ASpdb: an integrative knowledgebase of human protein isoforms from experimental and AI-predicted structures

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	Protein Summary
	AS Summary
	Protein Functional Features
	Gene Isoform Structures and Expression Levels
	Protein Structures
	pLDDT Score Distribution
	Ramachandran Plot of Protein Structures
	Potential Active Site Information
	Protein Structure and Feature Comparision
	Protein-Protein Interaction
	Related Drugs
	Related Diseases
	Clinically Important Variants

Protein:MICAL3

Protein Summary

Gene summary

Gene name: MICAL3
ASpdb.0 ID: 57553
	Gene
Gene symbol	MICAL3
Gene ID	57553
Gene name	microtubule associated monooxygenase, calponin and LIM domain containing 3
Synonyms	MICAL-3
Cytomap	22q11.21
Type of gene	protein-coding
Description	[F-actin]-monooxygenase MICAL3[F-actin]-methionine sulfoxide oxidase MICAL3flavoprotein oxidoreductase MICAL3molecule interacting with CasL protein 3protein MICAL-3protein-methionine sulfoxide oxidase MICAL3
Modification date	20240407
UniProtAcc	Q7RTP6

Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Gene	MICAL3	GO:0003779	actin binding	24440334
Gene	MICAL3	GO:0005634	nucleus	24440334
Gene	MICAL3	GO:0005654	nucleoplasm	-
Gene	MICAL3	GO:0005829	cytosol	-
Gene	MICAL3	GO:0005886	plasma membrane	-
Gene	MICAL3	GO:0007010	cytoskeleton organization	24440334
Gene	MICAL3	GO:0030042	actin filament depolymerization	24440334
Gene	MICAL3	GO:0045171	intercellular bridge	-
Gene	MICAL3	GO:0090543	Flemming body	-

AS Summary

Information of the canonical protein with experimentally identified structure from PDB (2023).

UniProt Acc	File name	PDB ID	Method	Resolution	Chain	Start	End
Q7RTP6-1	Q7RTP6-1_6ici_A.pdb	6ICI	X-ray	2.3	A	10	627

ASpdb's canonical and alternatively spliced isoform information.

accession_id	gene_name	canonical_id	alternative_id	canonical_length	alternative_length	canonical_start	canonical_end	type	originalSEQ	variationSEQ	alternative_start	alternative_end
Q7RTP6	MICAL3	Q7RTP6-1	Q7RTP6-2	2002	948	934	948	Substitution	SSSESEMEEEGEEEE	RSARRAAGRPPATRP	934	948
Q7RTP6	MICAL3	Q7RTP6-1	Q7RTP6-2	2002	948	949	2002	Deletion	none	none	948	948
Q7RTP6	MICAL3	Q7RTP6-1	Q7RTP6-3	2002	976	746	746	Substitution	R	RQLTQERGASQPSCCLPGQVRPAPTPRWK	746	774
Q7RTP6	MICAL3	Q7RTP6-1	Q7RTP6-3	2002	976	934	948	Substitution	SSSESEMEEEGEEEE	RSARRAAGRPPATRP	962	976
Q7RTP6	MICAL3	Q7RTP6-1	Q7RTP6-3	2002	976	949	2002	Deletion	none	none	976	976
Q7RTP6	MICAL3	Q7RTP6-1	Q7RTP6-4	2002	966	934	966	Substitution	SSSESEMEEEGEEEEEEPRLPPSDLGGVPWKEA	RDWVSPWLPRMVSNSWAQMIHPPQPPTVLGSQM	934	966
Q7RTP6	MICAL3	Q7RTP6-1	Q7RTP6-4	2002	966	967	2002	Deletion	none	none	966	966
Q7RTP6	MICAL3	Q7RTP6-1	Q7RTP6-5	2002	1073	747	747	Substitution	Q	QQREKECSRTCPKKVITLSPPPTPPPCRAHGGQQTYRDLDADNRGKQSPHHERPEPEPPRRFFVDQWELSLSLRSSARPASPSSDSLRQKYIKMYTGGVSSLAEQIANQLQRKEQPKALLDKKEL	747	871
Q7RTP6	MICAL3	Q7RTP6-1	Q7RTP6-5	2002	1073	871	949	Substitution	GVNGLEEPSIAKRLRGTPERIELENYRLSLRQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEEE	LTSLFGWVARHSLGLCDKAKGMSQHLQSNISSFGQQVAQNPLDSFFMCQLLAFGVPFLYGLSEVLVQIRGEFHWQAVAQ	995	1073
Q7RTP6	MICAL3	Q7RTP6-1	Q7RTP6-5	2002	1073	950	2002	Deletion	none	none	1073	1073

Multiple sequence alignment of our canonical and alternatively spliced MICAL3

Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of MICAL3

UniProt-id	ENSG	ENST	ENSP
Q7RTP6-1	ENSG00000243156.9	ENST00000441493.7	ENSP00000416015.2
Q7RTP6-2	ENSG00000243156.9	ENST00000383094.7	ENSP00000372574.3
Q7RTP6-3	ENSG00000243156.9	ENST00000414725.6	ENSP00000391827.2
Q7RTP6-4	ENSG00000243156.9	ENST00000400561.6	ENSP00000383406.2
Q7RTP6-5	ENSG00000243156.9	ENST00000585038.1	ENSP00000462033.1

UniProt-id	NM ID	NP ID
Q7RTP6-1	NM_015241.2	NP_056056.2
Q7RTP6-4	NM_001122731.2	NP_001116203.1
Q7RTP6-5	NM_001136004.3	NP_001129476.1

Amino acid sequences of our canonical and alternatively spliced MICAL3

accession_id	Protein sequence
Q7RTP6-1	MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYWKAKALWAKLDKRGSHKDYKKGKACTNTKCL IIGAGPCGLRTAIDLSLLGAKVVVIEKRDAFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGKLAIAITANFINRNTTAEAKVEEISGVAFIF NQKFFQELREATGIDLENIVYYKDDTHYFVMTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMDSAWMVRSWSLGTSPLEVLAERESIYRLLPQ TTPENVSKNFSQYSIDPVTRYPNINVNFLRPSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKEMASVGEPDKLSMVMYLTQFYEMFKDSLPSS DTLDLNAEEKAVLIASTRSPISFLSKLGQTISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN KVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAEGKFFHRSCFKCEYCATTLRLSAYAYDIEDG KFYCKPHYCYRLSGYAQRKRPAVAPLSGKEAKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSL RQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEEEEPRLPPSDLGGVPWKEAVRIHALLKGKSEEELEASKSFGPG NEEEEEEEEEYEEEEEEDYDEEEEESSEAGNQRLQQVMHAADPLEIQADVHWTHIREREEEERMAPASESSASGAPLDENDLEEDVDSEP AEIEGEAAEDGDPGDTGAELDDDQHWSDSPSDADRELRLPCPAEGEAELELRVSEDEEKLPASPKHQERGPSQATSPIRSPQESALLFIP VHSPSTEGPQLPPVPAATQEKSPEERLFPEPLLPKEKPKADAPSDLKAVHSPIRSQPVTLPEARTPVSPGSPQPQPPVAASTPPPSPLPI CSQPQPSTEATVPSPTQSPIRFQPAPAKTSTPLAPLPVQSQSDTKDRLGSPLAVDEALRRSDLVEEFWMKSAEIRRSLGLTPVDRSKGPE PSFPTPAFRPVSLKSYSVEKSPQDEGLHLLKPLSIPKRLGLPKPEGEPLSLPTPRSPSDRELRSAQEERRELSSSSGLGLHGSSSNMKTL GSQSFNTSDSAMLTPPSSPPPPPPPGEEPATLRRKLREAEPNASVVPPPLPATWMRPPREPAQPPREEVRKSFVESVEEIPFADDVEDTY DDKTEDSSLQEKFFTPPSCWPRPEKPRHPPLAKENGRLPALEGTLQPQKRGLPLVSAEAKELAEERMRAREKSVKSQALRDAMARQLSRM QQMELASGAPRPRKASSAPSQGKERRPDSPTRPTLRGSEEPTLKHEATSEEVLSPPSDSGGPDGSFTSSEGSSGKSKKRSSLFSPRRNKK EKKSKGEGRPPEKPSSNLLEEAAAKPKSLWKSVFSGYKKDKKKKADDKSCPSTPSSGATVDSGKHRVLPVVRAELQLRRQLSFSEDSDLS SDDVLEKSSQKSRREPRTYTEEELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLQQVEERQRRLEERGVAVEKALRGEAGMGKKDD PKLMQEWFKLVQEKNAMVRYESELMIFARELELEDRQSRLQQELRERMAVEDHLKTEEELSEEKQILNEMLEVVEQRDSLVALLEEQRLR
Q7RTP6-2	MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYWKAKALWAKLDKRGSHKDYKKGKACTNTKCL IIGAGPCGLRTAIDLSLLGAKVVVIEKRDAFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGKLAIAITANFINRNTTAEAKVEEISGVAFIF NQKFFQELREATGIDLENIVYYKDDTHYFVMTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMDSAWMVRSWSLGTSPLEVLAERESIYRLLPQ TTPENVSKNFSQYSIDPVTRYPNINVNFLRPSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKEMASVGEPDKLSMVMYLTQFYEMFKDSLPSS DTLDLNAEEKAVLIASTRSPISFLSKLGQTISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN KVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAEGKFFHRSCFKCEYCATTLRLSAYAYDIEDG KFYCKPHYCYRLSGYAQRKRPAVAPLSGKEAKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSL
Q7RTP6-3	MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYWKAKALWAKLDKRGSHKDYKKGKACTNTKCL IIGAGPCGLRTAIDLSLLGAKVVVIEKRDAFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGKLAIAITANFINRNTTAEAKVEEISGVAFIF NQKFFQELREATGIDLENIVYYKDDTHYFVMTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMDSAWMVRSWSLGTSPLEVLAERESIYRLLPQ TTPENVSKNFSQYSIDPVTRYPNINVNFLRPSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKEMASVGEPDKLSMVMYLTQFYEMFKDSLPSS DTLDLNAEEKAVLIASTRSPISFLSKLGQTISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN KVKYMATQLLAKFEENAPAQSIGIRRQLTQERGASQPSCCLPGQVRPAPTPRWKQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAEGK FFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKEAKGPLQDGATTDANGRANAVASSTERTPGSGV
Q7RTP6-4	MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYWKAKALWAKLDKRGSHKDYKKGKACTNTKCL IIGAGPCGLRTAIDLSLLGAKVVVIEKRDAFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGKLAIAITANFINRNTTAEAKVEEISGVAFIF NQKFFQELREATGIDLENIVYYKDDTHYFVMTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMDSAWMVRSWSLGTSPLEVLAERESIYRLLPQ TTPENVSKNFSQYSIDPVTRYPNINVNFLRPSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKEMASVGEPDKLSMVMYLTQFYEMFKDSLPSS DTLDLNAEEKAVLIASTRSPISFLSKLGQTISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN KVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAEGKFFHRSCFKCEYCATTLRLSAYAYDIEDG KFYCKPHYCYRLSGYAQRKRPAVAPLSGKEAKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSL
Q7RTP6-5	MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYWKAKALWAKLDKRGSHKDYKKGKACTNTKCL IIGAGPCGLRTAIDLSLLGAKVVVIEKRDAFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGKLAIAITANFINRNTTAEAKVEEISGVAFIF NQKFFQELREATGIDLENIVYYKDDTHYFVMTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMDSAWMVRSWSLGTSPLEVLAERESIYRLLPQ TTPENVSKNFSQYSIDPVTRYPNINVNFLRPSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKEMASVGEPDKLSMVMYLTQFYEMFKDSLPSS DTLDLNAEEKAVLIASTRSPISFLSKLGQTISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN KVKYMATQLLAKFEENAPAQSIGIRRQQREKECSRTCPKKVITLSPPPTPPPCRAHGGQQTYRDLDADNRGKQSPHHERPEPEPPRRFFV DQWELSLSLRSSARPASPSSDSLRQKYIKMYTGGVSSLAEQIANQLQRKEQPKALLDKKELGSMKKEFPQNLGGSDTCYFCQKRVYVMER LSAEGKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKEAKGPLQDGATTDANGRANAVASSTER

Protein Functional Features

Main function of this protein. (from UniProt)

MICAL3 (go to UniProt):Q7RTP6

Retention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Accession_id	Subsection	Start	End	Funcitonal feature	Splicing information
Q7RTP6	Domain	1841	1990	Note=BMERB;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01195	Type=Deletion;Start=949;End=2002
Q7RTP6	Domain	1841	1990	Note=BMERB;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01195	Type=Deletion;Start=949;End=2002
Q7RTP6	Domain	1841	1990	Note=BMERB;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01195	Type=Deletion;Start=967;End=2002
Q7RTP6	Domain	1841	1990	Note=BMERB;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01195	Type=Deletion;Start=950;End=2002
Q7RTP6	Region	835	883	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Substitution;Start=871;End=949
Q7RTP6	Region	907	1313	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Substitution;Start=934;End=948
Q7RTP6	Region	907	1313	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Region	907	1313	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Substitution;Start=934;End=948
Q7RTP6	Region	907	1313	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Region	907	1313	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Substitution;Start=934;End=966
Q7RTP6	Region	907	1313	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=967;End=2002
Q7RTP6	Region	907	1313	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Substitution;Start=871;End=949
Q7RTP6	Region	907	1313	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=950;End=2002
Q7RTP6	Region	1335	1776	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Region	1335	1776	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Region	1335	1776	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=967;End=2002
Q7RTP6	Region	1335	1776	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=950;End=2002
Q7RTP6	Region	1791	1821	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Region	1791	1821	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Region	1791	1821	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=967;End=2002
Q7RTP6	Region	1791	1821	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=950;End=2002
Q7RTP6	Coiled coil	1821	1992	Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=949;End=2002
Q7RTP6	Coiled coil	1821	1992	Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=949;End=2002
Q7RTP6	Coiled coil	1821	1992	Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=967;End=2002
Q7RTP6	Coiled coil	1821	1992	Ontology_term=ECO:0000255;evidence=ECO:0000255	Type=Deletion;Start=950;End=2002
Q7RTP6	Compositional bias	913	933	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Substitution;Start=871;End=949
Q7RTP6	Compositional bias	934	952	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Substitution;Start=934;End=948
Q7RTP6	Compositional bias	934	952	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	934	952	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Substitution;Start=934;End=948
Q7RTP6	Compositional bias	934	952	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	934	952	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Substitution;Start=934;End=966
Q7RTP6	Compositional bias	934	952	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Substitution;Start=871;End=949
Q7RTP6	Compositional bias	934	952	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=950;End=2002
Q7RTP6	Compositional bias	969	990	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	969	990	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	969	990	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=967;End=2002
Q7RTP6	Compositional bias	969	990	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=950;End=2002
Q7RTP6	Compositional bias	991	1017	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	991	1017	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	991	1017	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=967;End=2002
Q7RTP6	Compositional bias	991	1017	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=950;End=2002
Q7RTP6	Compositional bias	1039	1056	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1039	1056	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1039	1056	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=967;End=2002
Q7RTP6	Compositional bias	1039	1056	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=950;End=2002
Q7RTP6	Compositional bias	1068	1097	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1068	1097	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1068	1097	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=967;End=2002
Q7RTP6	Compositional bias	1068	1097	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=950;End=2002
Q7RTP6	Compositional bias	1098	1145	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1098	1145	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1098	1145	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=967;End=2002
Q7RTP6	Compositional bias	1098	1145	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=950;End=2002
Q7RTP6	Compositional bias	1148	1162	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1148	1162	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1148	1162	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=967;End=2002
Q7RTP6	Compositional bias	1148	1162	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=950;End=2002
Q7RTP6	Compositional bias	1193	1214	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1193	1214	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1193	1214	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=967;End=2002
Q7RTP6	Compositional bias	1193	1214	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=950;End=2002
Q7RTP6	Compositional bias	1237	1262	Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1237	1262	Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1237	1262	Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=967;End=2002
Q7RTP6	Compositional bias	1237	1262	Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=950;End=2002
Q7RTP6	Compositional bias	1263	1285	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1263	1285	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1263	1285	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=967;End=2002
Q7RTP6	Compositional bias	1263	1285	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=950;End=2002
Q7RTP6	Compositional bias	1293	1307	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1293	1307	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1293	1307	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=967;End=2002
Q7RTP6	Compositional bias	1293	1307	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=950;End=2002
Q7RTP6	Compositional bias	1421	1453	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1421	1453	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1421	1453	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=967;End=2002
Q7RTP6	Compositional bias	1421	1453	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=950;End=2002
Q7RTP6	Compositional bias	1454	1469	Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1454	1469	Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1454	1469	Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=967;End=2002
Q7RTP6	Compositional bias	1454	1469	Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=950;End=2002
Q7RTP6	Compositional bias	1484	1500	Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1484	1500	Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1484	1500	Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=967;End=2002
Q7RTP6	Compositional bias	1484	1500	Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=950;End=2002
Q7RTP6	Compositional bias	1501	1518	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1501	1518	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1501	1518	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=967;End=2002
Q7RTP6	Compositional bias	1501	1518	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=950;End=2002
Q7RTP6	Compositional bias	1589	1608	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1589	1608	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1589	1608	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=967;End=2002
Q7RTP6	Compositional bias	1589	1608	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=950;End=2002
Q7RTP6	Compositional bias	1638	1667	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1638	1667	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1638	1667	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=967;End=2002
Q7RTP6	Compositional bias	1638	1667	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=950;End=2002
Q7RTP6	Compositional bias	1672	1699	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1672	1699	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1672	1699	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=967;End=2002
Q7RTP6	Compositional bias	1672	1699	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=950;End=2002
Q7RTP6	Compositional bias	1744	1759	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1744	1759	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1744	1759	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=967;End=2002
Q7RTP6	Compositional bias	1744	1759	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=950;End=2002
Q7RTP6	Compositional bias	1800	1821	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1800	1821	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=949;End=2002
Q7RTP6	Compositional bias	1800	1821	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=967;End=2002
Q7RTP6	Compositional bias	1800	1821	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=950;End=2002

Gene Isoform Structures and Expression Levels for MICAL3

Gene structures of our canonical and alternative spliced genes of MICAL3
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Expression levels of gene isoforms across GTEx.

Expression levels of gene isoforms across TCGA.

Protein Structures

PDB and CIF files of the predicted protein structures
* Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

3D view using mol* of Q7RTP6-1

3D view using mol* of Q7RTP6-2

3D view using mol* of Q7RTP6-3

3D view using mol* of Q7RTP6-4

3D view using mol* of Q7RTP6-5

pLDDT Score Distribution

pLDDT score distribution of the predicted protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

pLDDT distribution across the protein length of Q7RTP6-1

pLDDT distribution across the protein length of Q7RTP6-2

pLDDT distribution across the protein length of Q7RTP6-3

pLDDT distribution across the protein length of Q7RTP6-4

pLDDT distribution across the protein length of Q7RTP6-5

Ramachandran Plot of Protein Structures

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide.

Ramachandran plot of Q7RTP6-1

Ramachandran plot of Q7RTP6-2

Ramachandran plot of Q7RTP6-3

Ramachandran plot of Q7RTP6-4

Potential Active Site Information

The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite.

UniProt-id	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
Q7RTP6-1	1.085	139	1.137	220.892	0.418	0.747	0.98	1.06	0.769	1.379	0.938	46,47,48,49,50,51,54,69,70,73,74,78,80,81,85,106,1 07,109,110,111,112,173,174,175
Q7RTP6-2	1.096	151	1.166	442.47	0.481	0.729	0.948	1.505	0.649	2.318	2.029	42,535,558,559,560,561,562,563,590,622,623,626,627 ,628,629,630,632,640,643,644,646,647,648,649,651
Q7RTP6-3	1.077	131	1.123	220.549	0.418	0.749	0.932	1.259	0.815	1.544	1.197	46,47,48,49,50,51,54,69,70,73,74,80,81,82,85,106,1 07,109,110,111,112,173,174,175
Q7RTP6-4	1.091	144	1.123	222.95	0.311	0.793	1.086	1.266	0.899	1.408	1.191	46,47,48,49,50,51,54,69,70,73,74,80,81,82,85,106,1 07,109,110,111,112,173,174,175,176
Q7RTP6-5	1.105	137	1.159	243.187	0.374	0.77	1.021	1.506	0.744	2.024	1.258	46,47,48,49,50,51,69,70,73,74,80,81,82,85,106,107, 109,110,111,112,173,174,175,176

Protein Structure and Feature Comparision

Protein Structure Comparision Using Template Modeling Scores (TM-score).

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green)

3D view using mol* of Q7RTP6-1_Q7RTP6-1_6ici_A.pdb

Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of Q7RTP6-1_6ici_A_Q7RTP6-2.pdb

3D view using mol* of Q7RTP6-1_6ici_A_Q7RTP6-3.pdb

3D view using mol* of Q7RTP6-1_6ici_A_Q7RTP6-4.pdb

3D view using mol* of Q7RTP6-1_6ici_A_Q7RTP6-5.pdb

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of Q7RTP6-1_Q7RTP6-2.pdb

3D view using mol* of Q7RTP6-1_Q7RTP6-3.pdb

3D view using mol* of Q7RTP6-1_Q7RTP6-4.pdb

3D view using mol* of Q7RTP6-1_Q7RTP6-5.pdb

Protein Feature Comparison of the protein sequendary structures among the protiens.

./stats/secondary_structure/figure/Q7RTP6-1_vs_Q7RTP6-2.png