Protein:TCF4 |
Protein Summary |
 Gene summary |
| Gene name: TCF4 | ASpdb.0 ID: 6925 | Gene | Gene symbol | TCF4 | Gene ID | 6925 |
| Gene name | transcription factor 4 |
| Synonyms | CDG2T|E2-2|FCD2|FECD3|ITF-2|ITF2|PTHS|SEF-2|SEF2|SEF2-1|SEF2-1A|SEF2-1B|SEF2-1D|TCF-4|bHLHb19 |
| Cytomap | 18q21.2 |
| Type of gene | protein-coding |
| Description | transcription factor 4SL3-3 enhancer factor 2class B basic helix-loop-helix protein 19immunoglobulin transcription factor 2 |
| Modification date | 20240411 |
| UniProtAcc | P15884 |
| Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Gene | TCF4 | GO:0000785 | chromatin | 21880741 |
| Gene | TCF4 | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | 12651860 |
| Gene | TCF4 | GO:0003677 | DNA binding | 1681116 |
| Gene | TCF4 | GO:0003700 | DNA-binding transcription factor activity | 2105528|11802795 |
| Gene | TCF4 | GO:0005634 | nucleus | 1681116|21828274 |
| Gene | TCF4 | GO:0045893 | positive regulation of DNA-templated transcription | 2105528|12651860 |
| Gene | TCF4 | GO:0070369 | beta-catenin-TCF7L2 complex | 12651860 |
| Gene | TCF4 | GO:1990837 | sequence-specific double-stranded DNA binding | 28473536 |
AS Summary |
| Information of the canonical protein with experimentally identified structure from PDB (2023). |
| UniProt Acc | File name | PDB ID | Method | Resolution | Chain | Start | End |
| P15884-1 | P15884-1_6od3_A.pdb | 6OD3 | X-ray | 1.49 | A | 565 | 624 |
| ASpdb's canonical and alternatively spliced isoform information. |
| accession_id | gene_name | canonical_id | alternative_id | canonical_length | alternative_length | canonical_start | canonical_end | type | originalSEQ | variationSEQ | alternative_start | alternative_end |
| P15884 | TCF4 | P15884-1 | P15884-10 | 667 | 625 | 1 | 49 | Substitution | MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSN | MEEDSRD | 1 | 7 |
| P15884 | TCF4 | P15884-1 | P15884-11 | 667 | 600 | 1 | 102 | Substitution | MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQS | MKDIFFQFIIARVRKCYSLSCLHTLPVVPTLR | 1 | 32 |
| P15884 | TCF4 | P15884-1 | P15884-11 | 667 | 600 | 123 | 123 | Deletion | none | none | 52 | 52 |
| P15884 | TCF4 | P15884-1 | P15884-11 | 667 | 600 | 545 | 545 | Substitution | T | TRSRS | 474 | 478 |
| P15884 | TCF4 | P15884-1 | P15884-12 | 667 | 664 | 1 | 24 | Substitution | MHHQQRMAALGTDKELSDLLDFSA | MQRAKTELFRLQIVTDDLRKNE | 1 | 22 |
| P15884 | TCF4 | P15884-1 | P15884-12 | 667 | 664 | 357 | 357 | Deletion | none | none | 354 | 354 |
| P15884 | TCF4 | P15884-1 | P15884-13 | 667 | 647 | 1 | 24 | Deletion | none | none | 0 | 0 |
| P15884 | TCF4 | P15884-1 | P15884-13 | 667 | 647 | 545 | 545 | Substitution | T | TRSRS | 521 | 525 |
| P15884 | TCF4 | P15884-1 | P15884-14 | 667 | 643 | 1 | 24 | Deletion | none | none | 0 | 0 |
| P15884 | TCF4 | P15884-1 | P15884-15 | 667 | 583 | 1 | 24 | Deletion | none | none | 0 | 0 |
| P15884 | TCF4 | P15884-1 | P15884-15 | 667 | 583 | 124 | 183 | Deletion | none | none | 99 | 99 |
| P15884 | TCF4 | P15884-1 | P15884-16 | 667 | 451 | 1 | 216 | Deletion | none | none | 0 | 0 |
| P15884 | TCF4 | P15884-1 | P15884-2 | 667 | 511 | 1 | 160 | Deletion | none | none | 0 | 0 |
| P15884 | TCF4 | P15884-1 | P15884-2 | 667 | 511 | 161 | 183 | Substitution | LHSSAMEVQTKKVRKVPPGLPSS | MYCAYTIPGMGGNSLMYYYNGKA | 1 | 23 |
| P15884 | TCF4 | P15884-1 | P15884-2 | 667 | 511 | 545 | 545 | Substitution | T | TRSRS | 385 | 389 |
| P15884 | TCF4 | P15884-1 | P15884-3 | 667 | 671 | 545 | 545 | Substitution | T | TRSRS | 545 | 549 |
| P15884 | TCF4 | P15884-1 | P15884-4 | 667 | 611 | 124 | 183 | Deletion | none | none | 123 | 123 |
| P15884 | TCF4 | P15884-1 | P15884-4 | 667 | 611 | 545 | 545 | Substitution | T | TRSRS | 485 | 489 |
| P15884 | TCF4 | P15884-1 | P15884-5 | 667 | 607 | 124 | 183 | Deletion | none | none | 123 | 123 |
| P15884 | TCF4 | P15884-1 | P15884-6 | 667 | 507 | 1 | 23 | Substitution | MHHQQRMAALGTDKELSDLLDFS | MYCAYTIPGMGGNSLMYYYNGKA | 1 | 23 |
| P15884 | TCF4 | P15884-1 | P15884-6 | 667 | 507 | 24 | 123 | Deletion | none | none | 23 | 23 |
| P15884 | TCF4 | P15884-1 | P15884-6 | 667 | 507 | 124 | 183 | Deletion | none | none | 23 | 23 |
| P15884 | TCF4 | P15884-1 | P15884-7 | 667 | 596 | 1 | 32 | Substitution | MHHQQRMAALGTDKELSDLLDFSAMFSPPVSS | MKDIFFQFIIARVRKCYSLSCLHTLPVVPTLR | 1 | 32 |
| P15884 | TCF4 | P15884-1 | P15884-7 | 667 | 596 | 33 | 102 | Deletion | none | none | 32 | 32 |
| P15884 | TCF4 | P15884-1 | P15884-7 | 667 | 596 | 123 | 123 | Deletion | none | none | 52 | 52 |
| P15884 | TCF4 | P15884-1 | P15884-8 | 667 | 507 | 1 | 23 | Substitution | MHHQQRMAALGTDKELSDLLDFS | MKFKQCRCSDTGLCCLDHEGKAE | 1 | 23 |
| P15884 | TCF4 | P15884-1 | P15884-8 | 667 | 507 | 24 | 183 | Deletion | none | none | 23 | 23 |
| P15884 | TCF4 | P15884-1 | P15884-9 | 667 | 537 | 1 | 130 | Deletion | none | none | 0 | 0 |
| Multiple sequence alignment of our canonical and alternatively spliced TCF4 |
| Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of TCF4 |
| UniProt-id | ENSG | ENST | ENSP |
| P15884-1 | ENSG00000196628.20 | ENST00000356073.8 | ENSP00000348374.4 |
| P15884-1 | ENSG00000196628.20 | ENST00000564999.5 | ENSP00000457649.1 |
| P15884-10 | ENSG00000196628.20 | ENST00000543082.5 | ENSP00000439656.1 |
| P15884-11 | ENSG00000196628.20 | ENST00000544241.6 | ENSP00000441562.2 |
| P15884-12 | ENSG00000196628.20 | ENST00000566286.5 | ENSP00000455418.2 |
| P15884-13 | ENSG00000196628.20 | ENST00000537578.5 | ENSP00000440731.1 |
| P15884-13 | ENSG00000196628.20 | ENST00000568673.5 | ENSP00000455135.1 |
| P15884-13 | ENSG00000196628.20 | ENST00000636400.2 | ENSP00000490006.1 |
| P15884-14 | ENSG00000196628.20 | ENST00000540999.5 | ENSP00000445202.1 |
| P15884-15 | ENSG00000196628.20 | ENST00000565018.6 | ENSP00000455984.2 |
| P15884-15 | ENSG00000196628.20 | ENST00000616053.4 | ENSP00000478549.1 |
| P15884-16 | ENSG00000196628.20 | ENST00000626584.2 | ENSP00000486072.1 |
| P15884-2 | ENSG00000196628.20 | ENST00000457482.7 | ENSP00000409447.2 |
| P15884-3 | ENSG00000196628.20 | ENST00000354452.8 | ENSP00000346440.3 |
| P15884-3 | ENSG00000196628.20 | ENST00000629387.2 | ENSP00000486670.1 |
| P15884-4 | ENSG00000196628.20 | ENST00000566279.5 | ENSP00000456125.1 |
| P15884-5 | ENSG00000196628.20 | ENST00000567880.5 | ENSP00000454366.1 |
| P15884-6 | ENSG00000196628.20 | ENST00000570287.6 | ENSP00000455763.1 |
| P15884-7 | ENSG00000196628.20 | ENST00000564228.5 | ENSP00000455261.1 |
| P15884-8 | ENSG00000196628.20 | ENST00000561831.7 | ENSP00000457765.1 |
| P15884-9 | ENSG00000196628.20 | ENST00000537856.7 | ENSP00000439827.2 |
| P15884-9 | ENSG00000196628.20 | ENST00000561992.5 | ENSP00000455179.1 |
| P15884-9 | ENSG00000196628.20 | ENST00000570177.6 | ENSP00000454647.1 |
| UniProt-id | NM ID | NP ID |
| P15884-1 | NM_003199.2 | NP_003190.1 |
| P15884-10 | NM_001243231.1 | NP_001230160.1 |
| P15884-11 | NM_001243232.1 | NP_001230161.1 |
| P15884-12 | NM_001243230.1 | NP_001230159.1 |
| P15884-13 | NM_001243227.1 | NP_001230156.1 |
| P15884-13 | NM_001348217.1 | NP_001335146.1 |
| P15884-13 | NM_001348218.1 | NP_001335147.1 |
| P15884-14 | NM_001306207.1 | NP_001293136.1 |
| P15884-14 | NM_001348219.1 | NP_001335148.1 |
| P15884-2 | NM_001243234.1 | NP_001230163.1 |
| P15884-3 | NM_001083962.1 | NP_001077431.1 |
| P15884-6 | NM_001243235.1 | NP_001230164.1 |
| P15884-7 | NM_001306208.1 | NP_001293137.1 |
| P15884-8 | NM_001243236.1 | NP_001230165.1 |
| P15884-9 | NM_001243233.1 | NP_001230162.1 |
| P15884-9 | NM_001348212.1 | NP_001335141.1 |
| Amino acid sequences of our canonical and alternatively spliced TCF4 |
| accession_id | Protein sequence |
| P15884-1 | MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDN LSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGL PSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSS ADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTA VWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAMPGGHGDMHGIIGPSHNGAMGGLGSGYGTGLLSANRHSLM VGTHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKD IKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKA |
| P15884-10 | MEEDSRDVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQQSLLGGDMD MGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHH SSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGS GAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRN HAVGPSTAMPGGHGDMHGIIGPSHNGAMGGLGSGYGTGLLSANRHSLMVGTHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQD PYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINE |
| P15884-11 | MKDIFFQFIIARVRKCYSLSCLHTLPVVPTLRKTERGSYSSYGRESNLQGCHQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPL HSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQS SSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNSF SSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAMPGGHGDMHGIIGPSHNGAMG GLGSGYGTGLLSANRHSLMVGTHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDE NLQDTKSSEDKKLDDDKKDIKSITRSRSSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLIL |
| P15884-12 | MQRAKTELFRLQIVTDDLRKNEMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLS PPFVNSRIQSKTERGSYSSYGRESNLQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGLPS SVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSSAD INSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSGTAVWS RNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAMPGGHGDMHGIIGPSHNGAMGGLGSGYGTGLLSANRHSLMVGT HREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKS ITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACL |
| P15884-13 | MFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGR ESNLQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSS KPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTS SCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQS RIEDRLERLDDAIHVLRNHAVGPSTAMPGGHGDMHGIIGPSHNGAMGGLGSGYGTGLLSANRHSLMVGTHREDGVALRGSHSLLPNQVPV PQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITRSRSSNNDDEDLTPEQKAE REKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSL |
| P15884-14 | MFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGR ESNLQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSS KPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTS SCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQS RIEDRLERLDDAIHVLRNHAVGPSTAMPGGHGDMHGIIGPSHNGAMGGLGSGYGTGLLSANRHSLMVGTHREDGVALRGSHSLLPNQVPV PQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITSNNDDEDLTPEQKAEREKE RRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPH |
| P15884-15 | MFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGR ESNLQGCHQVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLS YPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPS LSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAMPGGHGDMHGIIGPSHNGAMGGLGSGYGTGLLSA NRHSLMVGTHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKL DDDKKDIKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRER |
| P15884-16 | MQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSI MANRGSGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDA IHVLRNHAVGPSTAMPGGHGDMHGIIGPSHNGAMGGLGSGYGTGLLSANRHSLMVGTHREDGVALRGSHSLLPNQVPVPQLPVQSATSPD LNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITSNNDDEDLTPEQKAEREKERRMANNARERLR VRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDASNHMGQ |
| P15884-2 | MYCAYTIPGMGGNSLMYYYNGKAVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQ SSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNS FSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAMPGGHGDMHGIIGPSHNGAM GGLGSGYGTGLLSANRHSLMVGTHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGD ENLQDTKSSEDKKLDDDKKDIKSITRSRSSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLI |
| P15884-3 | MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDN LSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGL PSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSS ADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTA VWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAMPGGHGDMHGIIGPSHNGAMGGLGSGYGTGLLSANRHSLM VGTHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKD IKSITRSRSSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNL |
| P15884-4 | MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDN LSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAG MLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALAS IYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAMPGGHGDMHG IIGPSHNGAMGGLGSGYGTGLLSANRHSLMVGTHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGS SEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITRSRSSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLK |
| P15884-5 | MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDN LSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAG MLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALAS IYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAMPGGHGDMHG IIGPSHNGAMGGLGSGYGTGLLSANRHSLMVGTHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGS SEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKP |
| P15884-6 | MYCAYTIPGMGGNSLMYYYNGKAVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQ SSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNS FSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAMPGGHGDMHGIIGPSHNGAM GGLGSGYGTGLLSANRHSLMVGTHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGD ENLQDTKSSEDKKLDDDKKDIKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQA |
| P15884-7 | MKDIFFQFIIARVRKCYSLSCLHTLPVVPTLRKTERGSYSSYGRESNLQGCHQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPL HSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQS SSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNSF SSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAMPGGHGDMHGIIGPSHNGAMG GLGSGYGTGLLSANRHSLMVGTHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDE NLQDTKSSEDKKLDDDKKDIKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAV |
| P15884-8 | MKFKQCRCSDTGLCCLDHEGKAEVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQ SSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNS FSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAMPGGHGDMHGIIGPSHNGAM GGLGSGYGTGLLSANRHSLMVGTHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGD ENLQDTKSSEDKKLDDDKKDIKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQA |
| P15884-9 | MDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDG HHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANR GSGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVL RNHAVGPSTAMPGGHGDMHGIIGPSHNGAMGGLGSGYGTGLLSANRHSLMVGTHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPP QDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDI |
Protein Functional Features |
| Main function of this protein. (from UniProt) |
| TCF4 (go to UniProt):P15884 |
| Retention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Accession_id | Subsection | Start | End | Funcitonal feature | Splicing information |
| P15884 | Region | 1 | 83 | Note=Essential for MYOD1 inhibition;Ontology_term=ECO:0000250;evidence=ECO:0000250 | Type=Substitution;Start=1;End=49 |
| P15884 | Region | 1 | 83 | Note=Essential for MYOD1 inhibition;Ontology_term=ECO:0000250;evidence=ECO:0000250 | Type=Substitution;Start=1;End=102 |
| P15884 | Region | 1 | 83 | Note=Essential for MYOD1 inhibition;Ontology_term=ECO:0000250;evidence=ECO:0000250 | Type=Substitution;Start=1;End=24 |
| P15884 | Region | 1 | 83 | Note=Essential for MYOD1 inhibition;Ontology_term=ECO:0000250;evidence=ECO:0000250 | Type=Deletion;Start=1;End=24 |
| P15884 | Region | 1 | 83 | Note=Essential for MYOD1 inhibition;Ontology_term=ECO:0000250;evidence=ECO:0000250 | Type=Deletion;Start=1;End=24 |
| P15884 | Region | 1 | 83 | Note=Essential for MYOD1 inhibition;Ontology_term=ECO:0000250;evidence=ECO:0000250 | Type=Deletion;Start=1;End=24 |
| P15884 | Region | 1 | 83 | Note=Essential for MYOD1 inhibition;Ontology_term=ECO:0000250;evidence=ECO:0000250 | Type=Deletion;Start=1;End=216 |
| P15884 | Region | 1 | 83 | Note=Essential for MYOD1 inhibition;Ontology_term=ECO:0000250;evidence=ECO:0000250 | Type=Deletion;Start=1;End=160 |
| P15884 | Region | 1 | 83 | Note=Essential for MYOD1 inhibition;Ontology_term=ECO:0000250;evidence=ECO:0000250 | Type=Substitution;Start=1;End=23 |
| P15884 | Region | 1 | 83 | Note=Essential for MYOD1 inhibition;Ontology_term=ECO:0000250;evidence=ECO:0000250 | Type=Deletion;Start=24;End=123 |
| P15884 | Region | 1 | 83 | Note=Essential for MYOD1 inhibition;Ontology_term=ECO:0000250;evidence=ECO:0000250 | Type=Substitution;Start=1;End=32 |
| P15884 | Region | 1 | 83 | Note=Essential for MYOD1 inhibition;Ontology_term=ECO:0000250;evidence=ECO:0000250 | Type=Deletion;Start=33;End=102 |
| P15884 | Region | 1 | 83 | Note=Essential for MYOD1 inhibition;Ontology_term=ECO:0000250;evidence=ECO:0000250 | Type=Substitution;Start=1;End=23 |
| P15884 | Region | 1 | 83 | Note=Essential for MYOD1 inhibition;Ontology_term=ECO:0000250;evidence=ECO:0000250 | Type=Deletion;Start=24;End=183 |
| P15884 | Region | 1 | 83 | Note=Essential for MYOD1 inhibition;Ontology_term=ECO:0000250;evidence=ECO:0000250 | Type=Deletion;Start=1;End=130 |
| P15884 | Region | 24 | 245 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=1;End=49 |
| P15884 | Region | 24 | 245 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=1;End=102 |
| P15884 | Region | 24 | 245 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=123;End=123 |
| P15884 | Region | 24 | 245 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=1;End=24 |
| P15884 | Region | 24 | 245 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=24 |
| P15884 | Region | 24 | 245 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=24 |
| P15884 | Region | 24 | 245 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=24 |
| P15884 | Region | 24 | 245 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=124;End=183 |
| P15884 | Region | 24 | 245 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=216 |
| P15884 | Region | 24 | 245 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=160 |
| P15884 | Region | 24 | 245 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=161;End=183 |
| P15884 | Region | 24 | 245 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=124;End=183 |
| P15884 | Region | 24 | 245 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=124;End=183 |
| P15884 | Region | 24 | 245 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=24;End=123 |
| P15884 | Region | 24 | 245 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=124;End=183 |
| P15884 | Region | 24 | 245 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=1;End=32 |
| P15884 | Region | 24 | 245 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=33;End=102 |
| P15884 | Region | 24 | 245 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=123;End=123 |
| P15884 | Region | 24 | 245 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=24;End=183 |
| P15884 | Region | 24 | 245 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=130 |
| P15884 | Region | 336 | 379 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=357;End=357 |
| P15884 | Region | 466 | 570 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=545;End=545 |
| P15884 | Region | 466 | 570 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=545;End=545 |
| P15884 | Region | 466 | 570 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=545;End=545 |
| P15884 | Region | 466 | 570 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=545;End=545 |
| P15884 | Region | 466 | 570 | Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=545;End=545 |
| P15884 | Motif | 18 | 26 | Note=9aaTAD | Type=Substitution;Start=1;End=49 |
| P15884 | Motif | 18 | 26 | Note=9aaTAD | Type=Substitution;Start=1;End=102 |
| P15884 | Motif | 18 | 26 | Note=9aaTAD | Type=Substitution;Start=1;End=24 |
| P15884 | Motif | 18 | 26 | Note=9aaTAD | Type=Deletion;Start=1;End=24 |
| P15884 | Motif | 18 | 26 | Note=9aaTAD | Type=Deletion;Start=1;End=24 |
| P15884 | Motif | 18 | 26 | Note=9aaTAD | Type=Deletion;Start=1;End=24 |
| P15884 | Motif | 18 | 26 | Note=9aaTAD | Type=Deletion;Start=1;End=216 |
| P15884 | Motif | 18 | 26 | Note=9aaTAD | Type=Deletion;Start=1;End=160 |
| P15884 | Motif | 18 | 26 | Note=9aaTAD | Type=Substitution;Start=1;End=23 |
| P15884 | Motif | 18 | 26 | Note=9aaTAD | Type=Deletion;Start=24;End=123 |
| P15884 | Motif | 18 | 26 | Note=9aaTAD | Type=Substitution;Start=1;End=32 |
| P15884 | Motif | 18 | 26 | Note=9aaTAD | Type=Substitution;Start=1;End=23 |
| P15884 | Motif | 18 | 26 | Note=9aaTAD | Type=Deletion;Start=24;End=183 |
| P15884 | Motif | 18 | 26 | Note=9aaTAD | Type=Deletion;Start=1;End=130 |
| P15884 | Compositional bias | 28 | 65 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=1;End=49 |
| P15884 | Compositional bias | 28 | 65 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=1;End=102 |
| P15884 | Compositional bias | 28 | 65 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=216 |
| P15884 | Compositional bias | 28 | 65 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=160 |
| P15884 | Compositional bias | 28 | 65 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=24;End=123 |
| P15884 | Compositional bias | 28 | 65 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=1;End=32 |
| P15884 | Compositional bias | 28 | 65 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=33;End=102 |
| P15884 | Compositional bias | 28 | 65 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=24;End=183 |
| P15884 | Compositional bias | 28 | 65 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=130 |
| P15884 | Compositional bias | 86 | 124 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=1;End=102 |
| P15884 | Compositional bias | 86 | 124 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=123;End=123 |
| P15884 | Compositional bias | 86 | 124 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=124;End=183 |
| P15884 | Compositional bias | 86 | 124 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=216 |
| P15884 | Compositional bias | 86 | 124 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=160 |
| P15884 | Compositional bias | 86 | 124 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=124;End=183 |
| P15884 | Compositional bias | 86 | 124 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=124;End=183 |
| P15884 | Compositional bias | 86 | 124 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=24;End=123 |
| P15884 | Compositional bias | 86 | 124 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=124;End=183 |
| P15884 | Compositional bias | 86 | 124 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=33;End=102 |
| P15884 | Compositional bias | 86 | 124 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=123;End=123 |
| P15884 | Compositional bias | 86 | 124 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=24;End=183 |
| P15884 | Compositional bias | 86 | 124 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=130 |
| P15884 | Compositional bias | 139 | 160 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=124;End=183 |
| P15884 | Compositional bias | 139 | 160 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=216 |
| P15884 | Compositional bias | 139 | 160 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=160 |
| P15884 | Compositional bias | 139 | 160 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=124;End=183 |
| P15884 | Compositional bias | 139 | 160 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=124;End=183 |
| P15884 | Compositional bias | 139 | 160 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=124;End=183 |
| P15884 | Compositional bias | 139 | 160 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=24;End=183 |
| P15884 | Compositional bias | 184 | 245 | Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Deletion;Start=1;End=216 |
| P15884 | Compositional bias | 513 | 570 | Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=545;End=545 |
| P15884 | Compositional bias | 513 | 570 | Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=545;End=545 |
| P15884 | Compositional bias | 513 | 570 | Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=545;End=545 |
| P15884 | Compositional bias | 513 | 570 | Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=545;End=545 |
| P15884 | Compositional bias | 513 | 570 | Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite | Type=Substitution;Start=545;End=545 |
Gene Isoform Structures and Expression Levels for TCF4 |
| Gene structures of our canonical and alternative spliced genes of TCF4 * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Expression levels of gene isoforms across GTEx. |
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| Expression levels of gene isoforms across TCGA. |
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Protein Structures |
| PDB and CIF files of the predicted protein structures * Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| 3D view using mol* of P15884-1 |
| 3D view using mol* of P15884-10 |
| 3D view using mol* of P15884-11 |
| 3D view using mol* of P15884-12 |
| 3D view using mol* of P15884-13 |
| 3D view using mol* of P15884-14 |
| 3D view using mol* of P15884-15 |
| 3D view using mol* of P15884-16 |
| 3D view using mol* of P15884-2 |
| 3D view using mol* of P15884-3 |
| 3D view using mol* of P15884-4 |
| 3D view using mol* of P15884-5 |
| 3D view using mol* of P15884-6 |
| 3D view using mol* of P15884-7 |
| 3D view using mol* of P15884-8 |
| 3D view using mol* of P15884-9 |
pLDDT Score Distribution |
| pLDDT score distribution of the predicted protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
| pLDDT distribution across the protein length of P15884-1 |
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| pLDDT distribution across the protein length of P15884-10 |
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| pLDDT distribution across the protein length of P15884-11 |
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| pLDDT distribution across the protein length of P15884-12 |
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| pLDDT distribution across the protein length of P15884-13 |
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| pLDDT distribution across the protein length of P15884-14 |
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| pLDDT distribution across the protein length of P15884-15 |
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| pLDDT distribution across the protein length of P15884-16 |
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| pLDDT distribution across the protein length of P15884-2 |
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| pLDDT distribution across the protein length of P15884-3 |
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| pLDDT distribution across the protein length of P15884-4 |
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| pLDDT distribution across the protein length of P15884-5 |
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| pLDDT distribution across the protein length of P15884-6 |
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| pLDDT distribution across the protein length of P15884-7 |
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| pLDDT distribution across the protein length of P15884-8 |
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| pLDDT distribution across the protein length of P15884-9 |
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Ramachandran Plot of Protein Structures |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide. |
| Ramachandran plot of P15884-1 |
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| Ramachandran plot of P15884-10 |
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| Ramachandran plot of P15884-13 |
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| Ramachandran plot of P15884-14 |
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| Ramachandran plot of P15884-16 |
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| Ramachandran plot of P15884-2 |
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| Ramachandran plot of P15884-3 |
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| Ramachandran plot of P15884-6 |
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| Ramachandran plot of P15884-7 |
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| Ramachandran plot of P15884-8 |
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| Ramachandran plot of P15884-9 |
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Potential Active Site Information |
| The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite. |
| UniProt-id | Site score | Size | D score | Volume | Exposure | Enclosure | Contact | Phobic | Philic | Balance | Don/Acc | Residues |
| P15884-1 | 0.607 | 19 | 0.602 | 41.846 | 0.776 | 0.553 | 0.75 | 1.065 | 0.429 | 2.482 | 1.302 | 623,624,627,630,631,634
|
| P15884-10 | 0.609 | 20 | 0.586 | 42.189 | 0.643 | 0.583 | 0.894 | 1.312 | 0.565 | 2.323 | 0.555 | 357,358,361,362,400,401,402,403,404
|
| P15884-11 | 1.079 | 79 | 1.19 | 202.027 | 0.566 | 0.693 | 0.907 | 2.931 | 0.187 | 15.635 | 1.114 | 2,5,6,8,9,12,13,16,17,509,513,515,516,517,519,520, 540,543,544,547,548 |
| P15884-12 | 0.599 | 18 | 0.564 | 84.378 | 0.769 | 0.605 | 0.835 | 0.449 | 0.607 | 0.739 | 1.337 | 31,32,547,552,555,558,559
|
| P15884-13 | 0.708 | 19 | 0.731 | 34.643 | 0.587 | 0.633 | 0.91 | 3.345 | 0.18 | 18.578 | 0.582 | 567,570,571,574,590,593,594,597
|
| P15884-14 | 0.594 | 17 | 0.608 | 34.3 | 0.79 | 0.515 | 0.69 | 1.323 | 0.271 | 4.872 | 1.507 | 599,600,603,606,607,610,611
|
| P15884-15 | 0.541 | 16 | 0.523 | 38.416 | 0.792 | 0.512 | 0.645 | 0.851 | 0.492 | 1.727 | 0.472 | 539,540,543,546,547,550
|
| P15884-16 | 0.668 | 19 | 0.703 | 34.3 | 0.683 | 0.556 | 0.69 | 2.557 | 0.123 | 20.762 | 0.131 | 371,374,375,378,394,397,398,401
|
| P15884-2 | 0.712 | 44 | 0.601 | 85.75 | 0.6 | 0.636 | 1.025 | 0.298 | 1.238 | 0.241 | 0.817 | 5,6,7,8,9,10,12,13,14,15,16,25
|
| P15884-3 | 0.509 | 8 | 0.463 | 21.609 | 0.692 | 0.588 | 0.922 | 0.916 | 0.477 | 1.92 | 1.3 | 598,599,617,620,621,624
|
| P15884-4 | 0.502 | 23 | 0.385 | 37.73 | 0.744 | 0.525 | 0.796 | 0.1 | 1.166 | 0.086 | 0.243 | 301,302,303,304,385,387,388,389
|
| P15884-5 | 0.631 | 14 | 0.638 | 29.155 | 0.632 | 0.595 | 0.824 | 2.649 | 0.216 | 12.251 | 0.51 | 527,530,531,534,550,553,554
|
| P15884-6 | 0.735 | 48 | 0.666 | 95.697 | 0.583 | 0.638 | 0.966 | 0.332 | 1.128 | 0.294 | 0.927 | 5,6,7,8,9,10,12,13,14,15,16,25
|
| P15884-7 | 1.112 | 84 | 1.223 | 233.583 | 0.565 | 0.72 | 0.918 | 2.905 | 0.216 | 13.424 | 1.128 | 1,2,5,6,8,9,12,13,16,17,505,508,509,512,513,515,51 6,536,539,540,543,544 |
| P15884-8 | 0.494 | 17 | 0.45 | 24.353 | 0.828 | 0.491 | 0.721 | 0.59 | 0.713 | 0.827 | 0.703 | 2,3,4,5,16,17,18
|
| P15884-9 | 0.52 | 9 | 0.464 | 19.894 | 0.64 | 0.61 | 0.997 | 1.724 | 0.565 | 3.051 | 3.25 | 464,465,483,486,487,490
|
Protein Structure and Feature Comparision |
| Protein Structure Comparision Using Template Modeling Scores (TM-score). |
 |
| Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green) |
| 3D view using mol* of P15884-1_P15884-1_6od3_A.pdb |
| Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green) |
| 3D view using mol* of P15884-1_6od3_A_P15884-10.pdb |
| 3D view using mol* of P15884-1_6od3_A_P15884-11.pdb |
| 3D view using mol* of P15884-1_6od3_A_P15884-12.pdb |
| 3D view using mol* of P15884-1_6od3_A_P15884-13.pdb |
| 3D view using mol* of P15884-1_6od3_A_P15884-14.pdb |
| 3D view using mol* of P15884-1_6od3_A_P15884-15.pdb |
| 3D view using mol* of P15884-1_6od3_A_P15884-16.pdb |
| 3D view using mol* of P15884-1_6od3_A_P15884-2.pdb |
| 3D view using mol* of P15884-1_6od3_A_P15884-3.pdb |
| 3D view using mol* of P15884-1_6od3_A_P15884-4.pdb |
| 3D view using mol* of P15884-1_6od3_A_P15884-5.pdb |
| 3D view using mol* of P15884-1_6od3_A_P15884-6.pdb |
| 3D view using mol* of P15884-1_6od3_A_P15884-7.pdb |
| 3D view using mol* of P15884-1_6od3_A_P15884-8.pdb |
| 3D view using mol* of P15884-1_6od3_A_P15884-9.pdb |
| Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green) |
| 3D view using mol* of P15884-1_P15884-10.pdb |
| 3D view using mol* of P15884-1_P15884-11.pdb |
| 3D view using mol* of P15884-1_P15884-12.pdb |
| 3D view using mol* of P15884-1_P15884-13.pdb |
| 3D view using mol* of P15884-1_P15884-14.pdb |
| 3D view using mol* of P15884-1_P15884-15.pdb |
| 3D view using mol* of P15884-1_P15884-16.pdb |
| 3D view using mol* of P15884-1_P15884-2.pdb |
| 3D view using mol* of P15884-1_P15884-3.pdb |
| 3D view using mol* of P15884-1_P15884-4.pdb |
| 3D view using mol* of P15884-1_P15884-5.pdb |
| 3D view using mol* of P15884-1_P15884-6.pdb |
| 3D view using mol* of P15884-1_P15884-7.pdb |
| 3D view using mol* of P15884-1_P15884-8.pdb |
| 3D view using mol* of P15884-1_P15884-9.pdb |
| Protein Feature Comparison of the protein sequendary structures among the protiens. |
| ./stats/secondary_structure/figure/P15884-1_vs_P15884-10.png |
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| ./stats/secondary_structure/figure/P15884-1_vs_P15884-11.png |
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| ./stats/secondary_structure/figure/P15884-1_vs_P15884-12.png |
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| ./stats/secondary_structure/figure/P15884-1_vs_P15884-13.png |
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| ./stats/secondary_structure/figure/P15884-1_vs_P15884-14.png |
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| ./stats/secondary_structure/figure/P15884-1_vs_P15884-15.png |
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| ./stats/secondary_structure/figure/P15884-1_vs_P15884-16.png |
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| ./stats/secondary_structure/figure/P15884-1_vs_P15884-2.png |
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| ./stats/secondary_structure/figure/P15884-1_vs_P15884-3.png |
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| ./stats/secondary_structure/figure/P15884-1_vs_P15884-4.png |
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| ./stats/secondary_structure/figure/P15884-1_vs_P15884-5.png |
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| ./stats/secondary_structure/figure/P15884-1_vs_P15884-6.png |
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| ./stats/secondary_structure/figure/P15884-1_vs_P15884-7.png |
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| ./stats/secondary_structure/figure/P15884-1_vs_P15884-8.png |
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| ./stats/secondary_structure/figure/P15884-1_vs_P15884-9.png |
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| Protein Feature Comparison of the relative accessible surface area (ASA) among the protiens. |
| ./stats/relative_asa/P15884-1_vs_P15884-10.png |
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| ./stats/relative_asa/P15884-1_vs_P15884-11.png |
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| ./stats/relative_asa/P15884-1_vs_P15884-12.png |
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| ./stats/relative_asa/P15884-1_vs_P15884-13.png |
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| ./stats/relative_asa/P15884-1_vs_P15884-14.png |
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| ./stats/relative_asa/P15884-1_vs_P15884-15.png |
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| ./stats/relative_asa/P15884-1_vs_P15884-16.png |
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| ./stats/relative_asa/P15884-1_vs_P15884-2.png |
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| ./stats/relative_asa/P15884-1_vs_P15884-3.png |
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| ./stats/relative_asa/P15884-1_vs_P15884-4.png |
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| ./stats/relative_asa/P15884-1_vs_P15884-5.png |
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| ./stats/relative_asa/P15884-1_vs_P15884-6.png |
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| ./stats/relative_asa/P15884-1_vs_P15884-7.png |
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| ./stats/relative_asa/P15884-1_vs_P15884-8.png |
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| ./stats/relative_asa/P15884-1_vs_P15884-9.png |
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Protein-Protein Interaction |
| Interactors from UniProt. |
| Accession_id | Subsection | Start | End | Funcitonal feature | Splicing information |
| Interactors from STRING. |
| Gene name | Interactors |
Related Drugs to TCF4 |
| Drugs targeting this gene/protein. (DrugBank) |
| UniProt accession | Gene name | DrugBank ID | Drug name | Drug group | Actions |
Related Diseases to TCF4 |
| Previous studies relating to the alternative splicing of TCF4 and disease information from the MeSH term (PubMed) |
| Gene | PMID | Title | Abstract | MeSH ID | MeSH term |
| TCF4 | 17909039 | beta-catenin regulates multiple steps of RNA metabolism as revealed by the RNA aptamer in colon cancer cells. | Nuclear beta-catenin forms a transcription complex with TCF-4, which is implicated in colon cancer development and progression. Recently, we and others have shown that beta-catenin could be a regulator of RNA splicing and it also stabilizes the cyclooxygenase-2 (COX-2) mRNA. Here, we further explored the role of beta-catenin in the RNA metabolism in colon cancer cells. To specifically modulate the subcellular functions of beta-catenin, we expressed the RNA aptamer in the form of RNA intramers with unique cellular localizations. The nucleus-expressed RNA intramer proved to be effective in reducing the protein-protein interaction between beta-catenin and TCF-4, thus shown to be a specific regulator of beta-catenin-activated transcription. It could also regulate the alternative splicing of E1A minigene in diverse colon cancer cell lines. In addition, we tested whether beta-catenin could stabilize any other mRNAs and found that cyclin D1 mRNA was also bound and stabilized by beta-catenin. Significantly, the cytoplasm-expressed RNA intramer reverted the beta-catenin-induced COX-2 and cyclin D1 mRNA stabilization. We show here that beta-catenin regulated multiple steps of RNA metabolism in colon cancer cells and might be the protein factor coordinating RNA metabolism. We suggest that the RNA intramers could provide useful ways for inhibiting beta-catenin-mediated transcription and RNA metabolism, which might further enhance the antitumorigenic effects of these molecules in colon cancer cells. | D000230 | Adenocarcinoma |
| TCF4 | 17909039 | beta-catenin regulates multiple steps of RNA metabolism as revealed by the RNA aptamer in colon cancer cells. | Nuclear beta-catenin forms a transcription complex with TCF-4, which is implicated in colon cancer development and progression. Recently, we and others have shown that beta-catenin could be a regulator of RNA splicing and it also stabilizes the cyclooxygenase-2 (COX-2) mRNA. Here, we further explored the role of beta-catenin in the RNA metabolism in colon cancer cells. To specifically modulate the subcellular functions of beta-catenin, we expressed the RNA aptamer in the form of RNA intramers with unique cellular localizations. The nucleus-expressed RNA intramer proved to be effective in reducing the protein-protein interaction between beta-catenin and TCF-4, thus shown to be a specific regulator of beta-catenin-activated transcription. It could also regulate the alternative splicing of E1A minigene in diverse colon cancer cell lines. In addition, we tested whether beta-catenin could stabilize any other mRNAs and found that cyclin D1 mRNA was also bound and stabilized by beta-catenin. Significantly, the cytoplasm-expressed RNA intramer reverted the beta-catenin-induced COX-2 and cyclin D1 mRNA stabilization. We show here that beta-catenin regulated multiple steps of RNA metabolism in colon cancer cells and might be the protein factor coordinating RNA metabolism. We suggest that the RNA intramers could provide useful ways for inhibiting beta-catenin-mediated transcription and RNA metabolism, which might further enhance the antitumorigenic effects of these molecules in colon cancer cells. | D003110 | Colonic Neoplasms |
Clinically important variants in TCF4 |
| (ClinVar, 04/20/2024) |
| accession_id | uniprot_id | gene_name | Type | Variant | Clinical_significance |
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