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Center for Computational Systems Medicine
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Protein Summary

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AS Summary

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Protein Functional Features

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Gene Isoform Structures and Expression Levels

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Protein Structures

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pLDDT Score Distribution

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Ramachandran Plot of Protein Structures

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Potential Active Site Information

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Protein Structure and Feature Comparision

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Protein-Protein Interaction

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Related Drugs

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Related Diseases

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Clinically Important Variants

Protein:SLC4A8

Protein Summary

check button Gene summary
Gene name: SLC4A8
ASpdb.0 ID: 9498
Gene
Gene symbol

SLC4A8

Gene ID

9498

Gene namesolute carrier family 4 member 8
SynonymsNBC3|NDCBE
Cytomap

12q13.13

Type of geneprotein-coding
Descriptionelectroneutral sodium bicarbonate exchanger 1electroneutral Na(+)-driven Cl-HCO3 exchangerk-NBC3solute carrier family 4, sodium bicarbonate cotransporter, member 8
Modification date20240403
UniProtAcc

Q2Y0W8


check button Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
GeneSLC4A8

GO:0008510

sodium:bicarbonate symporter activity

11133997

GeneSLC4A8

GO:0015081

sodium ion transmembrane transporter activity

11133997

GeneSLC4A8

GO:0015106

bicarbonate transmembrane transporter activity

11133997

GeneSLC4A8

GO:0015108

chloride transmembrane transporter activity

11133997

GeneSLC4A8

GO:0015701

bicarbonate transport

11133997

GeneSLC4A8

GO:0030425

dendrite

17715183

GeneSLC4A8

GO:0035725

sodium ion transmembrane transport

11133997

GeneSLC4A8

GO:0042391

regulation of membrane potential

11133997|18577713

GeneSLC4A8

GO:0051453

regulation of intracellular pH

11133997|18577713

GeneSLC4A8

GO:1902476

chloride transmembrane transport

11133997



AS Summary

check button Information of the canonical protein with experimentally identified structure from PDB (2023).
UniProt AccFile namePDB IDMethodResolutionChainStartEnd
Q2Y0W8-1Q2Y0W8-1_5jho_A.pdb5JHOX-ray2.8A95397

check button ASpdb's canonical and alternatively spliced isoform information.
accession_idgene_namecanonical_idalternative_idcanonical_lengthalternative_lengthcanonical_startcanonical_endtypeoriginalSEQvariationSEQalternative_startalternative_end
Q2Y0W8SLC4A8Q2Y0W8-1Q2Y0W8-210931071116SubstitutionMPAAGSNEPDGVLSYQMFNKNNSNKLRSTPRYRRGDPGYLNFTELGPLKPEQKDQWSQH143
Q2Y0W8SLC4A8Q2Y0W8-1Q2Y0W8-21093107110281093SubstitutionEAEKMLEIGGDKFPLESRKLLSSPGKNISCRCDPSEINISDEMPKTTVWKALSMNSGNAKEKSLFNVIVLAPTVYLGASNYRT10551071
Q2Y0W8SLC4A8Q2Y0W8-1Q2Y0W8-31093104410281093SubstitutionEAEKMLEIGGDKFPLESRKLLSSPGKNISCRCDPSEINISDEMPKTTVWKALSMNSGNAKEKSLFNVIVLAPTVYLGASNYRT10281044
Q2Y0W8SLC4A8Q2Y0W8-1Q2Y0W8-41093991153Deletionnonenone00
Q2Y0W8SLC4A8Q2Y0W8-1Q2Y0W8-4109399110281093SubstitutionEAEKMLEIGGDKFPLESRKLLSSPGKNISCRCDPSEINISDEMPKTTVWKALSMNSGNAKEKSLFNVIVLAPTVYLGASNYRT975991
Q2Y0W8SLC4A8Q2Y0W8-1Q2Y0W8-61093691671691SubstitutionECQEMHGEFMGSACGHHGPYTVSLGAARCPSIVTTGLGGTSK671691
Q2Y0W8SLC4A8Q2Y0W8-1Q2Y0W8-610936916921093Deletionnonenone691691
Q2Y0W8SLC4A8Q2Y0W8-1Q2Y0W8-71093747153Deletionnonenone00
Q2Y0W8SLC4A8Q2Y0W8-1Q2Y0W8-71093747725800SubstitutionVRSMVSDFAVFLTIFTMVIIDFLIGVPSPKLQVPSVFKPTRDDRGWIINPIGPNPWWTVIAAIIPALLCTILIFMDMESCSVAWLECGGVILAHCNLRLLPSSWDYRHAPPQPANFCIFSRDGVSPCWPGWSQSLDLVICLPRPPKMLGLQA672747
Q2Y0W8SLC4A8Q2Y0W8-1Q2Y0W8-710937478011093Deletionnonenone747747
Q2Y0W8SLC4A8Q2Y0W8-1Q2Y0W8-81093638153Deletionnonenone00
Q2Y0W8SLC4A8Q2Y0W8-1Q2Y0W8-81093638671691SubstitutionECQEMHGEFMGSACGHHGPYTVSLGAARCPSIVTTGLGGTSK618638
Q2Y0W8SLC4A8Q2Y0W8-1Q2Y0W8-810936386921093Deletionnonenone638638

check buttonMultiple sequence alignment of our canonical and alternatively spliced SLC4A8

check button Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of SLC4A8
UniProt-idENSGENSTENSP
Q2Y0W8-1ENSG00000050438.17ENST00000453097.7ENSP00000405812.2
Q2Y0W8-7ENSG00000050438.17ENST00000514353.7ENSP00000442561.2
Q2Y0W8-8ENSG00000050438.17ENST00000535225.6ENSP00000441520.1

UniProt-idNM IDNP ID
Q2Y0W8-1NM_001039960.2NP_001035049.1
Q2Y0W8-6NM_001258402.1NP_001245331.1
Q2Y0W8-7NM_001258403.1NP_001245332.1
Q2Y0W8-8NM_001267615.1NP_001254544.1

check buttonAmino acid sequences of our canonical and alternatively spliced SLC4A8
accession_idProtein sequence
Q2Y0W8-1MPAAGSNEPDGVLSYQRPDEEAVVDQGGTSTILNIHYEKEELEGHRTLYVGVRMPLGRQSHRHHRTHGQKHRRRGRGKGASQGEEGLEAL
AHDTPSQRVQFILGTEEDEEHVPHELFTELDEICMKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLL
DMHANSIEEISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLIPIVRSFAEVGKKQSDPHLMDKHGQTVSPQSVPTTNLEV
KNGVNCEHSPVDLSKVDLHFMKKIPTGAEASNVLVGEVDILDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQYHEIGRSM
ATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKMPGVPNGNVCHIEQEPHGGHSGPELQRTGR
LFGGLVLDIKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQALTILGSTGP
VLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDH
LSLYYCRCTLPENPNNHTLQYWKDHNIVTAEVHWANLTVSECQEMHGEFMGSACGHHGPYTPDVLFWSCILFFTTFILSSTLKTFKTSRY
FPTRVRSMVSDFAVFLTIFTMVIIDFLIGVPSPKLQVPSVFKPTRDDRGWIINPIGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINR
KEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFVLMGCSVFMTAILK
FIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLIQLTCLVLLWVIKASPAAIVFPMMVLALVFVRK
VMDLCFSKRELSWLDDLMPESKKKKLDDAKKKAKEEEEAEKMLEIGGDKFPLESRKLLSSPGKNISCRCDPSEINISDEMPKTTVWKALS
Q2Y0W8-2MFNKNNSNKLRSTPRYRRGDPGYLNFTELGPLKPEQKDQWSQHRPDEEAVVDQGGTSTILNIHYEKEELEGHRTLYVGVRMPLGRQSHRH
HRTHGQKHRRRGRGKGASQGEEGLEALAHDTPSQRVQFILGTEEDEEHVPHELFTELDEICMKEGEDAEWKETARWLKFEEDVEDGGERW
SKPYVATLSLHSLFELRSCLINGTVLLDMHANSIEEISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLIPIVRSFAEVGK
KQSDPHLMDKHGQTVSPQSVPTTNLEVKNGVNCEHSPVDLSKVDLHFMKKIPTGAEASNVLVGEVDILDRPIVAFVRLSPAVLLSGLTEV
PIPTRFLFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKMPG
VPNGNVCHIEQEPHGGHSGPELQRTGRLFGGLVLDIKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIES
LFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICI
IFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCTLPENPNNHTLQYWKDHNIVTAEVHWANLTVSECQEMHGEFMGSACGHHGPYTPD
VLFWSCILFFTTFILSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVIIDFLIGVPSPKLQVPSVFKPTRDDRGWIINPIGPNPWWTV
IAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFL
GIREQRVTGLMIFVLMGCSVFMTAILKFIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLIQLTCL
Q2Y0W8-3MPAAGSNEPDGVLSYQRPDEEAVVDQGGTSTILNIHYEKEELEGHRTLYVGVRMPLGRQSHRHHRTHGQKHRRRGRGKGASQGEEGLEAL
AHDTPSQRVQFILGTEEDEEHVPHELFTELDEICMKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLL
DMHANSIEEISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLIPIVRSFAEVGKKQSDPHLMDKHGQTVSPQSVPTTNLEV
KNGVNCEHSPVDLSKVDLHFMKKIPTGAEASNVLVGEVDILDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQYHEIGRSM
ATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKMPGVPNGNVCHIEQEPHGGHSGPELQRTGR
LFGGLVLDIKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQALTILGSTGP
VLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDH
LSLYYCRCTLPENPNNHTLQYWKDHNIVTAEVHWANLTVSECQEMHGEFMGSACGHHGPYTPDVLFWSCILFFTTFILSSTLKTFKTSRY
FPTRVRSMVSDFAVFLTIFTMVIIDFLIGVPSPKLQVPSVFKPTRDDRGWIINPIGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINR
KEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFVLMGCSVFMTAILK
FIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLIQLTCLVLLWVIKASPAAIVFPMMVLALVFVRK
Q2Y0W8-4MPLGRQSHRHHRTHGQKHRRRGRGKGASQGEEGLEALAHDTPSQRVQFILGTEEDEEHVPHELFTELDEICMKEGEDAEWKETARWLKFE
EDVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLLDMHANSIEEISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLIP
IVRSFAEVGKKQSDPHLMDKHGQTVSPQSVPTTNLEVKNGVNCEHSPVDLSKVDLHFMKKIPTGAEASNVLVGEVDILDRPIVAFVRLSP
AVLLSGLTEVPIPTRFLFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNV
PSQEKRKMPGVPNGNVCHIEQEPHGGHSGPELQRTGRLFGGLVLDIKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEA
TEGRISAIESLFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYITRFT
EEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCTLPENPNNHTLQYWKDHNIVTAEVHWANLTVSECQEMHGEFMGSA
CGHHGPYTPDVLFWSCILFFTTFILSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVIIDFLIGVPSPKLQVPSVFKPTRDDRGWIIN
PIGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLKLESEC
SAPGEQPKFLGIREQRVTGLMIFVLMGCSVFMTAILKFIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVH
LFTLIQLTCLVLLWVIKASPAAIVFPMMVLALVFVRKVMDLCFSKRELSWLDDLMPESKKKKLDDAKKKAKEEEVIVLAPTVYLGASNYR
Q2Y0W8-6MPAAGSNEPDGVLSYQRPDEEAVVDQGGTSTILNIHYEKEELEGHRTLYVGVRMPLGRQSHRHHRTHGQKHRRRGRGKGASQGEEGLEAL
AHDTPSQRVQFILGTEEDEEHVPHELFTELDEICMKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLL
DMHANSIEEISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLIPIVRSFAEVGKKQSDPHLMDKHGQTVSPQSVPTTNLEV
KNGVNCEHSPVDLSKVDLHFMKKIPTGAEASNVLVGEVDILDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQYHEIGRSM
ATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKMPGVPNGNVCHIEQEPHGGHSGPELQRTGR
LFGGLVLDIKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQALTILGSTGP
VLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDH
Q2Y0W8-7MPLGRQSHRHHRTHGQKHRRRGRGKGASQGEEGLEALAHDTPSQRVQFILGTEEDEEHVPHELFTELDEICMKEGEDAEWKETARWLKFE
EDVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLLDMHANSIEEISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLIP
IVRSFAEVGKKQSDPHLMDKHGQTVSPQSVPTTNLEVKNGVNCEHSPVDLSKVDLHFMKKIPTGAEASNVLVGEVDILDRPIVAFVRLSP
AVLLSGLTEVPIPTRFLFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNV
PSQEKRKMPGVPNGNVCHIEQEPHGGHSGPELQRTGRLFGGLVLDIKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEA
TEGRISAIESLFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYITRFT
EEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCTLPENPNNHTLQYWKDHNIVTAEVHWANLTVSECQEMHGEFMGSA
CGHHGPYTPDVLFWSCILFFTTFILSSTLKTFKTSRYFPTRMESCSVAWLECGGVILAHCNLRLLPSSWDYRHAPPQPANFCIFSRDGVS
Q2Y0W8-8MPLGRQSHRHHRTHGQKHRRRGRGKGASQGEEGLEALAHDTPSQRVQFILGTEEDEEHVPHELFTELDEICMKEGEDAEWKETARWLKFE
EDVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLLDMHANSIEEISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLIP
IVRSFAEVGKKQSDPHLMDKHGQTVSPQSVPTTNLEVKNGVNCEHSPVDLSKVDLHFMKKIPTGAEASNVLVGEVDILDRPIVAFVRLSP
AVLLSGLTEVPIPTRFLFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNV
PSQEKRKMPGVPNGNVCHIEQEPHGGHSGPELQRTGRLFGGLVLDIKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEA
TEGRISAIESLFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYITRFT
EEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCTLPENPNNHTLQYWKDHNIVTAEVHWANLTVSVSLGAARCPSIVT

Protein Functional Features

check buttonMain function of this protein. (from UniProt)
SLC4A8 (go to UniProt):Q2Y0W8

check buttonRetention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
Accession_idSubsectionStartEndFuncitonal featureSplicing information
Q2Y0W8Topological domain1478Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Substitution;Start=1;End=16
Q2Y0W8Topological domain1478Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=1;End=53
Q2Y0W8Topological domain1478Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=1;End=53
Q2Y0W8Topological domain1478Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=1;End=53
Q2Y0W8Topological domain617687Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Substitution;Start=671;End=691
Q2Y0W8Topological domain617687Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Substitution;Start=671;End=691
Q2Y0W8Transmembrane688708Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Substitution;Start=671;End=691
Q2Y0W8Transmembrane688708Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Transmembrane688708Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Substitution;Start=671;End=691
Q2Y0W8Transmembrane688708Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Topological domain709731Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Topological domain709731Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Substitution;Start=725;End=800
Q2Y0W8Topological domain709731Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Transmembrane732752Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Transmembrane732752Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Substitution;Start=725;End=800
Q2Y0W8Transmembrane732752Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Topological domain753778Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Topological domain753778Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Substitution;Start=725;End=800
Q2Y0W8Topological domain753778Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Transmembrane779799Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Transmembrane779799Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Substitution;Start=725;End=800
Q2Y0W8Transmembrane779799Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Topological domain800824Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Topological domain800824Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Substitution;Start=725;End=800
Q2Y0W8Topological domain800824Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=801;End=1093
Q2Y0W8Topological domain800824Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Transmembrane825845Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Transmembrane825845Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=801;End=1093
Q2Y0W8Transmembrane825845Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Topological domain846881Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Topological domain846881Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=801;End=1093
Q2Y0W8Topological domain846881Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Transmembrane882902Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Transmembrane882902Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=801;End=1093
Q2Y0W8Transmembrane882902Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Topological domain903904Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Topological domain903904Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=801;End=1093
Q2Y0W8Topological domain903904Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Transmembrane905925Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Transmembrane905925Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=801;End=1093
Q2Y0W8Transmembrane905925Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Topological domain926962Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Topological domain926962Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=801;End=1093
Q2Y0W8Topological domain926962Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Transmembrane963983Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Transmembrane963983Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=801;End=1093
Q2Y0W8Transmembrane963983Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Topological domain9841093Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Substitution;Start=1028;End=1093
Q2Y0W8Topological domain9841093Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Substitution;Start=1028;End=1093
Q2Y0W8Topological domain9841093Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Substitution;Start=1028;End=1093
Q2Y0W8Topological domain9841093Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Topological domain9841093Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=801;End=1093
Q2Y0W8Topological domain9841093Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Region125Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-liteType=Substitution;Start=1;End=16
Q2Y0W8Region125Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-liteType=Deletion;Start=1;End=53
Q2Y0W8Region125Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-liteType=Deletion;Start=1;End=53
Q2Y0W8Region125Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-liteType=Deletion;Start=1;End=53
Q2Y0W8Coiled coil10101036Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Substitution;Start=1028;End=1093
Q2Y0W8Coiled coil10101036Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Substitution;Start=1028;End=1093
Q2Y0W8Coiled coil10101036Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Substitution;Start=1028;End=1093
Q2Y0W8Coiled coil10101036Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093
Q2Y0W8Coiled coil10101036Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=801;End=1093
Q2Y0W8Coiled coil10101036Ontology_term=ECO:0000255;evidence=ECO:0000255Type=Deletion;Start=692;End=1093


Gene Isoform Structures and Expression Levels for SLC4A8

check buttonGene structures of our canonical and alternative spliced genes of SLC4A8
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
gene isoform structure of SLC4A8

check button Expression levels of gene isoforms across GTEx.
gtex expression

check button Expression levels of gene isoforms across TCGA.
tcga expression


Protein Structures

check button PDB and CIF files of the predicted protein structures
* Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
3D view using mol* of Q2Y0W8-1
3D view using mol* of Q2Y0W8-2
3D view using mol* of Q2Y0W8-3
3D view using mol* of Q2Y0W8-4
3D view using mol* of Q2Y0W8-6
3D view using mol* of Q2Y0W8-7
3D view using mol* of Q2Y0W8-8


pLDDT Score Distribution

check button pLDDT score distribution of the predicted protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
pLDDT distribution across the protein length of Q2Y0W8-1
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pLDDT distribution across the protein length of Q2Y0W8-2
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pLDDT distribution across the protein length of Q2Y0W8-3
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pLDDT distribution across the protein length of Q2Y0W8-4
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pLDDT distribution across the protein length of Q2Y0W8-6
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pLDDT distribution across the protein length of Q2Y0W8-7
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pLDDT distribution across the protein length of Q2Y0W8-8
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Ramachandran Plot of Protein Structures


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide.
Ramachandran plot of Q2Y0W8-1
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Ramachandran plot of Q2Y0W8-2
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Ramachandran plot of Q2Y0W8-3
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Ramachandran plot of Q2Y0W8-6
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Ramachandran plot of Q2Y0W8-8
all structure

Potential Active Site Information


check button The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite.
UniProt-idSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
Q2Y0W8-11.051481.079597.8490.6460.7450.9150.7520.9460.7950.777492,494,495,496,498,499,502,503,510,537,538,539,54
0,542,543,546,547,549,550,553,597,600,601,604,605,
607,608,611,612,615,616,619,753,800,845,846,847,84
8,849,904,908,911,970,975,978
Q2Y0W8-21.0384051.0761058.1550.540.7130.9050.8080.8970.9020.919459,460,461,462,463,464,465,466,467,468,469,471,47
2,604,612,614,615,616,617,618,620,621,818,821,822,
825,826,833,836,837,838,839,841,842,845,846,848,97
3,1010,1013,1014,1016,1017,1020,1023,1025,1026,102
8,1029,1030,1032,1033,1034,1035,1036,1039,1040,104
3,1044,1045,1046,1047,1048,1051
Q2Y0W8-31.0541571.057558.7470.5880.7790.9640.7961.0770.7390.818492,494,495,496,498,499,500,502,503,510,536,537,53
8,539,540,542,543,546,597,601,604,605,607,608,611,
612,615,616,619,620,752,753,754,756,800,804,845,84
6,847,848,849,904,908,970,975,978
Q2Y0W8-41.0592131.07616.7140.560.7860.9810.5951.0480.5670.718424,431,538,542,545,653,657,660,661,663,664,677,67
8,680,681,682,754,757,759,760,761,798,799,801,802,
803,805,806,807,819,822,860,861,863,864,865,867,86
8,869,870,874,888,889,890,950,951,952,953,954,955,
956,957,960
Q2Y0W8-61.0361431.079393.0780.6140.70.90.8050.8620.9340.99555,56,57,58,103,105,107,112,113,114,115,116,117,11
8,138,139,140,141,142,144,156,290,293,295,364,365,
367,370,371,375,415,416,417,420
Q2Y0W8-71.0461151.13309.7290.7010.6380.8421.0620.5911.7972.28391,392,393,394,395,401,402,405,406,408,409,410,41
2,413,416,474,475,476,477,524,525,528,529,530,532,
533,536,540,541,544,744,745,747
Q2Y0W8-81.06881.133403.3680.6560.7110.8651.4110.5362.6343.469409,410,413,416,417,429,432,433,436,437,440,461,46
4,465,468,471,472,473,474,475,476,478,479,480,481,
482

Protein Structure and Feature Comparision


check button Protein Structure Comparision Using Template Modeling Scores (TM-score).
all structure

check button Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green)
3D view using mol* of Q2Y0W8-1_Q2Y0W8-1_5jho_A.pdb

check button Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green)
3D view using mol* of Q2Y0W8-1_5jho_A_Q2Y0W8-2.pdb
3D view using mol* of Q2Y0W8-1_5jho_A_Q2Y0W8-3.pdb
3D view using mol* of Q2Y0W8-1_5jho_A_Q2Y0W8-4.pdb
3D view using mol* of Q2Y0W8-1_5jho_A_Q2Y0W8-6.pdb
3D view using mol* of Q2Y0W8-1_5jho_A_Q2Y0W8-7.pdb
3D view using mol* of Q2Y0W8-1_5jho_A_Q2Y0W8-8.pdb

check button Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green)
3D view using mol* of Q2Y0W8-1_Q2Y0W8-2.pdb
3D view using mol* of Q2Y0W8-1_Q2Y0W8-3.pdb
3D view using mol* of Q2Y0W8-1_Q2Y0W8-4.pdb
3D view using mol* of Q2Y0W8-1_Q2Y0W8-6.pdb
3D view using mol* of Q2Y0W8-1_Q2Y0W8-7.pdb
3D view using mol* of Q2Y0W8-1_Q2Y0W8-8.pdb

check button Protein Feature Comparison of the protein sequendary structures among the protiens.
./stats/secondary_structure/figure/Q2Y0W8-1_vs_Q2Y0W8-2.png
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./stats/secondary_structure/figure/Q2Y0W8-1_vs_Q2Y0W8-3.png
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./stats/secondary_structure/figure/Q2Y0W8-1_vs_Q2Y0W8-4.png
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./stats/secondary_structure/figure/Q2Y0W8-1_vs_Q2Y0W8-6.png
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./stats/secondary_structure/figure/Q2Y0W8-1_vs_Q2Y0W8-7.png
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./stats/secondary_structure/figure/Q2Y0W8-1_vs_Q2Y0W8-8.png
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check button Protein Feature Comparison of the relative accessible surface area (ASA) among the protiens.
./stats/relative_asa/Q2Y0W8-1_vs_Q2Y0W8-2.png
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./stats/relative_asa/Q2Y0W8-1_vs_Q2Y0W8-3.png
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./stats/relative_asa/Q2Y0W8-1_vs_Q2Y0W8-4.png
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./stats/relative_asa/Q2Y0W8-1_vs_Q2Y0W8-6.png
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./stats/relative_asa/Q2Y0W8-1_vs_Q2Y0W8-7.png
all structure<
./stats/relative_asa/Q2Y0W8-1_vs_Q2Y0W8-8.png
all structure<


Protein-Protein Interaction


check button Interactors from UniProt.
Accession_idSubsectionStartEndFuncitonal featureSplicing information


check button Interactors from STRING.
Gene nameInteractors


Related Drugs to SLC4A8


check button Drugs targeting this gene/protein.
(DrugBank)
UniProt accessionGene nameDrugBank IDDrug nameDrug groupActions

Related Diseases to SLC4A8


check button Previous studies relating to the alternative splicing of SLC4A8 and disease information from the MeSH term (PubMed)
GenePMIDTitleAbstractMeSH IDMeSH term


Clinically important variants in SLC4A8


check button (ClinVar, 04/20/2024)
accession_iduniprot_idgene_nameTypeVariantClinical_significance