Protein:SIRT6 |
Protein Summary |
 Gene summary |
| Gene name: SIRT6 | ASpdb.0 ID: 51548 | Gene | Gene symbol | SIRT6 | Gene ID | 51548 |
| Gene name | sirtuin 6 |
| Synonyms | SIR2L6|hSIRT6 |
| Cytomap | 19p13.3 |
| Type of gene | protein-coding |
| Description | NAD-dependent protein deacylase sirtuin-6NAD-dependent protein deacetylase sirtuin-6SIR2-like protein 6protein mono-ADP-ribosyltransferase sirtuin-6regulatory protein SIR2 homolog 6sir2-related protein type 6sirtuin type 6 |
| Modification date | 20240317 |
| UniProtAcc | Q8N6T7 |
| Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Gene | SIRT6 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 24043303 |
| Gene | SIRT6 | GO:0000785 | chromatin | 23892288|26456828|27043296|27912097|30374165|33067423 |
| Gene | SIRT6 | GO:0003682 | chromatin binding | 27043296|27912097 |
| Gene | SIRT6 | GO:0003684 | damaged DNA binding | 31995034|32538779 |
| Gene | SIRT6 | GO:0005634 | nucleus | 26898756|29555651 |
| Gene | SIRT6 | GO:0005634 | nucleus | 25819580|26456828 |
| Gene | SIRT6 | GO:0005654 | nucleoplasm | 16079181 |
| Gene | SIRT6 | GO:0005721 | pericentric heterochromatin | 27043296 |
| Gene | SIRT6 | GO:0005730 | nucleolus | 16079181 |
| Gene | SIRT6 | GO:0005783 | endoplasmic reticulum | 23552949 |
| Gene | SIRT6 | GO:0006302 | double-strand break repair | 21680843|27568560 |
| Gene | SIRT6 | GO:0006338 | chromatin remodeling | 23892288|33067423|37023208 |
| Gene | SIRT6 | GO:0009411 | response to UV | 19109893 |
| Gene | SIRT6 | GO:0010569 | regulation of double-strand break repair via homologous recombination | 19135889|22753495 |
| Gene | SIRT6 | GO:0017136 | NAD-dependent histone deacetylase activity | 24043303|27912097 |
| Gene | SIRT6 | GO:0031490 | chromatin DNA binding | 33067423 |
| Gene | SIRT6 | GO:0031491 | nucleosome binding | 23892288|33067423 |
| Gene | SIRT6 | GO:0031508 | pericentric heterochromatin formation | 27043296 |
| Gene | SIRT6 | GO:0031648 | protein destabilization | 29474172 |
| Gene | SIRT6 | GO:0034979 | NAD-dependent protein deacetylase activity | 19109893|23142079|24052263|25009184|26787900|27322069|29474172 |
| Gene | SIRT6 | GO:0035861 | site of double-strand break | 21680843|23911928|27568560|31995034|32538779 |
| Gene | SIRT6 | GO:0042803 | protein homodimerization activity | 31995034|32538779 |
| Gene | SIRT6 | GO:0043231 | intracellular membrane-bounded organelle | - |
| Gene | SIRT6 | GO:0045721 | negative regulation of gluconeogenesis | 23142079|25009184 |
| Gene | SIRT6 | GO:0045820 | negative regulation of glycolytic process | 26456828 |
| Gene | SIRT6 | GO:0046827 | positive regulation of protein export from nucleus | 25009184|26787900 |
| Gene | SIRT6 | GO:0046969 | NAD-dependent histone H3K9 deacetylase activity | 18337721|23892288|26456828|30374165|33067423 |
| Gene | SIRT6 | GO:0050708 | regulation of protein secretion | 23552949 |
| Gene | SIRT6 | GO:0051697 | protein delipidation | 23552949 |
| Gene | SIRT6 | GO:0090734 | site of DNA damage | 19109893 |
| Gene | SIRT6 | GO:0097372 | NAD-dependent histone H3K18 deacetylase activity | 27043296 |
| Gene | SIRT6 | GO:0099115 | chromosome, subtelomeric region | 18337721 |
| Gene | SIRT6 | GO:0120186 | negative regulation of protein localization to chromatin | 27912097 |
| Gene | SIRT6 | GO:0140612 | DNA damage sensor activity | 31995034|32538779 |
| Gene | SIRT6 | GO:0140765 | NAD-dependent histone H3K56 deacetylase activity | 23911928|26456828|26898756|27912097|30374165 |
| Gene | SIRT6 | GO:0140773 | NAD-dependent protein demyristoylase activity | 23552949|24052263|26456828|27322069|30374165|31995034 |
| Gene | SIRT6 | GO:0140774 | NAD-dependent protein depalmitoylase activity | 23552949|24052263|27322069|28406396 |
| Gene | SIRT6 | GO:1902459 | positive regulation of stem cell population maintenance | 27912097 |
| Gene | SIRT6 | GO:1903076 | regulation of protein localization to plasma membrane | 28406396 |
| Gene | SIRT6 | GO:1990166 | protein localization to site of double-strand break | 27568560 |
| Gene | SIRT6 | GO:1990404 | NAD+-protein ADP-ribosyltransferase activity | 21680843|22753495|27322069|27568560 |
| Gene | SIRT6 | GO:2000738 | positive regulation of stem cell differentiation | 27912097 |
| Gene | SIRT6 | GO:2000773 | negative regulation of cellular senescence | 22753495|27043296 |
| Gene | SIRT6 | GO:2000781 | positive regulation of double-strand break repair | 23911928|31995034|32538779 |
AS Summary |
| Information of the canonical protein with experimentally identified structure from PDB (2023). |
| UniProt Acc | File name | PDB ID | Method | Resolution | Chain | Start | End |
| Q8N6T7-1 | Q8N6T7-1_5y2f_A.pdb | 5Y2F | X-ray | 2.53 | A | 3 | 299 |
| ASpdb's canonical and alternatively spliced isoform information. |
| accession_id | gene_name | canonical_id | alternative_id | canonical_length | alternative_length | canonical_start | canonical_end | type | originalSEQ | variationSEQ | alternative_start | alternative_end |
| Q8N6T7 | SIRT6 | Q8N6T7-1 | Q8N6T7-2 | 355 | 328 | 179 | 205 | Deletion | none | none | 178 | 178 |
| Multiple sequence alignment of our canonical and alternatively spliced SIRT6 |
| Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of SIRT6 |
| UniProt-id | ENSG | ENST | ENSP |
| Q8N6T7-1 | ENSG00000077463.15 | ENST00000337491.7 | ENSP00000337332.1 |
| Q8N6T7-2 | ENSG00000077463.15 | ENST00000305232.10 | ENSP00000305310.5 |
| UniProt-id | NM ID | NP ID |
| Q8N6T7-1 | NM_016539.3 | NP_057623.2 |
| Q8N6T7-2 | NM_001193285.2 | NP_001180214.1 |
| Amino acid sequences of our canonical and alternatively spliced SIRT6 |
| accession_id | Protein sequence |
| Q8N6T7-1 | MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESAR PTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGE LRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLG |
| Q8N6T7-2 | MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESAR PTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRNA DLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKL |
Protein Functional Features |
| Main function of this protein. (from UniProt) |
| SIRT6 (go to UniProt):Q8N6T7 |
| Retention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Accession_id | Subsection | Start | End | Funcitonal feature | Splicing information |
| Q8N6T7 | Domain | 27 | 272 | Note=Deacetylase sirtuin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00236 | Type=Deletion;Start=179;End=205 |
Gene Isoform Structures and Expression Levels for SIRT6 |
| Gene structures of our canonical and alternative spliced genes of SIRT6 * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Expression levels of gene isoforms across GTEx. |
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| Expression levels of gene isoforms across TCGA. |
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Protein Structures |
| PDB and CIF files of the predicted protein structures * Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| 3D view using mol* of Q8N6T7-1 |
| 3D view using mol* of Q8N6T7-2 |
pLDDT Score Distribution |
| pLDDT score distribution of the predicted protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
| pLDDT distribution across the protein length of Q8N6T7-1 |
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| pLDDT distribution across the protein length of Q8N6T7-2 |
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Ramachandran Plot of Protein Structures |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide. |
| Ramachandran plot of Q8N6T7-1 |
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| Ramachandran plot of Q8N6T7-2 |
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Potential Active Site Information |
| The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite. |
| UniProt-id | Site score | Size | D score | Volume | Exposure | Enclosure | Contact | Phobic | Philic | Balance | Don/Acc | Residues |
| Q8N6T7-1 | 1.043 | 331 | 1.011 | 627.004 | 0.464 | 0.762 | 1.023 | 0.423 | 1.186 | 0.357 | 0.615 | 5,9,12,14,16,17,20,22,52,53,54,57,58,60,61,62,63,6 4,65,66,67,68,69,71,80,81,83,113,114,115,116,133,1 86,187,188,190,191,192,214,215,216,217,218,219,220 ,221,240,241,242,243,244,245,256,257,258,259 |
| Q8N6T7-2 | 1.001 | 540 | 0.984 | 1199.814 | 0.551 | 0.699 | 0.953 | 0.37 | 1.153 | 0.321 | 0.576 | 5,8,9,10,11,12,14,15,16,17,20,22,24,52,53,54,55,57 ,58,60,62,63,64,65,66,67,68,69,71,73,80,81,83,92,1 09,113,114,115,120,126,127,129,130,131,132,133,134 ,135,136,138,139,140,141,142,143,144,145,146,147,1 48,150,154,156,157,158,159,160,161,162,163,164,165 ,166,167,168,171,172,173,174,175,176,177,187,188,1 89,190,191,192,193,213,214,215,216,217,218,219,220 ,221,229,230,231,232,256,257 |
Protein Structure and Feature Comparision |
| Protein Structure Comparision Using Template Modeling Scores (TM-score). |
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| Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green) |
| 3D view using mol* of Q8N6T7-1_Q8N6T7-1_5y2f_A.pdb |
| Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green) |
| 3D view using mol* of Q8N6T7-1_5y2f_A_Q8N6T7-2.pdb |
| Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green) |
| 3D view using mol* of Q8N6T7-1_Q8N6T7-2.pdb |
| Protein Feature Comparison of the protein sequendary structures among the protiens. |
| ./stats/secondary_structure/figure/Q8N6T7-1_vs_Q8N6T7-2.png |
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| Protein Feature Comparison of the relative accessible surface area (ASA) among the protiens. |
| ./stats/relative_asa/Q8N6T7-1_vs_Q8N6T7-2.png |
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Protein-Protein Interaction |
| Interactors from UniProt. |
| Accession_id | Subsection | Start | End | Funcitonal feature | Splicing information |
| Interactors from STRING. |
| Gene name | Interactors |
Related Drugs to SIRT6 |
| Drugs targeting this gene/protein. (DrugBank) |
| UniProt accession | Gene name | DrugBank ID | Drug name | Drug group | Actions |
Related Diseases to SIRT6 |
| Previous studies relating to the alternative splicing of SIRT6 and disease information from the MeSH term (PubMed) |
| Gene | PMID | Title | Abstract | MeSH ID | MeSH term |
Clinically important variants in SIRT6 |
| (ClinVar, 04/20/2024) |
| accession_id | uniprot_id | gene_name | Type | Variant | Clinical_significance |
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