ASpdb: an integrative knowledgebase of human protein isoforms from experimental and AI-predicted structures

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	Protein Summary
	AS Summary
	Protein Functional Features
	Gene Isoform Structures and Expression Levels
	Protein Structures
	pLDDT Score Distribution
	Ramachandran Plot of Protein Structures
	Potential Active Site Information
	Protein Structure and Feature Comparision
	Protein-Protein Interaction
	Related Drugs
	Related Diseases
	Clinically Important Variants

Protein:CAMK2D

Protein Summary

Gene summary

Gene name: CAMK2D
ASpdb.0 ID: 817
	Gene
Gene symbol	CAMK2D
Gene ID	817
Gene name	calcium/calmodulin dependent protein kinase II delta
Synonyms	CAMKD
Cytomap	4q26
Type of gene	protein-coding
Description	calcium/calmodulin-dependent protein kinase type II subunit deltaCaM kinase II delta subunitCaM-kinase II delta chainCaMK-II delta subunitcalcium/calmodulin-dependent protein kinase (CaM kinase) II deltacalcium/calmodulin-dependent protein kinase typ
Modification date	20240407
UniProtAcc	Q13557

Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Gene	CAMK2D	GO:0003254	regulation of membrane depolarization	22514276
Gene	CAMK2D	GO:0004674	protein serine/threonine kinase activity	22514276
Gene	CAMK2D	GO:0004683	calmodulin-dependent protein kinase activity	22514276\|23283722
Gene	CAMK2D	GO:0005954	calcium- and calmodulin-dependent protein kinase complex	20668654
Gene	CAMK2D	GO:0006468	protein phosphorylation	17179159\|23283722
Gene	CAMK2D	GO:0018105	peptidyl-serine phosphorylation	22514276\|23283722
Gene	CAMK2D	GO:0018107	peptidyl-threonine phosphorylation	22514276\|23283722
Gene	CAMK2D	GO:0019871	sodium channel inhibitor activity	22514276
Gene	CAMK2D	GO:0046777	protein autophosphorylation	22514276
Gene	CAMK2D	GO:1901897	regulation of relaxation of cardiac muscle	23283722
Gene	CAMK2D	GO:1902306	negative regulation of sodium ion transmembrane transport	22514276
Gene	CAMK2D	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	22514276

AS Summary

Information of the canonical protein with experimentally identified structure from PDB (2023).

UniProt Acc	File name	PDB ID	Method	Resolution	Chain	Start	End
Q13557-1	Q13557-1_2wel_A.pdb	2WEL	X-ray	1.9	A	11	316

ASpdb's canonical and alternatively spliced isoform information.

accession_id	gene_name	canonical_id	alternative_id	canonical_length	alternative_length	canonical_start	canonical_end	type	originalSEQ	variationSEQ	alternative_start	alternative_end
Q13557	CAMK2D	Q13557-1	Q13557-10	499	492	329	329	Substitution	E	EPQTTVIHNPDGNKE	329	343
Q13557	CAMK2D	Q13557-1	Q13557-10	499	492	479	499	Deletion	none	none	492	492
Q13557	CAMK2D	Q13557-1	Q13557-11	499	524	328	328	Substitution	K	KKRKSSSSVQMMEPQTTVIHNPDGNK	328	353
Q13557	CAMK2D	Q13557-1	Q13557-12	499	478	478	478	Substitution	K	N	478	478
Q13557	CAMK2D	Q13557-1	Q13557-12	499	478	479	499	Deletion	none	none	478	478
Q13557	CAMK2D	Q13557-1	Q13557-3	499	510	328	328	Substitution	K	KKRKSSSSVQMM	328	339
Q13557	CAMK2D	Q13557-1	Q13557-4	499	519	328	328	Substitution	K	KINNKANVVTSPKENIPTPAL	328	348
Q13557	CAMK2D	Q13557-1	Q13557-5	499	498	328	328	Substitution	K	KINNKANVVTSPKENIPTPAL	328	348
Q13557	CAMK2D	Q13557-1	Q13557-5	499	498	479	499	Deletion	none	none	498	498
Q13557	CAMK2D	Q13557-1	Q13557-6	499	513	329	329	Substitution	E	EPQTTVIHNPDGNKE	329	343
Q13557	CAMK2D	Q13557-1	Q13557-8	499	478	479	499	Deletion	none	none	478	478
Q13557	CAMK2D	Q13557-1	Q13557-9	499	489	328	328	Substitution	K	KKRKSSSSVQMM	328	339
Q13557	CAMK2D	Q13557-1	Q13557-9	499	489	479	499	Deletion	none	none	489	489

Multiple sequence alignment of our canonical and alternatively spliced CAMK2D

Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of CAMK2D

UniProt-id	ENSG	ENST	ENSP
Q13557-1	ENSG00000145349.20	ENST00000342666.9	ENSP00000339740.5
Q13557-1	ENSG00000145349.20	ENST00000683023.1	ENSP00000507073.1
Q13557-10	ENSG00000145349.20	ENST00000394522.7	ENSP00000378030.3
Q13557-11	ENSG00000145349.20	ENST00000699048.1	ENSP00000514100.1
Q13557-12	ENSG00000145349.20	ENST00000394524.7	ENSP00000378032.3
Q13557-3	ENSG00000145349.20	ENST00000515496.5	ENSP00000423482.1
Q13557-6	ENSG00000145349.20	ENST00000699047.1	ENSP00000514099.1
Q13557-6	ENSG00000145349.20	ENST00000699381.1	ENSP00000514346.1
Q13557-8	ENSG00000145349.20	ENST00000296402.9	ENSP00000296402.5
Q13557-8	ENSG00000145349.20	ENST00000379773.6	ENSP00000369098.2
Q13557-9	ENSG00000145349.20	ENST00000508738.5	ENSP00000422566.1

UniProt-id	NM ID	NP ID
Q13557-1	NM_001221.3	NP_001212.2
Q13557-10	NM_001321589.1	NP_001308518.1
Q13557-10	NM_172114.1	NP_742112.1
Q13557-11	NM_001321573.1	NP_001308502.1
Q13557-12	NM_172128.2	NP_742126.1
Q13557-4	NM_001321580.1	NP_001308509.1
Q13557-6	NM_001321566.1	NP_001308495.1
Q13557-8	NM_172115.2	NP_742113.1
Q13557-8	NM_172127.2	NP_742125.1
Q13557-9	NM_172129.1	NP_742127.1

Amino acid sequences of our canonical and alternatively spliced CAMK2D

accession_id	Protein sequence
Q13557-1	MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVF DLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEA INNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGSGMPKTMQSE
Q13557-10	MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVF DLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKEPQTTVIHNPDGNKESTESSNTTIEDEDVKAR KQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQ
Q13557-11	MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVF DLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKKRKSSSSVQMMEPQTTVIHNPDGNKESTESSN TTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDD
Q13557-12	MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVF DLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEA INNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGSGMPKTMQSE
Q13557-3	MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVF DLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKKRKSSSSVQMMESTESSNTTIEDEDVKARKQE IIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMD
Q13557-4	MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVF DLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKINNKANVVTSPKENIPTPALESTESSNTTIED EDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIA
Q13557-5	MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVF DLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKINNKANVVTSPKENIPTPALESTESSNTTIED EDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIA
Q13557-6	MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVF DLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKEPQTTVIHNPDGNKESTESSNTTIEDEDVKAR KQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQ
Q13557-8	MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVF DLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEA INNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGSGMPKTMQSE
Q13557-9	MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVF DLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKKRKSSSSVQMMESTESSNTTIEDEDVKARKQE IIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMD

Protein Functional Features

Main function of this protein. (from UniProt)

CAMK2D (go to UniProt):Q13557

Retention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Accession_id

Subsection

Start

End

Funcitonal feature

Splicing information

Gene Isoform Structures and Expression Levels for CAMK2D

Gene structures of our canonical and alternative spliced genes of CAMK2D
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Expression levels of gene isoforms across GTEx.

Expression levels of gene isoforms across TCGA.

Protein Structures

PDB and CIF files of the predicted protein structures
* Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

3D view using mol* of Q13557-1

3D view using mol* of Q13557-10

3D view using mol* of Q13557-11

3D view using mol* of Q13557-12

3D view using mol* of Q13557-3

3D view using mol* of Q13557-4

3D view using mol* of Q13557-5

3D view using mol* of Q13557-6

3D view using mol* of Q13557-8

3D view using mol* of Q13557-9

pLDDT Score Distribution

pLDDT score distribution of the predicted protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

pLDDT distribution across the protein length of Q13557-1

pLDDT distribution across the protein length of Q13557-10

pLDDT distribution across the protein length of Q13557-11

pLDDT distribution across the protein length of Q13557-12

pLDDT distribution across the protein length of Q13557-3

pLDDT distribution across the protein length of Q13557-4

pLDDT distribution across the protein length of Q13557-5

pLDDT distribution across the protein length of Q13557-6

pLDDT distribution across the protein length of Q13557-8

pLDDT distribution across the protein length of Q13557-9

Ramachandran Plot of Protein Structures

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide.

Ramachandran plot of Q13557-1

Ramachandran plot of Q13557-10

Ramachandran plot of Q13557-12

Ramachandran plot of Q13557-3

Ramachandran plot of Q13557-4

Ramachandran plot of Q13557-5

Ramachandran plot of Q13557-6

Potential Active Site Information

The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite.

UniProt-id	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
Q13557-1	1.092	113	1.101	302.869	0.498	0.836	1.047	1.084	1.044	1.039	0.833	361,362,369,377,381,383,395,398,399,402,403,406,40 8,409,410,433,435,437,438,439,447,449,451,453,464, 467,469,474,475
Q13557-10	1.059	101	1.09	234.612	0.557	0.753	0.956	0.822	0.925	0.889	1.349	375,376,416,417,420,422,424,447,449,451,452,453,45 4,455,461,463,465,483,486,487,488,489,490,491,492
Q13557-11	1.108	121	1.129	271.313	0.487	0.834	1.042	1.334	0.955	1.397	0.526	386,387,394,406,407,408,420,423,424,427,428,431,43 3,435,458,460,462,463,464,472,478,492,494,497,498, 499,500
Q13557-12	1.085	114	1.163	456.876	0.645	0.7	0.852	1.324	0.606	2.187	1.506	138,140,177,178,179,180,202,206,210,211,212,215,21 6,217,219,222,290,293,294,297,298,299,301,302,304, 305,306
Q13557-3	1.119	121	1.139	289.492	0.481	0.85	1.041	1.399	0.955	1.466	0.643	372,373,380,392,406,409,410,413,414,417,419,421,44 4,446,448,449,458,460,462,464,478,480,483,484,485, 486
Q13557-4	1.131	138	1.159	295.323	0.455	0.851	1.06	1.621	0.895	1.812	0.717	381,382,389,401,415,418,419,422,423,426,428,429,43 0,453,455,457,458,459,467,469,471,473,487,489,493, 494,495,496
Q13557-5	1.086	291	1.126	1173.746	0.549	0.771	0.941	1.061	0.848	1.251	0.873	20,21,23,24,25,26,28,41,43,45,50,54,57,58,60,61,65 ,74,90,91,92,93,94,96,135,136,138,140,141,143,156, 157,158,159,160,177,178,179,180,202,206,210,211,21 2,213,214,215,216,217,219,222,290,293,294,297,298, 299,301,302,303,305,306,309,313
Q13557-6	1.131	139	1.179	300.468	0.461	0.814	0.982	1.569	0.765	2.051	0.747	375,376,383,395,397,409,412,413,416,417,420,422,42 4,447,449,451,452,453,461,463,465,467,481,483,487, 488,489
Q13557-8	1.113	114	1.159	510.041	0.576	0.796	0.944	1.372	0.793	1.731	0.821	20,22,23,24,25,26,28,41,43,45,50,54,57,58,60,61,74 ,90,91,93,135,140,141,143,156,157,158,159,160
Q13557-9	1.089	251	1.128	1082.165	0.556	0.778	0.967	1.063	0.857	1.241	0.946	20,21,23,24,25,26,28,41,43,45,50,54,57,58,60,61,65 ,74,90,91,93,138,139,140,141,143,156,157,158,159,1 60,161,177,178,179,180,202,206,211,212,213,214,215 ,216,217,222,290,293,294,297,298,299,301,302,305,3 06,309,313

Protein Structure and Feature Comparision

Protein Structure Comparision Using Template Modeling Scores (TM-score).

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green)

3D view using mol* of Q13557-1_Q13557-1_2wel_A.pdb

Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of Q13557-1_2wel_A_Q13557-10.pdb

3D view using mol* of Q13557-1_2wel_A_Q13557-11.pdb

3D view using mol* of Q13557-1_2wel_A_Q13557-12.pdb

3D view using mol* of Q13557-1_2wel_A_Q13557-3.pdb

3D view using mol* of Q13557-1_2wel_A_Q13557-4.pdb

3D view using mol* of Q13557-1_2wel_A_Q13557-5.pdb

3D view using mol* of Q13557-1_2wel_A_Q13557-6.pdb

3D view using mol* of Q13557-1_2wel_A_Q13557-8.pdb

3D view using mol* of Q13557-1_2wel_A_Q13557-9.pdb

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of Q13557-1_Q13557-10.pdb

3D view using mol* of Q13557-1_Q13557-11.pdb

3D view using mol* of Q13557-1_Q13557-12.pdb

3D view using mol* of Q13557-1_Q13557-3.pdb

3D view using mol* of Q13557-1_Q13557-4.pdb

3D view using mol* of Q13557-1_Q13557-5.pdb

3D view using mol* of Q13557-1_Q13557-6.pdb

3D view using mol* of Q13557-1_Q13557-8.pdb

3D view using mol* of Q13557-1_Q13557-9.pdb

Protein Feature Comparison of the protein sequendary structures among the protiens.

./stats/secondary_structure/figure/Q13557-1_vs_Q13557-10.png

./stats/secondary_structure/figure/Q13557-1_vs_Q13557-11.png

./stats/secondary_structure/figure/Q13557-1_vs_Q13557-12.png

./stats/secondary_structure/figure/Q13557-1_vs_Q13557-3.png

./stats/secondary_structure/figure/Q13557-1_vs_Q13557-4.png

./stats/secondary_structure/figure/Q13557-1_vs_Q13557-5.png

./stats/secondary_structure/figure/Q13557-1_vs_Q13557-6.png

./stats/secondary_structure/figure/Q13557-1_vs_Q13557-8.png

./stats/secondary_structure/figure/Q13557-1_vs_Q13557-9.png

Protein Feature Comparison of the relative accessible surface area (ASA) among the protiens.

./stats/relative_asa/Q13557-1_vs_Q13557-10.png

./stats/relative_asa/Q13557-1_vs_Q13557-11.png

./stats/relative_asa/Q13557-1_vs_Q13557-12.png

./stats/relative_asa/Q13557-1_vs_Q13557-3.png

./stats/relative_asa/Q13557-1_vs_Q13557-4.png

./stats/relative_asa/Q13557-1_vs_Q13557-5.png

./stats/relative_asa/Q13557-1_vs_Q13557-6.png

./stats/relative_asa/Q13557-1_vs_Q13557-8.png

./stats/relative_asa/Q13557-1_vs_Q13557-9.png

Protein-Protein Interaction

Interactors from UniProt.

Accession_id

Subsection

Start

End

Funcitonal feature

Splicing information

Interactors from STRING.

Gene name

Interactors

Related Drugs to CAMK2D

Drugs targeting this gene/protein.
(DrugBank)

UniProt accession	Gene name	DrugBank ID	Drug name	Drug group	Actions
Q13557	CAMK2D	DB08039	(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE	experimental
Q13557	CAMK2D	DB07853	2-[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]iminocyclohexa-2,5-dien-1-yl]acetonitrile	experimental
Q13557	CAMK2D	DB12010	Fostamatinib	approved, investigational	inhibitor

Related Diseases to CAMK2D

Previous studies relating to the alternative splicing of CAMK2D and disease information from the MeSH term (PubMed)

Gene

PMID

Title

Abstract

MeSH ID

MeSH term

Clinically important variants in CAMK2D

(ClinVar, 04/20/2024)

accession_id

uniprot_id

gene_name

Type

Variant

Clinical_significance