
| Q08499 | PDE4D | DB06246 | Exisulind | investigational |
Related Diseases to PDE4D |
| Previous studies relating to the alternative splicing of PDE4D and disease information from the MeSH term (PubMed) |
| Gene | PMID | Title | Abstract | MeSH ID | MeSH term |
Clinically important variants in PDE4D |
| (ClinVar, 04/20/2024) |
| accession_id | uniprot_id | gene_name | Type | Variant | Clinical_significance |
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