ASpdb: an integrative knowledgebase of human protein isoforms from experimental and AI-predicted structures

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	Protein Summary
	AS Summary
	Protein Functional Features
	Gene Isoform Structures and Expression Levels
	Protein Structures
	pLDDT Score Distribution
	Ramachandran Plot of Protein Structures
	Potential Active Site Information
	Protein Structure and Feature Comparision
	Protein-Protein Interaction
	Related Drugs
	Related Diseases
	Clinically Important Variants

Protein:RGS6

Protein Summary

Gene summary

Gene name: RGS6
ASpdb.0 ID: 9628
	Gene
Gene symbol	RGS6
Gene ID	9628
Gene name	regulator of G protein signaling 6
Synonyms	GAP\|HA117\|S914
Cytomap	14q24.2
Type of gene	protein-coding
Description	regulator of G-protein signaling 6regulator of G-protein signalling 6
Modification date	20240407
UniProtAcc	P49758

Gene ontology of this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Gene	RGS6	GO:0005096	GTPase activator activity	10521509
Gene	RGS6	GO:0005829	cytosol	10521509
Gene	RGS6	GO:0016020	membrane	10521509
Gene	RGS6	GO:0043547	positive regulation of GTPase activity	10521509

AS Summary

Information of the canonical protein with experimentally identified structure from PDB (2023).

UniProt Acc	File name	PDB ID	Method	Resolution	Chain	Start	End
P49758-4	P49758-4_2es0_A.pdb	2ES0	X-ray	2.1	A	325	452

ASpdb's canonical and alternatively spliced isoform information.

accession_id	gene_name	canonical_id	alternative_id	canonical_length	alternative_length	canonical_start	canonical_end	type	originalSEQ	variationSEQ	alternative_start	alternative_end
P49758	RGS6	P49758-4	P49758-10	472	448	285	321	Deletion	none	none	284	284
P49758	RGS6	P49758-4	P49758-10	472	448	457	472	Substitution	GKSLAGKRLTGLMQSS	PESEQGRRTSLEKFTRSVLYSNTPLAKRP	420	448
P49758	RGS6	P49758-4	P49758-11	472	430	285	321	Deletion	none	none	284	284
P49758	RGS6	P49758-4	P49758-11	472	430	457	472	Substitution	GKSLAGKRLTGLMQSS	LYSNTPLAKRP	420	430
P49758	RGS6	P49758-4	P49758-12	472	346	1	139	Deletion	none	none	0	0
P49758	RGS6	P49758-4	P49758-12	472	346	457	472	Substitution	GKSLAGKRLTGLMQSS	PESEQGRRTSLEKFTRSVLYSNTPLAKRP	318	346
P49758	RGS6	P49758-4	P49758-13	472	475	457	472	Substitution	GKSLAGKRLTGLMQSS	PESEQGRRTSLEKFTRSVG	457	475
P49758	RGS6	P49758-4	P49758-14	472	477	457	472	Substitution	GKSLAGKRLTGLMQSS	PESEQGRRTSLEKFTRSVLLF	457	477
P49758	RGS6	P49758-4	P49758-15	472	480	457	472	Substitution	GKSLAGKRLTGLMQSS	PESEQGRRTSLEKFTRSVCLQLLF	457	480
P49758	RGS6	P49758-4	P49758-16	472	460	457	472	Substitution	GKSLAGKRLTGLMQSS	VWLL	457	460
P49758	RGS6	P49758-4	P49758-2	472	485	457	472	Substitution	GKSLAGKRLTGLMQSS	PESEQGRRTSLEKFTRSVLYSNTPLAKRP	457	485
P49758	RGS6	P49758-4	P49758-3	472	490	456	456	Substitution	K	KPESEQGRRTSLEKFTRSV	456	474
P49758	RGS6	P49758-4	P49758-5	472	465	457	472	Substitution	GKSLAGKRLTGLMQSS	KVSKVVELP	457	465
P49758	RGS6	P49758-4	P49758-6	472	428	285	321	Deletion	none	none	284	284
P49758	RGS6	P49758-4	P49758-6	472	428	457	472	Substitution	GKSLAGKRLTGLMQSS	KVSKVVELP	420	428
P49758	RGS6	P49758-4	P49758-7	472	435	285	321	Deletion	none	none	284	284
P49758	RGS6	P49758-4	P49758-8	472	467	457	472	Substitution	GKSLAGKRLTGLMQSS	LYSNTPLAKRP	457	467
P49758	RGS6	P49758-4	P49758-9	472	453	285	321	Deletion	none	none	284	284
P49758	RGS6	P49758-4	P49758-9	472	453	456	456	Substitution	K	KPESEQGRRTSLEKFTRSV	419	437

Multiple sequence alignment of our canonical and alternatively spliced RGS6

Matched gene isoform IDs with Ensembl and RefSeq of our canonical and alternative spliced genes of RGS6

UniProt-id	ENSG	ENST	ENSP
P49758-4	ENSG00000182732.18	ENST00000553530.5	ENSP00000452331.1
P49758-4	ENSG00000182732.18	ENST00000555571.5	ENSP00000450936.1
P49758-12	ENSG00000182732.18	ENST00000554782.1	ENSP00000451912.1
P49758-13	ENSG00000182732.18	ENST00000406236.8	ENSP00000384218.4
P49758-14	ENSG00000182732.18	ENST00000407322.8	ENSP00000384612.4
P49758-15	ENSG00000182732.18	ENST00000404301.6	ENSP00000385243.2
P49758-16	ENSG00000182732.18	ENST00000355512.10	ENSP00000347699.6
P49758-3	ENSG00000182732.18	ENST00000553525.6	ENSP00000451030.1
P49758-3	ENSG00000182732.18	ENST00000556437.5	ENSP00000451855.1
P49758-5	ENSG00000182732.18	ENST00000554474.5	ENSP00000450858.1

UniProt-id	NM ID	NP ID
P49758-4	NM_004296.6	NP_004287.3
P49758-10	NM_001204421.2	NP_001191350.1
P49758-11	NM_001204422.2	NP_001191351.1
P49758-13	XM_017021826.1	XP_016877315.1
P49758-16	XM_017021832.1	XP_016877321.1
P49758-2	NM_001204417.2	NP_001191346.1
P49758-3	NM_001204416.2	NP_001191345.1
P49758-3	NM_001204424.1	NP_001191353.1
P49758-5	XM_017021830.1	XP_016877319.1
P49758-7	NM_001204420.2	NP_001191349.1
P49758-8	NM_001204418.2	NP_001191347.1
P49758-9	NM_001204419.2	NP_001191348.1

Amino acid sequences of our canonical and alternatively spliced RGS6

accession_id	Protein sequence
P49758-4	MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAA QGYIFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKI DRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNA QIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSS ENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
P49758-10	MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAA QGYIFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKI DRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNA QIDRHCLKMSKVAESKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPGAP
P49758-11	MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAA QGYIFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKI DRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNA QIDRHCLKMSKVAESKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPGAP
P49758-12	MQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKV KKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDI EMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEI
P49758-13	MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAA QGYIFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKI DRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNA QIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSS ENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
P49758-14	MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAA QGYIFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKI DRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNA QIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSS ENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
P49758-15	MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAA QGYIFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKI DRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNA QIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSS ENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
P49758-16	MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAA QGYIFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKI DRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNA QIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSS ENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
P49758-2	MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAA QGYIFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKI DRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNA QIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSS ENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
P49758-3	MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAA QGYIFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKI DRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNA QIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSS ENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
P49758-5	MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAA QGYIFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKI DRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNA QIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSS ENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
P49758-6	MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAA QGYIFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKI DRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNA QIDRHCLKMSKVAESKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPGAP
P49758-7	MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAA QGYIFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKI DRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNA QIDRHCLKMSKVAESKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPGAP
P49758-8	MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAA QGYIFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKI DRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNA QIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSS ENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
P49758-9	MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAA QGYIFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKI DRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNA QIDRHCLKMSKVAESKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPGAP SAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDLLLAKKKPESEQGRRTSLEKFTRSVGKSLAGKRLTGLM

Protein Functional Features

Main function of this protein. (from UniProt)

RGS6 (go to UniProt):P49758

Retention analysis result of protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Accession_id	Subsection	Start	End	Funcitonal feature	Splicing information
P49758	Domain	40	115	Note=DEP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00066	Type=Deletion;Start=1;End=139
P49758	Domain	261	330	Note=G protein gamma	Type=Deletion;Start=285;End=321
P49758	Domain	261	330	Note=G protein gamma	Type=Deletion;Start=285;End=321
P49758	Domain	261	330	Note=G protein gamma	Type=Deletion;Start=285;End=321
P49758	Domain	261	330	Note=G protein gamma	Type=Deletion;Start=285;End=321
P49758	Domain	261	330	Note=G protein gamma	Type=Deletion;Start=285;End=321

Gene Isoform Structures and Expression Levels for RGS6

Gene structures of our canonical and alternative spliced genes of RGS6
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Expression levels of gene isoforms across GTEx.

Expression levels of gene isoforms across TCGA.

Protein Structures

PDB and CIF files of the predicted protein structures
* Here we show the 3D structure of the proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

3D view using mol* of P49758-4

3D view using mol* of P49758-10

3D view using mol* of P49758-11

3D view using mol* of P49758-12

3D view using mol* of P49758-13

3D view using mol* of P49758-14

3D view using mol* of P49758-15

3D view using mol* of P49758-16

3D view using mol* of P49758-2

3D view using mol* of P49758-3

3D view using mol* of P49758-5

3D view using mol* of P49758-6

3D view using mol* of P49758-7

3D view using mol* of P49758-8

3D view using mol* of P49758-9

pLDDT Score Distribution

pLDDT score distribution of the predicted protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

pLDDT distribution across the protein length of P49758-4

pLDDT distribution across the protein length of P49758-10

pLDDT distribution across the protein length of P49758-11

pLDDT distribution across the protein length of P49758-12

pLDDT distribution across the protein length of P49758-13

pLDDT distribution across the protein length of P49758-14

pLDDT distribution across the protein length of P49758-15

pLDDT distribution across the protein length of P49758-16

pLDDT distribution across the protein length of P49758-2

pLDDT distribution across the protein length of P49758-3

pLDDT distribution across the protein length of P49758-5

pLDDT distribution across the protein length of P49758-6

pLDDT distribution across the protein length of P49758-7

pLDDT distribution across the protein length of P49758-8

pLDDT distribution across the protein length of P49758-9

Ramachandran Plot of Protein Structures

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this protein peptide.

Ramachandran plot of P49758-4

Ramachandran plot of P49758-11

Ramachandran plot of P49758-12

Ramachandran plot of P49758-13

Ramachandran plot of P49758-14

Ramachandran plot of P49758-2

Ramachandran plot of P49758-3

Ramachandran plot of P49758-5

Ramachandran plot of P49758-6

Ramachandran plot of P49758-9

Potential Active Site Information

The potential binding sites of these proteins were identified using SiteMap, a module of the Schrodinger suite.

UniProt-id	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
P49758-4	1.029	145	1.065	534.737	0.649	0.703	0.902	0.561	0.91	0.617	0.727	54,55,56,57,97,98,100,112,117,118,124,126,130,133, 134,137,138,141,145,146,177,180,181,184,186,187,18 9,190,191,192,193,194,196,197,199,200
P49758-10	0.945	85	0.908	179.389	0.644	0.702	0.922	0.572	1.163	0.491	0.552	1,2,3,4,115,116,117,118,134,137,138,141,146,177,18 0,181,184,189,192,193,194,196,197
P49758-11	1.072	131	1.055	267.883	0.484	0.805	1.102	0.82	1.128	0.727	0.636	1,2,3,4,115,117,118,124,126,130,133,134,137,138,14 1,146,173,177,180,181,184,189,192,193,196,199,200
P49758-12	0.997	136	1.022	338.884	0.595	0.684	0.883	0.565	1.008	0.56	0.71	156,157,159,162,163,164,165,169,177,180,181,183,18 5,186,187,188,189,190,193,194,200,203,204,314,315, 316
P49758-13	0.987	215	1.013	608.825	0.606	0.669	0.869	0.396	1.008	0.393	1.012	11,12,13,14,15,16,17,18,19,20,21,22,23,24,26,91,12 0,123,124,125,126,202,203,204,211,212,213,215,222, 223,224,225,226,228,229,245,246,247,248,249,251
P49758-14	0.985	181	1.012	517.244	0.634	0.662	0.858	0.364	0.997	0.365	0.968	14,15,16,17,18,19,20,21,22,23,24,26,91,120,123,124 ,125,126,202,203,204,211,212,213,215,222,223,224,2 25,228,229,248,249,250,251
P49758-15	1.014	134	1.002	328.937	0.555	0.719	0.875	0.203	1.133	0.179	0.954	18,19,20,22,26,91,120,122,123,124,125,126,202,203, 204,212,213,215,223,224,225,226,228,229,230,231
P49758-16	1.007	94	1.026	365.981	0.612	0.724	0.949	0.681	0.98	0.695	0.479	1,2,3,117,118,124,126,130,133,134,137,141,173,177, 180,181,184,188,189,192,193,196,199,200
P49758-2	0.998	236	1.032	719.271	0.603	0.669	0.81	0.279	0.949	0.294	1.058	11,12,14,15,17,18,19,20,21,22,23,26,91,120,121,122 ,123,124,125,126,203,204,212,213,215,222,223,224,2 25,226,228,229,230,231,245,246,247,248,249,251
P49758-3	0.995	246	1.021	739.165	0.623	0.678	0.884	0.332	1	0.333	1.22	10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,26,91 ,120,121,122,123,124,125,126,203,204,212,213,215,2 22,223,224,225,226,227,228,229,230,231,245,246,247 ,249,251
P49758-5	1.007	134	1.007	334.425	0.552	0.709	0.868	0.193	1.099	0.175	1.266	20,22,26,91,120,123,124,125,126,203,204,212,213,21 4,215,223,225,226,228,229,230,231
P49758-6	1.078	111	1.038	221.921	0.517	0.815	1.127	0.888	1.2	0.74	0.567	1,2,3,115,117,118,124,126,129,130,133,134,137,138, 141,146,173,177,180,181,184,189,192,193,196,197,19 9,200
P49758-7	1.082	106	1.075	228.438	0.537	0.821	1.134	1.07	1.098	0.974	0.707	1,2,3,115,117,118,124,126,130,133,134,137,138,141, 146,177,180,181,184,189,192,193,196,197,199,200
P49758-8	0.988	215	1.018	680.855	0.637	0.661	0.843	0.273	0.976	0.279	1.264	12,13,14,15,16,17,18,19,20,21,22,23,24,26,91,120,1 23,124,125,126,202,203,204,211,212,213,214,215,222 ,223,224,225,226,227,228,229,230,247,248,249,250,2 51
P49758-9	0.93	68	0.807	143.031	0.561	0.786	1.11	0.49	1.35	0.363	0.464	1,2,3,117,118,134,137,138,141,146,177,180,181,184, 189,192,193,194,196,197

Protein Structure and Feature Comparision

Protein Structure Comparision Using Template Modeling Scores (TM-score).

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Canonical validated structure (PDB)(green)

3D view using mol* of P49758-4_P49758-4_2es0_A.pdb

Protein Structure Comparision Visualization with mol*. between Canonical validated structure (PDB)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of P49758-4_2es0_A_P49758-10.pdb

3D view using mol* of P49758-4_2es0_A_P49758-11.pdb

3D view using mol* of P49758-4_2es0_A_P49758-12.pdb

3D view using mol* of P49758-4_2es0_A_P49758-13.pdb

3D view using mol* of P49758-4_2es0_A_P49758-14.pdb

3D view using mol* of P49758-4_2es0_A_P49758-15.pdb

3D view using mol* of P49758-4_2es0_A_P49758-16.pdb

3D view using mol* of P49758-4_2es0_A_P49758-2.pdb

3D view using mol* of P49758-4_2es0_A_P49758-3.pdb

3D view using mol* of P49758-4_2es0_A_P49758-5.pdb

3D view using mol* of P49758-4_2es0_A_P49758-6.pdb

3D view using mol* of P49758-4_2es0_A_P49758-7.pdb

3D view using mol* of P49758-4_2es0_A_P49758-8.pdb

3D view using mol* of P49758-4_2es0_A_P49758-9.pdb

Protein Structure Comparision Visualization with mol*. between Canonical predicted structure (AF2)(orange) vs Alternative predicted structure (AF2)(green)

3D view using mol* of P49758-4_P49758-10.pdb

3D view using mol* of P49758-4_P49758-11.pdb

3D view using mol* of P49758-4_P49758-12.pdb

3D view using mol* of P49758-4_P49758-13.pdb

3D view using mol* of P49758-4_P49758-14.pdb

3D view using mol* of P49758-4_P49758-15.pdb

3D view using mol* of P49758-4_P49758-16.pdb

3D view using mol* of P49758-4_P49758-2.pdb

3D view using mol* of P49758-4_P49758-3.pdb

3D view using mol* of P49758-4_P49758-5.pdb

3D view using mol* of P49758-4_P49758-6.pdb

3D view using mol* of P49758-4_P49758-7.pdb

3D view using mol* of P49758-4_P49758-8.pdb

3D view using mol* of P49758-4_P49758-9.pdb

Protein Feature Comparison of the protein sequendary structures among the protiens.

./stats/secondary_structure/figure/P49758-4_vs_P49758-10.png

./stats/secondary_structure/figure/P49758-4_vs_P49758-11.png

./stats/secondary_structure/figure/P49758-4_vs_P49758-12.png

./stats/secondary_structure/figure/P49758-4_vs_P49758-13.png

./stats/secondary_structure/figure/P49758-4_vs_P49758-14.png

./stats/secondary_structure/figure/P49758-4_vs_P49758-15.png

./stats/secondary_structure/figure/P49758-4_vs_P49758-16.png

./stats/secondary_structure/figure/P49758-4_vs_P49758-2.png

./stats/secondary_structure/figure/P49758-4_vs_P49758-3.png

./stats/secondary_structure/figure/P49758-4_vs_P49758-5.png

./stats/secondary_structure/figure/P49758-4_vs_P49758-6.png

./stats/secondary_structure/figure/P49758-4_vs_P49758-7.png

./stats/secondary_structure/figure/P49758-4_vs_P49758-8.png

./stats/secondary_structure/figure/P49758-4_vs_P49758-9.png

Protein Feature Comparison of the relative accessible surface area (ASA) among the protiens.

./stats/relative_asa/P49758-4_vs_P49758-10.png

./stats/relative_asa/P49758-4_vs_P49758-11.png

./stats/relative_asa/P49758-4_vs_P49758-12.png

./stats/relative_asa/P49758-4_vs_P49758-13.png

./stats/relative_asa/P49758-4_vs_P49758-14.png

./stats/relative_asa/P49758-4_vs_P49758-15.png

./stats/relative_asa/P49758-4_vs_P49758-16.png

./stats/relative_asa/P49758-4_vs_P49758-2.png

./stats/relative_asa/P49758-4_vs_P49758-3.png

./stats/relative_asa/P49758-4_vs_P49758-5.png

./stats/relative_asa/P49758-4_vs_P49758-6.png

./stats/relative_asa/P49758-4_vs_P49758-7.png

./stats/relative_asa/P49758-4_vs_P49758-8.png

./stats/relative_asa/P49758-4_vs_P49758-9.png

Protein-Protein Interaction

Interactors from UniProt.

Accession_id

Subsection

Start

End

Funcitonal feature

Splicing information

Interactors from STRING.

Gene name

Interactors

Related Drugs to RGS6

Drugs targeting this gene/protein.
(DrugBank)

UniProt accession

Gene name

DrugBank ID

Drug name

Drug group

Actions

Related Diseases to RGS6

Previous studies relating to the alternative splicing of RGS6 and disease information from the MeSH term (PubMed)

Gene

PMID

Title

Abstract

MeSH ID

MeSH term

Clinically important variants in RGS6

(ClinVar, 04/20/2024)

accession_id

uniprot_id

gene_name

Type

Variant

Clinical_significance