ASpdb: an integrative knowledgebase of human protein isoforms from experimental and AI-predicted structures
ASpdb Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine
leaf

Protein Summary

leaf

AS Summary

leaf

Protein Functional Features

leaf

Gene Isoform Structures and Expression Levels

leaf

Protein Structures

leaf

pLDDT Score Distribution

leaf

Ramachandran Plot of Protein Structures

leaf

Potential Active Site Information

leaf

Protein Structure and Feature Comparision

leaf

Protein-Protein Interaction

leaf

Related Drugs

leaf

Related Diseases

leaf

Clinically Important Variants

Protein:PEG3

Protein Summary

check button Gene summary
Gene name: PEG3
ASpdb.0 ID: 5178
Gene
Gene symbol

PEG3

Gene ID

5178

Gene namepaternally expressed 3
SynonymsPW1|ZKSCAN22|ZNF904|ZSCAN24
Cytomap

19q13.43

Type of geneprotein-coding
Descriptionpaternally-expressed gene 3 proteinKruppel-type zinc finger proteinzinc finger and SCAN domain-containing protein 24
Modification date20240305
UniProtAcc

Q9GZU2


check button Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


AS Summary

check button Information of the canonical protein with experimentally identified structure from PDB (2023).
UniProt AccFile namePDB IDMethodResolutionChainStartEnd
Q9GZU2-1Q9GZU2-1_4bhx_B.pdb4BHXX-ray1.95B40129

check button ASpdb's canonical and alternatively spliced isoform information.
accession_idgene_namecanonical_idalternative_idcanonical_lengthalternative_lengthcanonical_startcanonical_endtypeoriginalSEQvariationSEQalternative_startalternative_end
Q9GZU2PEG3Q9GZU2-1Q9GZU2-31588520258287Deletionnonenone257257
Q9GZU2PEG3Q9GZU2-1Q9GZU2-31588520547550SubstitutionSPTFNPCL517520
Q9GZU2PEG3Q9GZU2-1Q9GZU2-315885205511588Deletionnonenone520520
Q9GZU2PEG3Q9GZU2-1Q9GZU2-4158814641126Deletionnonenone00
Q9GZU2PEG3Q9GZU2-1Q9GZU2-415881464161161SubstitutionSSG3536
Q9GZU2PEG3Q9GZU2-1Q9GZU2-415881464257257SubstitutionLLG132133

check buttonMultiple sequence alignment of our canonical and alternatively spliced PEG3

check button Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of PEG3
UniProt-idENSGENSTENSP
Q9GZU2-1ENSG00000198300.14ENST00000326441.15ENSP00000326581.7
Q9GZU2-1ENSG00000198300.14ENST00000599534.5ENSP00000472395.1
Q9GZU2-1ENSG00000198300.14ENST00000599577.5ENSP00000469486.1
Q9GZU2-4ENSG00000198300.14ENST00000598410.5ENSP00000473190.1
Q9GZU2-4ENSG00000198300.14ENST00000648694.1ENSP00000496914.1
Q9GZU2-4ENSG00000198300.14ENST00000649233.1ENSP00000498047.1
Q9GZU2-4ENSG00000198300.14ENST00000649428.1ENSP00000498138.1
Q9GZU2-4ENSG00000198300.14ENST00000649680.1ENSP00000497512.1
Q9GZU2-4ENSG00000198300.14ENST00000649876.1ENSP00000496867.1
Q9GZU2-4ENSG00000198300.14ENST00000650102.1ENSP00000497466.1
Q9GZU2-4ENSG00000198300.14ENST00000650632.1ENSP00000497971.1

UniProt-idNM IDNP ID
Q9GZU2-1NM_001146184.1NP_001139656.1
Q9GZU2-1NM_006210.2NP_006201.1
Q9GZU2-4NM_001146187.1NP_001139659.1

check buttonAmino acid sequences of our canonical and alternatively spliced PEG3
accession_idProtein sequence
Q9GZU2-1MLPPKHLSATKPKKSWAPNLYELDSDLTKEPDVIIGEGPTDSEFFHQRFRNLIYVEFVGPRKTLIKLRNLCLDWLQPETRTKEEIIELLV
LEQYLTIIPEKLKPWVRAKKPENCEKLVTLLENYKEMYQPEDDNNSDVTSDDDMTRNRRESSPPHSVHSFSDRDWDRRGRSRDMEPRDRW
SHTRNPRSRMPPRDLSLPVVAKTSFEMDREDDRDSRAYESRSQDAESYQNVVDLAEDRKPHNTIQDNMENYRKLLSLVQLAEDDGHSHMT
QGHSSRSKRSAYPSTSRGLKTMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRSSKSGRARESSDRSQRFPRMSDDNWKDISLNKRESV
IQQRVYEGNAFRGGFRFNSTLVSRKRVLERKRRYHFDTDGKGSIHDQKGCPRKKPFECGSEMRKAMSVSSLSSLSSPSFTESQPIDFGAM
PYVCDECGRSFSVISEFVEHQIMHTRENLYEYGESFIHSVAVSEVQKSQVGGKRFECKDCGETFNKSAALAEHRKIHARGYLVECKNQEC
EEAFMPSPTFSELQKIYGKDKFYECRVCKETFLHSSALIEHQKIHFGDDKDNEREHERERERERGETFRPSPALNEFQKMYGKEKMYECK
VCGETFLHSSSLKEHQKIHTRGNPFENKGKVCEETFIPGQSLKRRQKTYNKEKLCDFTDGRDAFMQSSELSEHQKIHSRKNLFEGRGYEK
SVIHSGPFTESQKSHTITRPLESDEDEKAFTISSNPYENQKIPTKENVYEAKSYERSVIHSLASVEAQKSHSVAGPSKPKVMAESTIQSF
DAINHQRVRAGGNTSEGREYSRSVIHSLVASKPPRSHNGNELVESNEKGESSIYISDLNDKRQKIPARENPCEGGSKNRNYEDSVIQSVF
RAKPQKSVPGEGSGEFKKDGEFSVPSSNVREYQKARAKKKYIEHRSNETSVIHSLPFGEQTFRPRGMLYECQECGECFAHSSDLTEHQKI
HDREKPSGSRNYEWSVIRSLAPTDPQTSYAQEQYAKEQARNKCKDFRQFFATSEDLNTNQKIYDQEKSHGEESQGENTDGEETHSEETHG
QETIEDPVIQGSDMEDPQKDDPDDKIYECEDCGLGFVDLTDLTDHQKVHSRKCLVDSREYTHSVIHTHSISEYQRDYTGEQLYECPKCGE
SFIHSSFLFEHQRIHEQDQLYSMKGCDDGFIALLPMKPRRNRAAERNPALAGSAIRCLLCGQGFIHSSALNEHMRLHREDDLLEQSQMAE
EAIIPGLALTEFQRSQTEERLFECAVCGESFVNPAELADHVTVHKNEPYEYGSSYTHTSFLTEPLKGAIPFYECKDCGKSFIHSTVLTKH
KELHLEEEEEDEAAAAAAAAAQEVEANVHVPQVVLRIQGLNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAEGPDGEAAEPIGEAGQPN
GEAEQPNGDADEPDGAGIEDPEERAEEPEGKAEEPEGDADEPDGVGIEDPEEGEDQEIQVEEPYYDCHECTETFTSSTAFSEHLKTHASM
Q9GZU2-3MLPPKHLSATKPKKSWAPNLYELDSDLTKEPDVIIGEGPTDSEFFHQRFRNLIYVEFVGPRKTLIKLRNLCLDWLQPETRTKEEIIELLV
LEQYLTIIPEKLKPWVRAKKPENCEKLVTLLENYKEMYQPEDDNNSDVTSDDDMTRNRRESSPPHSVHSFSDRDWDRRGRSRDMEPRDRW
SHTRNPRSRMPPRDLSLPVVAKTSFEMDREDDRDSRAYESRSQDAESYQNVVDLAEDRKPHNTIQDNMENYRKLLSLGLKTMPEAKKSTH
RRGICEDESSHGVIMEKFIKDVSRSSKSGRARESSDRSQRFPRMSDDNWKDISLNKRESVIQQRVYEGNAFRGGFRFNSTLVSRKRVLER
KRRYHFDTDGKGSIHDQKGCPRKKPFECGSEMRKAMSVSSLSSLSSPSFTESQPIDFGAMPYVCDECGRSFSVISEFVEHQIMHTRENLY
Q9GZU2-4MYQPEDDNNSDVTSDDDMTRNRRESSPPHSVHSFSGDRDWDRRGRSRDMEPRDRWSHTRNPRSRMPPRDLSLPVVAKTSFEMDREDDRDS
RAYESRSQDAESYQNVVDLAEDRKPHNTIQDNMENYRKLLSLGVQLAEDDGHSHMTQGHSSRSKRSAYPSTSRGLKTMPEAKKSTHRRGI
CEDESSHGVIMEKFIKDVSRSSKSGRARESSDRSQRFPRMSDDNWKDISLNKRESVIQQRVYEGNAFRGGFRFNSTLVSRKRVLERKRRY
HFDTDGKGSIHDQKGCPRKKPFECGSEMRKAMSVSSLSSLSSPSFTESQPIDFGAMPYVCDECGRSFSVISEFVEHQIMHTRENLYEYGE
SFIHSVAVSEVQKSQVGGKRFECKDCGETFNKSAALAEHRKIHARGYLVECKNQECEEAFMPSPTFSELQKIYGKDKFYECRVCKETFLH
SSALIEHQKIHFGDDKDNEREHERERERERGETFRPSPALNEFQKMYGKEKMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGKVCEE
TFIPGQSLKRRQKTYNKEKLCDFTDGRDAFMQSSELSEHQKIHSRKNLFEGRGYEKSVIHSGPFTESQKSHTITRPLESDEDEKAFTISS
NPYENQKIPTKENVYEAKSYERSVIHSLASVEAQKSHSVAGPSKPKVMAESTIQSFDAINHQRVRAGGNTSEGREYSRSVIHSLVASKPP
RSHNGNELVESNEKGESSIYISDLNDKRQKIPARENPCEGGSKNRNYEDSVIQSVFRAKPQKSVPGEGSGEFKKDGEFSVPSSNVREYQK
ARAKKKYIEHRSNETSVIHSLPFGEQTFRPRGMLYECQECGECFAHSSDLTEHQKIHDREKPSGSRNYEWSVIRSLAPTDPQTSYAQEQY
AKEQARNKCKDFRQFFATSEDLNTNQKIYDQEKSHGEESQGENTDGEETHSEETHGQETIEDPVIQGSDMEDPQKDDPDDKIYECEDCGL
GFVDLTDLTDHQKVHSRKCLVDSREYTHSVIHTHSISEYQRDYTGEQLYECPKCGESFIHSSFLFEHQRIHEQDQLYSMKGCDDGFIALL
PMKPRRNRAAERNPALAGSAIRCLLCGQGFIHSSALNEHMRLHREDDLLEQSQMAEEAIIPGLALTEFQRSQTEERLFECAVCGESFVNP
AELADHVTVHKNEPYEYGSSYTHTSFLTEPLKGAIPFYECKDCGKSFIHSTVLTKHKELHLEEEEEDEAAAAAAAAAQEVEANVHVPQVV
LRIQGLNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAEGPDGEAAEPIGEAGQPNGEAEQPNGDADEPDGAGIEDPEERAEEPEGKAEE
PEGDADEPDGVGIEDPEEGEDQEIQVEEPYYDCHECTETFTSSTAFSEHLKTHASMIIFEPANAFGECSGYIERASTSTGGANQADEKYF

Protein Functional Features

check buttonMain function of this protein. (from UniProt)
PEG3 (go to UniProt):Q9GZU2

check buttonRetention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
Accession_idSubsectionStartEndFuncitonal featureSplicing information
Q9GZU2Domain46128Note=SCAN box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00187Type=Deletion;Start=1;End=126
Q9GZU2Repeat13971403Note=2-1Type=Deletion;Start=551;End=1588
Q9GZU2Repeat14041410Note=2-2Type=Deletion;Start=551;End=1588
Q9GZU2Repeat14111417Note=2-3Type=Deletion;Start=551;End=1588
Q9GZU2Repeat14181422Note=1-1Type=Deletion;Start=551;End=1588
Q9GZU2Repeat14251429Note=1-2Type=Deletion;Start=551;End=1588
Q9GZU2Repeat14321436Note=1-3Type=Deletion;Start=551;End=1588
Q9GZU2Repeat14391443Note=1-4Type=Deletion;Start=551;End=1588
Q9GZU2Zinc finger563585Note=C2H2-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042Type=Deletion;Start=551;End=1588
Q9GZU2Zinc finger627649Note=C2H2-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042Type=Deletion;Start=551;End=1588
Q9GZU2Zinc finger969991Note=C2H2-type 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042Type=Deletion;Start=551;End=1588
Q9GZU2Zinc finger11071129Note=C2H2-type 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042Type=Deletion;Start=551;End=1588
Q9GZU2Zinc finger11631185Note=C2H2-type 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042Type=Deletion;Start=551;End=1588
Q9GZU2Zinc finger12251247Note=C2H2-type 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042Type=Deletion;Start=551;End=1588
Q9GZU2Zinc finger12821304Note=C2H2-type 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042Type=Deletion;Start=551;End=1588
Q9GZU2Zinc finger13321354Note=C2H2-type 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042Type=Deletion;Start=551;End=1588
Q9GZU2Zinc finger15051527Note=C2H2-type 11;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042Type=Deletion;Start=551;End=1588
Q9GZU2Zinc finger15641586Note=C2H2-type 12;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042Type=Deletion;Start=551;End=1588
Q9GZU2Region128231Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-liteType=Substitution;Start=161;End=161
Q9GZU2Region265304Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-liteType=Deletion;Start=258;End=287
Q9GZU2Region588608Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-liteType=Deletion;Start=551;End=1588
Q9GZU2Region839889Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-liteType=Deletion;Start=551;End=1588
Q9GZU2Region905929Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-liteType=Deletion;Start=551;End=1588
Q9GZU2Region10561104Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-liteType=Deletion;Start=551;End=1588
Q9GZU2Region13961495Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-liteType=Deletion;Start=551;End=1588
Q9GZU2Region13971417Note=3 X 7 AA repeat of P-E-V-E-A-A-EType=Deletion;Start=551;End=1588
Q9GZU2Region14181443Note=4 X 5 AA repeat of P-X-G-E-AType=Deletion;Start=551;End=1588
Q9GZU2Compositional bias139189Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-liteType=Substitution;Start=161;End=161
Q9GZU2Compositional bias864878Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-liteType=Deletion;Start=551;End=1588
Q9GZU2Compositional bias10561083Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-liteType=Deletion;Start=551;End=1588
Q9GZU2Compositional bias13981421Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-liteType=Deletion;Start=551;End=1588
Q9GZU2Compositional bias14471463Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-liteType=Deletion;Start=551;End=1588
Q9GZU2Compositional bias14721495Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-liteType=Deletion;Start=551;End=1588


Gene Isoform Structures and Expression Levels for PEG3

check buttonGene structures of our canonical and alternative spliced genes of PEG3
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
gene isoform structure of PEG3

check button Expression levels of gene isoforms across GTEx.
gtex expression

check button Expression levels of gene isoforms across TCGA.
tcga expression


Protein Structures

check button PDB and CIF files of the predicted protein structures
* Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
3D view using mol* of Q9GZU2-1
3D view using mol* of Q9GZU2-3
3D view using mol* of Q9GZU2-4


pLDDT Score Distribution

check button pLDDT score distribution of the predicted protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
pLDDT distribution across the protein length of Q9GZU2-1
all structure
pLDDT distribution across the protein length of Q9GZU2-3
all structure
pLDDT distribution across the protein length of Q9GZU2-4
all structure


Ramachandran Plot of Protein Structures


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide.
Ramachandran plot of Q9GZU2-1
all structure
Ramachandran plot of Q9GZU2-3
all structure
Ramachandran plot of Q9GZU2-4
all structure

Potential Active Site Information


check button The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite.
UniProt-idSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
Q9GZU2-11.0231501.071743.9670.6120.6750.8840.8380.8410.9961.2731,2,3,4,5,6,7,46,49,50,51,52,53,54,60,63,64,67,68,
71,74,86,89,90,92,93,100,103,107,1321,1322,1323,13
24,1326
Q9GZU2-31.0771081.175312.130.5990.6530.8391.8110.4823.7591.19149,64,67,68,71,72,75,77,78,80,81,82,85,86,89,285,2
88,289,292,293
Q9GZU2-40.811600.826271.9990.7860.5890.7480.3350.7850.4271.219371,372,373,374,375,376,377,378,379,380,381,391,39
2,393,1163,1179,1180,1182,1183,1184

Protein Structure and Feature Comparision


check button Protein Structure Comparision Using Template Modeling Scores (TM-score).
all structure

check button Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green)
3D view using mol* of Q9GZU2-1_Q9GZU2-1_4bhx_B.pdb

check button Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green)
3D view using mol* of Q9GZU2-1_4bhx_B_Q9GZU2-3.pdb
3D view using mol* of Q9GZU2-1_4bhx_B_Q9GZU2-4.pdb

check button Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green)
3D view using mol* of Q9GZU2-1_Q9GZU2-3.pdb
3D view using mol* of Q9GZU2-1_Q9GZU2-4.pdb

check button Protein Feature Comparison of the protein sequendary structures among the protiens.
./stats/secondary_structure/figure/Q9GZU2-1_vs_Q9GZU2-3.png
all structure<
./stats/secondary_structure/figure/Q9GZU2-1_vs_Q9GZU2-4.png
all structure<

check button Protein Feature Comparison of the relative accessible surface area (ASA) among the protiens.
./stats/relative_asa/Q9GZU2-1_vs_Q9GZU2-3.png
all structure<
./stats/relative_asa/Q9GZU2-1_vs_Q9GZU2-4.png
all structure<


Protein-Protein Interaction


check button Interactors from UniProt.
Accession_idSubsectionStartEndFuncitonal featureSplicing information


check button Interactors from STRING.
Gene nameInteractors


Related Drugs to PEG3


check button Drugs targeting this gene/protein.
(DrugBank)
UniProt accessionGene nameDrugBank IDDrug nameDrug groupActions

Related Diseases to PEG3


check button Previous studies relating to the alternative splicing of PEG3 and disease information from the MeSH term (PubMed)
GenePMIDTitleAbstractMeSH IDMeSH term


Clinically important variants in PEG3


check button (ClinVar, 04/20/2024)
accession_iduniprot_idgene_nameTypeVariantClinical_significance