ASpdb: an integrative knowledgebase of human protein isoforms from experimental and AI-predicted structures

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	Protein Summary
	AS Summary
	Protein Functional Features
	Gene Isoform Structures and Expression Levels
	Protein Structures
	pLDDT Score Distribution
	Ramachandran Plot of Protein Structures
	Potential Active Site Information
	Protein Structure and Feature Comparision
	Protein-Protein Interaction
	Related Drugs
	Related Diseases
	Clinically Important Variants

Protein:HNF1A

Protein Summary

Gene summary

Gene name: HNF1A
ASpdb.0 ID: 6927
	Gene
Gene symbol	HNF1A
Gene ID	6927
Gene name	HNF1 homeobox A
Synonyms	HNF-1-alpha\|HNF-1A\|HNF1\|HNF1alpha\|HNF4A\|IDDM20\|LFB1\|MODY3\|TCF-1\|TCF1
Cytomap	12q24.31
Type of gene	protein-coding
Description	hepatocyte nuclear factor 1-alphaalbumin proximal factorhepatic nuclear factor 1interferon production regulator factorliver-specific transcription factor LF-B1transcription factor 1, hepatic
Modification date	20240413
UniProtAcc	P20823

Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Gene	HNF1A	GO:0000976	transcription cis-regulatory region binding	12453420\|15961790
Gene	HNF1A	GO:0003677	DNA binding	1989880
Gene	HNF1A	GO:0003700	DNA-binding transcription factor activity	1989880\|11980910
Gene	HNF1A	GO:0005634	nucleus	15355349
Gene	HNF1A	GO:0005737	cytoplasm	15355349
Gene	HNF1A	GO:0006357	regulation of transcription by RNA polymerase II	10330009
Gene	HNF1A	GO:0032991	protein-containing complex	11980910
Gene	HNF1A	GO:0045893	positive regulation of DNA-templated transcription	1989880\|11980910\|12453420

AS Summary

Information of the canonical protein with experimentally identified structure from PDB (2023).

UniProt Acc	File name	PDB ID	Method	Resolution	Chain	Start	End
P20823-1	P20823-1_1ic8_B.pdb	1IC8	X-ray	2.6	B	85	278

ASpdb's canonical and alternatively spliced isoform information.

accession_id	gene_name	canonical_id	alternative_id	canonical_length	alternative_length	canonical_start	canonical_end	type	originalSEQ	variationSEQ	alternative_start	alternative_end
P20823	HNF1A	P20823-1	P20823-2	631	572	501	542	Substitution	ALYSHKPEVAQYTHTGLLPQTMLITDTTNLSALASLTPTKQV	GEHPVPHTAGDDDRGWLSMDAGERGAWQALQSACVSGTSVFP	501	542
P20823	HNF1A	P20823-1	P20823-2	631	572	543	601	Deletion	none	none	542	542
P20823	HNF1A	P20823-1	P20823-3	631	524	438	494	Substitution	LASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVTQSPFMATMA	KLVGMGGHLGGRLMGQPQNPGAGRATGTHSFIHSFIQHVFIQCLLWTSHCATSVIPG	438	494
P20823	HNF1A	P20823-1	P20823-3	631	524	495	601	Deletion	none	none	494	494
P20823	HNF1A	P20823-1	P20823-4	631	278	176	278	Substitution	QFTHAGQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFR	RRNASREGCPHHRHRGWAPTSSRRCVSTTGLPTGAKKKPSGTSWPWTRTAGPPQGQARDLRCPLTAPLACLHLPSPPVRSTVCAMDSLRPVRLQKYPQAAAVP	176	278
P20823	HNF1A	P20823-1	P20823-4	631	278	279	631	Deletion	none	none	278	278
P20823	HNF1A	P20823-1	P20823-5	631	247	239	247	Substitution	AECIQRGVS	CALWTACDQ	239	247
P20823	HNF1A	P20823-1	P20823-5	631	247	248	631	Deletion	none	none	247	247
P20823	HNF1A	P20823-1	P20823-6	631	403	1	117	Deletion	none	none	0	0
P20823	HNF1A	P20823-1	P20823-6	631	403	438	520	Substitution	LASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVTQSPFMATMAQLQSPHALYSHKPEVAQYTHTGLLPQ	KLVGMGGHLGGRLMGQPQNPGAGRATGTHSFIHTTCIYPVPTLDQSLCYISDTWVNQTDQNLSNSSREAGTKHNTSILWYLRR	321	403
P20823	HNF1A	P20823-1	P20823-6	631	403	521	631	Deletion	none	none	403	403
P20823	HNF1A	P20823-1	P20823-7	631	662	540	540	Substitution	K	KQVRSRPAGPPLACDRAPHPHIPRAQEAALLP	540	571
P20823	HNF1A	P20823-1	P20823-8	631	119	110	119	Substitution	EDPWRVAKMV	VHPCRAGRAD	110	119
P20823	HNF1A	P20823-1	P20823-8	631	119	120	631	Deletion	none	none	119	119

Multiple sequence alignment of our canonical and alternatively spliced HNF1A

Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of HNF1A

UniProt-id	ENSG	ENST	ENSP
P20823-4	ENSG00000135100.19	ENST00000538646.5	ENSP00000443964.1
P20823-5	ENSG00000135100.19	ENST00000541924.5	ENSP00000440361.1
P20823-8	ENSG00000135100.19	ENST00000540108.1	ENSP00000445445.1

UniProt-id

NM ID

NP ID

Amino acid sequences of our canonical and alternatively spliced HNF1A

accession_id	Protein sequence
P20823-1	MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLLAGEGPLDKGESCGGGRGELAELPNGLGETRGSEDETDDDGEDFTPPILKELE NLSPEEAAHQKAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHA GQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGSNLVTEVRVYNWFAN RRKEEAFRHKLAMDTYSGPPPGPGPGPALPAHSSPGLPPPALSPSKVHGVRYGQPATSETAEVPSSSGGPLVTVSTPLHQVSPTGLEPSH SLLSTEAKLVSAAGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGLASTQAQSVPVIN SMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVTQSPFMATMAQLQSPHALYSHKPEVAQYTHTGLLPQTMLITDTTNLSALASLTPTK QVFTSDTEASSESGLHTPASQATTLHVPSQDPAGIQHLQPAHRLSASPTVSSSSLVLYQSSDSSNGQSHLLPSNHSVIETFISTQMASSS
P20823-2	MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLLAGEGPLDKGESCGGGRGELAELPNGLGETRGSEDETDDDGEDFTPPILKELE NLSPEEAAHQKAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHA GQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGSNLVTEVRVYNWFAN RRKEEAFRHKLAMDTYSGPPPGPGPGPALPAHSSPGLPPPALSPSKVHGVRYGQPATSETAEVPSSSGGPLVTVSTPLHQVSPTGLEPSH SLLSTEAKLVSAAGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGLASTQAQSVPVIN SMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVTQSPFMATMAQLQSPHGEHPVPHTAGDDDRGWLSMDAGERGAWQALQSACVSGTSV
P20823-3	MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLLAGEGPLDKGESCGGGRGELAELPNGLGETRGSEDETDDDGEDFTPPILKELE NLSPEEAAHQKAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHA GQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGSNLVTEVRVYNWFAN RRKEEAFRHKLAMDTYSGPPPGPGPGPALPAHSSPGLPPPALSPSKVHGVRYGQPATSETAEVPSSSGGPLVTVSTPLHQVSPTGLEPSH SLLSTEAKLVSAAGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGKLVGMGGHLGGRL
P20823-4	MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLLAGEGPLDKGESCGGGRGELAELPNGLGETRGSEDETDDDGEDFTPPILKELE NLSPEEAAHQKAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQRRNAS REGCPHHRHRGWAPTSSRRCVSTTGLPTGAKKKPSGTSWPWTRTAGPPQGQARDLRCPLTAPLACLHLPSPPVRSTVCAMDSLRPVRLQK
P20823-5	MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLLAGEGPLDKGESCGGGRGELAELPNGLGETRGSEDETDDDGEDFTPPILKELE NLSPEEAAHQKAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHA
P20823-6	MVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHAGQGGLIEEPTGDELPTKKGRRNRFKWG PASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYSGPPPGPGPGP ALPAHSSPGLPPPALSPSKVHGVRYGQPATSETAEVPSSSGGPLVTVSTPLHQVSPTGLEPSHSLLSTEAKLVSAAGGPLPPVSTLTALH SLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGKLVGMGGHLGGRLMGQPQNPGAGRATGTHSFIHTTCIYPV
P20823-7	MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLLAGEGPLDKGESCGGGRGELAELPNGLGETRGSEDETDDDGEDFTPPILKELE NLSPEEAAHQKAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHA GQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGSNLVTEVRVYNWFAN RRKEEAFRHKLAMDTYSGPPPGPGPGPALPAHSSPGLPPPALSPSKVHGVRYGQPATSETAEVPSSSGGPLVTVSTPLHQVSPTGLEPSH SLLSTEAKLVSAAGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGLASTQAQSVPVIN SMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVTQSPFMATMAQLQSPHALYSHKPEVAQYTHTGLLPQTMLITDTTNLSALASLTPTK QVRSRPAGPPLACDRAPHPHIPRAQEAALLPQVFTSDTEASSESGLHTPASQATTLHVPSQDPAGIQHLQPAHRLSASPTVSSSSLVLYQ
P20823-8	MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLLAGEGPLDKGESCGGGRGELAELPNGLGETRGSEDETDDDGEDFTPPILKELE

Protein Functional Features

Main function of this protein. (from UniProt)

HNF1A (go to UniProt):P20823

Retention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Accession_id	Subsection	Start	End	Funcitonal feature	Splicing information
P20823	Domain	1	32	Note=HNF-p1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01286	Type=Deletion;Start=1;End=117
P20823	Domain	87	182	Note=POU-specific atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01285	Type=Substitution;Start=176;End=278
P20823	Domain	87	182	Note=POU-specific atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01285	Type=Deletion;Start=1;End=117
P20823	Domain	87	182	Note=POU-specific atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01285	Type=Substitution;Start=110;End=119
P20823	Domain	87	182	Note=POU-specific atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01285	Type=Deletion;Start=120;End=631
P20823	DNA binding	199	279	Note=Homeobox%3B HNF1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00108	Type=Substitution;Start=176;End=278
P20823	DNA binding	199	279	Note=Homeobox%3B HNF1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00108	Type=Deletion;Start=279;End=631
P20823	DNA binding	199	279	Note=Homeobox%3B HNF1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00108	Type=Substitution;Start=239;End=247
P20823	DNA binding	199	279	Note=Homeobox%3B HNF1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00108	Type=Deletion;Start=248;End=631
P20823	DNA binding	199	279	Note=Homeobox%3B HNF1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00108	Type=Deletion;Start=120;End=631
P20823	Region	1	31	Note=Dimerization	Type=Deletion;Start=1;End=117
P20823	Region	40	81	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=1;End=117
P20823	Region	130	132	Note=Interaction with DNA	Type=Deletion;Start=120;End=631
P20823	Region	143	149	Note=Interaction with DNA	Type=Deletion;Start=120;End=631
P20823	Region	155	158	Note=Interaction with DNA	Type=Deletion;Start=120;End=631
P20823	Region	183	205	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Substitution;Start=176;End=278
P20823	Region	183	205	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=120;End=631
P20823	Region	203	206	Note=Interaction with DNA	Type=Substitution;Start=176;End=278
P20823	Region	203	206	Note=Interaction with DNA	Type=Deletion;Start=120;End=631
P20823	Region	263	265	Note=Interaction with DNA	Type=Substitution;Start=176;End=278
P20823	Region	263	265	Note=Interaction with DNA	Type=Deletion;Start=248;End=631
P20823	Region	263	265	Note=Interaction with DNA	Type=Deletion;Start=120;End=631
P20823	Region	270	273	Note=Interaction with DNA	Type=Substitution;Start=176;End=278
P20823	Region	270	273	Note=Interaction with DNA	Type=Deletion;Start=248;End=631
P20823	Region	270	273	Note=Interaction with DNA	Type=Deletion;Start=120;End=631
P20823	Region	283	358	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=279;End=631
P20823	Region	283	358	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=248;End=631
P20823	Region	283	358	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=120;End=631
P20823	Region	545	573	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=543;End=601
P20823	Region	545	573	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=495;End=601
P20823	Region	545	573	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=279;End=631
P20823	Region	545	573	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=248;End=631
P20823	Region	545	573	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=521;End=631
P20823	Region	545	573	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=120;End=631
P20823	Motif	197	205	Note=Nuclear localization signal;Ontology_term=ECO:0000305;evidence=ECO:0000305	Type=Substitution;Start=176;End=278
P20823	Motif	197	205	Note=Nuclear localization signal;Ontology_term=ECO:0000305;evidence=ECO:0000305	Type=Deletion;Start=120;End=631
P20823	Compositional bias	288	312	Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=279;End=631
P20823	Compositional bias	288	312	Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=248;End=631
P20823	Compositional bias	288	312	Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=120;End=631
P20823	Compositional bias	328	358	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=279;End=631
P20823	Compositional bias	328	358	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=248;End=631
P20823	Compositional bias	328	358	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=120;End=631
P20823	Compositional bias	545	570	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=543;End=601
P20823	Compositional bias	545	570	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=495;End=601
P20823	Compositional bias	545	570	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=279;End=631
P20823	Compositional bias	545	570	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=248;End=631
P20823	Compositional bias	545	570	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=521;End=631
P20823	Compositional bias	545	570	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256\|SAM:MobiDB-lite	Type=Deletion;Start=120;End=631

Gene Isoform Structures and Expression Levels for HNF1A

Gene structures of our canonical and alternative spliced genes of HNF1A
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Expression levels of gene isoforms across GTEx.

Expression levels of gene isoforms across TCGA.

Protein Structures

PDB and CIF files of the predicted protein structures
* Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

3D view using mol* of P20823-1

3D view using mol* of P20823-2

3D view using mol* of P20823-3

3D view using mol* of P20823-4

3D view using mol* of P20823-5

3D view using mol* of P20823-6

3D view using mol* of P20823-7

3D view using mol* of P20823-8

pLDDT Score Distribution

pLDDT score distribution of the predicted protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

pLDDT distribution across the protein length of P20823-1

pLDDT distribution across the protein length of P20823-2

pLDDT distribution across the protein length of P20823-3

pLDDT distribution across the protein length of P20823-4

pLDDT distribution across the protein length of P20823-5

pLDDT distribution across the protein length of P20823-6

pLDDT distribution across the protein length of P20823-7

pLDDT distribution across the protein length of P20823-8

Ramachandran Plot of Protein Structures

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide.

Ramachandran plot of P20823-1

Ramachandran plot of P20823-2

Ramachandran plot of P20823-3

Ramachandran plot of P20823-4

Ramachandran plot of P20823-8

Potential Active Site Information

The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite.

UniProt-id	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
P20823-1	0.986	170	1.002	433.552	0.608	0.677	0.877	0.357	1.056	0.338	0.705	85,92,93,96,100,126,128,129,130,131,132,135,136,16 5,168,169,171,172,173,175,176,177,199,200,201,202, 203,204,205,244,253,254,255,256,257,258,263
P20823-2	1.002	176	0.947	478.142	0.58	0.7	0.918	0.236	1.268	0.186	0.705	84,85,88,92,93,96,100,126,128,129,131,132,135,136, 165,168,169,171,172,173,175,176,177,194,195,196,19 7,199,200,201,202,203,204,205,244,253,254,255,256, 257
P20823-3	1.002	181	0.995	404.397	0.539	0.701	0.9	0.272	1.123	0.242	0.701	85,92,96,100,126,128,129,131,132,135,136,165,168,1 69,171,172,173,175,176,177,199,200,201,202,203,204 ,205,244,253,254,255,256,257
P20823-4	0.886	62	0.901	106.33	0.519	0.678	0.9	1.384	0.752	1.839	0.79	120,123,124,127,128,129,130,131,145,148,149,221
P20823-5	0.997	103	0.921	257.593	0.528	0.693	1.051	0.525	1.333	0.394	1.041	84,85,88,92,96,100,129,131,132,135,136,165,168,169 ,171,172,175,199,200,201,202,203
P20823-6	1.01	136	0.951	327.222	0.565	0.712	0.953	0.222	1.278	0.174	0.73	9,10,11,12,14,15,18,19,48,51,52,54,55,56,58,59,60, 82,83,84,85,86,87,88,127,136,137,138,139,140
P20823-7	0.99	167	0.995	388.962	0.575	0.683	0.882	0.231	1.089	0.212	0.667	85,88,92,93,96,100,126,127,128,129,131,132,135,136 ,165,168,169,171,172,173,175,176,177,199,200,201,2 02,203,204,205,244,253,254,255,256,257
P20823-8	0.428	13	0.349	13.72	0.794	0.5	0.747	0.262	0.889	0.295	1.647	59,60,62,63,64,65

Protein Structure and Feature Comparision

Protein Structure Comparision Using Template Modeling Scores (TM-score).

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green)

3D view using mol* of P20823-1_P20823-1_1ic8_B.pdb

Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of P20823-1_1ic8_B_P20823-2.pdb

3D view using mol* of P20823-1_1ic8_B_P20823-3.pdb

3D view using mol* of P20823-1_1ic8_B_P20823-4.pdb

3D view using mol* of P20823-1_1ic8_B_P20823-5.pdb

3D view using mol* of P20823-1_1ic8_B_P20823-6.pdb

3D view using mol* of P20823-1_1ic8_B_P20823-7.pdb

3D view using mol* of P20823-1_1ic8_B_P20823-8.pdb

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of P20823-1_P20823-2.pdb

3D view using mol* of P20823-1_P20823-3.pdb

3D view using mol* of P20823-1_P20823-4.pdb

3D view using mol* of P20823-1_P20823-5.pdb

3D view using mol* of P20823-1_P20823-6.pdb

3D view using mol* of P20823-1_P20823-7.pdb

3D view using mol* of P20823-1_P20823-8.pdb

Protein Feature Comparison of the protein sequendary structures among the protiens.

./stats/secondary_structure/figure/P20823-1_vs_P20823-2.png

./stats/secondary_structure/figure/P20823-1_vs_P20823-3.png

./stats/secondary_structure/figure/P20823-1_vs_P20823-4.png

./stats/secondary_structure/figure/P20823-1_vs_P20823-5.png

./stats/secondary_structure/figure/P20823-1_vs_P20823-6.png

./stats/secondary_structure/figure/P20823-1_vs_P20823-7.png

./stats/secondary_structure/figure/P20823-1_vs_P20823-8.png

Protein Feature Comparison of the relative accessible surface area (ASA) among the protiens.

./stats/relative_asa/P20823-1_vs_P20823-2.png

./stats/relative_asa/P20823-1_vs_P20823-3.png

./stats/relative_asa/P20823-1_vs_P20823-4.png

./stats/relative_asa/P20823-1_vs_P20823-5.png

./stats/relative_asa/P20823-1_vs_P20823-6.png

./stats/relative_asa/P20823-1_vs_P20823-7.png

./stats/relative_asa/P20823-1_vs_P20823-8.png

Protein-Protein Interaction

Interactors from UniProt.

Accession_id	Subsection	Start	End	Funcitonal feature	Splicing information
P20823	Region	130	132	Note=Interaction with DNA	Type=Deletion;Start=120;End=631
P20823	Region	143	149	Note=Interaction with DNA	Type=Deletion;Start=120;End=631
P20823	Region	155	158	Note=Interaction with DNA	Type=Deletion;Start=120;End=631
P20823	Region	203	206	Note=Interaction with DNA	Type=Substitution;Start=176;End=278
P20823	Region	203	206	Note=Interaction with DNA	Type=Deletion;Start=120;End=631
P20823	Region	263	265	Note=Interaction with DNA	Type=Substitution;Start=176;End=278
P20823	Region	263	265	Note=Interaction with DNA	Type=Deletion;Start=248;End=631
P20823	Region	263	265	Note=Interaction with DNA	Type=Deletion;Start=120;End=631
P20823	Region	270	273	Note=Interaction with DNA	Type=Substitution;Start=176;End=278
P20823	Region	270	273	Note=Interaction with DNA	Type=Deletion;Start=248;End=631
P20823	Region	270	273	Note=Interaction with DNA	Type=Deletion;Start=120;End=631

Interactors from STRING.

Gene name

Interactors

Related Drugs to HNF1A

Drugs targeting this gene/protein.
(DrugBank)

UniProt accession	Gene name	DrugBank ID	Drug name	Drug group	Actions
P20823	HNF1A	DB04419	D-norleucine	experimental

Related Diseases to HNF1A

Previous studies relating to the alternative splicing of HNF1A and disease information from the MeSH term (PubMed)

Gene

PMID

Title

Abstract

MeSH ID

MeSH term

Clinically important variants in HNF1A

(ClinVar, 04/20/2024)

accession_id

uniprot_id

gene_name

Type

Variant

Clinical_significance