ASpdb: an integrative knowledgebase of human protein isoforms from experimental and AI-predicted structures

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	Protein Summary
	AS Summary
	Protein Functional Features
	Gene Isoform Structures and Expression Levels
	Protein Structures
	pLDDT Score Distribution
	Ramachandran Plot of Protein Structures
	Potential Active Site Information
	Protein Structure and Feature Comparision
	Protein-Protein Interaction
	Related Drugs
	Related Diseases
	Clinically Important Variants

Protein:DPP8

Protein Summary

Gene summary

Gene name: DPP8
ASpdb.0 ID: 54878
	Gene
Gene symbol	DPP8
Gene ID	54878
Gene name	dipeptidyl peptidase 8
Synonyms	DP8\|DPRP-1\|DPRP1\|MST097\|MSTP097\|MSTP135\|MSTP141
Cytomap	15q22.31
Type of gene	protein-coding
Description	dipeptidyl peptidase 8DPP VIIIdipeptidyl peptidase IV-related protein 1dipeptidyl peptidase VIIIprolyl dipeptidase DPP8
Modification date	20240403
UniProtAcc	Q6V1X1

Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Gene	DPP8	GO:0005737	cytoplasm	12534281
Gene	DPP8	GO:0005829	cytosol	-
Gene	DPP8	GO:0008239	dipeptidyl-peptidase activity	31525884\|32796818\|33731929\|33731932
Gene	DPP8	GO:0043069	negative regulation of programmed cell death	32796818\|33731929\|33731932

AS Summary

Information of the canonical protein with experimentally identified structure from PDB (2023).

UniProt Acc	File name	PDB ID	Method	Resolution	Chain	Start	End
Q6V1X1-1	Q6V1X1-1_6hp8_A.pdb	6HP8	X-ray	2.5	A	48	898

ASpdb's canonical and alternatively spliced isoform information.

accession_id

gene_name

canonical_id

alternative_id

canonical_length

alternative_length

canonical_start

canonical_end

type

originalSEQ

variationSEQ

alternative_start

alternative_end

Q6V1X1

DPP8

Q6V1X1-1

Q6V1X1-2

898

847

723

773

Deletion

none

722

Q6V1X1

DPP8

Q6V1X1-1

Q6V1X1-3

898

882

Deletion

none

Q6V1X1

DPP8

Q6V1X1-1

Q6V1X1-4

898

782

Deletion

none

Q6V1X1

DPP8

Q6V1X1-1

Q6V1X1-4

898

782

674

773

Deletion

none

657

Q6V1X1

DPP8

Q6V1X1-1

Q6V1X1-5

898

849

674

722

Deletion

none

673

Q6V1X1

DPP8

Q6V1X1-1

Q6V1X1-6

898

725

358

530

Deletion

none

357

Multiple sequence alignment of our canonical and alternatively spliced DPP8

Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of DPP8

UniProt-id	ENSG	ENST	ENSP
Q6V1X1-1	ENSG00000074603.19	ENST00000341861.9	ENSP00000339208.5
Q6V1X1-1	ENSG00000074603.19	ENST00000559233.5	ENSP00000453954.1
Q6V1X1-2	ENSG00000074603.19	ENST00000321147.10	ENSP00000318111.6
Q6V1X1-3	ENSG00000074603.19	ENST00000300141.11	ENSP00000300141.6
Q6V1X1-4	ENSG00000074603.19	ENST00000358939.8	ENSP00000351817.4

UniProt-id	NM ID	NP ID
Q6V1X1-1	NM_001320875.1	NP_001307804.1
Q6V1X1-1	NM_197960.3	NP_932064.1
Q6V1X1-2	NM_197961.3	NP_932065.1
Q6V1X1-3	NM_001320876.1	NP_001307805.1
Q6V1X1-3	NM_130434.4	NP_569118.1
Q6V1X1-4	NM_017743.5	NP_060213.2

Amino acid sequences of our canonical and alternatively spliced DPP8

accession_id	Protein sequence
Q6V1X1-1	MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRND PDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLF QAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVAT FVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVI DKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIH DIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYF EGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDY TPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKY KMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGS
Q6V1X1-2	MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRND PDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLF QAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVAT FVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVI DKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIH DIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYF EGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDY TPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKY KMVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYP
Q6V1X1-3	MAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSG ENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQG FTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWC PKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVE YIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEF IFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVS YVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTL YGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQY LASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLL
Q6V1X1-4	MAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSG ENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQG FTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWC PKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVE YIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEF IFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVS YVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTL YGMLYKPHDLQPGKKYPTVLFIYGGPQVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENV
Q6V1X1-5	MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRND PDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLF QAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVAT FVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVI DKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIH DIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYF EGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDY TPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRS DIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQI
Q6V1X1-6	MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRND PDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLF QAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVAT FVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIVDE VRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDS AGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLK FEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNE QGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIA

Protein Functional Features

Main function of this protein. (from UniProt)

DPP8 (go to UniProt):Q6V1X1

Retention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Accession_id

Subsection

Start

End

Funcitonal feature

Splicing information

Gene Isoform Structures and Expression Levels for DPP8

Gene structures of our canonical and alternative spliced genes of DPP8
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Expression levels of gene isoforms across GTEx.

Expression levels of gene isoforms across TCGA.

Protein Structures

PDB and CIF files of the predicted protein structures
* Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

3D view using mol* of Q6V1X1-1

3D view using mol* of Q6V1X1-2

3D view using mol* of Q6V1X1-3

3D view using mol* of Q6V1X1-4

3D view using mol* of Q6V1X1-5

3D view using mol* of Q6V1X1-6

pLDDT Score Distribution

pLDDT score distribution of the predicted protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

pLDDT distribution across the protein length of Q6V1X1-1

pLDDT distribution across the protein length of Q6V1X1-2

pLDDT distribution across the protein length of Q6V1X1-3

pLDDT distribution across the protein length of Q6V1X1-4

pLDDT distribution across the protein length of Q6V1X1-5

pLDDT distribution across the protein length of Q6V1X1-6

Ramachandran Plot of Protein Structures

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide.

Ramachandran plot of Q6V1X1-1

Ramachandran plot of Q6V1X1-2

Ramachandran plot of Q6V1X1-4

Potential Active Site Information

The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite.

UniProt-id	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
Q6V1X1-1	1.053	839	1.074	2957.346	0.593	0.764	0.937	0.634	0.995	0.637	0.733	65,68,69,72,73,74,76,77,81,82,83,84,85,104,105,106 ,107,109,147,148,150,151,152,153,154,155,156,157,1 58,159,160,161,162,163,164,165,166,167,168,169,170 ,180,181,182,183,213,214,215,216,217,218,219,220,2 22,231,232,233,234,253,255,256,257,258,259,262,263 ,264,265,267,268,269,270,271,272,274,275,276,278,2 79,280,281,282,284,285,287,308,313,319,326,327,328 ,329,330,332,339,380,381,382,383,391,451,522,523,5 24,525,526,527,528,530,540,541,550,572,573,574,575 ,576,577,578,579,587,588,589,595,667,668,669,672,6 73,674,675,676,678,680,681,682,684,685,686,687,688 ,691,692,708,709,754,755,756,757,781,784,787,791,8 32,834,835,836,862,863,864,865,866,867,868,869,870 ,873,876,877,881
Q6V1X1-2	1.062	189	1.057	498.722	0.497	0.79	0.93	0.842	1.096	0.769	0.954	150,151,154,155,158,159,213,216,217,231,233,234,25 3,255,257,258,259,262,263,264,265,267,268,269,270, 271,274,280,281,282,308,327,328,329,330
Q6V1X1-3	1.069	188	1.032	529.935	0.512	0.801	1.005	0.624	1.191	0.524	0.93	134,135,138,139,142,143,197,198,200,201,215,216,21 7,218,237,240,241,242,243,246,247,248,249,251,252, 253,254,255,256,258,264,265,266,292,311,312,313,31 4,316,323
Q6V1X1-4	1.119	168	1.131	508.326	0.406	0.866	1.095	1.115	1.008	1.106	1.009	134,135,138,139,142,143,197,200,201,215,216,217,21 8,237,243,246,247,248,249,252,253,254,255,256,258, 264,265,266,292,311,312,313,314,316,323
Q6V1X1-5	1.054	417	1.107	1370.628	0.627	0.706	0.816	0.84	0.786	1.07	0.972	15,17,18,19,20,21,22,23,24,25,26,51,53,54,56,61,64 ,75,446,548,549,550,570,571,572,573,574,587,588,58 9,590,591,592,594,626,627,630,632,633,634,635,636, 638,642,644,645,646,647,648,649,650,651,653,654,66 2,663,664,665,666,667,668,669,670,671,672,673,676, 677,680,681,684,685,688,694,695,832,835,836,839,84 0
Q6V1X1-6	1.069	204	1.077	547.771	0.477	0.801	1.003	0.805	1.053	0.765	0.877	149,150,151,154,155,158,159,213,214,216,217,231,23 2,233,234,253,255,257,259,262,263,264,265,267,268, 269,270,271,272,274,280,281,282,308,311,327,328,32 9,330,332,339

Protein Structure and Feature Comparision

Protein Structure Comparision Using Template Modeling Scores (TM-score).

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green)

3D view using mol* of Q6V1X1-1_Q6V1X1-1_6hp8_A.pdb

Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of Q6V1X1-1_6hp8_A_Q6V1X1-2.pdb

3D view using mol* of Q6V1X1-1_6hp8_A_Q6V1X1-3.pdb

3D view using mol* of Q6V1X1-1_6hp8_A_Q6V1X1-4.pdb

3D view using mol* of Q6V1X1-1_6hp8_A_Q6V1X1-5.pdb

3D view using mol* of Q6V1X1-1_6hp8_A_Q6V1X1-6.pdb

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of Q6V1X1-1_Q6V1X1-2.pdb

3D view using mol* of Q6V1X1-1_Q6V1X1-3.pdb

3D view using mol* of Q6V1X1-1_Q6V1X1-4.pdb

3D view using mol* of Q6V1X1-1_Q6V1X1-5.pdb

3D view using mol* of Q6V1X1-1_Q6V1X1-6.pdb

Protein Feature Comparison of the protein sequendary structures among the protiens.

./stats/secondary_structure/figure/Q6V1X1-1_vs_Q6V1X1-2.png